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YTHDF3 facilitates translation and decay of N6-methyladenosine-modified RNA
Open accessAbstract
N 6-methyladenosine (m 6 A) is the most abundant internal modification in eukaryotic messenger RNAs (mRNAs), and plays important roles in cell differentiation and tissue development. It regulates multiple steps throughout the RNA life cycle including RNA processing, translation, and decay, via the recognition by selective binding proteins. In the cytoplasm, m 6 A binding protein YTHDF1 facilitates translation of m 6 A-modified mRNAs, and YTHDF2 accelerates the decay of m 6 A-modified transcripts. The biological function of YTHDF3, another cytoplasmic m 6 A binder of the YTH (YT521-B homology) domain family, remains unknown. Here, we report that YTHDF3 promotes protein synthesis in synergy with YTHDF1, and affects methylated mRNA decay mediated through YTHDF2. Cells deficient in all three YTHDF proteins experience the most dramatic accumulation of m 6 A-modified transcripts. These results indicate that together with YTHDF1 and YTHDF2, YTHDF3 plays critical roles to accelerate metabolism of m 6 A-modified mRNAs in the cytoplasm. All three YTHDF proteins may act in an integrated and cooperative manner to impact fundamental biological processes related to m 6 A RNA methylation.
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“m6A modifications in the 3′UTR are recognized by YTHDF2 to regulate mRNA degradation (Wang et al., 2014), while synergistic interactions between YTHDF1 and YTHDF3 allow recognition of m6A in the 3′UTR to facilitate translation (Wang and Roundtree, 2015; Shi et al., 2017).”
From METTL3 uncouples chromatin accessibility from transcription during retinal development (2025) · cites this paper as Shi et al., 2017
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Cites
Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources
Huang, D. W., Sherman, B. T., & Lempicki, R. A. (2009) · Nature Protocols · doi:10.1038/nprot.2008.211 · Cited by 35,890
Cerami, E., Gao, J., Dogrusoz, U., Gross, B. E., Sumer, S. O., Aksoy, B. A., Jacobsen, A., Byrne, C. J., Heuer, M. L., Larsson, E., et al. (2012) · Cancer Discovery · doi:10.1158/2159-8290.cd-12-0095 · Cited by 17,455
Differential expression analysis for sequence count data
Anders, S., & Huber, W. (2010) · Genome Biology · doi:10.1186/gb-2010-11-10-r106 · Cited by 15,581
Integrative Analysis of Complex Cancer Genomics and Clinical Profiles Using the cBioPortal
Gao, J., Aksoy, B. A., Dogrusoz, U., Dresdner, G., Gross, B., Sumer, S. O., Sun, Y., Jacobsen, A., Sinha, R., Larsson, E., et al. (2013) · Science Signaling · doi:10.1126/scisignal.2004088 · Cited by 15,160
Huang, D. W., Sherman, B. T., & Lempicki, R. A. (2009) · Nucleic Acids Research · doi:10.1093/nar/gkn923 · Cited by 14,108
Heinz, S., Benner, C., Spann, N., Bertolino, E., Lin, Y. C., Laslo, P., Cheng, J. X., Murre, C., Singh, H., & Glass, C. K. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.05.004 · Cited by 13,382
TopHat: discovering splice junctions with RNA-Seq
Trapnell, C., Pachter, L. S., & Salzberg, S. L. (2009) · Bioinformatics · doi:10.1093/bioinformatics/btp120 · Cited by 11,682
Primer3—new capabilities and interfaces
Untergasser, A., Cutcutache, I., Kõressaar, T., Ye, J., Faircloth, B., Remm, M., & Rozen, S. (2012) · Nucleic Acids Research · doi:10.1093/nar/gks596 · Cited by 9,165
REVIGO summarizes and visualizes long lists of gene ontology terms
Supek, F., Bošnjak, M., Škunca, N., & Šmuc, T. (2011) · PLoS ONE · doi:10.1371/journal.pone.0021800 · Cited by 6,264
Genome-wide atlas of gene expression in the adult mouse brain
Lein, E. S., Hawrylycz, M. J., Ao, N., Ayres, M., Bensinger, A., Bernard, A., Boe, A. F., Boguski, M. S., Brockway, K. S., Byrnes, E. J., et al. (2007) · Nature · doi:10.1038/nature05453 · Cited by 5,572
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Dynamic RNA Modifications in Gene Expression Regulation
Roundtree, I. A., Evans, M., Pan, T., & He, C. (2017) · Cell · doi:10.1016/j.cell.2017.05.045 · Cited by 3,512
Self-citationReading, writing and erasing mRNA methylation
Zaccara, S., Ries, R. J., & Jaffrey, S. R. (2019) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-019-0168-5 · Cited by 2,597
The role of m6A modification in the biological functions and diseases
Jiang, X., Liu, B., Nie, Z., Duan, L., Xiong, Q., Jin, Z., Yang, C., & Chen, Y. (2021) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-020-00450-x · Cited by 2,335
Where, When, and How: Context-Dependent Functions of RNA Methylation Writers, Readers, and Erasers
Shi, H., Wei, J., & He, C. (2019) · Molecular Cell · doi:10.1016/j.molcel.2019.04.025 · Cited by 1,943
Self-citationExtensive translation of circular RNAs driven by N6-methyladenosine
Yang, Y., Fan, X., Mao, M., Song, X., Wu, P., Zhang, Y., Jin, Y., Yang, Y., Chen, L.-L., Wang, Y., et al. (2017) · Cell Research · doi:10.1038/cr.2017.31 · Cited by 1,855
Dynamic transcriptomic m6A decoration: writers, erasers, readers and functions in RNA metabolism
Yang, Y., Hsu, P. J., Chen, Y.-S., & Yang, Y. (2018) · Cell Research · doi:10.1038/s41422-018-0040-8 · Cited by 1,677
Self-citationFunctions of N6-methyladenosine and its role in cancer
He, L., Li, H., Wu, A., Peng, Y., Shu, G., & Yin, G. (2019) · Molecular Cancer · doi:10.1186/s12943-019-1109-9 · Cited by 1,410
m6A Modification in Coding and Non-coding RNAs: Roles and Therapeutic Implications in Cancer
Huang, H., Weng, H., & Chen, J. (2020) · Cancer Cell · doi:10.1016/j.ccell.2020.02.004 · Cited by 1,238
The role of m6A RNA methylation in human cancer
Chen, X., Zhang, J., & Zhu, J. (2019) · Molecular Cancer · doi:10.1186/s12943-019-1033-z · Cited by 1,081
The potential role of RNA N6-methyladenosine in Cancer progression
Wang, T., Kong, S., Tao, M., & Ju, S. (2020) · Molecular Cancer · doi:10.1186/s12943-020-01204-7 · Cited by 1,032
Ythdc2 is an N6-methyladenosine binding protein that regulates mammalian spermatogenesis
Hsu, P. J., Zhu, Y., Ma, H., Guo, Y., Shi, X., Liu, Y., Qi, M., Lu, Z., Shi, H., Wang, J., et al. (2017) · Cell Research · doi:10.1038/cr.2017.99 · Cited by 1,010
Self-citationWeng, H., Huang, H., Wu, H., Qin, X., Zhao, B. S., Dong, L., Shi, H., Skibbe, J. R., Shen, C., Hu, C., et al. (2017) · Cell stem cell · doi:10.1016/j.stem.2017.11.016 · Cited by 979
Self-citationThe role of m6A RNA methylation in cancer
Sun, T., Wu, R., & Ming, L. (2019) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2019.108613 · Cited by 961
Yue, Y., Liu, J., Cui, X., Cao, J., Luo, G., Zhang, Z., Cheng, T., Gao, M., Shu, X., Ma, H., et al. (2018) · Cell Discovery · doi:10.1038/s41421-018-0019-0 · Cited by 960
Self-citationSmall-Molecule Targeting of Oncogenic FTO Demethylase in Acute Myeloid Leukemia
Huang, Y., Su, R. J., Sheng, Y., Dong, L., Dong, Z., Xu, H., Ni, T., Zhang, Z. S., Zhang, T., Li, C., et al. (2019) · Cancer Cell · doi:10.1016/j.ccell.2019.03.006 · Cited by 895
RNA N6-methyladenosine modification in cancers: current status and perspectives
Deng, X., Su, R. J., Weng, H., Huang, H., Li, Z., & Chen, J. (2018) · Cell Research · doi:10.1038/s41422-018-0034-6 · Cited by 855
A Unified Model for the Function of YTHDF Proteins in Regulating m6A-Modified mRNA
Zaccara, S., & Jaffrey, S. R. (2020) · Cell · doi:10.1016/j.cell.2020.05.012 · Cited by 819
m6A RNA methylation: from mechanisms to therapeutic potential
He, P. C., & He, C. (2021) · The EMBO Journal · doi:10.15252/embj.2020105977 · Cited by 803
Self-citationLiu, J., Eckert, M. A., Harada, B. T., Liu, S., Lu, Z., Yu, K., Tienda, S. M., Chryplewicz, A., Zhu, A. C., Yang, Y., et al. (2018) · Nature Cell Biology · doi:10.1038/s41556-018-0174-4 · Cited by 781
Self-citationThe m6A reader YTHDF1 promotes ovarian cancer progression via augmenting EIF3C translation
Liu, T., Wei, Q., Jin, J., Luo, Q., Liu, Y., Yu, Y., Cheng, C., Li, L., Pi, J., Si, Y., et al. (2020) · Nucleic Acids Research · doi:10.1093/nar/gkaa048 · Cited by 751
The Critical Role of RNA m6A Methylation in Cancer
Lan, Q., Liu, P. Y., Haase, J., Bell, J. L., Hüttelmaier, S., & Liu, T. (2019) · Cancer Research · doi:10.1158/0008-5472.can-18-2965 · Cited by 724
Han, J., Wang, J.-Z., Yang, X. F., Yu, H., Zhou, R., Lu, H., Yuan, W., Lu, J.-C., Zhou, Z., Lü, Q., et al. (2019) · Molecular Cancer · doi:10.1186/s12943-019-1036-9 · Cited by 710
Warda, A. S., Kretschmer, J., Hackert, P., Lenz, C., Urlaub, H., Höbartner, C., Sloan, K. E., & Bohnsack, M. T. (2017) · EMBO Reports · doi:10.15252/embr.201744940 · Cited by 655
Roles of METTL3 in cancer: mechanisms and therapeutic targeting
Zeng, C., Huang, W., Li, Y., & Weng, H. (2020) · Journal of Hematology & Oncology · doi:10.1186/s13045-020-00951-w · Cited by 645
Chen, Y., Peng, C., Chen, J., Chen, D., Yang, B., He, B., Hu, W., Zhang, Y., Liu, H., Dai, L., et al. (2019) · Molecular Cancer · doi:10.1186/s12943-019-1053-8 · Cited by 643
Reading m6A in the Transcriptome: m6A-Binding Proteins
Patil, D. P., Pickering, B. F., & Jaffrey, S. R. (2017) · Trends in Cell Biology · doi:10.1016/j.tcb.2017.10.001 · Cited by 638
Ni, W., Yao, S., Zhou, Y., Liu, Y., Huang, P., Zhou, A., Liu, J., Che, L., & Li, J. (2019) · Molecular Cancer · doi:10.1186/s12943-019-1079-y · Cited by 589
The emerging role of RNA modifications in the regulation of mRNA stability
Boo, S. H., & Kim, Y. K. (2020) · Experimental & Molecular Medicine · doi:10.1038/s12276-020-0407-z · Cited by 588
Endoribonucleolytic Cleavage of m6A-Containing RNAs by RNase P/MRP Complex
Park, O. H., Ha, H., Lee, Y., Boo, S. H., Kwon, D. H., Song, H. K., & Kim, Y. K. (2019) · Molecular Cell · doi:10.1016/j.molcel.2019.02.034 · Cited by 587
N6-methyladenosine (m6A) recruits and repels proteins to regulate mRNA homeostasis
Edupuganti, R. R., Geiger, S., Lindeboom, R. G. H., Shi, H., Hsu, P. J., Lu, Z., Wang, S.-Y., Baltissen, M. P. A., Jansen, P. W. T. C., Rossa, M., et al. (2017) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.3462 · Cited by 568
Self-citationEmerging role of tumor-related functional peptides encoded by lncRNA and circRNA
Wu, P., Mo, Y., Miao, P., Tang, T. F., Zhong, Y. M., Deng, X., Xiong, F., Guo, C. J., Wu, X., Li, Y., et al. (2020) · Molecular Cancer · doi:10.1186/s12943-020-1147-3 · Cited by 538
Paris, J., Morgan, M., Campos, J., Spencer, G. J., Shmakova, A., Ivanova, I., Mapperley, C., Lawson, H., Wotherspoon, D., Sepúlveda, C., et al. (2019) · Cell stem cell · doi:10.1016/j.stem.2019.03.021 · Cited by 509
Jin, D., Guo, J., Wu, Y., Du, J., Yang, L., Wang, X., Di, W., Hu, B., An, J., Kong, L., et al. (2019) · Journal of Hematology & Oncology · doi:10.1186/s13045-019-0830-6 · Cited by 498
Self-citationRetractedThe role of m6A, m5C and Ψ RNA modifications in cancer: Novel therapeutic opportunities
Nombela, P., Miguel‐López, B., & Blanco, S. (2021) · Molecular Cancer · doi:10.1186/s12943-020-01263-w · Cited by 498
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García-Campos, M. A., Edelheit, S., Toth, U., Safra, M., Shachar, R., Viukov, S. V., Winkler, R., Nir, R., Lasman, L., Brandis, A. S., et al. (2019) · Cell · doi:10.1016/j.cell.2019.06.013 · Cited by 479
N6-methyladenosine links RNA metabolism to cancer progression
Dai, D., Wang, H., Zhu, L., Jin, H., & Wang, X. (2018) · Cell Death and Disease · doi:10.1038/s41419-017-0129-x · Cited by 472
Self-citationEngineering circular RNA for enhanced protein production
Chen, R., Wang, S. K., Belk, J. A., Amaya, L., Li, Z., Cardenas, A., Abe, B. T., Chen, C., Wender, P. A., & Chang, H. Y. (2022) · Nature Biotechnology · doi:10.1038/s41587-022-01393-0 · Cited by 476
m6A modification controls the innate immune response to infection by targeting type I interferons
Winkler, R., Gillis, E., Lasman, L., Safra, M., Geula, S., Soyris, C., Nachshon, A., Tai-Schmiedel, J., Friedman, N., Le‐Trilling, V. T. K., et al. (2018) · Nature Immunology · doi:10.1038/s41590-018-0275-z · Cited by 459
Molecular Mechanisms Driving mRNA Degradation by m6A Modification
Lee, Y., Choe, J., Park, O. H., & Kim, Y. K. (2020) · Trends in Genetics · doi:10.1016/j.tig.2019.12.007 · Cited by 454
Mettl3-mediated m6A regulates spermatogonial differentiation and meiosis initiation
Xu, K., Yang, Y., Feng, G.-H., Sun, B., Chen, J., Li, Y., Chen, Y., Zhang, X.-X., Wang, C.-X., Jiang, L.-Y., et al. (2017) · Cell Research · doi:10.1038/cr.2017.100 · Cited by 450
Self-citationInteractions, localization, and phosphorylation of the m6A generating METTL3–METTL14–WTAP complex
Schöller, E., Weichmann, F., Treiber, T., Ringle, S., Treiber, N., Flatley, A., Feederle, R., Bruckmann, A., & Meister, G. (2018) · RNA · doi:10.1261/rna.064063.117 · Cited by 439
m6A-dependent glycolysis enhances colorectal cancer progression
Shen, C., Xuan, B., Yan, T., Ma, Y., Xu, P., Tian, X., Zhang, X., Cao, Y., Ma, D., Zhu, X., et al. (2020) · Molecular Cancer · doi:10.1186/s12943-020-01190-w · Cited by 437
Wu, Y., Xie, L., Wang, M., Xiong, Q., Guo, Y., Liang, Y., Li, J., Sheng, R., Deng, P., Wang, Y., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-06898-4 · Cited by 432
The RNA modification N6-methyladenosine as a novel regulator of the immune system
Shulman, Z., & Stern‐Ginossar, N. (2020) · Nature Immunology · doi:10.1038/s41590-020-0650-4 · Cited by 417
m 6 A in mRNA: An Ancient Mechanism for Fine-Tuning Gene Expression
Roignant, J.-Y., & Soller, M. (2017) · Trends in Genetics · doi:10.1016/j.tig.2017.04.003 · Cited by 426
Dixit, D., Prager, B. C., Gimple, R. C., Poh, H. X., Wang, Y., Wu, Q., Qiu, Z., Kidwell, R. L., Kim, L. J. Y., Xie, Q., et al. (2020) · Cancer Discovery · doi:10.1158/2159-8290.cd-20-0331 · Cited by 418
Self-citationChang, G., Shi, L., Ye, Y., Shi, H., Zeng, L., Tiwary, S., Huse, J., Huo, L., Ma, L., Ma, Y.-J., et al. (2020) · Cancer Cell · doi:10.1016/j.ccell.2020.10.004 · Cited by 353
Self-citationThe Role of m6A/m-RNA Methylation in Stress Response Regulation
Engel, M., Eggert, C., Kaplick, P. M., Eder, M., Röh, S., Tietze, L., Namendorf, C., Arloth, J., Weber, P., Rex-Haffner, M., et al. (2018) · Neuron · doi:10.1016/j.neuron.2018.07.009 · Cited by 411
Epitranscriptomic m6A Regulation of Axon Regeneration in the Adult Mammalian Nervous System
Weng, Y., Wang, X., An, R., Cassin, J., Vissers, C. B., Liu, Y., Liu, Y., Xu, T., Wang, X., Wong, S. Z. H., et al. (2018) · Neuron · doi:10.1016/j.neuron.2017.12.036 · Cited by 402
Self-citationm6A in mRNA coding regions promotes translation via the RNA helicase-containing YTHDC2
Mao, Y., Dong, L., Liu, X., Guo, J., Ma, H., Shen, B., & Qian, S. (2019) · Nature Communications · doi:10.1038/s41467-019-13317-9 · Cited by 398
Self-citationEpigenetic regulation in the tumor microenvironment: molecular mechanisms and therapeutic targets
Yang, J., Xu, J., Wang, W. T., Zhang, B., Yu, X., & Shi, S. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01480-x · Cited by 412
Zhang, C., Huang, S., Zhuang, H., Ruan, S., Zhou, Z., Huang, K., Ji, F., Ma, Z., Hou, B., & He, X. (2020) · Oncogene · doi:10.1038/s41388-020-1303-7 · Cited by 393
The m 6 A Reader ECT2 Controls Trichome Morphology by Affecting mRNA Stability in Arabidopsis
Wei, L.-H., Song, P., Wang, Y., Lu, Z., Tang, Q., Yu, Q., Xiao, Y., Zhang, X., Duan, H., & Jia, G. (2018) · The Plant Cell · doi:10.1105/tpc.17.00934 · Cited by 392
Self-citationIvanova, I., Much, C., Giacomo, M. D., Azzi, C., Morgan, M., Moreira, P. N., Monahan, J., Carrieri, C., Enright, A. J., & O’Carroll, D. (2017) · Molecular Cell · doi:10.1016/j.molcel.2017.08.003 · Cited by 393
m6A mRNA methylation controls autophagy and adipogenesis by targeting Atg5 and Atg7
Wang, X., Wu, R., Liu, Y., Zhao, Y., Bi, Z., Yao, Y., Liu, Q., Shi, H., Wang, F., & Wang, Y. (2019) · Autophagy · doi:10.1080/15548627.2019.1659617 · Cited by 380
Self-citationZhang, J., Bai, R., Li, M., Ye, H., Wu, C. H., Wang, C., Li, S., Tan, L., Mai, D., Li, G., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-09712-x · Cited by 381
Link Between m6A Modification and Cancers
Liu, Z.-X., Li, L., Sun, H., & Liu, S. (2018) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2018.00089 · Cited by 370
Zhong, L., Liao, D., Zhang, M., Zeng, C., Li, X., Zhang, R., Ma, H., & Kang, T. (2018) · Cancer Letters · doi:10.1016/j.canlet.2018.11.006 · Cited by 374
Self-citationThe roles and implications of RNA m6A modification in cancer
Deng, X., Qing, Y., Horne, D. A., Huang, H., & Chen, J. (2023) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-023-00774-x · Cited by 381
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Deng, L., Deng, W.-Q., Fan, S.-R., Chen, M., Qi, M., Lyu, W.-Y., Qi, Q., Tiwari, A. K., Chen, J., Zhang, D., et al. (2022) · Molecular Cancer · doi:10.1186/s12943-022-01510-2 · Cited by 373
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Delaunay, S., & Frye, M. (2019) · Nature Cell Biology · doi:10.1038/s41556-019-0319-0 · Cited by 372
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Wu, R., Li, A., Sun, B., Sun, J.-G., Zhang, J., Zhang, T., Chen, Y., Xiao, Y., Gao, Y., Zhang, Q., et al. (2019) · Cell Research · doi:10.1038/s41422-018-0113-8 · Cited by 366
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Timoteo, G. D., Dattilo, D., Centrón-Broco, A., Colantoni, A., Guarnacci, M., Rossi, F., Incarnato, D., Oliviero, S., Fatica, A., Morlando, M., et al. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.107641 · Cited by 366
Ythdf2-mediated m6A mRNA clearance modulates neural development in mice
Li, M., Zhao, X., Wang, W., Shi, H., Pan, Q., Lu, Z., Perez, S. P., Suganthan, R., He, C., Bjørås, M., et al. (2018) · Genome biology · doi:10.1186/s13059-018-1436-y · Cited by 353
Self-citationBiological roles of adenine methylation in RNA
Boulias, K., & Greer, E. L. (2022) · Nature Reviews Genetics · doi:10.1038/s41576-022-00534-0 · Cited by 360
Jin, D., Guo, J., Wu, Y., Yang, L., Wang, X., Du, J., Dai, J., Chen, W., Gong, K., Miao, S., et al. (2020) · Molecular Cancer · doi:10.1186/s12943-020-01161-1 · Cited by 345
Self-citationm6A-binding YTHDF proteins promote stress granule formation
Fu, Y., & Zhuang, X. (2020) · Nature Chemical Biology · doi:10.1038/s41589-020-0524-y · Cited by 354
Li, J., Xie, H., Ying, Y., Chen, H., Yan, H., He, L., Xu, M., Xu, X., Liang, Z. C., Liu, B., et al. (2020) · Molecular Cancer · doi:10.1186/s12943-020-01267-6 · Cited by 336
Self-citationQing, Y., Dong, L., Gao, L., Li, C., Li, Y., Han, L., Prince, E. A., Tan, B., Deng, X., Wetzel, C., et al. (2021) · Molecular Cell · doi:10.1016/j.molcel.2020.12.026 · Cited by 328
Programmable m6A modification of cellular RNAs with a Cas13-directed methyltransferase
Wilson, C., Chen, P. J., Miao, Z., & Liu, D. R. (2020) · Nature Biotechnology · doi:10.1038/s41587-020-0572-6 · Cited by 332
Role of m6A RNA methylation in cardiovascular disease (Review)
Qin, Y., Li, L., Luo, E., Hou, J., Yan, G., Wang, D., Qiao, Y., & Tang, C. (2020) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2020.4746 · Cited by 328
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Livneh, I., Moshitch-Moshkovitz, S., Amariglio, N., Rechavi, G., & Dominissini, D. (2020) · Nature Reviews Neuroscience · doi:10.1038/s41583-019-0244-z · Cited by 330
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Berulava, T., Buchholz, E., Vakhtang, E., Peña, T., Islam, R., Lbik, D., Mohamed, B. A., Renner, A., von Lewinski, D., Sacherer, M., et al. (2019) · European Journal of Heart Failure · doi:10.1002/ejhf.1672 · Cited by 326
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Pan, Y., Ma, P., Liu, Y., Li, W., & Shu, Y. (2018) · Journal of Hematology & Oncology · doi:10.1186/s13045-018-0590-8 · Cited by 315
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Malbec, L., Zhang, T., Chen, Y., Zhang, Y., Sun, B., Shi, B., Zhao, Y., Yang, Y., & Yang, Y. (2019) · Cell Research · doi:10.1038/s41422-019-0230-z · Cited by 306
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Liu, J., Li, K., Cai, J., Zhang, M., Zhang, X., Xiong, X., Meng, H., Xu, X., Huang, Z., Peng, J., et al. (2019) · Molecular Cell · doi:10.1016/j.molcel.2019.09.032 · Cited by 291
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Murakami, S., & Jaffrey, S. R. (2022) · Molecular Cell · doi:10.1016/j.molcel.2022.05.029 · Cited by 285
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Scutenaire, J., Deragon, J., Jean, V., Benhamed, M., Raynaud, C., Favory, J.-J., Merret, R., & Bousquet‐Antonelli, C. (2018) · The Plant Cell · doi:10.1105/tpc.17.00854 · Cited by 286
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Dong, L., Chen, C., Zhang, Y., Guo, P., Wang, Z., Li, J., Liu, Y., Liu, J., Chang, R., Li, Y., et al. (2021) · Cancer Cell · doi:10.1016/j.ccell.2021.04.016 · Cited by 281
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Wang, M., Liu, J., Zhao, Y., He, R., Xu, X., Guo, X., Xu, L., Xu, S., Miao, J., Guo, J., et al. (2020) · Molecular Cancer · doi:10.1186/s12943-020-01249-8 · Cited by 267
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Metadata
- Authors
- Shi, H., Wang, X., Lu, Z., Zhao, B. S., Ma, H., Hsu, P. J., Liu, C., & He, C.
- Affiliations
- Howard Hughes Medical Institute (US)
- Corresponding author
- He, Chuan
- Venue
- Cell Research
- Published
- 2017-01-20
- Volume
- 27
- Issue
- 3
- Pages
- 315-328
- ISSN
- 1001-0602 (ISSN-L)
- 1748-7838
- PMC
- PMC5339834
- OpenAlex
- W2575691519
- Cited by
- 1,815
- References
- 55
- Citations by year
- 2026: 132 · 2025: 194 · 2024: 255 · 2023: 272 · 2022: 280 · 2021: 266 · 2020: 192 · 2019: 107 · 2018: 82 · 2017: 35
- FWCI
- 46.49
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Cell Research (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Science Foundation (1048528)
- Howard Hughes Medical Institute
- University of Chicago
- Fudan University
- National Institutes of Health
- National Institute of General Medical Sciences (R01GM071440, R01GM113194)
- Division of Chemistry (CHE-1048528)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA modifications and cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA regulation and disease
- Keywords
- YTHDF3, N6-methyladenosine, m6A RNA methylation, mRNA translation, mRNA degradation, YTHDF1, YTHDF2, YTH domain proteins
- MeSH terms
- Adenosine, Base Sequence, Cytosol, HeLa Cells, Humans, Models, Biological, Protein Binding, RNA, Protein Biosynthesis, RNA-Binding Proteins, RNA Stability
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