He, Chuan

N6-methyladenosine-dependent regulation of messenger RNA stability

Wang, X., Lu, Z., Gomez, A., Hon, G. C., Yue, Y., Han, D., Fu, Y., Parisien, M., Dai, Q., Jia, G., et al. (2014) · Nature

RNA modifications and cancerRNA Research and Splicing

Cited by 4,558

N6-Methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO

Jia, G., Fu, Y., Zhao, X., Dai, Q., Zheng, G., Yang, Y., Yi, C., Lindahl, T., Pan, T., Yang, Y.-G., et al. (2011) · Nature Chemical Biology

RNA modifications and cancerEpigenetics and DNA Methylation

Cited by 4,106

ALKBH5 Is a Mammalian RNA Demethylase that Impacts RNA Metabolism and Mouse Fertility

Zheng, G., Dahl, J. A., Niu, Y., Fedorcsak, P., Huang, C.-M., Li, C. J., Vågbø, C. B., Shi, Y., Wang, W.-L., Song, S.-H., et al. (2013) · Molecular Cell

RNA modifications and cancerRNA regulation and disease

Cited by 3,550

N6-methyladenosine Modulates Messenger RNA Translation Efficiency

Wang, X., Zhao, B. S., Roundtree, I. A., Lu, Z., Han, D., Ma, H., Weng, X., Chen, K., Shi, H., & He, C. (2015) · Cell

RNA modifications and cancerRNA and protein synthesis mechanisms

Cited by 3,483

Tet proteins can convert 5-methylcytosine to 5-formylcytosine and 5-carboxylcytosine

Ito, S., Shen, L., Dai, Q., Wu, S. C., Collins, L. B., Swenberg, J. A., He, C., & Zhang, Y. (2011) · Science

Epigenetics and DNA MethylationRNA modifications and cancer

Cited by 3,451

A METTL3–METTL14 complex mediates mammalian nuclear RNA N6-adenosine methylation

Liu, J., Yue, Y., Han, D., Wang, X., Fu, Y., Zhang, L., Jia, G., Yu, M., Lu, Z., Deng, X., et al. (2014) · Nature Chemical Biology

RNA modifications and cancerRNA regulation and disease

Cited by 3,433

Recognition of RNA N6-methyladenosine by IGF2BP proteins enhances mRNA stability and translation

Huang, H., Weng, H., Sun, W., Qin, X., Shi, H., Wu, H., Zhao, B. S., Mesquita, A., Liu, C., Yuan, C. L., et al. (2018) · Nature Cell Biology

RNA modifications and cancerRNA Research and Splicing

Cited by 2,997

N6-methyladenosine-dependent RNA structural switches regulate RNA–protein interactions

Liu, N., Dai, Q., Zheng, G., He, C., Parisien, M., & Pan, T. (2015) · Nature

RNA modifications and cancerRNA Research and Splicing

Cited by 1,988

Global epigenomic reconfiguration during mammalian brain development

Lister, R., Mukamel, E. A., Nery, J. R., Urich, M., Puddifoot, C. A., Johnson, N. D., Lucero, J., Huang, Y., Dwork, A. J., Schultz, M. D., et al. (2013) · Science

Epigenetics and DNA MethylationGenetic Syndromes and Imprinting

Cited by 1,830

YTHDF3 facilitates translation and decay of N6-methyladenosine-modified RNA

Shi, H., Wang, X., Lu, Z., Zhao, B. S., Ma, H., Hsu, P. J., Liu, C., & He, C. (2017) · Cell Research

RNA modifications and cancerRNA and protein synthesis mechanisms

Cited by 1,815

Tet2 loss leads to increased hematopoietic stem cell self-renewal and myeloid transformation

Moran-Crusio, K., Reavie, L., Shih, A., Abdel-Wahab, O., Ndiaye-Lobry, D., Lobry, C., Figueroa, M. E., Vasanthakumar, A., Patel, J., Zhao, X., et al. (2011) · Cancer Cell

Acute Myeloid Leukemia ResearchHematopoietic Stem Cell Transplantation

Cited by 1,339

R-2HG Exhibits Anti-tumor Activity by Targeting FTO/m6A/MYC/CEBPA Signaling

Su, R., Dong, L., Li, C., Nachtergaele, S., Wunderlich, M., Qing, Y., Deng, X., Wang, Y., Weng, X., Hu, C., et al. (2018) · Cell

RNA modifications and cancerAcute Myeloid Leukemia Research

Cited by 1,137

Anti-tumour immunity controlled through mRNA m6A methylation and YTHDF1 in dendritic cells

Han, D., Liu, J., Chen, C., Dong, L., Liu, Y., Chang, R., Huang, X., Liu, Y., Wang, J., Dougherty, U., et al. (2019) · Nature

Immunotherapy and Immune ResponsesRNA modifications and cancer

Cited by 955

N 6 -methyladenosine of chromosome-associated regulatory RNA regulates chromatin state and transcription

Liu, J., Dou, X., Chen, C., Chen, C., Liu, C., Xu, M. M., Zhao, S., Shen, B., Gao, Y., Han, D., et al. (2020) · Science

RNA modifications and cancerRNA regulation and disease

Cited by 709

Histone H3 trimethylation at lysine 36 guides m6A RNA modification co-transcriptionally

Huang, H., Weng, H., Zhou, K., Wu, T., Zhao, B. S., Sun, M., Chen, Z., Deng, X., Xiao, G., Auer, F., et al. (2019) · Nature

RNA modifications and cancerEpigenetics and DNA Methylation

Cited by 677

Efficient and quantitative high-throughput tRNA sequencing

Zheng, G., Qin, Y., Clark, W. C., Dai, Q., Yi, C., He, C., Lambowitz, A. M., & Pan, T. (2015) · Nature Methods

RNA and protein synthesis mechanismsRNA modifications and cancer

Cited by 550

m6A facilitates hippocampus-dependent learning and memory through YTHDF1

Shi, H., Zhang, X., Weng, Y.-L., Lu, Z., Liu, Y., Lu, Z., Li, J., Hao, P., Zhang, Y., Zhang, F., et al. (2018) · Nature

RNA modifications and cancerMemory and Neural Mechanisms

Cited by 546

An integrated multi-omics approach identifies epigenetic alterations associated with Alzheimer’s disease

Nativio, R., Lan, Y., Donahue, G., Sidoli, S., Berson, A., Srinivasan, A. R., Shcherbakova, O., Amlie-Wolf, A., Nie, J., Cui, X., et al. (2020) · Nature Genetics

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 380

FMRP modulates neural differentiation through m6A-dependent mRNA nuclear export.

Edens, B. M., Vissers, C., Su, J., Arumugam, S., Xu, Z., Shi, H., Miller, N., Rojas Ringeling, F., Ming, G.-L., He, C., et al. (2019) · Cell Reports

RNA modifications and cancerGenetics and Neurodevelopmental Disorders

Cited by 297

6-Phosphogluconate dehydrogenase links oxidative PPP, lipogenesis and tumour growth by inhibiting LKB1–AMPK signalling

Lin, R., Elf, S., Shan, C., Kang, H.-B., Ji, Q., Zhou, L., Hitosugi, T., Zhang, L., Zhang, S., Seo, J. H., et al. (2015) · Nature Cell Biology

Cancer, Hypoxia, and MetabolismMetabolism, Diabetes, and Cancer

Cited by 287

DNA N6-methyladenine: a new epigenetic mark in eukaryotes?

Luo, G.-Z., Blanco, M. A., Greer, E. L., He, C., & Shi, Y. (2015) · Nature Reviews Molecular Cell Biology

Epigenetics and DNA MethylationRNA modifications and cancer

Cited by 252

RNA cytosine methylation and methyltransferases mediate chromatin organization and 5-azacytidine response and resistance in leukaemia

Cheng, J. X., Chen, L., Li, Y., Cloe, A., Yue, M., Wei, J., Watanabe, K. A., Shammo, J. M., Anastasi, J., Shen, Q. J., et al. (2018) · Nature Communications

RNA modifications and cancerEpigenetics and DNA Methylation

Cited by 204

Potential functional roles of DNA demethylation intermediates

Song, C.-X., & He, C. (2013) · Trends in Biochemical Sciences

Epigenetics and DNA MethylationRNA modifications and cancer

Cited by 154

TET1 regulates hypoxia-induced epithelial-mesenchymal transition by acting as a co-activator

Tsai, Y.-P., Chen, H.-F., Chen, S.-Y., Cheng, W.-C., Wang, H.-W., Shen, Z.-J., Song, C., Teng, S.-C., He, C., & Wu, K.-J. (2014) · Genome biology

Epigenetics and DNA MethylationCancer, Hypoxia, and Metabolism

Cited by 152