Rapamycin upregulates glutamate transporter and IL-6 expression in astrocytes in a mouse model of Parkinson’s disease

TGFβ in the Context of an Inflammatory Cytokine Milieu Supports De Novo Differentiation of IL-17-Producing T Cells

Veldhoen, M., Hocking, R. J., Atkins, C. J., Locksley, R. M., & Stockinger, B. (2006) · Immunity · doi:10.1016/j.immuni.2006.01.001 · Cited by 3,605 · see citing works

mTOR is a key modulator of ageing and age-related disease

Johnson, S. C., Rabinovitch, P. S., & Kaeberlein, M. (2013) · Nature · doi:10.1038/nature11861 · Cited by 1,676 · see citing works

Melanized dopaminergic neurons are differentially susceptible to degeneration in Parkinson's disease

Hirsch, E., Graybiel, A. M., & Agid, Y. A. (1988) · Nature · doi:10.1038/334345a0 · Cited by 1,301 · see citing works

Protocol for the MPTP mouse model of Parkinson's disease

Jackson-Lewis, V. R., & Przedborski, S. (2007) · Nature Protocols · doi:10.1038/nprot.2006.342 · Cited by 1,118 · see citing works

Soluble Oligomers of Amyloid β Protein Facilitate Hippocampal Long-Term Depression by Disrupting Neuronal Glutamate Uptake

Li, S., Hong, S., Shepardson, N. E., Walsh, D. M., Shankar, G. M., & Selkoe, D. (2009) · Neuron · doi:10.1016/j.neuron.2009.05.012 · Cited by 972 · see citing works

Oxidative stress and Parkinson’s disease

Blesa, J., Trigo-Damas, I., Quiroga-Varela, A., & Jackson-Lewis, V. R. (2015) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2015.00091 · Cited by 878 · see citing works

Understanding Dopaminergic Cell Death Pathways in Parkinson Disease

Michel, P. P., Hirsch, É. C., & Hunot, S. (2016) · Neuron · doi:10.1016/j.neuron.2016.03.038 · Cited by 594 · see citing works

Nrf2-mediated neuroprotection in the MPTP mouse model of Parkinson’s disease: Critical role for the astrocyte

Chen, P.-C., Vargas, M. R., Pani, A. K., Smeyne, R. J., Johnson, D. A., Kan, Y. W., & Johnson, J. A. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0813361106 · Cited by 579 · see citing works

In situ detection of apoptotic nuclei in the substantia nigra compacta of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated mice using terminal deoxynucleotidyl transferase labelling and acridine orange staining

Tatton, N. A., & Kish, S. J. (1997) · Neuroscience · doi:10.1016/s0306-4522(96)00545-3 · Cited by 469 · see citing works

Rapamycin Protects against Neuron Death inIn VitroandIn VivoModels of Parkinson's Disease

Malagelada, C., Jin, Z. H., Jackson-Lewis, V. R., Przedborski, S., & Greene, L. A. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.3944-09.2010 · Cited by 458 · see citing works

Excitotoxicity and nitric oxide in parkinson's disease pathogenesis

Beal, M. F. (1998) · Annals of Neurology · doi:10.1002/ana.410440716 · Cited by 283 · see citing works

Mitochondrial dysfunction in the limelight of Parkinson's disease pathogenesis

Banerjee, R., Starkov, A. A., Beal, M. F., & Thomas, B. (2008) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2008.11.007 · Cited by 256 · see citing works

IFN-γ signaling, with the synergistic contribution of TNF-α, mediates cell specific microglial and astroglial activation in experimental models of Parkinson's disease

Barcia, C., Ros, C., Annese, V., Gómez, A., Ros-Bernal, F., Aguado-Yera, D., Martı́nez-Pagán, M., de Pablos, V., Fernández-Villalba, E., & Herrero, M. (2011) · Cell Death and Disease · doi:10.1038/cddis.2011.17 · Cited by 242 · see citing works

Short communication Interleukin-6 levels in cerebrospinal fluid inversely correlate to severity of Parkinson's disease

Müller, T., Blum-Degen, D., Przuntek, H., & Kuhn, W. (2009) · Acta Neurologica Scandinavica · doi:10.1111/j.1600-0404.1998.tb01736.x · Cited by 195 · see citing works

A further update on the role of excitotoxicity in the pathogenesis of Parkinson’s disease

Ambrosi, G., Cerri, S., & Blandini, F. (2014) · Journal of Neural Transmission · doi:10.1007/s00702-013-1149-z · Cited by 195 · see citing works

Inflammation in Parkinsons Diseases and Other Neurodegenerative Diseases: Cause and Therapeutic Implications

Wilms, H., Zecca, L., Rosenstiel, P. C., Sievers, J., Deuschl, G., & Lucius, R. (2007) · Current Pharmaceutical Design · doi:10.2174/138161207780858429 · Cited by 195 · see citing works

Soluble Aβ oligomers impair hippocampal LTP by disrupting glutamatergic/GABAergic balance

Lei, M., Xu, H., Li, Z., Wang, Z., O’Malley, T. T., Zhang, D., Walsh, D. M., Xu, P., Selkoe, D. J., & Li, S. (2015) · Neurobiology of Disease · doi:10.1016/j.nbd.2015.10.019 · Cited by 162 · see citing works

Astrogliopathology in neurological, neurodevelopmental and psychiatric disorders

Verkhratsky, A., & Parpura, V. (2015) · Neurobiology of Disease · doi:10.1016/j.nbd.2015.03.025 · Cited by 159 · see citing works

