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Cited by 124

The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.

BMPs functionally replace Klf4 and support efficient reprogramming of mouse fibroblasts by Oct4 alone

Chen, Jiekai, Liu, Jing, Yang, Jiaqi, Chen, You, Chen, Jing, Ni, Su, Song, Hong, Zeng, Lingwen, Ding, Ke, Pei, Duanqing·2011·Cell Research
DOI 10.1038/cr.2010.172
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Abstract

Generation of induced pluripotent stem cells by defined factors has become a useful model to investigate the mechanism of reprogramming and cell fate determination. However, the precise mechanism of factor-based reprogramming remains unclear. Here, we show that Klf4 mainly acts at the initial phase of reprogramming to initiate mesenchymal-to-epithelial transition and can be functionally replaced by bone morphogenetic proteins (BMPs). BMPs boosted the efficiency of Oct4/Sox2-mediated reprogramming of mouse embryonic fibroblasts (MEFs) to ∼1%. BMPs also promoted single-factor Oct4-based reprogramming of MEFs and tail tibial fibroblasts. Our studies clarify the contribution of Klf4 in reprogramming and establish Oct4 as a singular setter of pluripotency in differentiated cells.

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Crossref · 10.1038/cr.2010.172

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2 of 2 references verified0 citation errors · 0 not checkable

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  • Vitamin C, IL-6, TGFβ and bone morphogenetic proteins regulate cellular reprogramming by affecting DNA methylation levels, thereby adjusting the expression of certain microRNAs or facilitating the mesenchymal-to-epithelial transition (MET).

    “In addition to cell intrinsic transcription factors for cellular reprogramming, modulators such as vitamin C [62][63][64][65] , IL-6 [66][67][68] , TGFβ 69 and bone morphogenetic proteins 70 have been shown to regulate cellular reprogramming by affecting DNA methylation levels, thereby adjusting the expression of certain microRNAs or facilitating the mesenchymal-to-epithelial transition (MET).”

    From Mechanisms, pathways and strategies for rejuvenation through epigenetic reprogramming (2023) · cites this paper as [70]

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Research works printed but not linked: 23

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Metadata

Authors
Chen, J., Liu, J., Yang, J., Chen, Y., Chen, J., Ni, S., Song, H., Zeng, L., Ding, K., & Pei, D.
Venue
Cell Research
Publisher
Springer Science and Business Media LLC
Published
2010-12-07
Volume
21
Issue
1
Pages
205-212
ISSN
  • 1001-0602
  • 1748-7838
DOI
10.1038/cr.2010.172
Cited by
124
References
2
Language
en
Licence
www.springer.com/tdm (tdm)

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