Cited by 1,932Complement system in diseasesBiomarkers in Disease MechanismsImmune Response and Inflammation

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Complement and its role in innate and adaptive immune responses

Dunkelberger, Jason R, Song, Wen-Chao·2010·Cell Research

DOI 10.1038/cr.2009.139

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Abstract

The complement system plays a crucial role in the innate defense against common pathogens. Activation of complement leads to robust and efficient proteolytic cascades, which terminate in opsonization and lysis of the pathogen as well as in the generation of the classical inflammatory response through the production of potent proinflammatory molecules. More recently, however, the role of complement in the immune response has been expanded due to observations that link complement activation to adaptive immune responses. It is now appreciated that complement is a functional bridge between innate and adaptive immune responses that allows an integrated host defense to pathogenic challenges. As such, a study of its functions allows insight into the molecular underpinnings of host-pathogen interactions as well as the organization and orchestration of the host immune response. This review attempts to summarize the roles that complement plays in both innate and adaptive immune responses and the consequences of these interactions on host defense.

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Authors: Dunkelberger, J. R., & Song, W.-C.
Affiliations: University of Pennsylvania (US)
Corresponding author: Song, Wen-Chao
ORCID: Song, Wen-Chao
Venue: Cell Research
Publisher: Springer Science and Business Media LLC
Published: 2009-12-15
Volume: 20
Issue: 1
Pages: 34-50
ISSN: 1001-0602 (ISSN-L)
1748-7838
DOI: 10.1038/cr.2009.139
OpenAlex: W2005044790
Cited by: 1,932
References: 170
Citations by year: 2026: 163 · 2025: 207 · 2024: 239 · 2023: 192 · 2022: 149 · 2021: 186 · 2020: 103 · 2019: 85 · 2018: 103 · 2017: 98 · 2016: 95 · 2015: 67 · 2014: 65 · 2013: 49 · 2012: 68
FWCI: 3.37
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Cell Research (publishedVersion)
PubMed (publishedVersion)
Funders: American Heart Association
National Institutes of Health
Topics: Life Sciences › Immunology and Microbiology › Immunology › Complement system in diseases
Life Sciences › Immunology and Microbiology › Immunology › Biomarkers in Disease Mechanisms
Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Keywords: complement system, innate immunity, adaptive immunity, complement activation, opsonization, proinflammatory molecules, host-pathogen interaction
MeSH terms: Animals, B-Lymphocytes, Complement System Proteins, Humans, Immunity, Innate, Inflammation, T-Lymphocytes, Inflammation Mediators, Host-Pathogen Interactions, Adaptive Immunity, Immunity, Humoral

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Complement and its role in innate and adaptive immune responses

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