Cited by 1,932Complement system in diseasesBiomarkers in Disease MechanismsImmune Response and Inflammation

The DOI matches its Crossref record; 170 of the 170 references it cites were found in a registry or an index.

Complement and its role in innate and adaptive immune responses

Dunkelberger, Jason R, Song, Wen-Chao·2010·Cell Research

DOI 10.1038/cr.2009.139

Open this paper in CoChat — free account

Abstract

The complement system plays a crucial role in the innate defense against common pathogens. Activation of complement leads to robust and efficient proteolytic cascades, which terminate in opsonization and lysis of the pathogen as well as in the generation of the classical inflammatory response through the production of potent proinflammatory molecules. More recently, however, the role of complement in the immune response has been expanded due to observations that link complement activation to adaptive immune responses. It is now appreciated that complement is a functional bridge between innate and adaptive immune responses that allows an integrated host defense to pathogenic challenges. As such, a study of its functions allows insight into the molecular underpinnings of host-pathogen interactions as well as the organization and orchestration of the host immune response. This review attempts to summarize the roles that complement plays in both innate and adaptive immune responses and the consequences of these interactions on host defense.

Integrity signals

Registry

Crossref · 10.1038/cr.2009.139

Cites

170 of 170 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Toll-like receptor control of the adaptive immune responses
Iwasaki, A., & Medzhitov, R. M. (2004) · Nature Immunology · doi:10.1038/ni1112 · Cited by 4,166
Immunobiology: the immune system in health and disease
(1995) · Choice Reviews Online · doi:10.5860/choice.32-3876 · Cited by 4,111
Approaching the asymptote? Evolution and revolution in immunology.Preprint
Janeway, C. (1989) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.1989.054.01.003 · Cited by 3,396
Complement
Walport, M. J. (2001) · New England Journal of Medicine · doi:10.1056/nejm200104053441406 · Cited by 2,969
Decoding the Patterns of Self and Nonself by the Innate Immune System
Medzhitov, R., & Janeway, C. A. (2002) · Science · doi:10.1126/science.1068883 · Cited by 2,154
Anesthesiology
Wiklund, R. A., & Rosenbaum, S. H. (1997) · New England Journal of Medicine · doi:10.1056/nejm199710163371606 · Cited by 2,153
Innate Immunity
Medzhitov, R. M., & Janeway, C. A. (2000) · New England Journal of Medicine · doi:10.1056/nejm200008033430506 · Cited by 1,827
Complement
Walport, M. J. (2001) · New England Journal of Medicine · doi:10.1056/nejm200104123441506 · Cited by 1,502
C3d of complement as a molecular adjuvant: Bridging innate and acquired immunity
Dempsey, P. W., Allison, M. E. D., Akkaraju, S., Goodnow, C. C., & Fearon, D. T. (1996) · Science · doi:10.1126/science.271.5247.348 · Cited by 1,197
Pattern Recognition Receptors
Gordon, S. (2002) · Cell · doi:10.1016/s0092-8674(02)01201-1 · Cited by 1,153

