Impaired Mitochondrial Dynamics and Bioenergetics in Diabetic Skeletal Muscle
Open accessAbstract
In most cells, mitochondria are highly dynamic organelles that constantly fuse, divide and move. These processes allow mitochondria to redistribute in a cell and exchange contents among the mitochondrial population, and subsequently repair damaged mitochondria. However, most studies on mitochondrial dynamics have been performed on cultured cell lines and neurons, and little is known about whether mitochondria are dynamic organelles in vivo, especially in the highly specialized and differentiated adult skeletal muscle cells. Using mitochondrial matrix-targeted photoactivatable green fluorescent protein (mtPAGFP) and electroporation methods combined with confocal microscopy, we found that mitochondria are dynamic in skeletal muscle in vivo, which enables mitochondria exchange contents within the whole mitochondrial population through nanotunneling-mediated mitochondrial fusion. Mitochondrial network promotes rapid transfer of mtPAGFP within the cell. More importantly, the dynamic behavior was impaired in high-fat diet (HFD)-induced obese mice, accompanying with disturbed mitochondrial respiratory function and decreased ATP content in skeletal muscle. We further found that proteins controlling mitochondrial fusion MFN1 and MFN2 but not Opa1 were decreased and proteins governing mitochondrial fission Fis1 and Drp1 were increased in skeletal muscle of HFD-induced mice when compared to normal diet-fed mice. Altogether, we conclude that mitochondria are dynamic organelles in vivo in skeletal muscle, and it is essential in maintaining mitochondrial respiration and bioenergetics.
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Disruptions in mitochondrial dynamics can lead to aberrant mitochondrial morphology, compromised respiratory function, and decreased ATP content in skeletal muscle.
“Disruptions in mitochondrial dynamics can lead to aberrant mitochondrial morphology, compromised respiratory function, and decreased ATP content in skeletal muscle [60].”
From Mitochondrial Adaptation in Skeletal Muscle: Impact of Obesity, Caloric Restriction, and Dietary Compounds (2024) · cites this paper as [60]
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- Authors
- Liu, R., Jin, P., LiqunYu, Wang, Y., Han, L., Shi, T., & Li, X.
- Affiliations
- Wenzhou Medical University (CN)
- Venue
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2014-03-21
- Volume
- 9
- Issue
- 3
- Pages
- e92810
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC3962456
- OpenAlex
- W2090843323
- Cited by
- 146
- References
- 44
- Citations by year
- 2026: 2 · 2025: 9 · 2024: 16 · 2023: 11 · 2022: 6 · 2021: 14 · 2020: 17 · 2019: 9 · 2018: 18 · 2017: 14 · 2016: 10 · 2015: 14 · 2014: 6
- FWCI
- 6.02
- Type
- journal article
- Language
- en
- Update notices
- correction (2014-06-19)
- Open access
- gold
- doi.org
- Locations
- PLoS ONE (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Figshare (submittedVersion, cc-by)
- Funders
- National Natural Science Foundation of China (81100138)
- Wenzhou Municipal Science and Technology Bureau
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Keywords
- mitochondrial dynamics, mitochondrial fusion, mitochondrial fission, skeletal muscle, diabetes mellitus, high-fat diet, obesity, mitochondrial respiration, bioenergetics, Mfn1, mitofusin 2, Drp1, Fis1, OPA1, ATP levels
- MeSH terms
- Adenosine Triphosphate, Animals, Diabetes Mellitus, Diabetes Mellitus, Experimental, Energy Metabolism, Male, Mitochondria, Muscle, Obesity, Oxygen Consumption, Muscle, Skeletal, Mice, Diet, High-Fat, Mitochondrial Dynamics
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