Astroglia dynamics in ageing and Alzheimer's disease

Verkhratsky, A., Zorec, R., Rodriguez, J. J., & Parpura, V. (2015) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2015.09.011 · Cited by 145 · see citing works

IL-1β, IL-2, IL-6 and TNF-α production by peripheral blood mononuclear cells from patients with Parkinson's disease

Bessler, H., Djaldetti, R., Salman, H., Bergman, M., & Djaldetti, M. (1999) · Biomedicine & Pharmacotherapy · doi:10.1016/s0753-3322(99)80079-1 · Cited by 135 · see citing works

Neuropathology of α‐synuclein propagation and braak hypothesis

McCann, H., Cartwright, H., & Halliday, G. M. (2015) · Movement Disorders · doi:10.1002/mds.26421 · Cited by 132 · see citing works

Apoptosis Inducing Factor and PARP‐Mediated Injury in the MPTP Mouse Model of Parkinson's Disease

Wang, H., Shimoji, M., Yu, S.-W., Dawson, T. M., & Dawson, V. L. (2003) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2003.tb07471.x · Cited by 127 · see citing works

Role of Immunity and Inflammation in the Pathophysiology of Neurodegenerative Diseases

Fakhoury, M. (2015) · Neurodegenerative Diseases · doi:10.1159/000369933 · Cited by 119 · see citing works

Activation of microglia induces symptoms of Parkinson’s disease in wild-type, but not in IL-1 knockout mice

Tanaka, S., Ishii, A., Ohtaki, H., Shioda, S., Yoshida, T., & Numazawa, S. (2013) · Journal of Neuroinflammation · doi:10.1186/1742-2094-10-143 · Cited by 118 · see citing works

Astrocytic GAP43 Induced by the TLR4/NF-κB/STAT3 Axis Attenuates Astrogliosis-Mediated Microglial Activation and Neurotoxicity

Hung, C., Lin, C.-H., Chang, H. H., Wang, C.-Y., Lin, S.-H., Hsu, P.-C., Sun, Y., Lin, T., Shie, F., Kao, L., et al. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.3457-15.2016 · Cited by 114 · see citing works

Therapeutic Effects of Rapamycin on MPTP-Induced Parkinsonism in Mice

Liu, K., Shi, N., Sun, Y., Zhang, T., & Sun, X. (2012) · Neurochemical Research · doi:10.1007/s11064-012-0909-8 · Cited by 113 · see citing works

MPTP-Induced Neuroinflammation Increases the Expression of Pro-Inflammatory Cytokines and Their Receptors in Mouse Brain

Lofrumento, D. D., Saponaro, C., Cianciulli, A., Nuccio, F. D., Mitolo, V., Nicolardi, G., & Panaro, M. A. (2010) · NeuroImmunoModulation · doi:10.1159/000320027 · Cited by 109 · see citing works

Regulation of the glutamate transporter EAAT1 by the ubiquitin ligase Nedd4‐2 and the serum and glucocorticoid‐inducible kinase isoforms SGK1/3 and protein kinase B

Boehmer, C., Henke, G., Schniepp, R., Palmada, M., Rothstein, J. D., Bröer, S., & Lang, F. J. W. (2003) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2003.01937.x · Cited by 108 · see citing works

PI3K/Akt/mTOR signaling regulates glutamate transporter 1 in astrocytes

Wu, J., Kihara, T., Akaike, A., Niidome, T., & Sugimoto, H. (2010) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2010.02.038 · Cited by 105 · see citing works

Downregulation of glial glutamate transporters after dopamine denervation in the striatum of 6‐hydroxydopamine‐lesioned rats

Chung, E. K. Y., Chen, L. W., Chan, Y., & Yung, K. K. L. (2008) · The Journal of Comparative Neurology · doi:10.1002/cne.21852 · Cited by 105 · see citing works

The established and emerging roles of astrocytes and microglia in amyotrophic lateral sclerosis and frontotemporal dementia

Radford, R. A. W., Morsch, M., Rayner, S. L., Cole, N. J., Pountney, D. L., & Chung, R. S. (2015) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2015.00414 · Cited by 102 · see citing works

Post‐translational regulation of EAAT2 function by co‐expressed ubiquitin ligase Nedd4‐2 is impacted by SGK kinases

Boehmer, C., Palmada, M., Rajamanickam, J., Schniepp, R., Amara, S. G., & Lang, F. J. W. (2006) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.03629.x · Cited by 100 · see citing works

Astrocytes: New Targets for the Treatment of Neurodegenerative Diseases

Finsterwald, C., Magistretti, P. J., & Lengacher, S. (2015) · Current Pharmaceutical Design · doi:10.2174/1381612821666150710144502 · Cited by 98 · see citing works

Assessment of the Effects of MPTP and Paraquat on Dopaminergic Neurons and Microglia in the Substantia Nigra Pars Compacta of C57BL/6 Mice

Smeyne, R. J., Breckenridge, C. B., Beck, M. J., Jiao, Y., Butt, M. T., Wolf, J. C., Zadory, D., Minnema, D. J., Sturgess, N. C., Travis, K. Z., et al. (2016) · PLoS ONE · doi:10.1371/journal.pone.0164094 · Cited by 98 · see citing works

Emerging roles of microglial activation and non-motor symptoms in Parkinson's disease

Doorn, K. J., Lucassen, P. J., Boddeke, H. W. G. M., Prins, M., Berendse, H. W., Drukarch, B., & van Dam, A. (2012) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2012.06.005 · Cited by 97 · see citing works

Increased vulnerability of dopaminergic neurons in MPTP‐lesioned interleukin‐6 deficient mice

Bolin, L., Strycharska-Orczyk, I., Murray, R., Langston, J., & Monte, D. D. D. (2002) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2002.01131.x · Cited by 95 · see citing works

Chronic and progressive Parkinson's disease MPTP model in adult and aged mice

Muñoz‐Manchado, A. B., Villadiego, J., Romo‐Madero, S., Suárez‐Luna, N., Bermejo‐Navas, A., Rodríguez‐Gómez, J. A., Garrido‐Gil, P., Labandeira-García, J. L., Echevarrı́a, M., López‐Barneo, J., et al. (2015) · Journal of Neurochemistry · doi:10.1111/jnc.13409 · Cited by 91 · see citing works

An update on the potential role of excitotoxicity in the pathogenesis of Parkinson's disease.

Blandini, F. (2010) · PubMed · Cited by 90 · see citing works

Protein Kinase C (PKC)-promoted Endocytosis of Glutamate Transporter GLT-1 Requires Ubiquitin Ligase Nedd4-2-dependent Ubiquitination but Not Phosphorylation

García‐Tardón, N., González‐González, I. M., de Villarreal, J. M., Fernández-Sánchez, E., Giménez, C., & Zafra, F. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.355909 · Cited by 89 · see citing works

Curcumin exerts anti-inflammatory and antioxidative properties in 1-methyl-4-phenylpyridinium ion (MPP+)-stimulated mesencephalic astrocytes by interference with TLR4 and downstream signaling pathway

Yu, S., Wang, X., He, X., Wang, Y., Gao, S., Ren, L., & Shi, Y. (2016) · Cell Stress and Chaperones · doi:10.1007/s12192-016-0695-3 · Cited by 82 · see citing works

Reduced calcium/calmodulin‐dependent protein kinase II activity in the hippocampus is associated with impaired cognitive function in MPTP‐treated mice

Moriguchi, S., Yabuki, Y., & Fukunaga, K. (2011) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2011.07608.x · Cited by 81 · see citing works

Oxidative stress on EAAC1 is involved in MPTP‐induced glutathione depletion and motor dysfunction

Aoyama, K., Matsumura, N., Watabe, M., & Nakaki, T. (2007) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2007.05979.x · Cited by 81 · see citing works

Interferon-γ induces progressive nigrostriatal degeneration and basal ganglia calcification

Chakrabarty, P., Ceballos‐Diaz, C., Lin, W.-L., Beccard, A., Jansen‐West, K. R., McFarland, N. R., Janus, C., Dickson, D. W., Das, P., & Golde, T. E. (2011) · Nature Neuroscience · doi:10.1038/nn.2829 · Cited by 81 · see citing works

Interleukin-6 May Contribute to Mortality in Parkinson’s Disease Patients: A 4-Year Prospective Study

Dufek, M., Rektorová, I., Thon, V., Lokaj, J., & Rektor, I. (2015) · Parkinson s Disease · doi:10.1155/2015/898192 · Cited by 80 · see citing works

Inflammatory and Cell Death Pathways in Brain and Peripheral Blood in Parkinson’s Disease

Macchi, B., Paola, R. D., Marino‐Merlo, F., Felice, M. R., Cuzzocrea, S., & Mastino, A. (2015) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1871527314666150225124928 · Cited by 80 · see citing works

Upregulation of glutamate transporter GLT-1 by mTOR-Akt-NF-кB cascade in astrocytic oxygen-glucose deprivation

Ji, Y.-F., Zhou, L., Xie, Y., Xu, S., Zhu, J., Teng, P., Shao, C., Wang, Y., Luo, J., & Shen, Y. (2013) · Glia · doi:10.1002/glia.22566 · Cited by 57 · see citing works

Progressive Parkinsonism by acute dysfunction of excitatory amino acid transporters in the rat substantia nigra

Assous, M., Had‐Aissouni, L., Gubellini, P., Melon, C., Nafia, I., Salin, P., Goff, L. K., & Kachidian, P. (2014) · Neurobiology of Disease · doi:10.1016/j.nbd.2014.01.011 · Cited by 55 · see citing works

Relationship between increase in astrocytic GLT-1 glutamate transport and late-LTP

Pita-Almenar, J. D., Zou, S., Colbert, C. M., & Eskin, A. (2012) · Learning & Memory · doi:10.1101/lm.023259.111 · Cited by 52 · see citing works

Dopaminergic and behavioral correlates of progressive lesioning of the nigrostriatal pathway with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine

Goldberg, N. R. S., Haack, A. K., Lim, N. S., Janson, O. K., & Meshul, C. K. (2011) · Neuroscience · doi:10.1016/j.neuroscience.2011.02.027 · Cited by 49 · see citing works

Effects of IL-6 secreted from astrocytes on the survival of dopaminergic neurons in lipopolysaccharide-induced inflammation

Li, X., Bai, L.-M., Yang, Y., Luo, W.-F., Hu, W., Chen, J., Mao, C., & Liu, C.-F. (2009) · Neuroscience Research · doi:10.1016/j.neures.2009.07.007 · Cited by 47 · see citing works

Sex‐ and brain region‐specific role of cytochrome c oxidase in 1‐methyl‐4‐phenylpyridinium‐mediated astrocyte vulnerability

Boyalla, S. S., Victor, M. B., Roemgens, A., Beyer, C., & Arnold, S. (2011) · Journal of Neuroscience Research · doi:10.1002/jnr.22669 · Cited by 45 · see citing works

