Complement and its role in innate and adaptive immune responses

Toll-like receptor control of the adaptive immune responses

Iwasaki, A., & Medzhitov, R. M. (2004) · Nature Immunology · doi:10.1038/ni1112 · Cited by 4,166

Immunobiology: the immune system in health and disease

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Approaching the asymptote? Evolution and revolution in immunology.Preprint

Janeway, C. (1989) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.1989.054.01.003 · Cited by 3,396

Complement

Walport, M. J. (2001) · New England Journal of Medicine · doi:10.1056/nejm200104053441406 · Cited by 2,969

Decoding the Patterns of Self and Nonself by the Innate Immune System

Medzhitov, R., & Janeway, C. A. (2002) · Science · doi:10.1126/science.1068883 · Cited by 2,154

Anesthesiology

Wiklund, R. A., & Rosenbaum, S. H. (1997) · New England Journal of Medicine · doi:10.1056/nejm199710163371606 · Cited by 2,153

Innate Immunity

Medzhitov, R. M., & Janeway, C. A. (2000) · New England Journal of Medicine · doi:10.1056/nejm200008033430506 · Cited by 1,827

Complement

Walport, M. J. (2001) · New England Journal of Medicine · doi:10.1056/nejm200104123441506 · Cited by 1,502

C3d of complement as a molecular adjuvant: Bridging innate and acquired immunity

Dempsey, P. W., Allison, M. E. D., Akkaraju, S., Goodnow, C. C., & Fearon, D. T. (1996) · Science · doi:10.1126/science.271.5247.348 · Cited by 1,197

Pattern Recognition Receptors

Gordon, S. (2002) · Cell · doi:10.1016/s0092-8674(02)01201-1 · Cited by 1,153

Antitumor Immune Mechanisms of the Anti-Complement Factor H Antibody GT103

Bushey, R. T., Saxena, R., Campa, M. J., Gottlin, E. B., He, Y.-W., & Patz, E. F. (2023) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-22-0723 · Cited by 22

Revisiting the role of the complement system in intracerebral hemorrhage and therapeutic prospects

Li, Y., Tao, C., An, N., Liu, H., Liu, Z., Zhang, H., Sun, Y., Xing, Y., & Gao, Y. (2023) · International Immunopharmacology · doi:10.1016/j.intimp.2023.110744 · Cited by 26

Role of complement in myasthenia gravis

San, P. P., & Jacob, S. (2023) · Frontiers in Neurology · doi:10.3389/fneur.2023.1277596 · Cited by 22

An atlas of human vector-borne microbe interactions reveals pathogenicity mechanisms

Hart, T. M., Sonnert, N. D., Tang, X.-T., Chaurasia, R., Allen, P. E., Hunt, J. R., Read, C. B., Johnson, E. E., Arora, G., Dai, Y.-L., et al. (2024) · Cell · doi:10.1016/j.cell.2024.05.023 · Cited by 19

P2X receptor stimulation amplifies complement-induced haemolysis

Hejl, J., Skals, M., Leipziger, J., & Prætorius, H. A. (2012) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-012-1174-z · Cited by 22

Effects of Oxidized Konjac glucomannan (OKGM) on growth and immune function of Schizothorax prenanti

Zhang, L., Wu, Y., Wang, L., & Wang, H. (2013) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2013.07.023 · Cited by 22

Serum complement C4b, fibronectin, and prolidase are associated with the pathological changes of pulmonary tuberculosis

Wang, C., Li, Y., Li, X., Wei, L., Yang, X., Xu, D., Jiang, T., Li, Z., Chen, Z., Zhang, X., et al. (2014) · BMC Infectious Diseases · doi:10.1186/1471-2334-14-52 · Cited by 22

Anaphylatoxin receptors and complement regulatory proteins in human articular and non-articular chondrocytes: interrelation with cytokines

Schulze-Tanzil, G. G., Kohl, B., Sayed, K. E., Arens, S., Ertel, W., Stölzel, K., & John, T. (2012) · Cell and Tissue Research · doi:10.1007/s00441-012-1497-2 · Cited by 22

Effects of Medroxyprogesterone Acetate on Gene Expression in Myometrial Explants from Pregnant Women

Cordeaux, Y., Tattersall, M. L., Jones, D. S., & Smith, G. C. S. (2010) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2010-1541 · Cited by 22