Flagged first, then by citations

Show all 170 references

Sorted by citations

Items 301–400 of 1,003

Relationship between Complement Membrane Attack Complex, Chemokine (C-C Motif) Ligand 2 (CCL2) and Vascular Endothelial Growth Factor in Mouse Model of Laser-induced Choroidal Neovascularization
Liu, J., Jha, P., Lyzogubov, V. V., Tytarenko, R. G., Bora, N. S., & Bora, P. S. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.226266 · Cited by 50
Natural IgM and the Development of B Cell-Mediated Autoimmune Diseases
Nguyen, T. T. T., & Baumgarth, N. (2016) · Critical Reviews in Immunology · doi:10.1615/critrevimmunol.2016018175 · Cited by 53
The Alternative Receptor for Complement Component 5a, C5aR2, Conveys Neuroprotection in Traumatic Spinal Cord Injury
Biggins, P. J., Brennan, F. H., Taylor, S. M., Woodruff, T. M., & Ruitenberg, M. J. (2017) · Journal of Neurotrauma · doi:10.1089/neu.2016.4701 · Cited by 51
In Vitro and In Vivo Differences in Murine Third Complement Component (C3) Opsonization and Macrophage/Leukocyte Responses to Antibody-Functionalized Iron Oxide Nanoworms
Wang, G., Griffin, J. I., Inturi, S., Brenneman, B., Banda, N. K., Holers, V. M., Moghimi, S. M., & Simberg, D. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00151 · Cited by 49
An unexpected player in Gaucher disease: The multiple roles of complement in disease development
Pandey, M. K., Grabowski, G. A., & Köhl, J. (2018) · Seminars in Immunology · doi:10.1016/j.smim.2018.02.006 · Cited by 49
Complement Activation and Interleukin Response in Major Abdominal Surgery
Kvarnström, A., Sarbinowski, R., Bengtson, J. P., Jacobsson, L. M., & Bengtsson, A. (2012) · Scandinavian Journal of Immunology · doi:10.1111/j.1365-3083.2012.02672.x · Cited by 49
More than just immune evasion: Hijacking complement by Plasmodium falciparum
Schmidt, C. Q., Kennedy, A. T., & Tham, W. (2015) · Molecular Immunology · doi:10.1016/j.molimm.2015.03.006 · Cited by 49
Multivalent Antibody‐Recruiting Macromolecules: Linking Increased Binding Affinity with Enhanced Innate Immune Killing
Uvyn, A., & Geest, B. G. D. (2020) · ChemBioChem · doi:10.1002/cbic.202000261 · Cited by 46
Complement levels at admission as a reflection of coronavirus disease 2019 (COVID‐19) severity state
Henry, B. M., Szergyuk, I., de Oliveira, M. H. S., Lippi, G., Benoit, J. L., Vikse, J., & Benoit, S. W. (2021) · Journal of Medical Virology · doi:10.1002/jmv.27077 · Cited by 48
Reduced Neutrophil Extracellular Trap Formation During Ischemia Reperfusion Injury in C3 KO Mice: C3 Requirement for NETs Release
Wu, X., You, D., Cui, J., Yang, L., Lin, L., Chen, Y., Xu, C., Lian, G., & Wan, J. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.781273 · Cited by 51
Genetic and molecular basis of the immune system in the brachiopod Lingula anatina
Gerdol, M., Luo, Y., Satoh, N., & Pallavicini, A. (2017) · Developmental & Comparative Immunology · doi:10.1016/j.dci.2017.12.021 · Cited by 48
Complement Activation by PEGylated Gold Nanoparticles
Quach, H. Q., Kong, R. L. X., & Kah, J. C. Y. (2018) · Bioconjugate Chemistry · doi:10.1021/acs.bioconjchem.7b00793 · Cited by 47
Acute Heart Failure Following Myocardial Infarction: Complement Activation Correlates with the Severity of Heart Failure in Patients Developing Cardiogenic Shock
Orrem, H. L., Nilsson, P. H., Pischke, S. E., Grindheim, G., Garred, P., Seljeflot, I., Husebye, T., Aukrust, P., Yndestad, A., Andersen, G. Ø., et al. (2018) · ESC Heart Failure · doi:10.1002/ehf2.12266 · Cited by 48
Review of approved NMO therapies based on mechanism of action, efficacy and long-term effects
Brod, S. A. (2020) · Multiple Sclerosis and Related Disorders · doi:10.1016/j.msard.2020.102538 · Cited by 48
Extensive characterization of the composition and functional activities of five preparations of human platelet lysates for dedicated clinical uses
Delila, L., Wu, Y., Nebie, O., Widyaningrum, R., Chou, M., Devos, D., & Burnouf, T. P. R. (2020) · Platelets · doi:10.1080/09537104.2020.1849603 · Cited by 48
Complement After Trauma: Suturing Innate and Adaptive Immunity
Chakraborty, S., Karasu, E., & Huber-Lang, M. S. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02050 · Cited by 48
An inhibitor of complement C5 provides structural insights into activation
Reichhardt, M. P., Johnson, S., Tang, T. T. L., Morgan, T., Tebeka, N. N., Popitsch, N. P., Deme, J. C., Jore, M. M., & Lea, S. M. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1909973116 · Cited by 47
