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Generation of gene-modified mice via Cas9/RNA-mediated gene targeting
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Adding a 32 amino acid spacer between the NLS and Cas9 increases DNA cleavage activity.
“Increasing access to the NLS by adding a 32 amino acid spacer between the NLS and Cas9 was shown to increase DNA cleavage activity (Shen et al., 2013).”
From Delivering CRISPR: a review of the challenges and approaches (2018) · cites this paper as Shen et al., 2013
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RNA-guided genetic silencing systems in bacteria and archaea
Wiedenheft, B., Sternberg, S. H., & Doudna, J. A. (2012) · Nature · doi:10.1038/nature10886 · Cited by 1,851
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Metadata
- Authors
- Shen, B., Zhang, J., Wu, H., Wang, J., Ma, K., Li, Z., Zhang, X., Zhang, P., & Huang, X.
- Venue
- Cell Research
- Published
- 2013-04-02
- Volume
- 23
- Issue
- 5
- Pages
- 720-723
- ISSN
- 1001-0602
- 1748-7838
- Cited by
- 511
- References
- 4
- Language
- en
- Licence
- www.springer.com/tdm (tdm)
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