Functional Regeneration in a Rat Parkinson's Model after Intrastriatal Grafts of Glial Cell Line-Derived Neurotrophic Factor and Transforming Growth Factor β1-Expressing Extra-Adrenal Chromaffin Cells of the Zuckerkandl's Organ

Fernández‐Espejo, E., Gonzalez-Albo, M. C., Moraes, J.-P., Banoua, F. E., Flores, J. A., & Caraballo, I. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-24-09888.2001 · Cited by 45 · see citing works

FGF2 alleviates PTSD symptoms in rats by restoring GLAST function in astrocytes via the JAK/STAT pathway

Feng, D., Guo, B., Liu, G., Wang, B., Wang, W., Gao, G., Qin, H., & Wu, S. (2015) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2015.04.020 · Cited by 43 · see citing works

The influence of AAV2-mediated gene transfer of human IL-10 on neurodegeneration and immune response in a murine model of Parkinson's disease

Joniec‐Maciejak, I., Ciesielska, A., Wawer, A., Sznejder-Pachołek, A., Schwenkgrub, J., Cudna, A., Hadaczek, P., Bankiewicz, K. S., Członkowska, A., & Członkowski, A. (2014) · Pharmacological Reports · doi:10.1016/j.pharep.2014.03.008 · Cited by 42 · see citing works

IL6 Protects MN9D Cells and Midbrain Dopaminergic Neurons from MPP+-Induced Neurodegeneration

Spittau, B., Zhou, X., Ming, M., & KRIEGLSTEIN, K. G. (2012) · NeuroMolecular Medicine · doi:10.1007/s12017-012-8189-7 · Cited by 41 · see citing works

Targeting glutamatergic synapses in Parkinson's disease

Gardoni, F., & Luca, M. D. (2014) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2014.10.011 · Cited by 40 · see citing works

Ceftriaxone Protects Astrocytes from MPP+ via Suppression of NF-ΚB/JNK/c-Jun Signaling

Zhang, Y., Zhang, X., & Qu, S. (2015) · Molecular Neurobiology · doi:10.1007/s12035-014-8845-z · Cited by 39 · see citing works

Manganese‐induced downregulation of astroglial glutamine transporter SNAT3 involves ubiquitin‐mediated proteolytic system

Sidoryk‐Wȩgrzynowicz, M., Lee, E., Ni, M., & Aschner, M. (2010) · Glia · doi:10.1002/glia.21060 · Cited by 34 · see citing works

Donepezil Regulates 1-Methyl-4-phenylpyridinium-Induced Microglial Polarization in Parkinson’s Disease

Chen, T., Hou, R. H., Xu, S., & Wu, C. (2015) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.5b00026 · Cited by 29 · see citing works

MPTP modulates hippocampal synaptic transmission and activity‐dependent synaptic plasticity via dopamine receptors

Zhu, G., Huang, Y., Chen, Y., Zhuang, Y., & Behnisch, T. (2012) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2012.07815.x · Cited by 24 · see citing works

Protection of cultured dopamine neurons from MPP + requires a combination of neurotrophic factors

Jaumotte, J. D., Wyrostek, S. L., & Zigmond, M. J. (2016) · European Journal of Neuroscience · doi:10.1111/ejn.13252 · Cited by 24 · see citing works

Protection of Primary Dopaminergic Midbrain Neurons by GPR139 Agonists Supports Different Mechanisms of MPP+ and Rotenone Toxicity

Andersen, K. B., Johansen, J. L., Hentzer, M., Smith, G. P., & Dietz, G. P. H. (2016) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2016.00164 · Cited by 21 · see citing works

Possible Role of Interleukin-6 in PC12 Cell Death Induced by MPP+ and Tetrahydroisoquinoline

Shimma, N., Akiyama, N., Umezawa, M., Okuma, Y., Nomura, Y., Saito, T., Horie, S., & Murayama, T. (2003) · Journal of Pharmacological Sciences · doi:10.1254/jphs.93.471 · Cited by 14 · see citing works

SARS-CoV-2, COVID-19 and the aging immune system

Bartleson, J. M., Radenkovic, D., Covarrubias, A. J., Furman, D., Winer, D. A., & Verdin, E. (2021) · Nature Aging · doi:10.1038/s43587-021-00114-7 · Cited by 359 · see citing works

The Therapeutic Potential of Metformin in Neurodegenerative Diseases

Rotermund, C., Machetanz, G., & Fitzgerald, J. C. (2018) · Frontiers in Endocrinology · doi:10.3389/fendo.2018.00400 · Cited by 310 · see citing works

An update on Drug Repurposing: Re-written saga of the drug’s fate

S, H. S. G. N., Saraswathy, G. R., Murahari, M., & Krishnamurthy, M. (2018) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2018.11.127 · Cited by 160 · see citing works

Contribution of astrocytes to neuropathology of neurodegenerative diseases

Acıoğlu, Ç., Li, L., & Elkabes, S. (2021) · Brain Research · doi:10.1016/j.brainres.2021.147291 · Cited by 115 · see citing works

Biological characteristics of IL-6 and related intestinal diseases

Guo, Y., Wang, B., Wang, T., Gao, L., Yang, Z., Wang, F.-F., Shang, H., Hua, R., & Xu, J. (2020) · International Journal of Biological Sciences · doi:10.7150/ijbs.51362 · Cited by 114 · see citing works

Simvastatin Inhibits Activation of NADPH Oxidase/p38 MAPK Pathway and Enhances Expression of Antioxidant Protein in Parkinson Disease Models