Targeting autoimmune mechanisms by precision medicine in Myasthenia Gravis
Cavalcante, P., Mantegazza, R., & Antozzi, C. G. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1404191 · Cited by 49
Activation of the alternative pathway of complement during the acute phase of typical haemolytic uraemic syndrome
Ferraris, J. R., Ferraris, V., Acquier, A. B., Sorroche, P. B., Saez, M. S., Ginaca, A., & Méndez, C. F. (2015) · Clinical & Experimental Immunology · doi:10.1111/cei.12601 · Cited by 47
Identification of Novel Biomarker for Early Detection of Diabetic Nephropathy
Kim, K.-S., Lee, J.-S., Park, J.-H., Lee, E. Y., Moon, J., Lee, S., Lee, J.-S., Kim, J.-H., & Kim, H. S. (2021) · Biomedicines · doi:10.3390/biomedicines9050457 · Cited by 45
In vivo degradation forms, anti-degradation strategies, and clinical applications of therapeutic peptides in non-infectious chronic diseases
Tasdemiroglu, Y., Gourdie, R. G., & He, J. (2022) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2022.175192 · Cited by 49
The role of complement in mAb-based therapies of cancer
Taylor, R. P., & Lindorfer, M. A. (2013) · Methods · doi:10.1016/j.ymeth.2013.07.027 · Cited by 46
Molecular mechanisms of the antitumor effects of anti-CD20 antibodies
Winiarska, M. (2010) · Frontiers in bioscience · doi:10.2741/3688 · Cited by 46
CD59 Regulation by SOX2 Is Required for Epithelial Cancer Stem Cells to Evade Complement Surveillance
Chen, J., Ding, P., Li, L., Gu, H., Zhang, X., Zhang, L., Wang, N., Gan, L., Wang, Q., Zhang, W., et al. (2016) · Stem Cell Reports · doi:10.1016/j.stemcr.2016.11.008 · Cited by 46
A pilot study of high‐dose intravenous immunoglobulin 5% for autism: Impact on autism spectrum and markers of neuroinflammation
Melamed, I., Heffron, M., Testori, A., & Lipe, K. (2018) · Autism Research · doi:10.1002/aur.1906 · Cited by 46
How the Membrane Attack Complex Damages the Bacterial Cell Envelope and Kills Gram‐Negative Bacteria
Doorduijn, D. J., Rooijakkers, S. H. M., & Heesterbeek, D. A. C. (2019) · BioEssays · doi:10.1002/bies.201900074 · Cited by 46
Infectious Bronchitis Coronavirus Infection in Chickens: Multiple System Disease with Immune Suppression
Najimudeen, S. M., Hassan, M. S. H., Cork, S. C., & Abdul-Careem, M. F. (2020) · Pathogens · doi:10.3390/pathogens9100779 · Cited by 46
The Immunologic Effect of Early Intravenous Two and Four Gram Bolus Dosing of Tranexamic Acid Compared to Placebo in Patients With Severe Traumatic Bleeding (TAMPITI): A Randomized, Double-Blind, Placebo-Controlled, Single-Center Trial
Spinella, P. C., Thomas, K. A., Turnbull, I. R., Fuchs, A. G., Bochicchio, K. M., Schuerer, D. J. E., Reese, S., Centeno, A. A. C., Horn, C. B., Baty, J., et al. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.02085 · Cited by 46
Proximity-inducing modalities: the past, present, and future
Singh, S., Tian, W., Severance, Z. C., Chaudhary, S. K., Anokhina, V. S., Mondal, B., Pergu, R., Singh, P. R., Dhawa, U., Singha, S., et al. (2023) · Chemical Society Reviews · doi:10.1039/d2cs00943a · Cited by 47
Immunological and histopathological responses of the kidney of common carp (Cyprinus carpio L.) sublethally exposed to glyphosate
Ma, J., Bu, Y., & Li, X. (2014) · Environmental Toxicology and Pharmacology · doi:10.1016/j.etap.2014.11.004 · Cited by 45
Polysaccharides with immunomodulating activity from roots of Gentiana crassicaulis
Zou, Y., Fu, Y., Chen, X., Austarheim, I., Inngjerdingen, K. T., Huang, C., Lei, F., Song, X., Li, L., Ye, G., et al. (2017) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2017.04.049 · Cited by 45
Alzheimer’s Disease: From Genetic Variants to the Distinct Pathological Mechanisms
Sun, Q., Xie, N., Tang, B., Li, R., & Shen, Y. (2017) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2017.00319 · Cited by 46
Modulation of growth performance, non-specific immunity, intestinal morphology, the response to hypoxia stress and resistance to Aeromonas hydrophila of grass carp (Ctenopharyngodon idella) by dietary supplementation of a multi-strain probiotic
Chen, X., Xie, J., Liu, Z., Yin, P., Chen, M., Liu, Y., Tian, L., & Niu, J. (2020) · Comparative Biochemistry and Physiology Part C Toxicology & Pharmacology · doi:10.1016/j.cbpc.2020.108724 · Cited by 45
