Drp1-Dependent Mitochondrial Fission Plays Critical Roles in Physiological and Pathological Progresses in Mammals

Hu, Chenxia; Huang, Yong; Li, Lanjuan

doi:10.3390/ijms18010144

Cited by 303Mitochondrial Function and PathologyAutophagy in Disease and TherapyCell death mechanisms and regulation

Drp1-Dependent Mitochondrial Fission Plays Critical Roles in Physiological and Pathological Progresses in Mammals

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Hu, Chenxia, Huang, Yong, Li, Lanjuan·2017·International Journal of Molecular Sciences

DOI 10.3390/ijms18010144PMC PMC5297777

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Abstract

Current research has demonstrated that mitochondrial morphology, distribution, and function are maintained by the balanced regulation of mitochondrial fission and fusion, and perturbation of the homeostasis between these processes has been related to cell or organ dysfunction and abnormal mitochondrial redistribution. Abnormal mitochondrial fusion induces the fragmentation of mitochondria from a tubular morphology into pieces; in contrast, perturbed mitochondrial fission results in the fusion of adjacent mitochondria. A member of the dynamin family of large GTPases, dynamin-related protein 1 (Drp1), effectively influences cell survival and apoptosis by mediating the mitochondrial fission process in mammals. Drp1-dependent mitochondrial fission is an intricate process regulating both cellular and organ dynamics, including development, apoptosis, acute organ injury, and various diseases. Only after clarification of the regulative mechanisms of this critical protein in vivo and in vitro will it set a milestone for preventing mitochondrial fission related pathological processes and refractory diseases.

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Mitochondrial fission-fusion dynamics through alterations of Drp1, Parkin, and Pink1 functions are disrupted in various neurodegenerative diseases, including Parkinson's disease and Alzheimer's disease.
“Mitochondrial fission-fusion dynamics through alterations of Drp1, Parkin, and Pink1 functions (23,24), which play essential roles in mitophagy induction and mitochondrial quality control during healthy brain aging, are disrupted in various neurodegenerative diseases, including Parkinson’s disease (PD) and AD (25).”
From Alzheimer's Disease–Associated Amyloid-β Precursor Protein Prevents Aging Stress–Induced Mitophagy and Fumarate Depletion to Improve Antitumor Immunity (2025) · cites this paper as [25]
Section 6 (page unavailable) links altered Drp1-dependent mitochondrial dynamics to Parkinson’s and Alzheimer’s diseases and discusses parkin’s effects on neuronal mitochondrial morphology. Its PINK1 discussion concerns ischemic injury, not disruption in those neurodegenerative diseases; the copy does not establish the claimed disease link for all three proteins. (LLM, conf=0.86)
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Pim-1 preserves mitochondrial morphology by inhibiting dynamin-related protein 1 translocation
Din, S., Mason, M., Völkers, M., Johnson, B., Cottage, C. T., Wang, Z., Joyo, A. Y., Quijada, P. J., Erhardt, P., Magnuson, N. S., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1213294110 · Cited by 134 · see citing works
Growth Factorerv1-like Modulates Drp1 to Preserve Mitochondrial Dynamics and Function in Mouse Embryonic Stem Cells