On the value of therapeutic interventions targeting the complement system in acute myocardial infarction

Emmens, R. W., Wouters, D., Zeerleder, S. S., van Ham, S. M., Niessen, H. W. M., & Krijnen, P. A. J. (2016) · Translational research · doi:10.1016/j.trsl.2016.10.005 · Cited by 22

Human stem cell-derived retinal epithelial cells activate complement via collectin 11 in response to stress

Fanelli, G., Gonzalez-Cordero, A., Gardner, P. J., Peng, Q., Fernando, M., Kloc, M., Farrar, C. A., Naeem, A., Garred, P., Ali, R. R., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-15212-z · Cited by 22

The Salmonella type-3 secretion system-1 and flagellar motility influence the neutrophil respiratory burst

Westerman, T. L., Bogomolnaya, L. M., Andrews‐Polymenis, H. L., Sheats, M. K., & Elfenbein, J. R. (2018) · PLoS ONE · doi:10.1371/journal.pone.0203698 · Cited by 22

Immersion immunization with recombinant baculoviruses displaying cyprinid herpesvirus 2 membrane proteins induced protective immunity in gibel carp

Cao, Z., Liu, S., Nan, H., Zhao, K., Xu, X., Wang, G., Ji, H., & Chen, H. (2019) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2019.08.036 · Cited by 22

A deep analysis of the proteomic and phosphoproteomic alterations that occur in skeletal muscle after the onset of immobilization

Lin, K., Wilson, G. M., Blanco, R., Steinert, N. D., Zhu, W. G., Coon, J. J., & Hornberger, T. A. (2021) · The Journal of Physiology · doi:10.1113/jp281071 · Cited by 20

Mapping of the complement C9 binding domain on Trichinella spiralis paramyosin

Zhao, X., Hao, Y., Yang, J., Gu, Y., & Zhu, X. (2014) · Parasites & Vectors · doi:10.1186/1756-3305-7-80 · Cited by 22

Neuromonitoring During ECMO Support in Children

Felling, R. J., Kamerkar, A., Friedman, M. L., Said, A. S., LaRovere, K. L., Bell, M. J., & Bembea, M. M. (2023) · Neurocritical Care · doi:10.1007/s12028-023-01675-8 · Cited by 21

Single-Cell RNA Sequencing Deconstructs the Distribution of Immune Cells Within Abdominal Aortic Aneurysms in Mice

Yuan, Z. F., Shu, L., Fu, J., Yang, P., Wang, Y., Sun, J., Zheng, M., Liu, Z., Yang, J., Song, J., et al. (2024) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.124.321129 · Cited by 22

Complement regulators as novel targets for anti-cancer therapy: A comprehensive review

Saxena, R., Gottlin, E. B., Campa, M. J., He, Y.-W., & Patz, E. F. (2025) · Seminars in Immunology · doi:10.1016/j.smim.2025.101931 · Cited by 21

COMP Is a Biomarker of Cartilage Destruction, Extracellular Matrix and Vascular Remodeling and Tissue Repair

Smith, M. M., & Melrose, J. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26189182 · Cited by 21

The Alternative Pathway of Complement and the Evolving Clinical-Pathophysiological Spectrum of Atypical Hemolytic Uremic Syndrome

Berger, B. E. (2016) · The American Journal of the Medical Sciences · doi:10.1016/j.amjms.2016.05.003 · Cited by 21

Complement-targeted therapies in kidney transplantation—insights from preclinical studies

Anwar, I. J., DeLaura, I. F., Ladowski, J. M., Gao, Q., Knechtle, S. J., & Kwun, J. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.984090 · Cited by 21

The role of the complosome in health and disease

Xiao, F., Guo, J., Tomlinson, S., Yuan, G., & He, S. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1146167 · Cited by 21

A review on immunological aspects in male reproduction: An immune cells and cytokines

Wanjari, U. R., & Gopalakrishnan, A. V. (2023) · Journal of Reproductive Immunology · doi:10.1016/j.jri.2023.103984 · Cited by 22

Chitosan-based pulmonary particulate systems for anticancer and antiviral drug carriers: A promising delivery for COVID-19 vaccines