Tong, H., Zhang, X., Meng, X., Lu, L., Mai, D., & Qu, S. (2018) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2018.00165 · Cited by 109 · see citing works

The Role of Rapamycin in Healthspan Extension via the Delay of Organ Aging

Zhang, Y., Zhang, J., & Wang, S. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101376 · Cited by 92 · see citing works

Toll-Like Receptor 4 Mediates Methamphetamine-Induced Neuroinflammation through Caspase-11 Signaling Pathway in Astrocytes

Du, S., Qiao, D., Chen, C., Chen, S., Liu, C., Lin, Z., Wang, H., & Xie, W. (2017) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2017.00409 · Cited by 82 · see citing works

A Sentinel in the Crosstalk Between the Nervous and Immune System: The (Immuno)-Proteasome

Limanaqi, F., Biagioni, F., Gaglione, A., Busceti, C. L., & Fornai, F. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00628 · Cited by 69 · see citing works

Mitochondrial dysfunction as a therapeutic strategy for neurodegenerative diseases: Current insights and future directions

Gu, Y., Zhao, X., Zhang, N., Yang, Y., Yi, Y., Shao, Q.-H., Liu, M.-X., & Zhang, X.-L. (2024) · Ageing Research Reviews · doi:10.1016/j.arr.2024.102577 · Cited by 58 · see citing works

Rapamycin Responds to Alzheimer’s Disease: A Potential Translational Therapy

Hou, S.-J., Zhang, S., Li, Y., & Xu, S.-Y. (2023) · Clinical Interventions in Aging · doi:10.2147/cia.s429440 · Cited by 58 · see citing works

Zinc Oxide Nanoparticles Induce Autophagy and Apoptosis via Oxidative Injury and Pro-Inflammatory Cytokines in Primary Astrocyte Cultures

Song, W.-J., Jeong, M.-S., Choi, D.-M., Kim, K., & Wie, M. (2019) · Nanomaterials · doi:10.3390/nano9071043 · Cited by 57 · see citing works

Ginsenoside Rb1 confers neuroprotection via promotion of glutamate transporters in a mouse model of Parkinson's disease

Zhang, Y., Liu, Y., Kang, X.-P., Dou, C.-Y., Zhuo, R., Huang, S., Peng, L., & Wen, L. (2017) · Neuropharmacology · doi:10.1016/j.neuropharm.2017.12.012 · Cited by 56 · see citing works

Chinese Herbal Medicine Interventions in Neurological Disorder Therapeutics by Regulating Glutamate Signaling

Liu, Y., Wang, S., Kan, J., Zhang, J., Zhou, L., Huang, Y., & Zhang, Y. (2019) · Current Neuropharmacology · doi:10.2174/1570159x17666191101125530 · Cited by 55 · see citing works

Environmental enrichment prevents Aβ oligomer-induced synaptic dysfunction through mirna-132 and hdac3 signaling pathways

Wei, Z., Meng, X., Fatimy, R. E., Sun, B., Mai, D., Zhang, J., Arora, R., Zeng, A., Xu, P., Qu, S., et al. (2019) · Neurobiology of Disease · doi:10.1016/j.nbd.2019.104617 · Cited by 55 · see citing works

Generation of a Novel Mouse Model of Parkinson’s Disease via Targeted Knockdown of Glutamate Transporter GLT-1 in the Substantia Nigra

Zhang, Y., Meng, X., Jiao, Z., Liu, Y., Zhang, X., & Qu, S. (2020) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.9b00609 · Cited by 49 · see citing works

CNTNAP4 deficiency in dopaminergic neurons initiates parkinsonian phenotypes

Zhang, W., Zhou, M., Lu, W., Gong, J., Gao, F., Li, Y., Xu, X., Lin, Y., Zhang, X., Ding, L., et al. (2020) · Theranostics · doi:10.7150/thno.40798 · Cited by 47 · see citing works

Ginsenoside Rb1 prevents MPTP-induced changes in hippocampal memory via regulation of the α-synuclein/PSD-95 pathway

Qu, S., Meng, X., Liu, Y., Zhang, X., & Zhang, Y. (2019) · Aging · doi:10.18632/aging.101884 · Cited by 46 · see citing works

Harmol promotes α-synuclein degradation and improves motor impairment in Parkinson’s models via regulating autophagy-lysosome pathway

Xu, J., Ao, Y., Huang, C., Song, X., Zhang, G., Cui, W., Wang, Y., Zhang, X., & Zhang, Z. (2022) · npj Parkinson s Disease · doi:10.1038/s41531-022-00361-4 · Cited by 43 · see citing works

Ginsenoside Rb1 regulates prefrontal cortical GABAergic transmission in MPTP-treated mice

Liu, Y., Zong, X., Huang, J., Guan, Y., Li, Y., Du, T., Liu, K., Kang, X.-P., Dou, C., Sun, X., et al. (2019) · Aging · doi:10.18632/aging.102095 · Cited by 43 · see citing works

Lysosomal Functions in Glia Associated with Neurodegeneration

Kreher, C., Favret, J., Maulik, M., & Shin, D. (2021) · Biomolecules · doi:10.3390/biom11030400 · Cited by 38 · see citing works

Cyclin-dependent kinase inhibitors (CDKIs) and the DNA damage response: The link between signaling pathways and cancer

Amani, J., Gorjizadeh, N., Younesi, S., Najafi, M., Ashrafi, A. M., Irian, S., Gorjizadeh, N., & Azizian, K. (2021) · DNA repair · doi:10.1016/j.dnarep.2021.103103 · Cited by 38 · see citing works

