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A Mesenchymal-to-Epithelial Transition Initiates and Is Required for the Nuclear Reprogramming of Mouse Fibroblasts

Li, Ronghui, Liang, Jialiang, Ni, Su, Zhou, Ting, Qing, Xiaobing, Li, Huapeng, He, Wenzhi, Chen, Jiekai, Li, Feng, Zhuang, Qiang, Qin, Baoming, Xu, Jianyong, Li, Wen, Yang, Jiayin, Gan, Yi, Qin, Dajiang, Feng, Shipeng, Song, Hong, Yang, Dongshan, Zhang, Biliang, Zeng, Lingwen, Lai, Liangxue, Esteban, Miguel Angel, Pei, Duanqing·2010·Cell Stem Cell
DOI 10.1016/j.stem.2010.04.014
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  • Cells transition from the mesenchymal-to-epithelial state that is actively induced during the early phase and is required to progress through the reprogramming process.

    “At this point, cells also transition from the mesenchymal-to-epithelial state that is actively induced during this early phase and are required to progress through the reprogramming process [94][95][96] .”

    From Mechanisms, pathways and strategies for rejuvenation through epigenetic reprogramming (2023) · cites this paper as [94]

  • OSKM facilitates MET by suppressing the regulation of epithelial-to-mesenchymal transition through multiple mechanisms, such as OCT4 and MYC repression of TGFβ signaling, OCT4 and SOX2 activation of miR-200 family, and OCT4 and KLF4 chromatin opening and activation of epithelial genes.

    “Interestingly, OSKM facilitates MET by suppressing the regulation of epithelial-to-mesenchymal transition through multiple mechanisms, such as OCT4 and MYC repression of TGFβ signaling 33,94 , OCT4 and SOX2 activation of miR-200 family 33,98 , and OCT4 and KLF4 chromatin opening and activation of epithelial genes 37 .”

    From Mechanisms, pathways and strategies for rejuvenation through epigenetic reprogramming (2023) · cites this paper as [94]

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Research works printed but not linked: 51

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Metadata

Authors
Li, R., Liang, J., Ni, S., Zhou, T., Qing, X., Li, H., He, W., Chen, J., Li, F., Zhuang, Q., Qin, B., Xu, J., Li, W., Yang, J., Gan, Y., Qin, D., Feng, S., Song, H., Yang, D., Zhang, B., Zeng, L., Lai, L., Esteban, M. A., & Pei, D.
Venue
Cell Stem Cell
Publisher
Elsevier BV
Published
2010-07
Volume
7
Issue
1
Pages
51-63
ISSN
1934-5909
DOI
10.1016/j.stem.2010.04.014
Cited by
1,072
References
4
Language
en
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