Tousian, B., & Khosravi, A. (2023) · Results in Chemistry · doi:10.1016/j.rechem.2023.101146 · Cited by 21

Improvement of non-specific immunity, intestinal health and microbiota of crucian carp (Carassius auratus) juvenile with dietary supplementation of Bacillus coagulans BC1

Hu, R., Yang, B., Zheng, Z., Liang, Z., Kang, Y., & Cong, W. (2023) · Aquaculture · doi:10.1016/j.aquaculture.2023.740327 · Cited by 21

Computational identification of natural senotherapeutic compounds that mimic dasatinib based on gene expression data

Meiners, F., Hinz, B., Boeckmann, L., Secci, R., Sueto, S. O. B., Kuepfer, L., Fuellen, G., & Barrantes, I. (2024) · Scientific Reports · doi:10.1038/s41598-024-55870-4 · Cited by 22

Complement Component C5 Recruits Neutrophils in the Absence of C3 during Respiratory Infection with Modified Vaccinia Virus Ankara

Price, P. J. R., Bánki, Z., Scheideler, A., Stoiber, H., Verschoor, A., Sutter, G., & Lehmann, M. H. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1301410 · Cited by 21

Imaging complement by phase-plate cryo-electron tomography from initiation to pore formation

Sharp, T. H., Faas, F. G. A., Koster, A. J., & Gros, P. (2016) · Journal of Structural Biology · doi:10.1016/j.jsb.2016.09.008 · Cited by 21

The tumour microenvironment links complement system dysregulation and hypoxic signalling

Olcina, M. M., Kim, R. K., Melemenidis, S., Graves, E. E., & Giaccia, A. J. (2018) · British Journal of Radiology · doi:10.1259/bjr.20180069 · Cited by 20

The role of B7 costimulation in benzene immunotoxicity and its potential association with cancer risk

Saüer, E., Gauer, B., Nascimento, S., Nardi, J., Göethel, G., da Costa, B. S., Correia, D., Matte, Ú. D. S., Charão, M. F., Arbo, M. D., et al. (2018) · Environmental Research · doi:10.1016/j.envres.2018.05.029 · Cited by 21

Expression and functional characterization of a mannose-binding lectin-associated serine protease-1 (MASP-1) from Nile tilapia (Oreochromis niloticus) in host defense against bacterial infection

Mu, L., Yin, X., Wu, H., Han, K., Wu, L., Ding, M., Bian, X., Li, B., Fu, S., Liang, F., et al. (2019) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2019.05.014 · Cited by 21

Causes of recurrent miscarriage after spontaneous pregnancy and after in vitro fertilization

Bilibio, J. P., Gama, T. B., Nascimento, I. C. M., Meireles, A. J. C., de Aguiar, A. S. C., do Nascimento, F. C., & Lorenzzoni, P. L. (2020) · American Journal of Reproductive Immunology · doi:10.1111/aji.13226 · Cited by 22

A rational search for discovering potential neutraligands of human complement fragment 5a (hC5a)

Mishra, R., & Rana, S. (2019) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2019.115052 · Cited by 21

Astrocyte-derived complement C3 facilitated microglial phagocytosis of synapses in Staphylococcus aureus-associated neurocognitive deficits

Zhang, H., Jin, Q., Li, J., Wang, J., Li, M., Yin, Q., Li, Q., Qi, Y., Feng, L., Shen, L., et al. (2025) · PLoS Pathogens · doi:10.1371/journal.ppat.1013126 · Cited by 23

Modulation of the innate immune responses in Indian major carp, Catla catla following experimental infection with Flavobacterium columnare

RAVINDRA, R., Pradhan, P. K., Pande, V., Yadav, M., Verma, D. K., & Sood, N. (2019) · Aquaculture · doi:10.1016/j.aquaculture.2019.05.015 · Cited by 20

A higher burden of multiple sclerosis genetic risk confers an earlier onset

Misicka, E., Davis, M. F., Kim, W., Brugger, S. W., Beales, J. T., Loomis, S. J., Bronson, P. G., & Briggs, F. B. S. (2021) · Multiple Sclerosis Journal · doi:10.1177/13524585211053155 · Cited by 21

Intracellular Complement Component 3 Attenuated Ischemia-Reperfusion Injury in the Isolated Buffer-Perfused Mouse Heart and Is Associated With Improved Metabolic Homeostasis