Immunological and physiopathological approach of COVID-19 in pregnancy
Ferrer‐Oliveras, R., Mendoza, M., Capote, S., Pratcorona, L., Esteve‐Valverde, E., Cabero, L., & Alijotas‐Reig, J. (2021) · Archives of Gynecology and Obstetrics · doi:10.1007/s00404-021-06061-3 · Cited by 46
Complement C3a receptor–mediated vascular dysfunction: a complex interplay between aging and neurodegeneration
Bhatia, K., Ahmad, S., Kindelin, A., & Ducruet, A. F. (2021) · Journal of Clinical Investigation · doi:10.1172/jci144348 · Cited by 44
Complement and Coagulation System Crosstalk in Synaptic and Neural Conduction in the Central and Peripheral Nervous Systems
Berkowitz, S. H., Chapman, J., Dori, A., Gofrit, S. G., Maggio, N., & Stein, E. S. (2021) · Biomedicines · doi:10.3390/biomedicines9121950 · Cited by 43
Glycosaminoglycan-based injectable hydrogels with multi-functions in the alleviation of osteoarthritis
Chen, Y., Li, L., Dong, L., Wu, A., Dong, Q., Jia, S., Li, Y., Li, Y., Guo, X., & Zang, H. (2022) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2022.119492 · Cited by 44
Inflammatory and Immunological Basis of Periodontal Diseases
Baima, G., Arce, M., Romandini, M., & Dyke, T. E. V. (2025) · Journal of Periodontal Research · doi:10.1111/jre.70040 · Cited by 53
Humoral immunity in phenotypes of chronic lung allograft dysfunction: A broncho-alveolar lavage fluid analysis
Vandermeulen, E., Verleden, S. E., Bellon, H., Ruttens, D., Lammertyn, E. J., Claes, S., Vandooren, J., Ugarte-Berzal, E., Schols, D., Emonds, M., et al. (2016) · Transplant Immunology · doi:10.1016/j.trim.2016.08.004 · Cited by 44
Variability of Complement Response toward Preclinical and Clinical Nanocarriers in the General Population
Benasutti, H., Wang, G., Vu, V. P., Scheinman, R. I., Groman, E., Saba, L. M., & Simberg, D. (2017) · Bioconjugate Chemistry · doi:10.1021/acs.bioconjchem.7b00496 · Cited by 45
Peripheral complement is increased in schizophrenia and inversely related to cortical thickness
Ji, E., Boerrigter, D., Cai, H. Q., Lloyd, D., Bruggemann, J. M., O׳Donnell, M., Galletly, C. A., Lloyd, A. R., Liu, D., Lenroot, R., et al. (2021) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2021.11.014 · Cited by 44
Transcriptome analysis revealed multiple immune processes and energy metabolism pathways involved in the defense response of the large yellow croaker Larimichthys crocea against Pseudomonas plecoglossicida
Zhang, Y., Lu, L., Li, C., Shao, G., & Chen, X. (2021) · Comparative Biochemistry and Physiology Part D Genomics and Proteomics · doi:10.1016/j.cbd.2021.100886 · Cited by 43
Innate and Innate-Like Immune System in Hypertension and Vascular Injury
Higaki, A., Caillon, A., Paradis, P., & Schiffrin, E. L. (2019) · Current Hypertension Reports · doi:10.1007/s11906-019-0907-1 · Cited by 43
The Diverse Roles of Phagocytes During Bacterial and Fungal Infections and Sterile Inflammation: Lessons From Zebrafish
Linnerz, T., & Hall, C. J. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01094 · Cited by 41
Role of IFN and Complements System: Innate Immunity in SARS-CoV-2
Shibabaw, T., Molla, M. D., Teferi, B., & Ayelign, B. (2020) · Journal of Inflammation Research · doi:10.2147/jir.s267280 · Cited by 51
Personalized Profiling Reveals Donor- and Lactation-Specific Trends in the Human Milk Proteome and Peptidome
Zhu, J., Dingess, K. A., Mank, M., Stahl, B., & Heck, A. J. R. (2020) · Journal of Nutrition · doi:10.1093/jn/nxaa445 · Cited by 46
Complement System in Cutaneous Squamous Cell Carcinoma
Riihilä, P., Nissinen, L. M., Knuutila, J. S., Nezhad, P. R., Viiklepp, K., & Kähäri, V. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20143550 · Cited by 47
Complement disorders and hemolytic uremic syndrome
Joseph, C., & Gattineni, J. (2013) · Current Opinion in Pediatrics · doi:10.1097/mop.0b013e32835df48a · Cited by 42
Effect of thiol functionalization on the hemo‐compatibility of PLGA nanoparticles
Thasneem, Y. M., Sajeesh, S., & Sharma, C. P. (2011) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.33220 · Cited by 42
Trichinella spiralis Paramyosin Binds Human Complement C1q and Inhibits Classical Complement Activation
Sun, R., Zhao, X., Wang, Z., Yang, J., Zhao, L., Zhan, B., & Zhu, X. (2015) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0004310 · Cited by 42
Turbot (Scophthalmus maximus) vs. VHSV (Viral Hemorrhagic Septicemia Virus): A Review