Lysosomal acidification impairment in astrocyte-mediated neuroinflammation

Zeng, J., Indajang, J., Pitt, D., & Lo, C. H. (2025) · Journal of Neuroinflammation · doi:10.1186/s12974-025-03410-w · Cited by 38 · see citing works

mGluR5 Allosteric Modulation Promotes Neurorecovery in a 6-OHDA-Toxicant Model of Parkinson’s Disease

Farmer, K., Abd‐Elrahman, K. S., Derksen, A., Rowe, E. M., Thompson, A., Rudyk, C., Prowse, N. A., Dwyer, Z., Bureau, S. C., Fortin, T., et al. (2019) · Molecular Neurobiology · doi:10.1007/s12035-019-01818-z · Cited by 34 · see citing works

Alpha-Synuclein: The Interplay of Pathology, Neuroinflammation, and Environmental Factors in Parkinson’s Disease

He, S., Zhong, S., Liu, G., & Yang, J. (2020) · Neurodegenerative Diseases · doi:10.1159/000511083 · Cited by 36 · see citing works

Fenpropathrin induces degeneration of dopaminergic neurons via disruption of the mitochondrial quality control system

Jiao, Z., Wu, Y., & Qu, S. (2020) · Cell Death Discovery · doi:10.1038/s41420-020-00313-y · Cited by 35 · see citing works

Overexpression of miR-132-3p contributes to neuronal protection in in vitro and in vivo models of Alzheimer’s disease

Zeng, C., Meng, X., Mai, D., Xu, K. Y., & Qu, S. (2021) · Behavioural Brain Research · doi:10.1016/j.bbr.2021.113584 · Cited by 33 · see citing works

Activated Schwann cells and increased inflammatory cytokines IL‐1β, IL‐6, and TNF‐α in patients' sural nerve are lack of tight relationship with specific sensory disturbances in Parkinson's disease

Zhang, H., Wu, J., Shen, F., Yuan, Y., Li, X., Ji, P., Zhu, L., Sun, L., Ding, J., Niu, Q., et al. (2019) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.13282 · Cited by 31 · see citing works

MiR-30a-5p Regulates GLT-1 Function via a PKCα-Mediated Ubiquitin Degradation Pathway in a Mouse Model of Parkinson’s Disease

Meng, X., Zhong, J., Zeng, C., Yung, K. K. L., Zhang, X., Wu, X., & Qu, S. (2021) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.1c00076 · Cited by 25 · see citing works

Cellular antiseizure mechanisms of everolimus in pediatric tuberous sclerosis complex, cortical dysplasia, and non–mTOR‐mediated etiologies

Cepeda, C., Levinson, S. R., Yazon, V.-W., Barry, J., Mathern, G. W., Fallah, A., Vinters, H. V., Levine, M. S., & Wu, J. Y. (2018) · Epilepsia Open · doi:10.1002/epi4.12253 · Cited by 24 · see citing works

The use of geroprotectors to prevent multimorbidity: Opportunities and challenges

Morsli, S., & Bellantuono, I. (2020) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2020.111391 · Cited by 23 · see citing works

Topical administration of rapamycin promotes retinal ganglion cell survival and reduces intraocular pressure in a rat glaucoma model

Wang, F., Ma, F., Song, Y., Li, N., Li, X., Pang, Y., Hu, P., Shao, A., Deng, C., & Zhang, X. (2020) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2020.173369 · Cited by 20 · see citing works

Role of autophagy and oxidative stress to astrocytes in fenpropathrin-induced Parkinson-like damage

Wu, Y., Jiao, Z., Wan, Z., & Qu, S. (2021) · Neurochemistry International · doi:10.1016/j.neuint.2021.105000 · Cited by 18 · see citing works

A bistable, multiport valve enables microformulators creating microclinical analyzers that reveal aberrant glutamate metabolism in astrocytes derived from a tuberous sclerosis patient

Miller, D. R., Schaffer, D. K., Neely, M. D., McClain, E. S., Travis, A. R., Block, F. E., McKenzie, J. R., Werner, E. M., Armstrong, L. C., Markov, D. A., et al. (2021) · Sensors and Actuators B Chemical · doi:10.1016/j.snb.2021.129972 · Cited by 16 · see citing works

Targeting inflammation and gut microbiota with antibacterial therapy: implications for central nervous system health

Wei, J., Liu, C., Qin, D., Ren, F., Duan, J., Chen, T., & Wu, A. (2024) · Ageing Research Reviews · doi:10.1016/j.arr.2024.102544 · Cited by 15 · see citing works

Induction of Parkinsonian-Like Changes via Targeted Downregulation of Astrocytic Glutamate Transporter GLT-1 in the Striatum

Ren, C., He, K.-J., Hu, H., Zhang, J.-B., Dong, L.-G., Li, D., Chen, J., Mao, C.-J., Wang, F., & Liu, C.-F. (2021) · Journal of Parkinson s Disease · doi:10.3233/jpd-212640 · Cited by 15 · see citing works

The Role of Pathogens and Anti-Infective Agents in Parkinson’s Disease, from Etiology to Therapeutic Implications

Shen, S., Zhang, C., Xu, Y.-M., & Shi, C.-H. (2021) · Journal of Parkinson s Disease · doi:10.3233/jpd-212929 · Cited by 15 · see citing works

Effects of lifespan-extending interventions on cognitive healthspan

Čulig, L., Sahbaz, B. D., & Bohr, V. A. (2022) · Expert Reviews in Molecular Medicine · doi:10.1017/erm.2022.36 · Cited by 14 · see citing works

Rapamycin Alleviates Protein Aggregates, Reduces Neuroinflammation, and Rescues Demyelination in Globoid Cell Leukodystrophy

Lin, D., Huang, Y.-W., Lee, T., Chang, L., Huang, Z., Wu, T., Wang, T.-J., & Ho, C. (2023) · Cells · doi:10.3390/cells12070993 · Cited by 14 · see citing works

Intranasal Delivery of Rapamycin Via Brain-Targeting Polymeric Micelles for Alzheimer's Disease Treatment

Sugandhi, V. V., Gattu, K., Mundrathi, V., Khairnar, R., Arshad, T., Kumar, S., & Cho, H. (2025) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2025.126011 · Cited by 13 · see citing works

MicroRNA-mediated regulation of reactive astrocytes in central nervous system diseases

Fan, Y., Huang, H., Shao, J., & Huang, W. (2023) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2022.1061343 · Cited by 13 · see citing works

Downregulation of Ambra1 by altered DNA methylation exacerbates dopaminergic neuron damage in a fenpropathrin-induced Parkinson-like mouse model.

He, S., Qu, Q., Chen, X., Zhao, L., Jiao, Z.-G., Wan, Z.-T., Kwok, H.-F., & Qu, S.-G. (2024) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2024.115995 · Cited by 11 · see citing works

Circulating metabolomics profiling reveals novel pathways associated with cognitive decline in patients with hypertension

Huang, Y., Zheng, H., Tan, K., Sun, X., Ye, J., & Zhang, Y. (2020) · Therapeutic Advances in Neurological Disorders · doi:10.1177/1756286420947973 · Cited by 11 · see citing works

Sirolimus reduces T cell cycling, immune checkpoint marker expression, and HIV-1 DNA in people with HIV

Henrich, T. J., Bosch, R. J., Godfrey, C. C., Mar, H., Nair, A., Keefer, M. C., Fichtenbaum, C. J., Moisi, D. D., Clagett, B. M., Buck, A. M., et al. (2024) · Cell Reports Medicine · doi:10.1016/j.xcrm.2024.101745 · Cited by 9 · see citing works

Rapamycin exerts neuroprotective effects by inhibiting FKBP12 instead of mTORC1 in the mouse model of Parkinson's disease

Zhang, Z., Shen, Z., Xie, S., Li, J., Zhang, Z., Zhang, S., Peng, B., Huang, Q., Li, M., Ma, S., et al. (2025) · Neuropharmacology · doi:10.1016/j.neuropharm.2025.110504 · Cited by 9 · see citing works

Design, synthesis and bioactivity evaluation of 4-hydroxycoumarin derivatives as potential anti-inflammatory agents against acute lung injury and colitis

Li, X., Huang, X., Zhao, Y., Zheng, Z., Guo, M., Chen, Z., Chen, P., Li, X., Liao, J., Jiang, M., et al. (2024) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2024.116487 · Cited by 9 · see citing works

[Neuroprotective effect of rapamycin against Parkinson's disease in mice].

Zhu, F., Fan, M., Xu, Z., Cai, Y., Chen, Y., Yu, S., & Zeng, L. (2018) · PubMed Central · doi:10.3785/j.issn.1008-9292.2018.10.04 · Cited by 8 · see citing works

Protective effects of prucalopride in MPTP-induced Parkinson’s disease mice: Neurochemistry, motor function and gut barrier

Shi, Y. W., Qiao, C.-M., Zhou, Y., Wu, J. Y., Cui, C., Hong, H., Jia, X.-B., Huang, S.-B., Li, Y., Zhao, W., et al. (2021) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2021.03.109 · Cited by 8 · see citing works

Potential protective role of astrocytes in the pathogenesis of astrocyte-mediated synaptic plasticity of Parkinson’s disease

Zhang, Y., & Lu, K. (2021) · Journal of Integrative Neuroscience · doi:10.31083/j.jin2002055 · Cited by 8 · see citing works

Rapamycin Pretreatment Attenuates High Glucose-induced Alteration of Synaptic Transmission in Hippocampal Dentate Gyrus Neurons

Jiang, T., Zhang, W., Wang, Y., Zhang, T., Wang, H., & Yang, Z. R. (2022) · Neuroscience · doi:10.1016/j.neuroscience.2022.03.012 · Cited by 7 · see citing works

Plant‐Based Therapies to Ameliorate Neuroinflammation in Parkinson's Disease, Alzheimer's Disease, and Epilepsy: A Narrative Review

Sharma, D., Rajbongshi, B., Isphak, T., Basumatary, S., Dutta, K., Rudrapal, M., & Goswami, A. K. (2025) · Chemistry & Biodiversity · doi:10.1002/cbdv.202500038 · Cited by 5 · see citing works

microRNAs profiling of small extracellular vesicles from midbrain tissue of Parkinson’s disease

Li, Z., Chen, D., Pan, R., Zhong, Y.-B., Zhong, T., & Jiao, Z. (2023) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2023.1090556 · Cited by 5 · see citing works

Neurotransmitter Dysregulation in Parkinson’s Disease: Pathophysiological Insights and Therapeutic Perspectives

Aslan, F. Ş., Barut, B., Ozturk, S., Eyigürbüz, T., & Akyüz, E. (2026) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.5c00809 · Cited by 3 · see citing works

Aβ oligomers induce sex-selective differences in mGluR5 pharmacology and pathophysiological signaling in Alzheimer micePreprint

Abd‐Elrahman, K. S., Albaker, A. B., de Souza, J. M., Ribeiro, F. M., Schlossmacher, M. G., Tiberi, M., Hamilton, A., & Ferguson, S. S. G. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/803262 · Cited by 3 · see citing works

Impact of Rapamycin on Longevity: Updated Insights

Sanati, M., Afshari, A. R., Aminyavari, S., Banach, M., & Sahebkar, A. (2024) · Archives of Medical Science · doi:10.5114/aoms/191565 · Cited by 3 · see citing works

Astrocyte Glutamate Transporter EAAT2 in Alzheimer Dementia

Kurkinen, M. T. (2022) · Springer eBooks · doi:10.1007/978-3-030-87480-3_7 · Cited by 2 · see citing works

Cogs in the autophagic machine—equipped to combat dementia-prone neurodegenerative diseases

de Wet, S., Theart, R. P., & Loos, B. (2023) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2023.1225227 · Cited by 1 · see citing works

Neuroinflammation and Its Impact on Autophagy in Neurodegeneration

Bhattacharya, K., Chanu, N. R., Das, D., & Kumpakha, R. (2025) · Springer eBooks · doi:10.1007/978-981-95-3945-1_1 · Cited by 1 · see citing works

Exercise promotes glutamate transporter-mediated glutamate uptake in the striatum to regulate MSN plasticity and alleviate behavioral and functional impairments in PD rats

Chen, P., Zhou, W.-H., Li, G., Yang, Q., Liu, B., Yi, X.-Y., & Zeng, Y. (2026) · The Journals of Gerontology Series A · doi:10.1093/gerona/glag173 · Cited by 1 · see citing works

PINK1 loss in astrocytes triggers inflammatory dysfunction and neuronal deathPreprint

Fiorino, G., Florio, D. N. D., Hadley, D. H., Ross, O. A., Fiesel, F. C., & Springer, W. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.06.04.729996 · Cited by 1 · see citing works

Transcranial sonography depicts a larger substantia nigra echogenic area in renal transplant patients on calcineurin inhibitors than on rapamycin

Araújo, N. C., Suassuna, J. H. R., & Fernandes, R. D. C. L. (2022) · BMC Nephrology · doi:10.1186/s12882-022-02741-7

Nutrition in Brain Aging: Its Relevance to Age-Associated Neurodegeneration

Maruyama, W., Shamoto‐Nagai, M., & Naoi, M. (2022) · Springer eBooks · doi:10.1007/978-3-319-56015-1_20-1

Nutrition in Brain Aging: Its Relevance to Age-Associated Neurodegeneration

Maruyama, W., Nagai, M. S., & Naoi, M. (2022) · Springer eBooks · doi:10.1007/978-3-030-62059-2_20 · Cited by 1 · see citing works

Rapamycin Protects Dopaminergic Neurons by Suppressing Tlr2 Mediated Neuroinflammation and Enhancing Autophagy in Rotenone-Induced Pd MicePreprint

xie, X., Su, S., Huang, Y., Cui, Q., & Zang, W. (2023) · Research Square · doi:10.21203/rs.3.rs-2906856/v1

Repurposing antimicrobial agents for neuroprotection: Mechanisms, clinical potential, and challenges

Manavi, M. A., Salehi, M., Jafari, R. M., Goudarzi, R., Khosravi, S., & Dehpour, A. R. (2026) · Neuroprotection/Neuroprotection (Chichester, England. Print) · doi:10.1002/nep3.70042

Autophagy-lysosomal pathway in neurodegeneration

McDonough, S. R., Rao, A. K., McAleer, J. M., Babrowicz, B. M., & Sharma, M. (2026) · Molecular Neurodegeneration Advances · doi:10.1186/s44477-026-00041-0

[Neuroprotective effect of rapamycin against Parkinson's disease in mice].

Zhu, F., Fan, M., Xu, Z., Cai, Y., Chen, Y., Yu, S., & Zeng, L. (2018) · PubMed Central · doi:10.3785/j.issn.1008-9292.2018.10.04 · Cited by 8 · see citing works

RIPK1-Induced A1 Reactive Astrocytes in Brain in MPTP-Treated Murine Model of Parkinson’s Disease

Qiao, C.-M., Niu, G.-Y., Zhao, W., Quan, W., Zhou, Y., Zhang, M., Li, T., Zhou, S., Huang, W., Zhao, L., et al. (2023) · Brain Sciences · doi:10.3390/brainsci13050733 · Cited by 10 · see citing works

Rapamycin Protects Dopaminergic Neurons by Suppressing Tlr2 Mediated Neuroinflammation and Enhancing Autophagy in Rotenone-Induced Pd MicePreprint

xie, X., Su, S., Huang, Y., Cui, Q., & Zang, W. (2023) · Research Square · doi:10.21203/rs.3.rs-2906856/v1

Genetic suppression of IKK2/NF-κB in astrocytes inhibits neuroinflammation and reduces neuronal loss in the MPTP-Probenecid model of Parkinson's disease

Kirkley, K. S., Popichak, K. A., Hammond, S. L., Davies, C., Hunt, L. G., & Tjalkens, R. B. (2019) · Neurobiology of Disease · doi:10.1016/j.nbd.2019.02.020 · Cited by 37 · see citing works

Rapamycin Protects against Neuron Death inIn VitroandIn VivoModels of Parkinson's Disease

Malagelada, C., Jin, Z. H., Jackson-Lewis, V. R., Przedborski, S., & Greene, L. A. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.3944-09.2010 · Cited by 458 · see citing works