Cited by 1,932Complement system in diseasesBiomarkers in Disease MechanismsImmune Response and Inflammation

The DOI matches its Crossref record; 170 of the 170 references it cites were found in a registry or an index.

Complement and its role in innate and adaptive immune responses

Dunkelberger, Jason R, Song, Wen-Chao·2010·Cell Research

DOI 10.1038/cr.2009.139

Open this paper in CoChat — free account

Abstract

The complement system plays a crucial role in the innate defense against common pathogens. Activation of complement leads to robust and efficient proteolytic cascades, which terminate in opsonization and lysis of the pathogen as well as in the generation of the classical inflammatory response through the production of potent proinflammatory molecules. More recently, however, the role of complement in the immune response has been expanded due to observations that link complement activation to adaptive immune responses. It is now appreciated that complement is a functional bridge between innate and adaptive immune responses that allows an integrated host defense to pathogenic challenges. As such, a study of its functions allows insight into the molecular underpinnings of host-pathogen interactions as well as the organization and orchestration of the host immune response. This review attempts to summarize the roles that complement plays in both innate and adaptive immune responses and the consequences of these interactions on host defense.

Integrity signals

Registry

Crossref · 10.1038/cr.2009.139

Cites

170 of 170 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Toll-like receptor control of the adaptive immune responses
Iwasaki, A., & Medzhitov, R. M. (2004) · Nature Immunology · doi:10.1038/ni1112 · Cited by 4,166
Immunobiology: the immune system in health and disease
(1995) · Choice Reviews Online · doi:10.5860/choice.32-3876 · Cited by 4,111
Approaching the asymptote? Evolution and revolution in immunology.Preprint
Janeway, C. (1989) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.1989.054.01.003 · Cited by 3,396
Complement
Walport, M. J. (2001) · New England Journal of Medicine · doi:10.1056/nejm200104053441406 · Cited by 2,969
Decoding the Patterns of Self and Nonself by the Innate Immune System
Medzhitov, R., & Janeway, C. A. (2002) · Science · doi:10.1126/science.1068883 · Cited by 2,154
Anesthesiology
Wiklund, R. A., & Rosenbaum, S. H. (1997) · New England Journal of Medicine · doi:10.1056/nejm199710163371606 · Cited by 2,153
Innate Immunity
Medzhitov, R. M., & Janeway, C. A. (2000) · New England Journal of Medicine · doi:10.1056/nejm200008033430506 · Cited by 1,827
Complement
Walport, M. J. (2001) · New England Journal of Medicine · doi:10.1056/nejm200104123441506 · Cited by 1,502
C3d of complement as a molecular adjuvant: Bridging innate and acquired immunity
Dempsey, P. W., Allison, M. E. D., Akkaraju, S., Goodnow, C. C., & Fearon, D. T. (1996) · Science · doi:10.1126/science.271.5247.348 · Cited by 1,197
Pattern Recognition Receptors
Gordon, S. (2002) · Cell · doi:10.1016/s0092-8674(02)01201-1 · Cited by 1,153