Pereiro, P., Figueras, A. J., & Novoa, B. (2016) · Frontiers in Physiology · doi:10.3389/fphys.2016.00192 · Cited by 43
Complement in Kidney Transplantation
Cernoch, M., & Viklický, O. (2017) · Frontiers in Medicine · doi:10.3389/fmed.2017.00066 · Cited by 42
SALSA—A dance on a slippery floor with changing partners
Reichhardt, M. P., Holmskov, U., & Meri, S. (2017) · Molecular Immunology · doi:10.1016/j.molimm.2017.05.029 · Cited by 41
Differential contribution of C5aR and C5b-9 pathways to renal thrombic microangiopathy and macrovascular thrombosis in mice carrying an atypical hemolytic syndrome–related factor H mutation
Ueda, Y., Miwa, T., Ito, D., Kim, H., Sato, S., Gullipalli, D., Zhou, L., Golla, M., Song, D., Dunaief, J. L., et al. (2019) · Kidney International · doi:10.1016/j.kint.2019.01.009 · Cited by 42
Self-citation
Relief of hypersaline stress in Nile tilapia Oreochromis niloticus by dietary supplementation of a host-derived Bacillus subtilis strain
Tang, S., Liu, S., Zhang, J., Zhou, L. Y., Wang, X., Zhao, Q., Weng, W., Qin, J. G., Chen, L., & Li, E. (2020) · Aquaculture · doi:10.1016/j.aquaculture.2020.735542 · Cited by 42
Broadly neutralizing antibodies for HIV-1 prevention and therapy
Jülg, B. D., & Barouch, D. H. (2021) · Seminars in Immunology · doi:10.1016/j.smim.2021.101475 · Cited by 42
Pathophysiological Roles of Stress-Activated Protein Kinases in Pulmonary Fibrosis
Kasuya, Y., Kim, J., Hatano, M., Tatsumi, K., & Matsuda, S. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22116041 · Cited by 40
Identification of Potential Prognostic and Predictive Immunological Biomarkers in Patients with Stage I and Stage III Non-Small Cell Lung Cancer (NSCLC): A Prospective Exploratory Study
Vaes, R. D. W., Reynders, K., Sprooten, J., Nevola, K. T., Rouschop, K. M. A., Vooijs, M., Garg, A. D., Lambrecht, M. L. F., Hendriks, L. E. L., Ručević, M., et al. (2021) · Cancers · doi:10.3390/cancers13246259 · Cited by 41
Periprosthetic joint infection and immunity: Current understanding of host–microbe interplay
Piuzzi, N. S., Klika, A. K., Lu, Q., Higuera, C. A., Stappenbeck, T. S., & Visperas, A. (2023) · Journal of Orthopaedic Research® · doi:10.1002/jor.25723 · Cited by 41
Age, sex and Alzheimer’s disease: a longitudinal study of 3xTg-AD mice reveals sex-specific disease trajectories and inflammatory responses mirrored in postmortem brains from Alzheimer’s patients
Barber, A. J., del Genio, C. L., Swain, A. B., Pizzi, E. M., Watson, S. C., Tapiavala, V. N., Zanazzi, G. J., & Gaur, A. B. (2024) · Alzheimer's Research & Therapy · doi:10.1186/s13195-024-01492-x · Cited by 41
Age-Related Macular Degeneration: A Disease of Systemic or Local Complement Dysregulation?
Warwick, A., Khandhadia, S., Ennis, S., & Lotery, A. J. (2014) · Journal of Clinical Medicine · doi:10.3390/jcm3041234 · Cited by 42
Antler extracts stimulate chondrocyte proliferation and possess potent anti-oxidative, anti-inflammatory, and immune-modulatory properties
Yao, B., Zhang, M., Leng, X., Liu, M., Liu, Y., Hu, Y., Zhao, D., & Zhao, Y. (2018) · In Vitro Cellular & Developmental Biology - Animal · doi:10.1007/s11626-018-0266-2 · Cited by 41
Complement C3a and C5a receptor blockade modulates regulatory T cell conversion in head and neck cancer
Gadwa, J., Bickett, T. E., Darragh, L. B., Knitz, M. W., Bhatia, S., Piper, M., Court, B. V., Bhuvane, S., Nguyen, D., Nangia, V., et al. (2021) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2021-002585 · Cited by 41
Photodynamic therapy for enhancing antitumour immunity
Pížová, K., Tomankova, K. B., Daskova, A., Binder, S., Bajgar, R., & Kolářová, H. (2012) · Biomedical Papers · doi:10.5507/bp.2012.056 · Cited by 41
RNA sequencing analysis to capture the transcriptome landscape during skin ulceration syndrome progression in sea cucumber Apostichopus japonicus
Yang, A., Zhou, Z., Pan, Y., Jiang, J., Dong, Y., Guan, X., Sun, H., Gao, S., & Chen, Z. (2016) · BMC Genomics · doi:10.1186/s12864-016-2810-3 · Cited by 41
The Role of Oxidative Stress and Inflammation in the Pathogenesis and Treatment of Vascular Dementia
Altahrawi, A. Y., James, A. W., & Shah, Z. A. (2025) · Cells · doi:10.3390/cells14080609 · Cited by 41
Bifunctional Lipocalin Ameliorates Murine Immune Complex-induced Acute Lung Injury
Roversi, P., Ryffel, B., Togbe, D., Maillet, I., Teixeira, M. M., Ahmat, N., Paesen, G. C., Lissina, O., Boland, W., Ploss, K., et al. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.420331 · Cited by 40
