MicroRNA-21 expression is associated with overall survival in patients with glioma
Open accessAbstract
BACKGROUND: MicroRNA-21 has been proved to be associated with glioma proliferation and invasion; thus, we sought to clarify the clinical value of miR-21 expression in glioma tissues with WHO grade I to IV. METHODS: One hundred and fifty-two pairs of human gliomas and non-neoplastic brain tissues were evaluated using real-time PCR. The association of miR-21 expression with clinicopathological factors or the prognosis of glioma patients was also analyzed. In this study, survival analysis was performed using the Kaplan-Meier method and Cox's proportional hazards model. RESULTS: MiR-21 was more greatly expressed in glioma tissues compared to the corresponding non-neoplastic brain tissues (P < 0.001). This observed high miR-21 expression was significantly associated with high pathological grades and the Karnofsky performance score of glioma patients. In addition, overall patient survival for those with low miR-21 expression was significantly longer than those patients with high miR-21 expression (P < 0.001). Moreover, multivariate Cox regression analysis indicated that miR-21 might be an independent prognostic marker for glioma patient survival. CONCLUSIONS: Our data show that miR-21 may be a candidate independent marker for gliomas, especially those with high pathological grades, and this could also be a potential therapeutic target for molecular glioma therapy. VIRTUAL SLIDE: The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/1445749171109834.
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miR-21 is significantly upregulated in glioma tissues and strongly correlates with tumor characteristics and invasiveness.
“miR-21, an oncomiR in glioma, showed significant upregulation in glioma tissues, strongly correlating with tumor characteristics and invasiveness [26].”
From miR-21 as a diagnostic and prognostic biomarker in glioma: tissue and serum expression analysis in a Pakistani cohort (2026) · cites this paper as [26]
The Results section reports significantly higher miR-21 expression in glioma tissues than in non-neoplastic brain tissues, and the Discussion reports a significant correlation with aggressive clinicopathological features. The Abstract Background says miR-21 is associated with glioma invasion, but the paper does not establish the claimed strong correlation between expression and invasiveness specifically. (LLM, conf=0.84)
Experimental — accuracy not yet measuredSerum miR-21 expression levels were significantly higher in pre-operative glioma samples than in postoperative serum of grade 2 (p=0.0079), grade 3 (p=0.0079) and grade 4 (p=0.0096).
“Moreover, the serum expression levels were also significantly higher in pre-operative glioma samples than in postoperative serum of grade 2 (p=0.0079 ), grade 3 (p=0.0079) and grade 4 (p=0.0096)which is consistent with previous findings [26,30] .”
From miR-21 as a diagnostic and prognostic biomarker in glioma: tissue and serum expression analysis in a Pakistani cohort (2026) · cites this paper as [26]
The Results section ('Increased expression of miR-21 in glioma tissues') compares resected glioma tissue with adjacent non-neoplastic brain tissue, not pre-operative and postoperative serum. The Methods section ('Patients and tissue samples') likewise describes tissue specimens; searches for serum, pre/postoperative comparisons, and the stated p-values found no supporting passage in our copy. (LLM, conf=0.78)
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- Authors
- Wu, L., Li, G., Feng, D., Qin, H., Gong, L., Zhang, J., & Zhang, Z.
- Affiliations
- State Key Laboratory of Cancer Biology (CN)
- Tang Du Hospital (CN)
- Wuhan General Hospital of Guangzhou (CN)
- Corresponding author
- Zhang, Zhiguo
- Venue
- Diagnostic Pathology
- Published
- 2013-12
- Volume
- 8
- Issue
- 1
- Pages
- 200-200
- ISSN
- 1746-1596 (ISSN-L)
- PMC
- PMC3933412
- OpenAlex
- W1968325334
- Cited by
- 53
- References
- 25
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 4 · 2023: 3 · 2022: 3 · 2021: 3 · 2020: 5 · 2019: 3 · 2018: 2 · 2017: 4 · 2016: 5 · 2015: 5 · 2014: 9
- FWCI
- 2.23
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Diagnostic Pathology (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- World Health Organization
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
- Health Sciences › Medicine › Genetics › Glioma Diagnosis and Treatment
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer-related molecular mechanisms research
- Keywords
- miR-21, glioma, overall survival, prognostic factors, tumor grade, Karnofsky performance status, therapeutic target
- MeSH terms
- Adolescent, Adult, Aged, Aged, 80 and over, Brain Neoplasms, Child, Child, Preschool, Female, Glioma, Humans, Male, Middle Aged, Risk Factors, Time Factors, Biomarkers, Tumor, Up-Regulation, Multivariate Analysis, Proportional Hazards Models, Karnofsky Performance Status, MicroRNAs, Kaplan-Meier Estimate, Young Adult, Neoplasm Grading, Real-Time Polymerase Chain Reaction
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