Show all 170 references

Sorted by citations

Items 201–300 of 1,003

Microglia undergo sex-dimorphic transcriptional and metabolic rewiring during aging
Kang, S., Ko, E. Y., Andrews, A. E., Shin, J. E., Nance, K. J., Barman, P. K., Heeger, P. S., Freeman, W. M., Benayoun, B. A., & Goodridge, H. S. (2024) · Journal of Neuroinflammation · doi:10.1186/s12974-024-03130-7 · Cited by 76
Molecular characterization and expression analysis of a complement component 3 in the sea cucumber (Apostichopus japonicus)
Zhou, Z., Sun, D., Yang, A., Dong, Y., Chen, Z., Wang, X., Guan, X., Jiang, B., & Wang, B. (2011) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2011.06.023 · Cited by 71
Time‐resolved dual RNA‐seq of tissue uncovers Pseudomonas plecoglossicida key virulence genes in host‐pathogen interaction with Epinephelus coioides
Luo, G., Sun, Y., Huang, L., Su, Y., Zhao, L., Qin, Y., Xu, X., & Yan, Q. (2019) · Environmental Microbiology · doi:10.1111/1462-2920.14884 · Cited by 69
Complement activation as a biomarker for Alzheimer's disease
Aiyaz, M., Lupton, M. K., Proitsi, P., Powell, J. F., & Lovestone, S. (2011) · Immunobiology · doi:10.1016/j.imbio.2011.07.023 · Cited by 69
Human anti-CAIX antibodies mediate immune cell inhibition of renal cell carcinoma in vitro and in a humanized mouse model in vivo
Chang, D.-K., Moniz, R. J., Xu, Z., Sun, J., Signoretti, S., Zhu, Q. K., & Marasco, W. A. (2015) · Molecular Cancer · doi:10.1186/s12943-015-0384-3 · Cited by 70
The role of complement activation in atherogenesis: the first 40 years
Vlaicu, S. I., Tatomir, A., Rus, V., Mekala, A. P., Mircea, P. A., Niculescu, F. I., & Rus, H. (2015) · Immunologic Research · doi:10.1007/s12026-015-8669-6 · Cited by 70
Plasma-based proteomics reveals immune response, complement and coagulation cascades pathway shifts in heat-stressed lactating dairy cows
Li, M., Cheng, J., Zhao, S., Tian, H., Zhang, Y., Li, S., Yang, H., Zheng, N., & Wang, J. (2016) · Journal of Proteomics · doi:10.1016/j.jprot.2016.06.008 · Cited by 70
Regulation of epithelial cell expressed C3 in the intestine – Relevance for the pathophysiology of inflammatory bowel disease?
Sünderhauf, A., Skibbe, K., Preisker, S., Ebbert, K., Verschoor, A., Karsten, C. M., Kemper, C., Huber-Lang, M. S., Basic, M., Bleich, A., et al. (2017) · Molecular Immunology · doi:10.1016/j.molimm.2017.08.003 · Cited by 70
Untitled work
Paun (2018) · doi:10.1016/j.ophtha.2017.12.023 · Cited by 70
Latest advances in zwitterionic structures modified dialysis membranes
Mollahosseini, A., Abdelrasoul, A., & Shoker, A. (2020) · Materials Today Chemistry · doi:10.1016/j.mtchem.2019.100227 · Cited by 70
Complement activation in COVID-19 and targeted therapeutic options: A scoping review
Lim, E. H. T., van Amstel, R. B. E., de Boer, V. V., van Vught, L. A., de Bruin, S., Brouwer, M. C., Vlaar, A. P. J., & van de Beek, D. (2022) · Blood Reviews · doi:10.1016/j.blre.2022.100995 · Cited by 70
Staphylococcal mastitis in dairy cows
Dego, O. K., & Vidlund, J. (2024) · Frontiers in Veterinary Science · doi:10.3389/fvets.2024.1356259 · Cited by 84
Subcutaneous injection of water-soluble multi-walled carbon nanotubes in tumor-bearing mice boosts the host immune activity
Meng, J., Yang, M. G., Jia, F., Kong, H., Zhang, W., Wang, C., Xing, J., Xie, S., & Xu, H. (2010) · Nanotechnology · doi:10.1088/0957-4484/21/14/145104 · Cited by 67
Blocking Properdin, the Alternative Pathway, and Anaphylatoxin Receptors Ameliorates Renal Ischemia-Reperfusion Injury in Decay-Accelerating Factor and CD59 Double-Knockout Mice
Miwa, T., Sato, S., Gullipalli, D., Nangaku, M., & Song, W. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1202275 · Cited by 68
Self-citation
Connecting the innate and adaptive immune responses in mouse choroidal neovascularization via the anaphylatoxin C5a and γδT-cells
Coughlin, B., Schnabolk, G., Joseph, K., Raikwar, H., Kunchithapautham, K., Johnson, K., Moore, K., Wang, Y., & Rohrer, B. (2016) · Scientific Reports · doi:10.1038/srep23794 · Cited by 65
Modifiable, Non-Modifiable, and Clinical Factors Associated with Progression of Alzheimer’s Disease
Loeffler, D. A. (2021) · Journal of Alzheimer s Disease · doi:10.3233/jad-201182 · Cited by 71
Annexin A2 in Fibrinolysis, Inflammation and Fibrosis
Lim, H. I., & Hajjar, K. A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22136836 · Cited by 69
Dysregulation of complement and coagulation pathways: emerging mechanisms in the development of psychosis
Heurich, M., Föcking, M., Mongan, D., Cagney, G., & Cotter, D. (2021) · Molecular Psychiatry · doi:10.1038/s41380-021-01197-9 · Cited by 68
Immunosuppression following dietary aflatoxin B1 exposure: a review of the existing evidence
Mohsenzadeh, M. S., Hedayati, N., Riahi‐Zanjani, B., & Karimi, G. (2016) · Toxin Reviews · doi:10.1080/15569543.2016.1209523 · Cited by 68
Functional variability in butyrylcholinesterase activity regulates intrathecal cytokine and astroglial biomarker profiles in patients with Alzheimer's disease
Darreh‐Shori, T., Vijayaraghavan, S., Aeinehband, S., Piehl, F., Lindblom, R. P. F., Nilsson, B., Ekdahl, K. N., Långström, B., Almkvist, O., & Nordberg, A. K. (2013) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2013.04.027 · Cited by 65
C5a Receptor Targeting in Neointima Formation After Arterial Injury in Atherosclerosis-Prone Mice
Shagdarsuren, E., Bidzhekov, K., Mause, S. F., Simsekyilmaz, S., Polakowski, T., Hawlisch, H., Gessner, J. E., Zernecke, A., & Weber, C. (2010) · Circulation · doi:10.1161/circulationaha.110.954370 · Cited by 65
A novel long non-coding RNA in the rheumatoid arthritis risk locus TRAF1-C5 influences C5 mRNA levels
Messemaker, T. C., Frank‐Bertoncelj, M., Marques, R. B., Adriaans, A. E., Bakker, A. M., Daha, N. A., Gay, S., Huizinga, T. W. J., Toes, R. E. M., Mikkers, H. M. M., et al. (2015) · Genes and Immunity · doi:10.1038/gene.2015.54 · Cited by 66
Immunotherapy of cancer: from monoclonal to oligoclonal cocktails of anti‐cancer antibodies: IUPHAR Review 18
Carvalho, S., Levi‐Schaffer, F., Sela, M., & Yarden, Y. (2016) · British Journal of Pharmacology · doi:10.1111/bph.13450 · Cited by 64
Association of Blood Concentrations of Complement Split Product iC 3b and Serum C3 With Systemic Lupus Erythematosus Disease Activity
Kim, A. H. J., Strand, V., Sen, D., Fu, Q. J., Mathis, N. L., Schmidt, M. J., Bruchas, R. R., Staten, N. R., Olson, P. K., Stiening, C. M., et al. (2018) · Arthritis & Rheumatology · doi:10.1002/art.40747 · Cited by 64
Ocular Vascular Diseases: From Retinal Immune Privilege to Inflammation
Wang, X., Wang, T., Lam, E., Álvarez, D., & Sun, Y. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241512090 · Cited by 71
MBL-associated serine proteases (MASPs) and infectious diseases
Beltrame, M. H., Boldt, A. B. W., Catarino, S. J., Mendes, H. W., Boschmann, S. E., Goeldner, I., & Messias-Reason, I. (2015) · Molecular Immunology · doi:10.1016/j.molimm.2015.03.245 · Cited by 64
Role of dietary Spirulina platensis in improving mucosal immune responses and disease resistance of rainbow trout (Oncorhynchus mykiss)
Sheikhzadeh, N., Mousavi, S., Hamidian, G., Firouzamandi, M., Oushani, A. K., & Mardani, K. (2019) · Aquaculture · doi:10.1016/j.aquaculture.2019.05.009 · Cited by 64
The Alternative and Terminal Pathways of Complement Mediate Post-Traumatic Spinal Cord Inflammation and Injury
Qiao, F., Atkinson, C., Kindy, M. S., Shunmugavel, A., Morgan, B. P., Song, H., & Tomlinson, S. (2010) · American Journal Of Pathology · doi:10.2353/ajpath.2010.100158 · Cited by 63
Understanding the Role of Host Hemocytes in a Squid/Vibrio Symbiosis Using Transcriptomics and Proteomics
Collins, A. J., Schleicher, T. R., Rader, B. A., & Nyholm, S. V. (2012) · Frontiers in Immunology · doi:10.3389/fimmu.2012.00091 · Cited by 65
Expanding horizons in complement drug discovery: challenges and emerging strategies
Harris, C. L. (2017) · Seminars in Immunopathology · doi:10.1007/s00281-017-0655-8 · Cited by 63
Cloaking Silica Nanoparticles with Functional Protein Coatings for Reduced Complement Activation and Cellular Uptake
Park, J. H., Jackman, J. A., Ferhan, A. R., Belling, J. N., Mokrzecka, N., Weiss, P. S., & Cho, N. (2020) · ACS Nano · doi:10.1021/acsnano.0c05097 · Cited by 63
C1q binding to surface-bound IgG is stabilized by C1r 2 s 2 proteases
Zwarthoff, S. A., Widmer, K., Kuipers, A., Strasser, J., Ruyken, M., Aerts, P. C., de Haas, C. J. C., Ugurlar, D., den Boer, M. A., Vidarsson, G., et al. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2102787118 · Cited by 62
Complement dysregulation is a prevalent and therapeutically amenable feature of long COVID