Mannose-Binding Lectin and Susceptibility to Schistosomiasis
Antony, J. S., Ojurongbe, O. D., Tong, H. V., Ouf, E. A., Engleitner, T., Akindele, A. A., Sina-Agbaje, O. R., Adeyeba, A. O., Kremsner, P. G., & Velavan, T. P. (2013) · The Journal of Infectious Diseases · doi:10.1093/infdis/jit081 · Cited by 40
Matriptase activation connects tissue factor–dependent coagulation initiation to epithelial proteolysis and signaling
Gall, S. M. L., Szabo, R., Lee, M., Kirchhofer, D., Craik, C. S., Bugge, T. H., & Camerer, E. (2016) · Blood · doi:10.1182/blood-2015-11-683110 · Cited by 41
Characterization and toxicity of citral incorporated with nanostructured lipid carrier
Nordin, N., Yeap, S. K., Zamberi, N. R., Abu, N., Mohamad, N. E., Rahman, H. S., How, C. W., Masarudin, M. J., Abdullah, R., & Alitheen, N. B. (2018) · PeerJ · doi:10.7717/peerj.3916 · Cited by 39
Hyaluronan interactions with innate immunity in lung biology
Tighe, R. M., & Garantziotis, S. (2018) · Matrix Biology · doi:10.1016/j.matbio.2018.01.027 · Cited by 40
Circadian Clock and Complement Immune System—Complementary Control of Physiology and Pathology?
Shivshankar, P., Fekry, B., Eckel‐Mahan, K. L., & Wetsel, R. A. (2020) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2020.00418 · Cited by 40
Integrative Analysis of Complement System to Prognosis and Immune Infiltrating in Colon Cancer and Gastric Cancer
Bao, D., Zhang, C., Li, L., Wang, H., Li, Q., Ni, L., Lin, Y., Huang, R., Yang, Z., Zhang, Y., et al. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2020.553297 · Cited by 40
Complement System Response to Adeno-Associated Virus Vector Gene Therapy
Kropf, E., Markusic, D. M., Majowicz, A., Mingozzi, F., & Kuranda, K. (2024) · Human Gene Therapy · doi:10.1089/hum.2023.194 · Cited by 39
Pathogenicity and virulence of Borrelia burgdorferi
Strnad, M., Rudenko, N., & Rego, R. O. M. (2023) · Virulence · doi:10.1080/21505594.2023.2265015 · Cited by 51
Complement Activation and Complement Receptors on Follicular Dendritic Cells Are Critical for the Function of a Targeted Adjuvant
Mattsson, J., Yrlid, U., Stensson, A., Schön, K., Karlsson, M. C. I., Ravetch, J. V., & Lycke, N. Y. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1101107 · Cited by 39
Subclinical endometritis in dairy cattle is associated with distinct mRNA expression patterns in blood and endometrium
Raliou, M., Dembélé, D., Düvel, A., Bolifraud, P., Aubert, J., Mary‐Huard, T., Rocha, D., Piumi, F., Mockly, S., Heppelmann, M., et al. (2019) · PLoS ONE · doi:10.1371/journal.pone.0220244 · Cited by 39
The dynamic interdependence of amebiasis, innate immunity, and undernutrition
Verkerke, H., Petri, W. A., & Marie, C. S. (2012) · Seminars in Immunopathology · doi:10.1007/s00281-012-0349-1 · Cited by 40
Lysine-specific demethylase 1 (LSD1) and histone deacetylase 1 (HDAC1) synergistically repress proinflammatory cytokines and classical complement pathway components
Janzer, A., Lim, S., Fronhoffs, F., Niazy, N., Buettner, R., & Kirfel, J. (2012) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2012.04.057 · Cited by 43
Advances in Ferritin Physiology and Possible Implications in Bacterial Infection
Gehrer, C. M., Mitterstiller, A., Grubwieser, P., Meyron‐Holtz, E. G., Weiß, G., & Nairz, M. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24054659 · Cited by 42
Mesenchymal stromal cells in renal ischemia/reperfusion injury
de Vries, D. K., Schaapherder, A. F., & Reinders, M. E. J. (2012) · Frontiers in Immunology · doi:10.3389/fimmu.2012.00162 · Cited by 38
Role of complement and potential of complement inhibitors in myasthenia gravis and neuromyelitis optica spectrum disorders: a brief review
Chamberlain, J. L., Huda, S., Whittam, D. H., Matiello, M., Morgan, B. P., & Jacob, A. (2019) · Journal of Neurology · doi:10.1007/s00415-019-09498-4 · Cited by 38
A receptor for the complement regulator factor H increases transmission of trypanosomes to tsetse flies
Macleod, O. J. S., Bart, J.-M., MacGregor, P., Peacock, L., Savill, N. J., Hester, S., Ravel, S., Sunter, J. D., Trevor, C., Rust, S. J., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-15125-y · Cited by 38
New insights into the Manila clam and PAMPs interaction based on RNA-seq analysis of clam through in vitro challenges with LPS, PGN, and poly(I:C)