Torp, M. K., Ranheim, T., Schjalm, C., Hjorth, M., Heiestad, C. M., Dalen, K. T., Nilsson, P. H., Mollnes, T. E., Pischke, S. E., Lien, E., et al. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.870811 · Cited by 19

Complementing Testicular Immune Regulation: The Relationship between Sertoli Cells, Complement, and the Immune Response

Washburn, R. L., & Dufour, J. M. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24043371 · Cited by 20

Receptor–ligand interaction controls microglial chemotaxis and amelioration of Alzheimer's disease pathology

Lau, S., Fu, A. K. Y., & Ip, N. Y. (2023) · Journal of Neurochemistry · doi:10.1111/jnc.15933 · Cited by 21

The schizophrenia risk gene C4 induces pathological synaptic loss by impairing AMPAR trafficking

Phadke, R. A., Brack, A., Fournier, L. A., Kruzich, E., Sha, M., Picard, I., Johnson, C., Stroumbakis, D., Salgado, M., Yeung, C., et al. (2025) · Molecular Psychiatry · doi:10.1038/s41380-024-02701-7 · Cited by 20

Beyond the Norm: The emerging interplay of complement system and extracellular matrix in the tumor microenvironment

Balduit, A., Agostinis, C., & Bulla, R. (2025) · Seminars in Immunology · doi:10.1016/j.smim.2025.101929 · Cited by 20

Complement-Targeted Therapeutics in Periodontitis

Hajishengallis, G., & Lambris, J. D. (2012) · Advances in experimental medicine and biology · doi:10.1007/978-1-4614-4118-2_13 · Cited by 20

Complement regulatory protein Crry deficiency contributes to the antigen specific recall response in experimental autoimmune myasthenia gravis

Šoltýs, J., & Wu, X. (2012) · Journal of Inflammation · doi:10.1186/1476-9255-9-20 · Cited by 20

Molecular Characterization and Expression Analyses of the Complement Component C8α, C8β and C9 Genes in Yellow Catfish (Pelteobagrus fulvidraco) after the Aeromonas hydrophila Challenge

Zheng, H., Ji, W., Zhang, G., Zhang, X., Shi, Z.-C., Wei, K.-J., Yang, R., & Gardner, J. P. A. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17030345 · Cited by 20

K+ channel blocker-induced neuroinflammatory response and neurological disorders: immunomodulatory effects of astaxanthin

Ahras-Sifi, N., Martin‐Eauclaire, M., & Laraba‐Djebari, F. (2016) · Inflammation Research · doi:10.1007/s00011-016-0945-y · Cited by 20

Correlates of immune defenses in golden eagle nestlings

MacColl, E., Vanesky, K., Buck, J. A., Dudek, B. M., Eagles‐Smith, C. A., Heath, J. A., Herring, G., Vennum, C. R., & Downs, C. J. (2017) · Journal of Experimental Zoology Part A Ecological and Integrative Physiology · doi:10.1002/jez.2081 · Cited by 20

The Lectin Pathway in Thrombotic Conditions—A Systematic Review

Larsen, J. B., Hvas, C. L., & Hvas, A. (2018) · Thrombosis and Haemostasis · doi:10.1055/s-0038-1654714 · Cited by 20

Differential immunoglobulin and complement levels in leprosy prior to development of reversal reaction and erythema nodosum leprosum

Amorim, F. M., Nobre, M. L., Nascimento, L. S., Miranda, A. M., Monteiro, G. R., Freire‐Neto, F. P., Queiroz, M. D. C. P., Queiroz, J. W., Duthie, M. S., Costa, M. R., et al. (2019) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0007089 · Cited by 20

Glutamine protects against LPS-induced inflammation via adjusted NODs signaling and enhanced immunoglobulins secretion in rainbow trout leukocytes

Li, S., Guo, Q., Li, S., Zheng, H., Chi, S., Xu, Z., & Wang, Q. (2019) · Developmental & Comparative Immunology · doi:10.1016/j.dci.2019.05.006 · Cited by 20

Proteomics reveals the gender differences in humoral immunity and physiological characteristics associated with reproduction in the sea cucumber Apostichopus japonicus

Jiang, J., Zhao, Z., Pan, Y., Dong, Y., Gao, S., Jiang, B., Xiao, Y., Jiang, P., Zhang, G., Wang, X., et al. (2020) · Journal of Proteomics · doi:10.1016/j.jprot.2020.103687 · Cited by 20

Contribution to HIV Prevention and Treatment by Antibody-Mediated Effector Function and Advances in Broadly Neutralizing Antibody Delivery by Vectored Immunoprophylaxis

Phelps, M., & Balazs, A. B. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.734304 · Cited by 21

Increased Serum Thromboxane A2 and Prostacyclin but Lower Complement C3 and C4 Levels in COVID-19: Associations with Chest CT Scan Anomalies and Lowered Peripheral Oxygen Saturation

Al‐Hakeim, H. K., Al-Hamami, S. A., Almulla, A. F., & Maes, M. H. J. (2021) · COVID · doi:10.3390/covid1020042 · Cited by 20

Vascular Dementia and Crosstalk Between the Complement and Coagulation Systems

Parsi, M. M., Duval, C., & Ariëns, R. A. S. (2021) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2021.803169 · Cited by 21

Inhibition of the classical pathway of the complement system by saliva of Amblyomma cajennense (Acari: Ixodidae)

Franco, P. F., Silva, N. C. S., do Vale, V. F., Abreu, J. F., dos Santos, V. C., Gontijo, N. F., Valenzuela, J. G., Pereira, M. H., Sant'Anna, M. R. V., Gomes, A. P. S., et al. (2016) · Experimental Parasitology · doi:10.1016/j.exppara.2016.03.002 · Cited by 20

Inhibition of the complement system by saliva of Anopheles (Nyssorhynchus) aquasalis

Mendes‐Sousa, A. F., do Vale, V. F., Queiroz, D. C., Filho, A. A. P., da Silva, N. C. S., Koerich, L. B., Moreira, L. A., Pereira, M. H., Sant'Anna, M. R. V., Araújo, R. N., et al. (2017) · Insect Biochemistry and Molecular Biology · doi:10.1016/j.ibmb.2017.11.004 · Cited by 20

Stabilizing Polymer Coatings Alter the Protein Corona of DNA Origami and Can Be Engineered to Bias the Cellular Uptake

Rodríguez-Franco, H. J., Weiden, J., & Bastings, M. M. C. (2023) · ACS Polymers Au · doi:10.1021/acspolymersau.3c00009 · Cited by 19

Complement activation drives the phagocytosis of necrotic cell debris and resolution of liver injury

Vandendriessche, S., Mattos, M. S., Bialek, E. L., Schuermans, S., Proost, P., & Marques, P. E. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1512470 · Cited by 19

Complement activation in a phase Ib study of fordadistrogene movaparvovec for Duchenne muscular dystrophy

Byrne, B. J., Butterfield, R. J., Shieh, P. B., Smith, E. C., Licht, C. P. B., Binks, M. H., Casinghino, S. R., Delnomdedieu, M., Ravindra, K. C., McDonnell, T. G., et al. (2025) · Molecular Therapy · doi:10.1016/j.ymthe.2025.06.032 · Cited by 19

The Immuno-Glial Connectome in Alzheimer’s Disease: Integrating Central and Peripheral Inflammatory Networks

Gopalakrishna, P. K., Nassir, C. M. N. C. M., Anandan, S., Hussan, F., Dandala, K. C. R., Sura, S., Jagadeesan, S., Moklas, M. A. M., Vishnumukkala, T., & Hein, Z. M. (2026) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-026-01671-4 · Cited by 23

Effect of Aerobic and Anaerobic Exercise on the Complement System of Proteins in Healthy Young Males

Kostrzewa‐Nowak, D., Kubaszewska, J., Nowakowska, A., & Nowak, R. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9082357 · Cited by 19

Flexor Tendon Injury and Repair

Shen, H., Yoneda, S., Sakiyama‐Elbert, S. E., Zhang, Q., Thomopoulos, S., & Gelberman, R. H. (2021) · Journal of Bone and Joint Surgery · doi:10.2106/jbjs.20.01253 · Cited by 19

Investigating Cellular Trajectories in the Severity of COVID-19 and Their Transcriptional Programs Using Machine Learning Approaches

Jeong, H.-H., Jia, J. D., Dai, Y., Simon, L. M., & Zhao, Z. (2021) · Genes · doi:10.3390/genes12050635 · Cited by 19

Affinity Purification-Mass Spectrometry Identifies a Novel Interaction between a Polerovirus and a Conserved Innate Immunity Aphid Protein that Regulates Transmission Efficiency.

DeBlasio, S., Wilson, J. R., Tamborindeguy, C., Johnson, R. S., Pinheiro, P., MacCoss, M., Gray, S., & Heck, M. (2021) · Journal of Proteome Research · doi:10.1021/acs.jproteome.1c00313 · Cited by 16

Folic Acid-Coated Nanochitosan Ameliorated the Growth Performance, Hematological Parameters, Antioxidant Status, and Immune Responses of Rainbow Trout (Oncorhynchus mykiss)

Roudsari, S. F., Islami, H. R., Mousavi, S. A., & Mehrgan, M. S. (2021) · Frontiers in Veterinary Science · doi:10.3389/fvets.2021.647722 · Cited by 19

The Complement System in Ovarian Cancer: An Underexplored Old Path

Senent, Y., Ajona, D., González-Martı́n, A., Pı́o, R., & Tavira, B. (2021) · Cancers · doi:10.3390/cancers13153806 · Cited by 19

Glial-mediated neuroinflammatory mechanisms in age-related macular degeneration

Dhodapkar, R. M., Martell, D., & Hafler, B. P. (2022) · Seminars in Immunopathology · doi:10.1007/s00281-022-00939-3 · Cited by 19

Shrimp Immune System and Immune Responses

Rajendran, K. V., Sreedharan, K., Deepika, A., & Kulkarni, A. D. (2022) · Springer eBooks · doi:10.1007/978-981-19-1268-9_2 · Cited by 22

Hematopoietic stem cell transplantation-associated thrombotic microangiopathy and the role of advanced practice providers and pharmacists

Mahmoudjafari, Z., Alencar, M. C., Alexander, M. D., Johnson, D., Yeh, J. C., & Evans, M. D. (2023) · Bone Marrow Transplantation · doi:10.1038/s41409-023-01951-3 · Cited by 19

Gonococcal PorB: a multifaceted modulator of host immune responses

Jones, R. A., Jerse, A. E., & Tang, C. M. (2023) · Trends in Microbiology · doi:10.1016/j.tim.2023.10.002 · Cited by 19

Sex- and species-associated differences in complement-mediated immunity in humans and rhesus macaques

Kelkar, N. S., Goldberg, B. S., Dufloo, J., Bruel, T., Schwartz, O., Hessell, A. J., & Ackerman, M. E. (2024) · mBio · doi:10.1128/mbio.00282-24 · Cited by 19

Epidermal Growth Factor Receptor Targeting IgG3 Triggers Complement-Mediated Lysis of Decay-Accelerating Factor Expressing Tumor Cells through the Alternative Pathway Amplification Loop

Rösner, T., Lohse, S., Peipp, M., Valerius, T., & Derer, S. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1400329 · Cited by 19

Development of a large scale human complement source for use in bacterial immunoassays

Brookes, C., Kuisma, E., Alexander, F., Allen, L., Tipton, T. R. W., Ram, S., GORRINGE, A. R., & Taylor, S. C. (2013) · Journal of Immunological Methods · doi:10.1016/j.jim.2013.02.007 · Cited by 19

Antibody Therapeutics in Oncology

Wold, E. D., & Smider, V. V. (2016) · Immunotherapy Open Access · doi:10.4172/2471-9552.1000108 · Cited by 19

Characterization of Chemical Features of Potent Myeloperoxidase Inhibitors

Soubhye, J., Meyer, F., Furtmüller, P. G., Obinger, C., Dufrasne, F., & Antwerpen, P. V. (2016) · Future Medicinal Chemistry · doi:10.4155/fmc-2016-0031 · Cited by 19

Anti-Tumor Necrosis Factor α Therapeutics Differentially Affect Leishmania Infection of Human Macrophages

Arens, K., Filippis, C., Kleinfelder, H., Goetzee, A. G., Reichmann, G., Crauwels, P., Waibler, Z., Bagola, K., & van Zandbergen, G. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.01772 · Cited by 19

Demystifying Excess Immune Response in COVID-19 to Reposition an Orphan Drug for Down-Regulation of NF-κB: A Systematic Review

Peddapalli, A., Gehani, M., Kalle, A. M., Peddapalli, S. R., Peter, A. E., & Sharad, S. (2021) · Viruses · doi:10.3390/v13030378 · Cited by 19

Targeting the Complement Cascade in the Pathophysiology of COVID-19 Disease

Ng, N., & Powell, C. A. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10102188 · Cited by 20

Pharmacokinetic, pharmacodynamic, and immunogenic rationale for optimal dosing of pegvaliase, a PEGylated bacterial enzyme, in adult patients with phenylketonuria

Qi, Y., Patel, G., Henshaw, J., Gupta, S., Olbertz, J., Larimore, K., Harding, C. O., Merilainen, M. J., Zori, R. T., Longo, N., et al. (2021) · Clinical and Translational Science · doi:10.1111/cts.13043 · Cited by 19

Interaction of Human C5a with the Major Peptide Fragments of C5aR1: Direct Evidence in Support of “Two-Site” Binding Paradigm

Das, A., Behera, L. M., & Rana, S. (2021) · ACS Omega · doi:10.1021/acsomega.1c03400 · Cited by 19

The Pathogenesis of Autoimmune Hepatitis

Vierling, J. M. (2011) · Springer eBooks · doi:10.1007/978-1-60761-569-9_2 · Cited by 19

Complement activity of polysaccharides from three different plant parts of Terminalia macroptera extracted as healers do

Zou, Y., Zhang, B., Inngjerdingen, K. T., Barsett, H., Diallo, D., Michaelsen, T. E., & Paulsen, B. S. (2014) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2014.06.017 · Cited by 19

Exogenous C3 protein enhances the adaptive immune response to polymicrobial sepsis through down-regulation of regulatory T cells

Yuan, Y., Ren, J., Cao, S., Zhang, W., & Li, J. (2011) · International Immunopharmacology · doi:10.1016/j.intimp.2011.11.022 · Cited by 19

Complement‐mediated inhibition of adiponectin regulates perivascular inflammation and vascular injury in hypertension

Ruan, C., Ma, Y., Ge, Q., Li, Y., Zhu, L.-M., Zhang, Y., Kong, L., Wu, Q., Li, F., Cheng, L., et al. (2016) · The FASEB Journal · doi:10.1096/fj.201600780r · Cited by 19

Evaluation of the Ability of Immune Humanized Mice to Demonstrate CD 20‐Specific Cytotoxicity Induced by Ofatumumab

Semple, K. M., González, C. M., Zarr, M. A., Austin, J. R., Patel, V. P., & Howard, K. E. (2019) · Clinical and Translational Science · doi:10.1111/cts.12613 · Cited by 19

Analytical and Functional Similarity Assessment of ABP 710, a Biosimilar to Infliximab Reference Product

Saleem, R. A., Cantin, G. T., Wikström, M., Bolton, G., Kuhns, S. T., McBride, H. J., & Liu, J. (2020) · Pharmaceutical Research · doi:10.1007/s11095-020-02816-w · Cited by 19

Chitosan for Aquaculture: Growth Promotion, Immune Modulation, Antimicrobial Activity, Bio-Carrier Utility, Water Quality Management, and Safety Considerations – A Review

Abu‐Elala, N. M., Hossam-Elden, N., Marzouk, M. S., & Basuini, M. F. E. (2024) · Annals of Animal Science · doi:10.2478/aoas-2024-0079 · Cited by 20

Role of the complement cascade in cerebral aneurysm formation, growth, and rupture

Appelboom, G., Chapel, D. B., Connolly, E. S., Goodman, A. M., LoPresti, M. A., Taylor, B. E. S., & Zilinyi, R. S. (2015) · Neuroimmunology and Neuroinflammation · doi:10.4103/2347-8659.154888 · Cited by 18

AGI-134: a fully synthetic α-Gal glycolipid that converts tumors into in situ autologous vaccines, induces anti-tumor immunity and is synergistic with an anti-PD-1 antibody in mouse melanoma models

Shaw, S. M., Middleton, J., Wigglesworth, K., Charlemagne, A., Schulz, O., Glossop, M. S., Whalen, G. F., Old, R. W., Westby, M., Pickford, C., et al. (2019) · Cancer Cell International · doi:10.1186/s12935-019-1059-8 · Cited by 18

Paroxysmal nocturnal hemoglobinuria: role of the complement system, pathogenesis, and pathophysiology

Bektas, M., Copley‐Merriman, C., Khan, S., Sarda, S. P., & Shammo, J. M. (2020) · Journal of Managed Care & Specialty Pharmacy · doi:10.18553/jmcp.2020.26.12-b.s3 · Cited by 18

Delirium in COVID-19 patients: a multicentric observational study in Italy

Martinotti, G., Bonanni, L., Barlati, S., Miuli, A., Sepede, G., Prestía, D., Trabucco, A., Palumbo, C., Massaro, A., Martina, O., et al. (2021) · Neurological Sciences · doi:10.1007/s10072-021-05461-2 · Cited by 18

Inflammation and convergent placenta gene co-option contributed to a novel reproductive tissue

Hilgers, L., Roth, O., Nolte, A. W., Schuller, A. M., Spanke, T., Flury, J. M., Utama, I. V., Altmüller, J., Wowor, D., Misof, B. Y., et al. (2021) · Current Biology · doi:10.1016/j.cub.2021.12.004 · Cited by 18

Human Properdin Released By Infiltrating Neutrophils Can Modulate Influenza A Virus Infection

Varghese, P. M., Mukherjee, S., Al-Mohanna, F. A., Saleh, S. M., Almajhdi, F. N., Beirag, N., Alkahtani, S. H., Rajkumari, R., Nal, B., Sim, R. B., et al. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.747654 · Cited by 18

Small-molecule screen reveals pathways that regulate C4 secretion in stem cell-derived astrocytes

Rapino, F. A., Natoli, T. E., Limone, F., O’Connor, E., Blank, J., Tegtmeyer, M., Chen, W., Norabuena, E. M., Narula, J. G., Hazelbaker, D. Z., et al. (2022) · Stem Cell Reports · doi:10.1016/j.stemcr.2022.11.018 · Cited by 18

gC1qR: A New Target for Cancer Immunotherapy

Lei, Y.-N., Li, X., Qin, D.-Y., Zhang, Y.-G., & Wang, Y. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1095943 · Cited by 17

Ras-Related Protein Rab5a Regulates Complement C5a Receptor Trafficking, Chemotaxis, and Chemokine Secretion in Human Macrophages

Wu, K., Condon, N. D., Hill, T. A., Reid, R. C., Fairlie, D. P., & Lim, J. (2023) · Journal of Innate Immunity · doi:10.1159/000530012 · Cited by 18

High-force catch bonds between the Staphylococcus aureus surface protein SdrE and complement regulator factor H drive immune evasion

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Laterosporulin25: A probiotically produced, novel defensin-like bacteriocin and its immunogenic properties

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Exploring Immunome and Microbiome Interplay in Reproductive Health: Current Knowledge, Challenges, and Novel Diagnostic Tools

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ptx3a+ fibroblast/epicardial cells provide a transient macrophage niche to promote heart regeneration

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Proteomic profiling of bronchoalveolar lavage fluid uncovers protein clusters linked to survival in idiopathic forms of interstitial lung disease

Ngo, L. T., Rekowski, M. J., Koestler, D. C., Yorozuya, T., Saitô, A., Azeem, I., Harrison, A., Demoruelle, M. K., Boomer, J. S., England, B. R., et al. (2024) · ERJ Open Research · doi:10.1183/23120541.00192-2024 · Cited by 18

The Role of Complement in Antibody Therapy for Infectious Diseases

Wibroe, P. P., Helvig, S. Y., & Moghimi, S. M. (2015) · ASM Press eBooks · doi:10.1128/9781555817411.ch4

The Role of the Complement System in Innate Immunity

Rus, H., Cudrici, C. D., & Niculescu, F. I. (2005) · Immunologic Research · doi:10.1385/ir:33:2:103 · Cited by 288

Let’s Tie the Knot: Marriage of Complement and Adaptive Immunity in Pathogen Evasion, for Better or Worse

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The “ins and outs” of complement‐driven immune responses

Freeley, S. J., Kemper, C., & Friec, G. L. (2016) · Immunological Reviews · doi:10.1111/imr.12472 · Cited by 166

Complement: coming full circle

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