Baillie, K. L., Davies, H. E., Keat, S., Ladell, K., Miners, K. L., Jones, S., Melou, E., Toonen, E. J. M., Price, D. A., Morgan, B. P., et al. (2024) · Med · doi:10.1016/j.medj.2024.01.011 · Cited by 62
Fast‐Track Surgery Improves Postoperative Clinical Recovery and Immunity After Elective Surgery for Colorectal Carcinoma: Randomized Controlled Clinical Trial
Yang, D., He, W., Zhang, S., Chen, H., Zhang, C., & He, Y. (2012) · World Journal of Surgery · doi:10.1007/s00268-012-1606-0 · Cited by 60
Subretinal macrophages produce classical complement activator C1q leading to the progression of focal retinal degeneration
Jiao, H., Rutar, M., Fernando, N., Yednock, T. A., Sankaranarayanan, S., Aggio‐Bruce, R., Provis, J. M., & Natoli, R. (2018) · Molecular Neurodegeneration · doi:10.1186/s13024-018-0278-0 · Cited by 62
Advances in Molecular Imaging Strategies forIn VivoTracking of Immune Cells
Lee, H., Gangadaran, P., Kalimuthu, S., & Ahn, B. (2016) · BioMed Research International · doi:10.1155/2016/1946585 · Cited by 61
Succinate and inosine coordinate innate immune response to bacterial infection
Jiang, M., Chen, Z., Li, H., Zhang, T., Yang, M., Peng, X., & Peng, B. (2022) · PLoS Pathogens · doi:10.1371/journal.ppat.1010796 · Cited by 64
Immunotoxicity of aluminum
Zhu, Y., Li, Y., Miao, L., Wang, Y., Liu, Y., Yan, X., Cui, X., & Li, H. (2013) · Chemosphere · doi:10.1016/j.chemosphere.2013.10.052 · Cited by 61
Immune responses of BALB/c mice to subcutaneously injected multi-walled carbon nanotubes
Meng, J., Yang, M. G., Jia, F., Xu, Z., Kong, H., & Xu, H. (2010) · Nanotoxicology · doi:10.3109/17435390.2010.523483 · Cited by 61
B Cell Activation and Escape of Tolerance Checkpoints: Recent Insights from Studying Autoreactive B Cells
Bonasia, C. G., Abdulahad, W. H., Rutgers, A., Heeringa, P., & Bos, N. A. (2021) · Cells · doi:10.3390/cells10051190 · Cited by 68
Tailoring the physicochemical properties of nanomaterials for immunomodulation
Deng, J., Wang, J., Shi, J., Li, H., Lu, M., Fan, Z., Gu, Z., & Cheng, H. (2021) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2021.114039 · Cited by 62
Tumor antigen-targeting monoclonal antibody-based immunotherapy: Orchestrating combined strategies for the development of long-term antitumor immunity
Michaud, H., Eliaou, J., Lafont, V., Bonnefoy, N., & Gros, L. (2014) · OncoImmunology · doi:10.4161/21624011.2014.955684 · Cited by 63
C5aR Expression in a Novel GFP Reporter Gene Knockin Mouse: Implications for the Mechanism of Action of C5aR Signaling in T Cell Immunity
Dunkelberger, J., Zhou, L., Miwa, T., & Song, W. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1103141 · Cited by 60
Self-citation
Influenza Virus-Specific Neutralizing IgM Antibodies Persist for a Lifetime
Skountzou, I., Satyabhama, L., Stavropoulou, A., Ashraf, Z., Esser, E. S., Vassilieva, E. V., Koutsonanos, D., Compans, R. W., & Jacob, J. (2014) · Clinical and Vaccine Immunology · doi:10.1128/cvi.00374-14 · Cited by 60
Murine systemic thrombophilia and hemolytic uremic syndrome from a factor H point mutation
Ueda, Y., Mohammed, I., Song, D., Gullipalli, D., Zhou, L., Sato, S., Wang, Y., Gupta, S., Cheng, Z. A., Wang, H., et al. (2017) · Blood · doi:10.1182/blood-2016-07-728253 · Cited by 61
Self-citation
Self-Anticoagulant Nanocomposite Spheres for the Removal of Bilirubin from Whole Blood: A Step toward a Wearable Artificial Liver
Song, X., Xu, T., Li, Y., Li, Y., Yang, Y., Jin, L., Zhang, J., Zhong, R., Sun, S., Zhao, W., et al. (2020) · Biomacromolecules · doi:10.1021/acs.biomac.9b01686 · Cited by 60
Selective Host Cell Death by Staphylococcus aureus: A Strategy for Bacterial Persistence
Missiakas, D. M., & Winstel, V. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2020.621733 · Cited by 61
Infectious Bronchitis Virus (Gammacoronavirus) in Poultry Farming: Vaccination, Immune Response and Measures for Mitigation
Bhuiyan, M. S. A., Amin, Z., Rodrigues, K. F., Saallah, S., Shaarani, S. M., Sarker, S., & Siddiquee, S. (2021) · Veterinary Sciences · doi:10.3390/vetsci8110273 · Cited by 65
Emerging Treatment Options for Geographic Atrophy (GA) Secondary to Age-Related Macular Degeneration
Khan, H., Aziz, A. A., Sulahria, H., Khan, H., Ahmed, A., Choudhry, N., Narayanan, R., Danzig, C. J., & Khanani, A. M. (2023) · Clinical ophthalmology · doi:10.2147/opth.s367089 · Cited by 59