Todd, L. R., Damin, M. N., Gomathinayagam, R., Horn, S. R. G.-V., Means, A. R., & Sankar, U. (2010) · Molecular Biology of the Cell · doi:10.1091/mbc.e09-11-0937 · Cited by 127 · see citing works
Disturbed mitochondrial and peroxisomal dynamics due to loss of MFF causes Leigh-like encephalopathy, optic atrophy and peripheral neuropathy
Koch, J., Feichtinger, R. G., Freisinger, P., Pies, M., Schrödl, F., Iuso, A., Sperl, W., Mayr, J. A., Prokisch, H., & Haack, T. B. (2016) · Journal of Medical Genetics · doi:10.1136/jmedgenet-2015-103500 · Cited by 127 · see citing works
MARCH5-mediated quality control on acetylated Mfn1 facilitates mitochondrial homeostasis and cell survival
Park, Y.-Y., Nguyen, T. K. O., Kang, H. C., & Cho, H. (2014) · Cell Death and Disease · doi:10.1038/cddis.2014.142 · Cited by 126 · see citing works
Blockage of GSK3β-mediated Drp1 phosphorylation provides neuroprotection in neuronal and mouse models of Alzheimer's disease
Yan, J., Liu, X.-H., Han, M., Wang, Y., Sun, X., Yu, N., Li, T., Su, B., & Chen, Z.-Y. (2014) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2014.08.005 · Cited by 125 · see citing works
S-Nitrosylation of Dynamin-Related Protein 1 Mediates Mutant Huntingtin-Induced Mitochondrial Fragmentation and Neuronal Injury in Huntington's Disease
Haun, F., Nakamura, T., Shiu, A. D., Cho, D.-H., Tsunemi, T., Holland, E. A., Spada, A. R. L., & Lipton, S. A. (2013) · Antioxidants and Redox Signaling · doi:10.1089/ars.2012.4928 · Cited by 125 · see citing works
DRP1 inhibition rescues retinal ganglion cells and their axons by preserving mitochondrial integrity in a mouse model of glaucoma
Kim, K., Perkins, G. A., Shim, M. S., Bushong, E., Alcasid, N. J., Ju, S., Ellisman, M. H., Weinreb, R. N., & Ju, W.-K. (2015) · Cell Death and Disease · doi:10.1038/cddis.2015.180 · Cited by 123 · see citing works
GSK3beta-Mediated Drp1 Phosphorylation Induced Elongated Mitochondrial Morphology against Oxidative Stress
Chou, C., Lin, C., Yang, M., Wei, C., Liao, H.-D., Lin, R.-C., Tu, W., Kao, T.-C., Hsu, C., Cheng, J., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0049112 · Cited by 122 · see citing works
AMPK Regulates ER Morphology and Function in Stressed Pancreatic β-Cells via Phosphorylation of DRP1
Wikström, J. D., Israeli, T., Bachar-Wikström, E., Swisa, A., Ariav, Y., Waiss, M., Kaganovich, D., Dor, Y., Cerasi, E., & Leibowitz, G. (2013) · Molecular Endocrinology · doi:10.1210/me.2013-1109 · Cited by 119 · see citing works
Nitric oxide inhibition of Drp1-mediated mitochondrial fission is critical for myogenic differentiation
Palma, C. D., Falcone, S., Pisoni, S., Cipolat, S., Panzeri, C., Pambianco, S., Pisconti, A., Allevi, R., Bassi, M. T., Cossu, G., et al. (2010) · Cell Death and Differentiation · doi:10.1038/cdd.2010.48 · Cited by 117 · see citing works
Drp1, Mff, Fis1, and MiD51 are coordinated to mediate mitochondrial fission during UV irradiation‐induced apoptosis
Zhang, Z., Liu, L., Wu, S., & Xing, D. (2015) · The FASEB Journal · doi:10.1096/fj.15-274258 · Cited by 117 · see citing works
Cyclin-dependent kinases regulate splice-specific targeting of dynamin-related protein 1 to microtubules
Strack, S., Wilson, T. J., & Cribbs, J. T. (2013) · The Journal of Cell Biology · doi:10.1083/jcb.201210045 · Cited by 113 · see citing works
Cytoplasmic Irradiation Results in Mitochondrial Dysfunction and DRP1-Dependent Mitochondrial Fission