Jiang, K., Nie, H., Li, D., & Yan, X. (2020) · BMC Genomics · doi:10.1186/s12864-020-06914-2 · Cited by 38
Characterization of the seminal plasma proteome in men with prostatitis by mass spectrometry
Kagedan, D. J., Lecker, I., Batruch, I., Smith, C. R., Kaploun, I., Lo, K. C., Grober, E. D., Diamandis, E. P., & Jarvi, K. A. (2012) · Clinical Proteomics · doi:10.1186/1559-0275-9-2 · Cited by 38
Bacillus anthracis Spore Surface Protein BclA Mediates Complement Factor H Binding to Spores and Promotes Spore Persistence
Wang, Y., Jenkins, S. A., Gu, C., Shree, A., Martinez-Moczygemba, M., Herold, J., Botto, M., Wetsel, R. A., & Xu, Y. (2016) · PLoS Pathogens · doi:10.1371/journal.ppat.1005678 · Cited by 38
The amphibian immune system
Ruiz, V. L., & Robert, J. (2023) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2022.0123 · Cited by 37
Complement C3 of tumor-derived extracellular vesicles promotes metastasis of RCC via recruitment of immunosuppressive myeloid cells
Zhang, Y., Wang, X., Gu, Y., Liu, T., Zhao, X., Cheng, S., Duan, L., Huang, C., Wu, S., & Gao, S. (2025) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2420005122 · Cited by 37
Different Host Complement Systems and Their Interactions with Saliva from Lutzomyia longipalpis (Diptera, Psychodidae) and Leishmania infantum Promastigotes
Mendes‐Sousa, A. F., Nascimento, A. A. S., Queiroz, D. C., do Vale, V. F., Fujiwara, R. T., Araújo, R. N., Pereira, M. H., & Gontijo, N. F. (2013) · PLoS ONE · doi:10.1371/journal.pone.0079787 · Cited by 37
Immunological effects of paraquat on common carp, Cyprinus carpio L.
Ma, J., Li, Y., Niu, D., Li, Y., & Li, X. (2014) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2014.01.015 · Cited by 37
Molecular and functional characterization of CD59 from Nile tilapia (Oreochromis niloticus) involved in the immune response to Streptococcus agalactiae
Gan, Z., Wang, B., Zhou, W. X., Lu, Y., Zhu, W., Tang, J., Jian, J., & Wu, Z. (2015) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2015.01.035 · Cited by 37
The membrane complement regulatory protein CD59 promotes tumor growth and predicts poor prognosis in breast cancer
Ouyang, Q., Zhang, L., Jiang, Y., Ni, X., Chen, S., YE, F., Du, Y., Huang, L., Ding, P., Wang, N., et al. (2016) · International Journal of Oncology · doi:10.3892/ijo.2016.3408 · Cited by 37
Neutralizing antibodies for HIV-1 prevention
Jülg, B. D., & Barouch, D. H. (2019) · Current Opinion in HIV and AIDS · doi:10.1097/coh.0000000000000556 · Cited by 37
Suppressing MDSC Infiltration in Tumor Microenvironment Serves as an Option for Treating Ovarian Cancer Metastasis
Li, Y., Zhang, Q., Wu, M., Zhang, P., Huang, L., Ai, X., Yang, Z., Shen, Q., Wang, Y., Wang, P., et al. (2022) · International Journal of Biological Sciences · doi:10.7150/ijbs.70013 · Cited by 37
From Bench to Bedside: Implications of Lipid Nanoparticle Carrier Reactogenicity for Advancing Nucleic Acid Therapeutics
Korzun, T., Moses, A. S., Diba, P., Sattler, A. L., Taratula, O. R., Sahay, G., Taratula, O., & Marks, D. L. (2023) · Pharmaceuticals · doi:10.3390/ph16081088 · Cited by 40
Ensemble refinement shows conformational flexibility in crystal structures of human complement factor D
Forneris, F., Burnley, B. T., & Gros, P. (2014) · Acta Crystallographica Section D Biological Crystallography · doi:10.1107/s1399004713032549 · Cited by 37
Tremelimumab and Durvalumab in the Treatment of Unresectable, Advanced Hepatocellular Carcinoma
Castria, T. B. D., Khalil, D. N., Harding, J. J., O'Reilly, E. M., & Abou‐Alfa, G. K. (2022) · Future Oncology · doi:10.2217/fon-2022-0652 · Cited by 36
Astrocyte-neuron communication through the complement C3-C3aR pathway in Parkinson’s disease
Chi, X., Yin, S., Sun, Y., Kou, L., Zou, W., Wang, Y., Jin, Z., Wang, T., & Xia, Y. F. (2024) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2024.09.022 · Cited by 42
Advancements in Serine Protease Inhibitors: From Mechanistic Insights to Clinical Applications
Wei, Y., Huang, M., & Jiang, L. (2024) · Catalysts · doi:10.3390/catal14110787 · Cited by 38
Interferon-beta therapy in multiple sclerosis: the short-term and long-term effects on the patients’ individual gene expression in peripheral blood
Hecker, M., Hartmann, C., Kandulski, O., Paap, B. K., Koczan, D., Thiesen, H., & Zettl, U. K. (2013) · Molecular Neurobiology · doi:10.1007/s12035-013-8463-1 · Cited by 36

Authors: Dunkelberger, J. R., & Song, W.-C.
Affiliations: University of Pennsylvania (US)
Corresponding author: Song, Wen-Chao
ORCID: Song, Wen-Chao
Venue: Cell Research
Publisher: Springer Science and Business Media LLC
Published: 2009-12-15
Volume: 20
Issue: 1
Pages: 34-50
ISSN: 1001-0602 (ISSN-L)
1748-7838
DOI: 10.1038/cr.2009.139
OpenAlex: W2005044790
Cited by: 1,932
References: 170
Citations by year: 2026: 163 · 2025: 207 · 2024: 239 · 2023: 192 · 2022: 149 · 2021: 186 · 2020: 103 · 2019: 85 · 2018: 103 · 2017: 98 · 2016: 95 · 2015: 67 · 2014: 65 · 2013: 49 · 2012: 68
FWCI: 3.37
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Cell Research (publishedVersion)
PubMed (publishedVersion)
Funders: American Heart Association
National Institutes of Health
Topics: Life Sciences › Immunology and Microbiology › Immunology › Complement system in diseases
Life Sciences › Immunology and Microbiology › Immunology › Biomarkers in Disease Mechanisms
Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Keywords: complement system, innate immunity, adaptive immunity, complement activation, opsonization, proinflammatory molecules, host-pathogen interaction
MeSH terms: Animals, B-Lymphocytes, Complement System Proteins, Humans, Immunity, Innate, Inflammation, T-Lymphocytes, Inflammation Mediators, Host-Pathogen Interactions, Adaptive Immunity, Immunity, Humoral

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Complement and its role in innate and adaptive immune responses

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks