Cited by 191MicroRNA in disease regulationCancer-related molecular mechanisms researchHead and Neck Cancer Studies

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Regulation of the cell cycle gene, BTG2, by miR-21 in human laryngeal carcinoma

Liu, Min, Wu, Haidong, Liu, Tao, Li, Yixuan, Wang, Fang, Wan, Haiying, Li, Xin, Tang, Hua·2009·Cell Research

DOI 10.1038/cr.2009.72

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Abstract

MicroRNAs are short regulatory RNAs that negatively modulate gene expression at the post-transcriptional level, and are deeply involved in the pathogenesis of several types of cancers. To investigate whether specific miRNAs and their target genes participate in the molecular pathogenesis of laryngeal carcinoma, oligonucleotide microarrays were used to assess the differential expression profiles of microRNAs and mRNAs in laryngeal carcinoma tissues compared with normal tissues. The oncogenic miRNA, microRNA-21 (miR-21), was found to be upregulated in laryngeal carcinoma tissues. Knockdown of miR-21 by specific antisense oligonucleotides inhibited the proliferation potential of HEp-2 cells, whereas overexpression of miR-21 elevated growth activity of the cells, as detected by the colony formation assay. The cell number reduction caused by miR-21 inhibition was due to the loss of control of the G1-S phase transition, instead of a noticeable increase in apoptosis. Subsequently, a new target gene of miR-21, BTG2, was found to be downregulated in laryngeal carcinoma tissues. BTG2 is known to act as a pan-cell cycle regulator and tumor suppressor. These findings indicate that aberrant expression of miR-21 may contribute to the malignant phenotype of laryngeal carcinoma by maintaining a low level of BTG2. The identification of the oncogenic miR-21 and its target gene, BTG2, in laryngeal carcinoma is potentially valuable for cancer diagnosis and therapy.

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Krek, A., Grün, D., Poy, M. N., Wolf, R., Rosenberg, L., Epstein, E. J., MacMenamin, P., da Piedade, I., Gunsalus, K. C., Stoffel, M., et al. (2005) · Nature Genetics · doi:10.1038/ng1536 · Cited by 4,603
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Shi, Y., Gong, H.-L., Zhou, L. F., Tian, J., & Wang, Y. (2012) · ORL · doi:10.1159/000335584 · Cited by 24
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Retracted
Expression and significance of miRNA-21 and BTG2 in lung cancer
Sun, Q., Hang, M., Guo, X., Shao, W., & Zeng, G. (2013) · Tumor Biology · doi:10.1007/s13277-013-0992-8 · Cited by 23
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Authors: Liu, M., Wu, H., Liu, T., Li, Y., Wang, F., Wan, H., Li, X., & Tang, H.
Affiliations: Tianjin Medical University (CN)
Corresponding author: Tang, Hua
ORCID: Liu, Min
Wu, Haidong
Liu, Tao
Li, Yixuan
Wang, Fang
Li, Xin
Tang, Hua
Venue: Cell Research
Publisher: Springer Science and Business Media LLC
Published: 2009-06-23
Volume: 19
Issue: 7
Pages: 828-837
ISSN: 1001-0602 (ISSN-L)
1748-7838
DOI: 10.1038/cr.2009.72
OpenAlex: W2083966895
Cited by: 189
References: 33
Citations by year: 2026: 6 · 2025: 4 · 2024: 7 · 2023: 6 · 2022: 6 · 2021: 18 · 2020: 11 · 2019: 4 · 2018: 11 · 2017: 10 · 2016: 14 · 2015: 20 · 2014: 20 · 2013: 8 · 2012: 14
FWCI: 4.92
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Cell Research (publishedVersion)
PubMed (publishedVersion)
Funders: National Natural Science Foundation of China (30873017)
Tianjin Medical University
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer-related molecular mechanisms research
Health Sciences › Medicine › Otorhinolaryngology › Head and Neck Cancer Studies
Keywords: miR-21, BTG2, laryngeal cancer, miRNA target genes, cell cycle regulation, G1/S transition, tumor suppressor, cell proliferation, HEp-2 cells, post-transcriptional regulation, oncogenic microRNA
MeSH terms: Carcinoma, Humans, Laryngeal Neoplasms, Down-Regulation, Gene Expression Regulation, Neoplastic, G1 Phase, S Phase, Oligonucleotides, Antisense, Immediate-Early Proteins, Tumor Suppressor Proteins, MicroRNAs, Cell Line, Tumor, Gene Knockdown Techniques

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Regulation of the cell cycle gene, BTG2, by miR-21 in human laryngeal carcinoma

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