Zhang, B., Davidson, M. M., Zhou, H., Wang, C., Walker, W. F., & Hei, T. K. (2013) · Cancer Research · doi:10.1158/0008-5472.can-13-1411 · Cited by 112 · see citing works
Mfn2 downregulation in excitotoxicity causes mitochondrial dysfunction and delayed neuronal death
Riera, A. M., Segarra‐Mondejar, M., Muñoz, J. P., Ginet, V., Olloquequi, J., Pérez‐Clausell, J., Palacı́n, M., Reina, M., Puyal, J., Zorzano, A., et al. (2014) · The EMBO Journal · doi:10.15252/embj.201488327 · Cited by 112 · see citing works
Drp1-mediated mitochondrial fission promotes cell proliferation through crosstalk of p53 and NF-κB pathways in hepatocellular carcinoma
Zhan, L., Cao, H., Wang, G., Lyu, Y., Sun, X., An, J., Wu, Z., Huang, Q., Liu, B.-R., & Xing, J. (2016) · Oncotarget · doi:10.18632/oncotarget.11339 · Cited by 108 · see citing works
Drp1 levels constitutively regulate mitochondrial dynamics and cell survival in cortical neurons
Uo, T., Dworzak, J., Kinoshita, C., Inman, D. M., Kinoshita, Y., Horner, P. J., & Morrison, R. S. (2009) · Experimental Neurology · doi:10.1016/j.expneurol.2009.05.010 · Cited by 106 · see citing works
Drp1 Loss-of-function Reduces Cardiomyocyte Oxygen Dependence Protecting the Heart From Ischemia-reperfusion Injury
Zepeda, R. J., Kuzmicic, J., Parra, V., Troncoso, R., Pennanen, C., Riquelme, J. A., Pedrozo, Z., Chiong, M., Sánchez, G., & Lavandero, S. (2014) · Journal of Cardiovascular Pharmacology · doi:10.1097/fjc.0000000000000071 · Cited by 106 · see citing works
Drp1 Mediates Caspase-Independent Type III Cell Death in Normal and Leukemic Cells
Bras, M., Yuste, V. J., Roué, G., Barbier, S., Sancho, P., Virely, C., Rubio, M., Baudet, S., Esquerda, J. E., Merle‐Béral, H., et al. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.02116-06 · Cited by 103 · see citing works
Inhibition of Drp1-dependent mitochondrial division impairs myogenic differentiation
Kim, B., Kim, J.-S., Yoon, Y., Santiago, M. C., Brown, M. D., & Park, J. (2013) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00502.2012 · Cited by 103 · see citing works
Dynamin-related Protein 1 Oligomerization in Solution Impairs Functional Interactions with Membrane-anchored Mitochondrial Fission Factor
Clinton, R. W., Francy, C. A., Ramachandran, R., Qi, X., & Mears, J. A. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.680025 · Cited by 103 · see citing works
Mitochondrial Calcium Uniporter MCU Supports Cytoplasmic Ca2+ Oscillations, Store-Operated Ca2+ Entry and Ca2+-Dependent Gene Expression in Response to Receptor Stimulation
Samanta, K., Douglas, S. G., & Parekh, A. B. (2014) · PLoS ONE · doi:10.1371/journal.pone.0101188 · Cited by 102 · see citing works
Regulation of mitochondrial morphology by APC/CCdh1-mediated control of Drp1 stability
Horn, S. R. G.-V., Thomenius, M. J., Johnson, E. S., Freel, C. D., Wu, J. Q., Coloff, J. L., Yang, C., Tang, W., An, J., Ilkayeva, O., et al. (2011) · Molecular Biology of the Cell · doi:10.1091/mbc.e10-07-0567 · Cited by 101 · see citing works
Novel combination of mitochondrial division inhibitor 1 (mdivi-1) and platinum agents produces synergistic pro-apoptotic effect in drug resistant tumor cells
Qian, W., Wang, J., Roginskaya, V. Y., McDermott, L. A., Edwards, R. P., Stolz, D. B., Llambi, F., Green, D. R., & Houten, B. V. (2014) · Oncotarget · doi:10.18632/oncotarget.1944 · Cited by 101 · see citing works
Mitochondria: A kinase anchoring protein 1, a signaling platform for mitochondrial form and function
Merrill, R. A., & Strack, S. (2014) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2013.12.012 · Cited by 100 · see citing works
Postnatal microcephaly and pain insensitivity due to a de novo heterozygous DNM1L mutation causing impaired mitochondrial fission and function
Sheffer, R. N., Douiev, L., Edvardson, S., Shaag, A., Tamimi, K., Soiferman, D., Meiner, V., & Saada, A. (2016) · American Journal of Medical Genetics Part A · doi:10.1002/ajmg.a.37624 · Cited by 100 · see citing works
Role of Dynamin-Related Protein 1 (Drp1)-Mediated Mitochondrial Fission in Oxygen Sensing and Constriction of the Ductus Arteriosus
Hong, Z., Kutty, S., Tóth, P. T., Marsboom, G., Hammel, J. M., Chamberlain, C., Ryan, J. J., Zhang, H. J., Sharp, W. W., Morrow, E., et al. (2013) · Circulation Research · doi:10.1161/circresaha.111.300285 · Cited by 99 · see citing works
Distinct Splice Variants of Dynamin-related Protein 1 Differentially Utilize Mitochondrial Fission Factor as an Effector of Cooperative GTPase Activity
Macdonald, P. J., Francy, C. A., Stepanyants, N., Lehman, L., Baglio, A. J., Mears, J. A., Qi, X., & Ramachandran, R. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.680181 · Cited by 96 · see citing works
Sodium butyrate induces DRP1-mediated mitochondrial fusion and apoptosis in human colorectal cancer cells
Tailor, D., Hahm, E., Kale, R. K., Singh, S. V., & Singh, R. P. (2013) · Mitochondrion · doi:10.1016/j.mito.2013.10.004 · Cited by 94 · see citing works
Ugo1 and Mdm30 act sequentially during Fzo1-mediated mitochondrial outer membrane fusion
den Brave, F., Fres, J. M., Schauss, A. C., Pinson, B., Praefcke, G. J. K., Langer, T., & Escobar‐Henriques, M. (2011) · Journal of Cell Science · doi:10.1242/jcs.073080 · Cited by 92 · see citing works
Dynamin-related protein Drp1 is required for Bax translocation to mitochondria in response to irradiation-induced apoptosis
Wang, P., Wang, P., Liu, B., Zhao, J., Pang, Q., Agrawal, S. G., Jia, L., & Liu, F. (2015) · Oncotarget · doi:10.18632/oncotarget.4200 · Cited by 84 · see citing works
Cyclosporine A-induced apoptosis in renal tubular cells is related to oxidative damage and mitochondrial fission
de Arriba, G., Calvino, M., Martínez, S. B., & Parra, T. (2013) · Toxicology Letters · doi:10.1016/j.toxlet.2013.01.007 · Cited by 83 · see citing works
SENP5, a SUMO isopeptidase, induces apoptosis and cardiomyopathy
Kim, E. Y., Zhang, Y., Beketaev, I., Segura, A. M., Yu, W., Xi, Y. T., Chang, J., & Wang, J. (2014) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2014.08.003 · Cited by 78 · see citing works
Regulation of Mitochondrial Morphology by Positive Feedback Interaction Between PKCδ and Drp1 in Vascular Smooth Muscle Cell
Lim, S., Lee, S., Seo, H., Ham, O., Lee, C., Park, J., Lee, J., Seung, M., Yun, I., Han, S. M., et al. (2014) · Journal of Cellular Biochemistry · doi:10.1002/jcb.25016 · Cited by 74 · see citing works
Suppressor of cytokine signaling 6 (SOCS6) promotes mitochondrial fission via regulating DRP1 translocation
Lin, H., Lai, R.-H., St, L., Lin, R.-C., Wang, M.-J., Lin, C.-C., Lee, H.-C., Ff, W., & Chen, J.-Y. (2012) · Cell Death and Differentiation · doi:10.1038/cdd.2012.106 · Cited by 73 · see citing works
Mitochondrial translocation and interaction of cofilin and Drp1 are required for erucin-induced mitochondrial fission and apoptosis
Li, G., Zhou, J., Budhraja, A., Hu, X., Chen, Y., Cheng, Q., Liu, L., Zhou, T., Li, P., Liu, E., et al. (2014) · Oncotarget · doi:10.18632/oncotarget.2795 · Cited by 72 · see citing works
Rhein Protects Pancreatic β-Cells From Dynamin-Related Protein-1–Mediated Mitochondrial Fission and Cell Apoptosis Under Hyperglycemia
Liu, J., Chen, Z., Zhang, Y., Zhang, M., Zhu, X., Fan, Y., Shi, S., Zen, K., & Liu, Z. (2013) · Diabetes · doi:10.2337/db13-0251 · Cited by 72 · see citing works
Astaxanthin prevents pulmonary fibrosis by promoting myofibroblast apoptosis dependent on Drp1‐mediated mitochondrial fission
Zhang, J., Xu, P., Wang, Y., Wang, M., Li, H., Lin, S., Mao, C., Wang, B., Song, X., & Lv, C. (2015) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.12609 · Cited by 71 · see citing works
Optimized two-color super resolution imaging of Drp1 during mitochondrial fission with a slow-switching Dronpa variant
Rosenbloom, A. B., Lee, S.-H., To, M., Lee, A., Shin, J. Y., & Bustamante, C. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1320044111 · Cited by 71 · see citing works
Amelioration of rhabdomyolysis-induced renal mitochondrial injury and apoptosis through suppression of Drp-1 translocation
Tang, W., Wu, W., Qiu, H., Bo, H., & Huang, S. (2013) · Journal of Nephrology · doi:10.5301/jn.5000268 · Cited by 65 · see citing works
Stress-Induced Nuclear-to-Cytoplasmic Translocation of Cyclin C Promotes Mitochondrial Fission in Yeast
Cooper, K. F., Khakhina, S., Kim, S. K., & Strich, R. (2014) · Developmental Cell · doi:10.1016/j.devcel.2013.12.009 · Cited by 64 · see citing works
A reduction in Drp1-mediated fission compromises mitochondrial health in autosomal recessive spastic ataxia of Charlevoix Saguenay
Bradshaw, T. Y., Romano, L. E. L., Duncan, E. J., Nethisinghe, S., Abeti, R., Michael, G. J., Giunti, P., Vermeer, S., & Chapple, J. P. (2016) · Human Molecular Genetics · doi:10.1093/hmg/ddw173 · Cited by 58 · see citing works
Crystal structure and functional analysis of MiD49, a receptor for the mitochondrial fission protein Drp1
Losón, O. C., Meng, S., Ngo, H., Liu, R., Kaiser, J. T., & Chan, D. C. (2015) · Protein Science · doi:10.1002/pro.2629 · Cited by 57 · see citing works
Declines in Drp1 and Parkin Expression Underlie DNA Damage-Induced Changes in Mitochondrial Length and Neuronal Death
Wang, D. B., Garden, G. A., Kinoshita, C., Wyles, C. C., Babazadeh, N., Sopher, B. L., Kinoshita, Y., & Morrison, R. S. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.3365-12.2013 · Cited by 54 · see citing works
Mitochondrial division inhibitor-1 induces mitochondrial hyperfusion and sensitizes human cancer cells to TRAIL-induced apoptosis
Akita, M., Suzuki‐Karasaki, M., Fujiwara, K., Nakagawa, C., Soma, M., Yoshida, Y., Ochiai, T., Tokuhashi, Y., & Suzuki‐Karasaki, Y. (2014) · International Journal of Oncology · doi:10.3892/ijo.2014.2608 · Cited by 50 · see citing works
Sabutoclax (BI97C1) and BI112D1, Putative Inhibitors of MCL-1, Induce Mitochondrial Fragmentation Either Upstream of or Independent of Apoptosis
Varadarajan, S., Butterworth, M., Wei, J., Pellecchia, M., Dinsdale, D. D., & Cohen, G. M. (2013) · Neoplasia · doi:10.1593/neo.13230 · Cited by 49 · see citing works
Dynamin-related protein 1 (Drp1) mediating mitophagy contributes to the pathophysiology of nervous system diseases and brain injury.
Wu, Q., Luo, C.-L., & Tao, L. (2017) · Histology and Histopathology · doi:10.14670/hh-11-841 · Cited by 48 · see citing works
Necrostatin-1 Attenuates Ischemia Injury Induced Cell Death in Rat Tubular Cell Line NRK-52E through Decreased Drp1 Expression
Zhang, L., Jiang, F., Chen, Y., Luo, J., Liu, S., Zhang, B., Ye, Z., Wang, W., Liang, X., & Shi, W. (2013) · International Journal of Molecular Sciences · doi:10.3390/ijms141224742 · Cited by 47 · see citing works
N‐terminal phosphorylation of protein phosphatase 2A/Bβ2 regulates translocation to mitochondria, dynamin‐related protein 1 dephosphorylation, and neuronal survival
Merrill, R. A., Slupe, A. M., & Strack, S. (2012) · FEBS Journal · doi:10.1111/j.1742-4658.2012.08631.x · Cited by 46 · see citing works
Beta-nodavirus B2 protein induces hydrogen peroxide production, leading to Drp1-recruited mitochondrial fragmentation and cell death via mitochondrial targeting
Su, Y., Chiu, H. W., Hung, J.-C., & Hong, J. (2014) · APOPTOSIS · doi:10.1007/s10495-014-1016-x · Cited by 46 · see citing works
Drp1 Is Dispensable for Mitochondria Biogenesis in Induction to Pluripotency but Required for Differentiation of Embryonic Stem Cells
Wang, L., Ye, X., Zhao, Q., Zhou, Z., Dan, J., Zhu, Y., Chen, Q., & Liu, L. (2014) · Stem Cells and Development · doi:10.1089/scd.2014.0059 · Cited by 45 · see citing works
Death-associated Protein 3 Regulates Mitochondrial-encoded Protein Synthesis and Mitochondrial Dynamics
Xiao, L., Xian, H., Lee, K. Y., Xiao, B., Wang, H., Yu, F., Shen, H., & Liou, Y. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.673343 · Cited by 44 · see citing works
Roles of PTEN-induced putative kinase 1 and dynamin-related protein 1 in transient global ischemia-induced hippocampal neuronal injury
Chen, S., Lin, T., Yang, D., Lee, S.-Y., Shaw, F.-Z., Liou, C., & Chuang, Y. (2015) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2015.03.045 · Cited by 44 · see citing works
Inhibition of Drp1 by Mdivi-1 attenuates cerebral ischemic injury via inhibition of the mitochondria-dependent apoptotic pathway after cardiac arrest
Li, Y., Wang, P., Wei, J., Fan, R. Z., Zuo, Y., Shi, M., Wu, H., Zhou, M., Lin, J., Mei-yuan, W., et al. (2015) · Neuroscience · doi:10.1016/j.neuroscience.2015.10.020 · Cited by 43 · see citing works
A novel mitochondrial pool of Cyclin E, regulated by Drp1, is linked to cell density dependent cell proliferation
Parker, D. J., Iyer, A. P., Shah, S., Moran, A., Hjelmeland, A. B., Basu, M. K., Liu, R., & Mitra, K. (2015) · Journal of Cell Science · doi:10.1242/jcs.172429 · Cited by 42 · see citing works
Bax is essential for Drp1‐mediated mitochondrial fission but not for mitochondrial outer membrane permeabilization caused by photodynamic therapy
Wu, S., Zhou, F., Zhang, Z., & Xing, D. (2010) · Journal of Cellular Physiology · doi:10.1002/jcp.22362 · Cited by 40 · see citing works
Interaction with the effector dynamin-related protein 1 (Drp1) is an ancient function of Rab32 subfamily proteins
Ortiz-Sandoval, C. G., Hughes, S. C., Dacks, J. B., & Simmen, T. (2014) · Cellular Logistics · doi:10.4161/21592799.2014.986399 · Cited by 40 · see citing works
TRAP1 Controls Mitochondrial Fusion/Fission Balance through Drp1 and Mff Expression
Takamura, H., Koyama, Y., Matsuzaki, S., Yamada, K., Hattori, T., Miyata, S., Takemoto, K., Tohyama, M., & Katayama, T. (2012) · PLoS ONE · doi:10.1371/journal.pone.0051912 · Cited by 39 · see citing works
Drp 1 is dispensable for apoptotic cytochrome c release in primed MCF 10 A and fibroblast cells but affects Bcl ‐2 antagonist‐induced respiratory changes
Clerc, P., Ge, S. X., Hwang, H., Waddell, J., Roelofs, B. A., Karbowski, M., Sesaki, H., & Polster, B. M. (2013) · British Journal of Pharmacology · doi:10.1111/bph.12515 · Cited by 38 · see citing works
Peroxisome proliferator-activated receptor-gamma dependent pathway reduces the phosphorylation of dynamin-related protein 1 and ameliorates hippocampal injury induced by global ischemia in rats
Chuang, Y., Lin, T., Yang, D., Yang, J., Liou, C., & Chen, S. (2016) · Journal of Biomedical Science · doi:10.1186/s12929-016-0262-3 · Cited by 38 · see citing works
Mitochondrial morphology and cellular distribution are altered in SPG31 patients and are linked to DRP1 hyperphosphorylation
Lavie, J., Serrat, R., Bellancé, N., Courtand, G., Dupuy, J., Tesson, C., Coupry, I., Brice, A., Lacombe, D., Dürr, A., et al. (2016) · Human Molecular Genetics · doi:10.1093/hmg/ddw425 · Cited by 38 · see citing works
Phosphorylation and ubiquitination of dynamin‐related proteins (AtDRP3A/3B) synergically regulate mitochondrial proliferation during mitosis
Wang, F., Liu, P., Zhang, Q., Zhu, J. C., Chen, T., Arimura, S., Tsutsumi, N., & Lin, J. (2012) · The Plant Journal · doi:10.1111/j.1365-313x.2012.05052.x · Cited by 38 · see citing works
A receptor tyrosine kinase inhibitor, Tyrphostin A9 induces cancer cell death through Drp1 dependent mitochondria fragmentation
Park, S. J., Park, Y. J., Shin, J. H., Kim, E. S., Hwang, J. J., Jin, D., Kim, J. C., & Cho, D. (2011) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2011.04.053 · Cited by 34 · see citing works
Small Molecule Inhibition of the Bcl-XL-BH3 Protein-Protein Interaction: Proof-of-Concept of an In Vivo Chemopotentiator ABT-737
Stauffer, S. R. (2007) · Current Topics in Medicinal Chemistry · doi:10.2174/156802607780906843 · Cited by 33 · see citing works
Appoptosin interacts with mitochondrial outer-membrane fusion proteins and regulates mitochondrial morphology
Zhang, C., Shi, Z., Zhang, L., Zhou, Z., Zheng, X., Liu, G., Bu, G., Fraser, P. E., Xu, H., & Zhang, Y. (2016) · Journal of Cell Science · doi:10.1242/jcs.176792 · Cited by 33 · see citing works
Early Stage Functions of Mitochondrial Autophagy and Oxidative Stress in Acetaminophen‐Induced Liver Injury
Gao, Y., Chu, S., Zhang, Z., Zuo, W., Xia, C., Ai, Q., Luo, P., Cao, P., & Chen, N. (2016) · Journal of Cellular Biochemistry · doi:10.1002/jcb.25788 · Cited by 32 · see citing works
Parkin suppresses Drp1-independent mitochondrial division
Roy, M., Itoh, K., Iijima, M., & Sesaki, H. (2016) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2016.05.038 · Cited by 32 · see citing works
A novel Gfer-Drp1 link in preserving mitochondrial dynamics and function in pluripotent stem cells
Todd, L. R., Gomathinayagam, R., & Sankar, U. (2010) · Autophagy · doi:10.4161/auto.6.6.12625 · Cited by 31 · see citing works
Mitochondrial chaperone DnaJA3 induces Drp1-dependent mitochondrial fragmentation
Elwi, A. N., Lee, B., Meijndert, H. C., Braun, J. E. A., & Kim, S.-W. (2012) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2012.05.004 · Cited by 26 · see citing works
Endoplasmic reticulum‐specific BH3‐only protein BNIP1 induces mitochondrial fragmentation in a Bcl‐2‐ and Drp1‐dependent manner
Ryu, S., Choi, K., Yoon, J. W., Kim, S., & Choi, C. (2011) · Journal of Cellular Physiology · doi:10.1002/jcp.23044 · Cited by 25 · see citing works
Drp1 in Ischemic Neuronal Death: An Unusual Suspect
Pradeep, H., Sharma, B., & Rajanikant, G. K. (2014) · Current Medicinal Chemistry · doi:10.2174/0929867321666131228203513 · Cited by 25 · see citing works
The Drosophila retinoblastoma protein, Rbf1, induces a debcl and drp1-dependent mitochondrial apoptosis.
Clavier, A., Ruby, V., Rincheval‐Arnold, A., Mignotte, B., & Guénal, I. (2015) · Journal of Cell Science · doi:10.1242/jcs.169896 · Cited by 20 · see citing works
Cytotoxicity of Ultrafine Monodispersed Nanoceria on Human Gastric Cancer Cells
Li, C., Zhao, W., Liu, B., Xu, G., Liu, L., Lv, H., Shang, D., Yang, D., Damirin, A., & Zhang, J. (2014) · Journal of Biomedical Nanotechnology · doi:10.1166/jbn.2014.1863 · Cited by 19 · see citing works

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Mitochondrial Dysfunction and Oxidative Stress in Alzheimer’s Disease
Misrani, A., Tabassum, S., & Yang, L. (2021) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2021.617588 · Cited by 654 · see citing works
Reactive Oxygen Species and Mitochondrial Dynamics: The Yin and Yang of Mitochondrial Dysfunction and Cancer Progression
Ježek, J., Cooper, K. F., & Strich, R. (2018) · Antioxidants · doi:10.3390/antiox7010013 · Cited by 515 · see citing works
Drp1-dependent mitochondrial fission in cardiovascular disease
Jin, J., Wei, X., Zhi, X., Wang, X., & Meng, D. (2020) · Acta Pharmacologica Sinica · doi:10.1038/s41401-020-00518-y · Cited by 386 · see citing works
Mitofusin 2: from functions to disease
Filadi, R., Pendin, D., & Pizzo, P. (2018) · Cell Death and Disease · doi:10.1038/s41419-017-0023-6 · Cited by 359 · see citing works
High-fat diet promotes renal injury by inducing oxidative stress and mitochondrial dysfunction
Sun, Y., Ge, X., Li, X., He, J., Wei, X., Du, J., Sun, J. H., Li, X., Xun, Z., Liu, W., et al. (2020) · Cell Death and Disease · doi:10.1038/s41419-020-03122-4 · Cited by 331 · see citing works
Mitochondrial dysfunction and oxidative stress in Alzheimer’s disease, and Parkinson’s disease, Huntington’s disease and Amyotrophic Lateral Sclerosis -An updated review
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Authors: Hu, C., Huang, Y., & Li, L.
Affiliations: First Affiliated Hospital Zhejiang University (CN)
Corresponding author: Li, Lanjuan
ORCID: Hu, Chenxia
Huang, Yong
Li, Lanjuan
Venue: International Journal of Molecular Sciences
Publisher: MDPI AG
Published: 2017-01-13
Volume: 18
Issue: 1
Pages: 144
ISSN: 1422-0067 (ISSN-L)
DOI: 10.3390/ijms18010144
PMC: PMC5297777
OpenAlex: W2573555074
Cited by: 302
References: 144
Citations by year: 2026: 27 · 2025: 34 · 2024: 33 · 2023: 32 · 2022: 29 · 2021: 36 · 2020: 35 · 2019: 27 · 2018: 28 · 2017: 18 · 2016: 1
FWCI: 2.76
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (vor)
Locations: International Journal of Molecular Sciences (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders: National Natural Science Foundation of China (81471794, 10002004, 81121002)
Science Fund for Creative Research Groups
National Science and Technology Major Project (2012ZX10002004)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
Keywords: Drp1, mitochondrial fission, mitochondrial fusion, mitochondrial morphology, apoptosis, mitochondrial distribution, organ damage, mitochondrial homeostasis, mitochondrial disease
MeSH terms: Animals, Disease, Humans, Mammals, Protein Processing, Post-Translational, Apoptosis, Dynamins, Mitochondrial Dynamics

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Drp1-Dependent Mitochondrial Fission Plays Critical Roles in Physiological and Pathological Progresses in Mammals

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