Blast-induced moderate neurotrauma (BINT) elicits early complement activation and tumor necrosis factor alpha (TNFα) release in a rat brain
Lucca, J. J. D., Chavko, M., Dubick, M. A., Adeeb, S., Falabella, M. J., Slack, J. L., McCarron, R. M., & Li, Y. (2012) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2012.02.002 · Cited by 59
The Complement System Contributes to Functional Antibody-Mediated Responses Induced by Immunization with Plasmodium falciparum Malaria Sporozoites
Behet, M. C., Kurtovic, L., van Gemert, G., Haukes, C. M., Siebelink‐Stoter, R., Graumans, W., van de Vegte‐Bolmer, M., Scholzen, A., Langereis, J. D., Diavatopoulos, D. A., et al. (2018) · Infection and Immunity · doi:10.1128/iai.00920-17 · Cited by 61
Role of Complement-Related Inflammation and Vascular Dysfunction in Hypertension
Ruan, C., & Gao, P. (2019) · Hypertension · doi:10.1161/hypertensionaha.118.11210 · Cited by 62
Mesenchymal Stem Cells Engineered to Inhibit Complement-Mediated Damage
Soland, M. A., Bego, M. G., Colletti, E. J., Zanjani, E. D., Jeor, S. S., Porada, C. D., & Almeida-Porada, G. D. (2013) · PLoS ONE · doi:10.1371/journal.pone.0060461 · Cited by 58
Immune Evasion by Kaposi‘s Sarcoma-Associated Herpesvirus
Lee, H.-R., Lee, S., Chaudhary, P. M., Gill, P. S., & Jung, J. U. (2010) · Future Microbiology · doi:10.2217/fmb.10.105 · Cited by 58
Size-dependent neutralizing activity of gold nanoparticle-based subunit vaccine against dengue virus
Quach, H. Q., Ang, S. K., Chu, J. J. H., & Kah, J. C. Y. (2018) · Acta Biomaterialia · doi:10.1016/j.actbio.2018.08.011 · Cited by 58
Trichinella spiralis Paramyosin Binds to C8 and C9 and Protects the Tissue-Dwelling Nematode from Being Attacked by Host Complement
Zhang, Z., Yang, J., Wei, J., Yang, Y., Chen, X., Zhao, X., Gu, Y., Cui, S., & Zhu, X. (2011) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0001225 · Cited by 58
IgY ‑ turning the page toward passive immunization in COVID-19 infection (Review)
Constantin, C., Neagu, M. T., Supeanu, T., Chiurciu, V., & Spandidos, D. A. (2020) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2020.8704 · Cited by 57
The Immune System in Duchenne Muscular Dystrophy Pathogenesis
Tripodi, L., Villa, C., Molinaro, D., Torrente, Y., & Farini, A. (2021) · Biomedicines · doi:10.3390/biomedicines9101447 · Cited by 63
Complement inhibition in pre-clinical models of periodontitis and prospects for clinical application
Hajishengallis, G., Hajishengallis, E., Kajikawa, T., Wang, B., Yancopoulou, D., Ricklin, D., & Lambris, J. D. (2016) · Seminars in Immunology · doi:10.1016/j.smim.2016.03.006 · Cited by 57
Cell surface engineering and application in cell delivery to heart diseases
Lee, D., Cha, B.-H., Jung, M., Kim, A. S., Bull, D. A., & Won, Y. (2018) · Journal of Biological Engineering · doi:10.1186/s13036-018-0123-6 · Cited by 59
Mechanism for the attenuation of neutrophil and complement hyperactivity by MSC exosomes
Loh, J. T., Zhang, B., Teo, J. K. H., Lai, R. C., Choo, A. B. H., Lam, K., & Lim, S. K. (2022) · Cytotherapy · doi:10.1016/j.jcyt.2021.12.003 · Cited by 60
Proteomic analysis of the skin of Chinese giant salamander (Andrias davidianus)
Geng, X., Hong Kui, W. E. I., Shang, H., Zhou, M., Chen, B., Zhang, F., Zang, X., Li, P., Sun, J., Che, J., et al. (2015) · Journal of Proteomics · doi:10.1016/j.jprot.2015.02.008 · Cited by 56
Carbohydrate-based cancer vaccines: target cancer with sugar bullets
Liu, C., & Ye, X. (2012) · Glycoconjugate Journal · doi:10.1007/s10719-012-9399-9 · Cited by 56
Host defense (antimicrobial) peptides
Sun, E., Belanger, C. R., Haney, E. F., & Hancock, R. E. W. (2017) · Elsevier eBooks · doi:10.1016/b978-0-08-100736-5.00010-7 · Cited by 53
Trial watch: Tumor-targeting monoclonal antibodies for oncological indications
Vacchelli, E., Pol, J. G., Bloy, N., Eggermont, A. M. M., Cremer, I., Fridman, W. H., Galon, J., Marabelle, A., Kohrt, H. E. K., Zitvogel, L., et al. (2015) · OncoImmunology · doi:10.4161/2162402x.2014.985940 · Cited by 59
New Insights into the Role of the Complement System in Human Viral Diseases
Ostrycharz, E., & Hukowska-Szematowicz, B. (2022) · Biomolecules · doi:10.3390/biom12020226 · Cited by 61
Antibody‐mediated phagocytosis in cancer immunotherapy
Wagoner, C. M. V., Rivera‐Escalera, F., Jaimes‐Delgadillo, N. C., Chu, C. C., Zent, C. S., & Elliott, M. R. (2023) · Immunological Reviews · doi:10.1111/imr.13265 · Cited by 54
Mechanisms of antibody-dependent enhancement of infectious disease
Wells, T. J., Esposito, T., Henderson, I. R., & Labzin, L. I. (2024) · Nature reviews. Immunology · doi:10.1038/s41577-024-01067-9 · Cited by 61
Biophysical, biopharmaceutical and toxicological significance of biomedical nanoparticles
Aula, S., Lakkireddy, S., Jamil, K., Kapley, A., Swamy, A. V. N., & Reddy, L. H. (2015) · RSC Advances · doi:10.1039/c5ra05889a · Cited by 57
Gene expression profile analysis of Manila clam (Ruditapes philippinarum) hemocytes after a Vibrio alginolyticus challenge using an immune-enriched oligo-microarray
Moreira, R., Milan, M., Balseiro, P., Romero, A., Babbucci, M., Figueras, A. J., Bargelloni, L., & Novoa, B. (2014) · BMC Genomics · doi:10.1186/1471-2164-15-267 · Cited by 55
Difenoconazole causes spleen tissue damage and immune dysfunction of carp through oxidative stress and apoptosis
Liu, F., Li, X., Bello, B. K., Zhang, T., Yang, H., Wang, K., & Dong, J. (2022) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2022.113563 · Cited by 54
Candida lusitaniae: Biology, Pathogenicity, Virulence Factors, Diagnosis, and Treatment
Mendoza-Reyes, D. F., Gómez-Gaviria, M., & Mora-Montes, H. M. (2022) · Infection and Drug Resistance · doi:10.2147/idr.s383785 · Cited by 61
Interactions between sleep, inflammation, immunity and infections: A narrative review
Feuth, T. (2024) · Immunity Inflammation and Disease · doi:10.1002/iid3.70046 · Cited by 58
Leishmania, the phagosome, and host responses: The journey of a parasite
Séguin, O., & Descoteaux, A. (2016) · Cellular Immunology · doi:10.1016/j.cellimm.2016.08.004 · Cited by 60
Tick Salivary Compounds for Targeted Immunomodulatory Therapy
Aounallah, H., Bensaoud, C., M’ghirbi, Y., Faria, F., Chmelař, J., & Kotsyfakis, M. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.583845 · Cited by 54
Inflammatory and Oxidative Pathways Are New Drug Targets in Multiple Episode Schizophrenia and Leaky Gut, Klebsiella pneumoniae, and C1q Immune Complexes Are Additional Drug Targets in First Episode Schizophrenia
Maes, M., Vojdani, A., Sirivichayakul, S., Barbosa, D., & Kanchanatawan, B. (2020) · Molecular Neurobiology · doi:10.1007/s12035-021-02343-8 · Cited by 40
Trastuzumab/pertuzumab combination therapy stimulates antitumor responses through complement-dependent cytotoxicity and phagocytosis
Tsao, L.-C., Crosby, E. J., Trotter, T. N., Wei, J.-P., Wang, T., Yang, X. Y., Summers, A. N., Lei, G., Rabiola, C. A., Chodosh, L. A., et al. (2022) · JCI Insight · doi:10.1172/jci.insight.155636 · Cited by 57
A comprehensive analysis of the genetic diversity and environmental adaptability in worldwide Merino and Merino-derived sheep breeds
Ceccobelli, S., Landi, V., Senczuk, G., Mastrangelo, S., Sardina, M. T., Jemaa, S. B., Persichilli, C., Karslı, T., Bâlteanu, V.-A., Raschia, M. A., et al. (2023) · Genetics Selection Evolution · doi:10.1186/s12711-023-00797-z · Cited by 63
Role of the Yersinia pestis Ail Protein in Preventing a Protective Polymorphonuclear Leukocyte Response during Bubonic Plague
Hinnebusch, B. J., Jarrett, C. O., Callison, J. A., Gardner, D. J., Buchanan, S. K., & Plano, G. V. (2011) · Infection and Immunity · doi:10.1128/iai.05307-11 · Cited by 53
The dual role of complement in cancer and its implication in anti-tumor therapy
Kourtzelis, I., & Rafail, S. (2016) · Annals of Translational Medicine · doi:10.21037/atm.2016.06.26 · Cited by 55
Tumour‐associated B cells in urothelial urinary bladder cancer
Zirakzadeh, A. A., Sherif, A. M., Rosenblatt, R., Bergman, E. A., Winerdal, M., Yang, D., Cederwall, J., Jakobsson, V., Hyllienmark, M., Winqvist, O., et al. (2019) · Scandinavian Journal of Immunology · doi:10.1111/sji.12830 · Cited by 55
Immune System of Fish: An Evolutionary Perspective
Sahoo, S., Banu, H., Prakash, A., & Tripathi, G. (2021) · IntechOpen eBooks · doi:10.5772/intechopen.99541 · Cited by 52
Complement: The Road Less Traveled
Kemper, C., Ferreira, V. P., Paz, J. T., Holers, V. M., Lionakis, M. S., & Alexander, J. J. (2023) · The Journal of Immunology · doi:10.4049/jimmunol.2200540 · Cited by 53
Cathepsin H: Molecular characteristics and clues to function and mechanism
Wang, Y., Zhao, J., Gu, Y., Wang, H., Jiang, M., Zhao, S., Qing, H., & Ni, J. (2023) · Biochemical Pharmacology · doi:10.1016/j.bcp.2023.115585 · Cited by 52
Modulation of the host immune response by cowpox virus
Alzhanova, D. V., & Früh, K. (2010) · Microbes and Infection · doi:10.1016/j.micinf.2010.07.007 · Cited by 52
Complement receptor type 1 (CR1, CD35) is a potent inhibitor of B-cell functions in rheumatoid arthritis patients
Kremlitzka, M., Polgar, A. A., Fülöp, L., Kiss, E. V., Poór, G., & Erdei, A. (2012) · International Immunology · doi:10.1093/intimm/dxs090 · Cited by 50
Staphylococcus aureus SdrE captures complement factor H's C-terminus via a novel ‘close, dock, lock and latch' mechanism for complement evasion
Zhang, Y., Wu, M., Hang, T., Wang, C., Yang, Y., Pan, W., Zang, J., Zhang, M., & Zhang, X. (2017) · Biochemical Journal · doi:10.1042/bcj20170085 · Cited by 52
A Preliminary Proteomic Investigation of Circulating Exosomes and Discovery of Biomarkers Associated with the Progression of Osteosarcoma in a Clinical Model of Spontaneous Disease
Brady, J. V., Troyer, R. M., Ramsey, S. A., Leeper, H. J., Yang, L., Maier, C. S., Goodall, C. P., Ruby, C. E., Albarqi, H. A., Taratula, O., et al. (2018) · Translational Oncology · doi:10.1016/j.tranon.2018.07.004 · Cited by 52
A C1q domain containing protein from Crassostrea gigas serves as pattern recognition receptor and opsonin with high binding affinity to LPS
Jiang, S., Li, H., Zhang, D., Zhang, H., Wang, L., Sun, J., & Song, L. (2015) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2015.05.021 · Cited by 52
The role of complement in brain injury following intracerebral hemorrhage: A review
Holste, K. G., Xia, F., Garton, H. J. L., Wan, S., Hua, Y., Keep, R. F., & Xi, G. (2021) · Experimental Neurology · doi:10.1016/j.expneurol.2021.113654 · Cited by 52
Total coumarin derivates from Hydrangea paniculata attenuate renal injuries in cationized-BSA induced membranous nephropathy by inhibiting complement activation and interleukin 10-mediated interstitial fibrosis
Wang, W., Li, S., Chen, Y., Li, Z., Wu, H., Ma, J., Zhang, D., Chen, X., & Zhang, S. (2021) · Phytomedicine · doi:10.1016/j.phymed.2021.153886 · Cited by 51
The Complement C3a–C3aR Axis Promotes Development of Thoracic Aortic Dissection via Regulation of MMP2 Expression
Ren, W., Liu, Y., Wang, X., Piao, C., Ma, Y., Qiu, S., Jia, L., Chen, B., Wang, Y., Jiang, W., et al. (2018) · The Journal of Immunology · doi:10.4049/jimmunol.1601386 · Cited by 51
Self-citation
Air pollution exposure and immunological and systemic inflammatory alterations among schoolchildren in China
Li, X., Zhang, X., Zhang, Z., Han, L., Gong, D., Li, J., Wang, T., Wang, Y., Gao, S., Duan, H., et al. (2018) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2018.12.153 · Cited by 51
Neutrophils as emerging protagonists and targets in chronic inflammatory diseases
Rawat, K., & Shrivastava, A. (2022) · Inflammation Research · doi:10.1007/s00011-022-01627-6 · Cited by 55
New insights into the immune functions of podocytes: the role of complement
Bruno, V., Mühlig, A. K., Oh, J. S., & Licht, C. P. B. (2023) · Molecular and Cellular Pediatrics · doi:10.1186/s40348-023-00157-3 · Cited by 52
Complement Activation Contributes to the Injury and Outcome of Kidney in Human Anti-glomerular Basement Membrane Disease
Ma, R., Cui, Z., Liao, Y., & Zhao, M. (2012) · Journal of Clinical Immunology · doi:10.1007/s10875-012-9772-2 · Cited by 50
Structural and functional characterization of human and murine C5a anaphylatoxins
Schatz-Jakobsen, J. A., Yatime, L., Larsen, C., Petersen, S. V., Klos, A., & Andersen, G. R. (2014) · Acta Crystallographica Section D Biological Crystallography · doi:10.1107/s139900471400844x · Cited by 50
PMA-Induced THP-1 Macrophage Differentiation is Not Impaired by Citrate-Coated Platinum Nanoparticles
Gatto, F., Cagliani, R., Catelani, T., Guarnieri, D., Moglianetti, M., Pompa, P. P., & Bardi, G. (2017) · Nanomaterials · doi:10.3390/nano7100332 · Cited by 52
Immunological Responses to Envenomation
Ryan, R. Y. M., Seymour, J., Loukas, A., Lopez, J. A., Ikonomopoulou, M. P., & Miles, J. J. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.661082 · Cited by 49
Full-length recombinant antibodies from Escherichia coli : production, characterization, effector function (Fc) engineering, and clinical evaluation
Rashid, M. H. (2022) · mAbs · doi:10.1080/19420862.2022.2111748 · Cited by 47

Authors: Dunkelberger, J. R., & Song, W.-C.
Affiliations: University of Pennsylvania (US)
Corresponding author: Song, Wen-Chao
ORCID: Song, Wen-Chao
Venue: Cell Research
Publisher: Springer Science and Business Media LLC
Published: 2009-12-15
Volume: 20
Issue: 1
Pages: 34-50
ISSN: 1001-0602 (ISSN-L)
1748-7838
DOI: 10.1038/cr.2009.139
OpenAlex: W2005044790
Cited by: 1,932
References: 170
Citations by year: 2026: 163 · 2025: 207 · 2024: 239 · 2023: 192 · 2022: 149 · 2021: 186 · 2020: 103 · 2019: 85 · 2018: 103 · 2017: 98 · 2016: 95 · 2015: 67 · 2014: 65 · 2013: 49 · 2012: 68
FWCI: 3.37
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Cell Research (publishedVersion)
PubMed (publishedVersion)
Funders: American Heart Association
National Institutes of Health
Topics: Life Sciences › Immunology and Microbiology › Immunology › Complement system in diseases
Life Sciences › Immunology and Microbiology › Immunology › Biomarkers in Disease Mechanisms
Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Keywords: complement system, innate immunity, adaptive immunity, complement activation, opsonization, proinflammatory molecules, host-pathogen interaction
MeSH terms: Animals, B-Lymphocytes, Complement System Proteins, Humans, Immunity, Innate, Inflammation, T-Lymphocytes, Inflammation Mediators, Host-Pathogen Interactions, Adaptive Immunity, Immunity, Humoral

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Complement and its role in innate and adaptive immune responses

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks