Inhibition of the B7-H3 immune checkpoint limits tumor growth by enhancing cytotoxic lymphocyte function

PD-1 and PD-L1 Immune Checkpoint Blockade to Treat Breast Cancer

Hartkopf, A. D., Taran, F., Wallwiener, M., Walter, C. B., Krämer, B., Grischke, E., & Brucker, S. Y. (2016) · Breast Care · doi:10.1159/000453569 · Cited by 30,989 · see citing works

Safety, activity, and immune correlates of anti–PD-1 antibody in cancer

Topalian, S. L., Hodi, F. S., Brahmer, J. R., Gettinger, S. N., Smith, D. C., McDermott, D. F., Powderly, J. D., Carvajal, R. D., Sosman, J. A., Atkins, M. B., et al. (2012) · New England Journal of Medicine · doi:10.1056/nejmoa1200690 · Cited by 12,628 · see citing works

Myeloid-derived-suppressor cells as regulators of the immune system

Gabrilovich, D. I., & Nagaraj, S. (2009) · Nature Reviews Immunology · doi:10.1038/nri2506 · Cited by 6,753 · see citing works

The B7–CD28 superfamily

Sharpe, A. H., & Freeman, G. J. (2002) · Nature reviews. Immunology · doi:10.1038/nri727 · Cited by 1,719 · see citing works

Blockade of B7-H1 improves myeloid dendritic cell-mediated antitumor immunity

Curiel, T. J., Wei, S., Dong, H., Alvarez, X., Cheng, P., Mottram, P., Krzysiek, R., Knutson, K. L., Daniel, B., Zimmermann, M. C., et al. (2003) · Nature Medicine · doi:10.1038/nm863 · Cited by 1,314 · see citing works

B7-H3: A costimulatory molecule for T cell activation and IFN-γ production

Chapoval, A. I., Ni, J., Lau, J. S., Wilcox, R. A., Flies, D. B., Liu, D., Dong, H., Sica, G., Zhu, G., Tamada, K., et al. (2001) · Nature Immunology · doi:10.1038/85339 · Cited by 1,013 · see citing works

T Helper 17 Cells Promote Cytotoxic T Cell Activation in Tumor Immunity

Martín‐Orozco, N., Muranski, P. J., Chung, Y., Yang, X. O., Yamazaki, T., Lu, S., Hwu, P., Restifo, N. P., Overwijk, W. W., & Dong, C. (2009) · Immunity · doi:10.1016/j.immuni.2009.09.014 · Cited by 797 · see citing works

The B7 family member B7-H3 preferentially down-regulates T helper type 1–mediated immune responses

Suh, W.-K., Gajewska, B. U., Okada, H., Gronski, M. A., Bertram, E. M., Dawicki, W., Duncan, G. S., Bukczynski, J., Plyte, S., Elia, A., et al. (2003) · Nature Immunology · doi:10.1038/ni967 · Cited by 576 · see citing works

Antagonist Antibodies to PD-1 and B7-H1 (PD-L1) in the Treatment of Advanced Human Cancer—Response

Sznol, M., & Chen, L. (2013) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-13-2234 · Cited by 529 · see citing works

PD ‐1 as a potential target in cancer therapy

McDermott, D. F., & Atkins, M. B. (2013) · Cancer Medicine · doi:10.1002/cam4.106 · Cited by 418 · see citing works

B7-H3 and B7x are highly expressed in human prostate cancer and associated with disease spread and poor outcome

Zang, X., Thompson, R. H., Al-Ahmadie, H. A., Serio, A. M., Reuter, V. E., Eastham, J. A., Scardino, P. T., Sharma, P., & Allison, J. P. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0709802104 · Cited by 401 · see citing works

Murine B7-H3 is a negative regulator of T cells

Prasad, D. V. R., Nguyen, T., Li, Z., Yang, Y., Duong, J., Wang, Y., & Dong, C. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.173.4.2500 · Cited by 368 · see citing works

Anti–Cytotoxic T-Lymphocyte Antigen-4 Antibody: The First in an Emerging Class of Immunomodulatory Antibodies for Cancer Treatment

Fong, L. H., & Small, E. J. (2008) · Journal of Clinical Oncology · doi:10.1200/jco.2008.17.8954 · Cited by 320 · see citing works

B7-H3 and B7-H4 expression in non-small-cell lung cancer

Sun, Y., Wang, Y., Zhao, J., Gu, M., Giscombe, R., Lefvert, A. K., & Wang, X. (2006) · Lung Cancer · doi:10.1016/j.lungcan.2006.05.012 · Cited by 313 · see citing works

Characterization of Mouse and Human B7-H3 Genes

Sun, M., Richards, S., Prasad, D. V. R., Mai, X. M., Rudensky, A. Y., & Dong, C. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.168.12.6294 · Cited by 295 · see citing works

Identification of 4Ig-B7-H3 as a neuroblastoma-associated molecule that exerts a protective role from an NK cell-mediated lysis

Castriconi, R., Dondero, A., Augugliaro, R., Cantoni, C., Carnemolla, B., Sementa, A. R., Negri, F., Conte, R., Corrias, M. V., Moretta, L., et al. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0405025101 · Cited by 293 · see citing works

B7‐H3 is a potent inhibitor of human T‐cell activation: No evidence for B7‐H3 and TREML2 interaction

Leitner, J. M., Klauser, C., Pickl, W. F., Stöckl, J., Majdic, O., Bardet, A. F., Kreil, D. P., Dong, C., Yamazaki, T., Zlabinger, G. J., et al. (2009) · European Journal of Immunology · doi:10.1002/eji.200839028 · Cited by 292 · see citing works

Tumor Cell and Tumor Vasculature Expression of B7-H3 Predict Survival in Clear Cell Renal Cell Carcinoma

Crispen, P. L., Sheinin, Y. M., Roth, T. J., Lohse, C. M., Kuntz, S. M., Frigola, X., Thompson, R. H., Boorjian, S. A., Dong, H., Leibovich, B. C., et al. (2008) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-08-0536 · Cited by 272 · see citing works

T-Cell Coregulatory Molecule Expression in Urothelial Cell Carcinoma: Clinicopathologic Correlations and Association with Survival

Boorjian, S. A., Sheinin, Y. M., Crispen, P. L., Farmer, S. A., Lohse, C. M., Kuntz, S. M., Leibovich, B. C., Kwon, E. D., & Frank, I. (2008) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-08-0731 · Cited by 270 · see citing works

B7-H3 Ligand Expression by Prostate Cancer: A Novel Marker of Prognosis and Potential Target for Therapy

Roth, T. J., Sheinin, Y., Lohse, C. M., Kuntz, S. M., Frigola, X., Inman, B. A., Krambeck, A. E., Mckenney, M. E., Karnes, R. J., Blute, M. L., et al. (2007) · Cancer Research · doi:10.1158/0008-5472.can-07-1068 · Cited by 267 · see citing works

Tumor associated endothelial expression of B7-H3 predicts survival in ovarian carcinomas

Zang, X., Sullivan, P. S., Soslow, R. A., Waitz, R., Reuter, V. E., Wilton, A. S., Thaler, H. T., Arul, M., Slovin, S. F., Wei, J., et al. (2010) · Modern Pathology · doi:10.1038/modpathol.2010.95 · Cited by 249 · see citing works

Triggering receptor expressed on myeloid cell-like transcript 2 (TLT-2) is a counter-receptor for B7-H3 and enhances T cell responses

Hashiguchi, M., Kobori, H., Ritprajak, P., Kamimura, Y., Kozono, H., & Azuma, M. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0802423105 · Cited by 225 · see citing works

Integrin-Dependent Organization and Bidirectional Vesicular Traffic at Cytotoxic Immune Synapses

Liu, D., Bryceson, Y. T., Meckel, T., Vasiliver-Shamis, G., Dustin, M. L., & Long, E. O. (2009) · Immunity · doi:10.1016/j.immuni.2009.05.009 · Cited by 190 · see citing works

Effective Innate and Adaptive Antimelanoma Immunity through Localized TLR7/8 Activation

Singh, M., Khong, H., Dai, Z., Huang, X.-F., Wargo, J. A., Cooper, Z. A., Vasilakos, J. P., Hwu, P., & Overwijk, W. W. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1401160 · Cited by 167 · see citing works

Clinical significance and regulation of the costimulatory molecule B7-H3 in human colorectal carcinoma

Sun, J., Chen, L., Zhang, G., Jiang, J., Zhu, M. L., Tan, Y. Q., Wang, H.-T., Lu, B., & Zhang, X. (2010) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-010-0841-1 · Cited by 159 · see citing works

Yin–Yang of costimulation: crucial controls of immune tolerance and function

Nurieva, R. I., Liu, X., & Dong, C. (2009) · Immunological Reviews · doi:10.1111/j.1600-065x.2009.00769.x · Cited by 157 · see citing works

Glycoprotein B7-H3 overexpression and aberrant glycosylation in oral cancer and immune response

Chen, J., Chen, C., Ku, K.-L., Hsiao, M., Chiang, C., Hsu, T.-L., Chen, M., & Wong, C. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1516991112 · Cited by 131 · see citing works

The Adaptor Protein Crk Controls Activation and Inhibition of Natural Killer Cells

Liu, D., Peterson, M., & Long, E. O. (2012) · Immunity · doi:10.1016/j.immuni.2012.03.007 · Cited by 95 · see citing works

Diagnosis value of serum B7-H3 expression in non-small cell lung cancer

Zhang, G., Xu, Y., Lü, X., Huang, H., Zhou, Y., Lu, B., & Zhang, X. (2009) · Lung Cancer · doi:10.1016/j.lungcan.2009.01.017 · Cited by 89 · see citing works

A sensitive flow cytometry-based cytotoxic T-lymphocyte assay through detection of cleaved caspase 3 in target cells

He, L., Hakimi, J., Salha, D., Miron, I. M., Dunn, P., & Radvanyi, L. G. (2005) · Journal of Immunological Methods · doi:10.1016/j.jim.2005.06.005 · Cited by 82 · see citing works

Inhibitory costimulation and anti-tumor immunity

Martín‐Orozco, N., & Dong, C. (2007) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2007.06.003 · Cited by 26 · see citing works

Enhancing CTL responses to melanoma cell vaccines in vivo: synergistic increases obtained using IFNγ primed and IFNβ treated B7‐1+ B16‐F10 melanoma cells

Dezfouli, S., Hatzinisiriou, I., & Ralph, S. J. (2003) · Immunology and Cell Biology · doi:10.1046/j.0818-9641.2003.01189.x · Cited by 21 · see citing works

Cancer stemness, intratumoral heterogeneity, and immune response across cancers

Miranda, A., Hamilton, P. T., Zhang, A. W., Pattnaik, S., Becht, É., Mezheyeuski, A., Bruun, J., Micke, P., de Reyniès, A., & Nelson, B. H. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1818210116 · Cited by 580 · see citing works

Immunotherapy for osteosarcoma: Fundamental mechanism, rationale, and recent breakthroughs

Chen, C., Xie, L., Ren, T., Huang, Y., Xu, J. H., & Guo, W. (2020) · Cancer Letters · doi:10.1016/j.canlet.2020.12.024 · Cited by 573 · see citing works

Patient-derived xenograft models in cancer therapy: technologies and applications

Liu, Y., Wu, W., Cai, C., Zhang, H., Shen, H., & Han, Y. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01419-2 · Cited by 524 · see citing works

Antitumor Responses in the Absence of Toxicity in Solid Tumors by Targeting B7-H3 via Chimeric Antigen Receptor T Cells

Du, H., Hirabayashi, K., Ahn, S., Kren, N. P., Montgomery, S. A., Wang, X., Tiruthani, K., Mirlekar, B., Michaud, D. E., Greene, K. G., et al. (2019) · Cancer Cell · doi:10.1016/j.ccell.2019.01.002 · Cited by 480 · see citing works

MHC Class I Downregulation in Cancer: Underlying Mechanisms and Potential Targets for Cancer Immunotherapy

Cornel, A. M., Mimpen, I. L., & Nierkens, S. (2020) · Cancers · doi:10.3390/cancers12071760 · Cited by 471 · see citing works

PD-1 expression and clinical PD-1 blockade in B-cell lymphomas

Xu-Monette, Z. Y., Zhou, J., & Young, K. H. (2017) · Blood · doi:10.1182/blood-2017-07-740993 · Cited by 430 · see citing works

B7-H3: An Attractive Target for Antibody-based Immunotherapy

Kontos, F., Michelakos, T. P., Kurokawa, T., Sadagopan, A., Schwab, J. H., Ferrone, C. R., & Ferrone, S. (2020) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-20-2584 · Cited by 399 · see citing works

CD276 expression enables squamous cell carcinoma stem cells to evade immune surveillance

Wang, C., Li, Y., Jia, L., Kim, J. K., Li, J., Deng, P., Zhang, W., Krebsbach, P. H., & Wang, C. (2021) · Cell stem cell · doi:10.1016/j.stem.2021.04.011 · Cited by 314 · see citing works

B7-H3/CD276: An Emerging Cancer Immunotherapy

Zhou, W.-T., & Jin, W. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.701006 · Cited by 295 · see citing works

Mechanisms of immune activation and regulation: lessons from melanoma

Kalaora, S., Nagler, A., Wargo, J. A., & Samuels, Y. (2022) · Nature reviews. Cancer · doi:10.1038/s41568-022-00442-9 · Cited by 243 · see citing works

Enhancing CAR-T cell efficacy in solid tumors by targeting the tumor microenvironment

Liu, G., Rui, W., Zhao, X., & Lin, X. (2021) · Cellular and Molecular Immunology · doi:10.1038/s41423-021-00655-2 · Cited by 241 · see citing works

Managing the immune microenvironment of osteosarcoma: the outlook for osteosarcoma treatment

Tian, H., Cao, J., Li, B., Nice, E. C., Mao, H., Zhang, Y., & Huang, C. (2023) · Bone Research · doi:10.1038/s41413-023-00246-z · Cited by 239 · see citing works

Exploiting innate immunity for cancer immunotherapy

Yi, M., Li, T., Niu, M., Mei, Q., Zhao, B., Chu, Q., Dai, Z., & Wu, K. (2023) · Molecular Cancer · doi:10.1186/s12943-023-01885-w · Cited by 236 · see citing works

B7-H3 as a Novel CAR-T Therapeutic Target for Glioblastoma

Tang, X., Zhao, S., Zhang, Y., Wang, Y., Zhang, Z., Yang, M., Zhu, Y., Zhang, G., Guo, G. F., Tong, A., et al. (2019) · Molecular Therapy — Oncolytics · doi:10.1016/j.omto.2019.07.002 · Cited by 196 · see citing works

Predictive biomarkers in gastric cancer

Röcken, C. (2022) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/s00432-022-04408-0 · Cited by 188 · see citing works

FUT8-mediated aberrant N-glycosylation of B7H3 suppresses the immune response in triple-negative breast cancer

Huang, Y., Zhang, H., Li, Z., Du, T., Chen, Y., Wang, Y., Ni, H.-H., Zhang, K., Mai, J., Hu, B., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-22618-x · Cited by 186 · see citing works

A comprehensive review of immune checkpoint inhibitors for cancer treatment

Hossain, M. A. (2024) · International Immunopharmacology · doi:10.1016/j.intimp.2024.113365 · Cited by 196 · see citing works

FcγR-Binding Is an Important Functional Attribute for Immune Checkpoint Antibodies in Cancer Immunotherapy

Chen, X., Song, X., Li, K., & Zhang, T. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00292 · Cited by 177 · see citing works

Natural-Killer-Derived Extracellular Vesicles: Immune Sensors and Interactors

Federici, C., Shahaj, E., Cecchetti, S., Camerini, S., Casella, M., Iessi, E., Camisaschi, C., Paolino, G., Calvieri, S., Ferro, S., et al. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00262 · Cited by 163 · see citing works

Targeting tumor-associated macrophages as an antitumor strategy

Cheng, N., Bai, X., Shu, Y., Ahmad, O., & Shen, P. (2020) · Biochemical Pharmacology · doi:10.1016/j.bcp.2020.114354 · Cited by 162 · see citing works

B7-H3 Suppresses Antitumor Immunity via the CCL2–CCR2–M2 Macrophage Axis and Contributes to Ovarian Cancer Progression

Miyamoto, T., Murakami, R., Hamanishi, J., Tanigaki, K., Hosoe, Y., Mise, N., Takamatsu, S., Mise, Y., Ukita, M., Taki, M., et al. (2021) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-21-0407 · Cited by 154 · see citing works

Dual checkpoint targeting of B7-H3 and PD-1 with enoblituzumab and pembrolizumab in advanced solid tumors: interim results from a multicenter phase I/II trial

Aggarwal, C., Prawira, A., Antonia, S. J., Rahma, O. E., Tolcher, A. W., Cohen, R. B., Lou, Y., Hauke, R. J., Vogelzang, N. J., Zandberg, D. P., et al. (2022) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2021-004424 · Cited by 151 · see citing works

Loss of BAP1 expression is associated with an immunosuppressive microenvironment in uveal melanoma, with implications for immunotherapy development

Figueiredo, C. R., Kalirai, H., Sacco, J. J., Azevedo, R., Duckworth, A. D., Slupsky, J. R., Coulson, J. M., & Coupland, S. E. (2020) · The Journal of Pathology · doi:10.1002/path.5384 · Cited by 146 · see citing works

Prognostic value of immune checkpoint molecules in breast cancer

Fang, J., Chen, F., Liu, D., Gu, F., Chen, Z., & Wang, Y.-Z. (2020) · Bioscience Reports · doi:10.1042/bsr20201054 · Cited by 139 · see citing works

B7-H3-Targeted CAR-T Cells Exhibit Potent Antitumor Effects on Hematologic and Solid Tumors

Zhang, Z., Jiang, C., Liu, Z., Yang, M., Tang, X., Wang, Y., Zheng, M., Huang, J., Zhong, K., Zhao, S., et al. (2020) · Molecular Therapy — Oncolytics · doi:10.1016/j.omto.2020.03.019 · Cited by 134 · see citing works

Tumor-Associated Macrophages: A Potential Target for Cancer Therapy

Tan, Y., Wang, M., Zhang, Y., Ge, S., Zhong, F., Xia, G., & Sun, C. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.693517 · Cited by 134 · see citing works

Tumor-expressed B7-H3 mediates the inhibition of antitumor T-cell functions in ovarian cancer insensitive to PD-1 blockade therapy

Cai, D., Li, J., Liu, D., Hong, S., Qiao, Q., Sun, Q., Li, P., Lyu, N., Sun, T., Xie, S., et al. (2019) · Cellular and Molecular Immunology · doi:10.1038/s41423-019-0305-2 · Cited by 133 · see citing works

mTORC1 upregulates B7-H3/CD276 to inhibit antitumor T cells and drive tumor immune evasion

Liu, H.-J., Du, H., Khabibullin, D., Zarei, M., Wei, K., Freeman, G. J., Kwiatkowski, D. J., & Henske, E. P. (2023) · Nature Communications · doi:10.1038/s41467-023-36881-7 · Cited by 123 · see citing works

The B7-H3–Targeting Antibody–Drug Conjugate m276-SL-PBD Is Potently Effective Against Pediatric Cancer Preclinical Solid Tumor Models

Kendsersky, N. M., Lindsay, J., Kolb, E. A., Smith, M. A., Teicher, B. A., Erickson, S. W., Earley, E. J., Mosse, Y. P., Martinez, D., Pogoriler, J., et al. (2021) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-20-4221 · Cited by 120 · see citing works

Cancer exosomes and natural killer cells dysfunction: biological roles, clinical significance and implications for immunotherapy

Hosseini, R., Sarvnaz, H., Arabpour, M., Ramshe, S. M., Asef‐Kabiri, L., Yousefi, H., Akbari, M. E., & Eskandari, N. (2022) · Molecular Cancer · doi:10.1186/s12943-021-01492-7 · Cited by 118 · see citing works

Neoadjuvant enoblituzumab in localized prostate cancer: a single-arm, phase 2 trial

Shenderov, E., Marzo, A. M. D., Lotan, T. L., Wang, H., Chan, S., Lim, S. J., Ji, H., Allaf, M. E., Chapman, C. G., Moore, P. A., et al. (2023) · Nature Medicine · doi:10.1038/s41591-023-02284-w · Cited by 116 · see citing works

B7-H3 Suppresses Antitumor Immunity via the CCL2–CCR2–M2 Macrophage Axis and Contributes to Ovarian Cancer Progression

Miyamoto, T., Murakami, R., Hamanishi, J., Tanigaki, K., Hosoe, Y., Mise, N., Takamatsu, S., Mise, Y., Ukita, M., Taki, M., et al. (2022) · Institutional Repositories DataBase (IRDB) · doi:10.14989/doctor.k23801 · Cited by 112 · see citing works

Cancer Immunotherapy: A Focus on the Regulation of Immune Checkpoints

Shi, T., Ma, Y., Yu, L., Jiang, J., Shen, S., Hou, Y., & Wang, T. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19051389 · Cited by 108 · see citing works

Autophagy protein ATG5 regulates CD36 expression and anti-tumor MHC class II antigen presentation in dendritic cells

Oh, D. S., & Lee, H. K. (2019) · Autophagy · doi:10.1080/15548627.2019.1596493 · Cited by 109 · see citing works

Expression of the inhibitory B7 family molecule VISTA in human colorectal carcinoma tumors

Xie, S., Huang, J., Qiao, Q., Zang, W., Hong, S., Tan, H., Dong, C., Yang, Z., & Ni, L. (2018) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-018-2227-8 · Cited by 105 · see citing works

B7-H3 as a Therapeutic Target in Advanced Prostate Cancer

Guo, C. W., Figueiredo, I., Gürel, B., Neeb, A., Seed, G., Crespo, M., Carreira, S., Rekowski, J., Buroni, L., Welti, J. C., et al. (2022) · European Urology · doi:10.1016/j.eururo.2022.09.004 · Cited by 105 · see citing works

Engineering MMP-2 Activated Nanoparticles Carrying B7-H3 Bispecific Antibodies for Ferroptosis-Enhanced Glioblastoma Immunotherapy

Fan, R., Chen, C., Mu, M., Chuan, D., Liu, H., Hou, H., Huang, J., Tong, A., Guo, G. F., & Xu, J. (2023) · ACS Nano · doi:10.1021/acsnano.2c12217 · Cited by 104 · see citing works

Genetic and clinical characterization of B7‐H3 (CD276) expression and epigenetic regulation in diffuse brain glioma

Wang, Z., Wang, Z., Zhang, C., Liu, X., Li, G., Liu, S., Sun, L., Liang, J., Hu, H., Liu, Y., et al. (2018) · Cancer Science · doi:10.1111/cas.13744 · Cited by 101 · see citing works

Targeting B7-H3 via chimeric antigen receptor T cells and bispecific killer cell engagers augments antitumor response of cytotoxic lymphocytes

Liu, J., Yang, S., Cao, B., Zhou, G., Zhang, F., Wang, Y., Wang, R., Zhu, L., Meng, Y., Hu, C., et al. (2021) · Journal of Hematology & Oncology · doi:10.1186/s13045-020-01024-8 · Cited by 96 · see citing works

The importance of immune checkpoints in immune monitoring: A future paradigm shift in the treatment of cancer

Alemohammad, H., Najafzadeh, B., Asadzadeh, Z., Baghbanzadeh, A., Ghorbaninezhad, F., Najafzadeh, A., Safarpour, H., Bernardini, R., Brunetti, O., Sonnessa, M., et al. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.112516 · Cited by 92 · see citing works

Beyond CTLA-4 and PD-1 Inhibition: Novel Immune Checkpoint Molecules for Melanoma Treatment

Ziogas, D. C., Theocharopoulos, C., Lialios, P., Foteinou, D., Koumprentziotis, I., Xynos, G., & Gogas, H. J. (2023) · Cancers · doi:10.3390/cancers15102718 · Cited by 92 · see citing works

Large-scale analysis reveals the specific clinical and immune features of B7-H3 in glioma

Zhang, C., Zhang, Z., Li, F., Shen, Z., Qiao, Y., Li, L., Liu, S., Song, M., Zhao, X., Ren, F., et al. (2018) · OncoImmunology · doi:10.1080/2162402x.2018.1461304 · Cited by 90 · see citing works

Preclinical Evaluation of B7-H3–specific Chimeric Antigen Receptor T Cells for the Treatment of Acute Myeloid Leukemia

Lichtman, E. I., Du, H., Shou, P., Song, F., Suzuki, K., Ahn, S., Li, G., Ferrone, S., Su, L., Savoldo, B., et al. (2021) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-20-2540 · Cited by 87 · see citing works

Transcriptomic and immunophenotypic profiling reveals molecular and immunological hallmarks of colorectal cancer tumourigenesis

Roelands, J. P., van der Ploeg, M., Ijsselsteijn, M. E., Dang, H., Boonstra, J. J., Hardwick, J. C. H., Hawinkels, L. J. A. C., Morreau, H. M., & de Miranda, N. F. C. C. (2022) · Gut · doi:10.1136/gutjnl-2022-327608 · Cited by 84 · see citing works

B7-H3 inhibits the IFN-γ-dependent cytotoxicity of Vγ9Vδ2 T cells against colon cancer cells

Lu, H., Shi, T., Wang, M., Li, X., Gu, Y., Zhang, X., Zhang, G., & Chen, W. (2020) · OncoImmunology · doi:10.1080/2162402x.2020.1748991 · Cited by 81 · see citing works

B7-H3 promotes multiple myeloma cell survival and proliferation by ROS-dependent activation of Src/STAT3 and c-Cbl-mediated degradation of SOCS3

Lin, L., Cao, L., Liu, Y., Wang, K., Zhang, X., Qin, X., Zhao, D., Hao, J., Chang, Y., Huang, X., et al. (2018) · Leukemia · doi:10.1038/s41375-018-0331-6 · Cited by 78 · see citing works

B7-H3 Immune Checkpoint Protein in Human Cancer

Karlsen, K. F., Fodstad, Ø., & Nunes‐Xavier, C. E. (2019) · Current Medicinal Chemistry · doi:10.2174/0929867326666190517115515 · Cited by 78 · see citing works

CAR‐T cell therapy for lung cancer: Potential and perspective

Chen, L., Chen, F., Li, J., Pu, Y., Yang, C., Wang, Y., Lei, Y., & Huang, Y. (2022) · Thoracic Cancer · doi:10.1111/1759-7714.14375 · Cited by 77 · see citing works

Targeting B7-H3 Immune Checkpoint With Chimeric Antigen Receptor-Engineered Natural Killer Cells Exhibits Potent Cytotoxicity Against Non-Small Cell Lung Cancer

Yang, S., Cao, B., Zhou, G., Zhu, L., Wang, L., Zhang, L., Kwok, H. F., Zhang, Z., & Zhao, Q. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.01089 · Cited by 76 · see citing works

B7-H3 Regulates Glioma Growth and Cell Invasion Through a JAK2/STAT3/Slug-Dependent Signaling Pathway

Zhong, C., Tao, B., Chen, Y., Guo, Z., Yang, X., Peng, L., Xia, X., & Chen, L. (2020) · OncoTargets and Therapy · doi:10.2147/ott.s237841 · Cited by 76 · see citing works

Therapeutic targeting of TGF-β in cancer: hacking a master switch of immune suppression

van den Bulk, J., de Miranda, N. F. C. C., & ten Dijke, P. (2021) · Clinical Science · doi:10.1042/cs20201236 · Cited by 75 · see citing works

High-resolution structural genomics reveals new therapeutic vulnerabilities in glioblastomaPreprint

Johnston, M. J. G., Nikolić, A., Ninkovic, N., Guilhamon, P., Cavalli, F. M. G., Seaman, S., Zemp, F. J., Lee, J., Abdelkareem, A. O., Ellestad, K. I., et al. (2019) · Genome Research · doi:10.1101/gr.246520.118 · Cited by 67 · see citing works

CD276 regulates the immune escape of esophageal squamous cell carcinoma through CXCL1–CXCR2 induced NETs

Xiong, G., Chen, Z., Liu, Q., Peng, F., Zhang, C., Cheng, M., Ling, R., Chen, S., Liang, Y., Chen, D., et al. (2024) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2023-008662 · Cited by 74 · see citing works

FN1 overexpression is correlated with unfavorable prognosis and immune infiltrates in breast cancer

Zhang, X., Luo, J.-H., & Wu, L. (2022) · Frontiers in Genetics · doi:10.3389/fgene.2022.913659 · Cited by 72 · see citing works

Natural Killer Cells: Angels and Devils for Immunotherapy

Martín-Antonio, B., Suñé, G., Pérez-Amill, L., Castellà, M., & Urbano-Ispizúa, Á. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18091868 · Cited by 71 · see citing works

Monocyte-derived APCs are central to the response of PD1 checkpoint blockade and provide a therapeutic target for combination therapy

Schetters, S. T. T., Rodríguez, E., Kruijssen, L. J. W., Crommentuijn, M. H. W., Boon, L., den Bossche, J. V., den Haan, J. M. M., & van Kooyk, Y. (2020) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2020-000588 · Cited by 71 · see citing works

B7-H3 augments the pro-angiogenic function of tumor-associated macrophages and acts as a novel adjuvant target for triple-negative breast cancer therapy

Cheng, N., Bei, Y., Song, Y., Zhang, W., Xu, L., Zhang, W., Yang, N., Bai, X., Shu, Y., & Shen, P. (2020) · Biochemical Pharmacology · doi:10.1016/j.bcp.2020.114298 · Cited by 71 · see citing works

Immune infiltration profiling in gastric cancer and their clinical implications

Ren, F., Zhao, Q., Zhao, M., Shaogong, Z., Liu, B., Bukhari, I., Zhang, K., Wu, W., Fu, Y., Yu, Y., et al. (2021) · Cancer Science · doi:10.1111/cas.15057 · Cited by 71 · see citing works

Inhibitory Receptors and Immune Checkpoints Regulating Natural Killer Cell Responses to Cancer

Buckle, I., & Guillerey, C. (2021) · Cancers · doi:10.3390/cancers13174263 · Cited by 71 · see citing works

Effects of B7-H3 expression on tumour-infiltrating immune cells and clinicopathological characteristics in non–small-cell lung cancer

Yim, J., Koh, J., Kim, S., Song, S. G., Ahn, H. K., Kim, Y. A., Jeon, Y. K., & Chung, D. H. (2020) · European Journal of Cancer · doi:10.1016/j.ejca.2020.03.033 · Cited by 67 · see citing works

Microbiota-dependent activation of the myeloid calcineurin-NFAT pathway inhibits B7H3- and B7H4-dependent anti-tumor immunity in colorectal cancer

Peuker, K., Strigli, A., Tauriello, D. V. F., Hendricks, A., Schönfels, W. V., Burmeister, G., Brosch, M., Herrmann, A., Krüger, S., Nitsche, J., et al. (2022) · Immunity · doi:10.1016/j.immuni.2022.03.008 · Cited by 64 · see citing works

Development of pharmacological immunoregulatory anti-cancer therapeutics: current mechanistic studies and clinical opportunities

Yin, N., Li, X., Zhang, X., Xue, S., Cao, Y., Niedermann, G., Lu, Y., & Xue, J. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01826-z · Cited by 66 · see citing works

The role of B7-H3 in tumors and its potential in clinical application

Feng, R.-R., Chen, Y., Liu, Y., Zhou, Q., & Zhang, W. (2021) · International Immunopharmacology · doi:10.1016/j.intimp.2021.108153 · Cited by 60 · see citing works

CAR T Cell Therapy for Pediatric Brain Tumors

Patterson, J. D., Henson, J. C., Breese, R. O., Bielamowicz, K., & Rodriguez, A. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.01582 · Cited by 58 · see citing works

Glycosylation of Immune Receptors in Cancer

Sun, R., Kim, A. M. J., & Lim, S. (2021) · Cells · doi:10.3390/cells10051100 · Cited by 58 · see citing works

Inhibitor of glutamine metabolism V9302 promotes ROS-induced autophagic degradation of B7H3 to enhance antitumor immunity

Li, Q., Zhong, X., Yao, W., Yu, J., Wang, C., Li, Z., Lai, S., Qu, F., Fu, X., Huang, X., et al. (2022) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2022.101753 · Cited by 58 · see citing works

B7-H3 immunoregulatory roles in cancer

Mortezaee, K. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.114890 · Cited by 57 · see citing works

B7-H3×4-1BB bispecific antibody augments antitumor immunity by enhancing terminally differentiated CD8 + tumor-infiltrating lymphocytes

You, G., Lee, Y., Kang, Y., Park, H. W., Park, K., Kim, H., Kim, Y., Kim, S., Kim, J., Moon, D., et al. (2021) · Science Advances · doi:10.1126/sciadv.aax3160 · Cited by 56 · see citing works

VSIG4+ tumor-associated macrophages mediate neutrophil infiltration and impair antigen-specific immunity in aggressive cancers through epigenetic regulation of SPP1

Pan, Z., Chen, J., Xu, T. C., Cai, A., Han, B., Li, Y., Fang, Z., Yu, D., Wang, S., Zhou, J., et al. (2025) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-025-03303-z · Cited by 56 · see citing works

PLA2G4A promotes right-sided colorectal cancer progression by inducing CD39+γδ Treg polarization

Zhan, Y., Zheng, L., Liu, J., Hu, D., Wang, J., Liu, K., Guo, J., Zhang, T., & Kong, D. (2021) · JCI Insight · doi:10.1172/jci.insight.148028 · Cited by 53 · see citing works

Lipid Nanoparticle Delivery System for mRNA Encoding B7H3‐redirected Bispecific Antibody Displays Potent Antitumor Effects on Malignant Tumors

Huang, C., Duan, X., Wang, J., Tian, Q., Ren, Y., Chen, K., Zhang, Z., Li, Y., Feng, Y., Zhong, K., et al. (2022) · Advanced Science · doi:10.1002/advs.202205532 · Cited by 54 · see citing works

B7-H3 targeted CAR-T cells show highly efficient anti-tumor function against osteosarcoma both in vitro and in vivo

Zhang, Q., Zhang, Z., Liu, G., Li, D., Gu, Z., Zhang, L., Pan, Y., Cui, X., Wang, L., Liu, G., et al. (2022) · BMC Cancer · doi:10.1186/s12885-022-10229-8 · Cited by 51 · see citing works

Identification of m6A methyltransferase-related lncRNA signature for predicting immunotherapy and prognosis in patients with hepatocellular carcinoma

Li, L., Xie, R., & Lu, G. (2021) · Bioscience Reports · doi:10.1042/bsr20210760 · Cited by 51 · see citing works

Pediatric versus adult high grade glioma: Immunotherapeutic and genomic considerations

Aggarwal, P., Luo, W., Pehlivan, K. C., Hoang, H., Rajappa, P., Cripe, T. P., Cassady, K. A., Lee, D. A., & Cairo, M. S. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1038096 · Cited by 56 · see citing works

B7-H3 immune checkpoint expression is a poor prognostic factor in colorectal carcinoma

Lu, Z., Zhao, Z., Cheng, P., Huang, F., Guan, X., Zhang, M., Chen, H., Liu, Z., Jiang, Z., Zheng, Z., et al. (2020) · Modern Pathology · doi:10.1038/s41379-020-0587-z · Cited by 49 · see citing works

Immune Checkpoints in Cancers: From Signaling to the Clinic

Pisibon, C., Ouertani, A., Bertolotto, C., Ballotti, R., & Chéli, Y. (2021) · Cancers · doi:10.3390/cancers13184573 · Cited by 49 · see citing works

Over-Expression and Prognostic Significance of FN1, Correlating With Immune Infiltrates in Thyroid Cancer

Geng, Q., Huang, T., Li, L., Shen, Z., Xue, W., & Zhao, J. (2022) · Frontiers in Medicine · doi:10.3389/fmed.2021.812278 · Cited by 49 · see citing works

B7-H3 in Brain Malignancies: Immunology and Immunotherapy

Guo, X., Chang, M., Wang, Y., Xing, B., & Ma, W. (2023) · International Journal of Biological Sciences · doi:10.7150/ijbs.85813 · Cited by 54 · see citing works

The Role of TIM-3 in Hepatocellular Carcinoma: A Promising Target for Immunotherapy?

Ganjalıkhani-Hakemi, M., Jafarinia, M., Azizi, M., Rezaeepoor, M., Isayev, O., & Bazhin, A. V. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.601661 · Cited by 50 · see citing works

LINC01123 promotes immune escape by sponging miR-214-3p to regulate B7–H3 in head and neck squamous-cell carcinoma

Li, H., Yang, Z., Yang, X., Zhang, F., Wang, J., Wu, Z., Wanyan, C., Meng, Q., Gao, W., Yang, X., et al. (2022) · Cell Death and Disease · doi:10.1038/s41419-022-04542-0 · Cited by 46 · see citing works

Novel bispecific antibody-drug conjugate targeting PD-L1 and B7-H3 enhances antitumor efficacy and promotes immune-mediated antitumor responses

Dong, Y., Zhang, Z., Luan, S., Zheng, M., Wang, Z., Chen, Y., Chen, X., Tong, A., & Yang, H. (2024) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2024-009710 · Cited by 49 · see citing works

Transcriptome analysis of desmoplastic small round cell tumors identifies actionable therapeutic targets: a report from the Children’s Oncology Group

Hingorani, P., Dinu, V., Zhang, X., Lei, H., Shern, J. F., Park, J. H., Steel, J., Rauf, F., Parham, D. M., Gastier, J. M., et al. (2020) · Scientific Reports · doi:10.1038/s41598-020-69015-w · Cited by 46 · see citing works

MYCN Drives a Tumor Immunosuppressive Environment Which Impacts Survival in Neuroblastoma

Raieli, S., Renzo, D. D., Lampis, S., Amadesi, C., Montemurro, L., Pession, A., Hrelia, P., Fischer, M., & Tonelli, R. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.625207 · Cited by 43 · see citing works

To kill a cancer: Targeting the immune inhibitory checkpoint molecule, B7-H3

Kanchan, R. K., Doss, D., Κhan, P., Nasser, M. W., & Mahapatra, S. (2022) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2022.188783 · Cited by 43 · see citing works

Interleukin-17D Promotes Pathogenicity During Infection by Suppressing CD8 T Cell Activity

Lee, Y., Clinton, J., Yao, C., & Chang, S. H. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01172 · Cited by 42 · see citing works

MicroRNA-326 attenuates immune escape and prevents metastasis in lung adenocarcinoma by targeting PD-L1 and B7-H3

Shao, L., He, Q., Wang, J., He, F., Lin, S., Wu, L., Gao, Y., Ma, W., Dong, J., Yang, X., et al. (2021) · Cell Death Discovery · doi:10.1038/s41420-021-00527-8 · Cited by 42 · see citing works

B7-H3 targeted antibody-based immunotherapy of malignant diseases

Michelakos, T. P., Kontos, F., Barakat, O., Maggs, L., Schwab, J. H., Ferrone, C. R., & Ferrone, S. (2020) · Expert Opinion on Biological Therapy · doi:10.1080/14712598.2021.1862791 · Cited by 41 · see citing works

Expression of Programmed Cell Death-Ligands in Hepatocellular Carcinoma: Correlation With Immune Microenvironment and Survival Outcomes

Liao, H., Chen, W., Dai, Y., Richardson, J. J., Guo, J., Yuan, K., Zeng, Y., & Xie, K. (2019) · Frontiers in Oncology · doi:10.3389/fonc.2019.00883 · Cited by 41 · see citing works

Potential Therapeutic Targets of B7 Family in Colorectal Cancer

Wang, C., Feng, H., Cheng, X., Liu, K., Cai, D., & Zhao, R. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00681 · Cited by 40 · see citing works

Approaches to Enhance Natural Killer Cell-Based Immunotherapy for Pediatric Solid Tumors

Quamine, A. E., Olsen, M. R., Cho, M. M., & Capitini, C. M. (2021) · Cancers · doi:10.3390/cancers13112796 · Cited by 39 · see citing works

Surfaceome Profiling of Rhabdomyosarcoma Reveals B7-H3 as a Mediator of Immune Evasion

Lavoie, R. R., Gargollo, P. C., Ahmed, M. E., Kim, Y., Baer, E., Phelps, D. A., Charlesworth, C. M., Madden, B. J., Wang, L., Houghton, P. J., et al. (2021) · Cancers · doi:10.3390/cancers13184528 · Cited by 38 · see citing works

Regulation of autophagy fires up the cold tumor microenvironment to improve cancer immunotherapy

Jin, Z., Sun, X., Wang, Y., Zhou, C., Yang, H., & Zhou, S. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1018903 · Cited by 39 · see citing works

B7-H3 Specific CAR T Cells for the Naturally Occurring, Spontaneous Canine Sarcoma Model

Zhang, S., Black, R. G., Kohli, K., Hayes, B. J., Miller, C., Koehne, A. L., Schroeder, B., Abrams, K., Schulte, B. C., Alexiev, B. A., et al. (2022) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-21-0726 · Cited by 39 · see citing works

EBV-Upregulated B7-H3 Inhibits NK cell–Mediated Antitumor Function and Contributes to Nasopharyngeal Carcinoma Progression

Chen, H., Duan, X., Deng, X., Huang, Y., Zhou, X., Zhang, S., Zhang, X., Liu, P., Yang, C., Liu, G., et al. (2023) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-22-0374 · Cited by 38 · see citing works

Tracers for non-invasive radionuclide imaging of immune checkpoint expression in cancer

Wierstra, P. J., Sandker, G. W., Aarntzen, E. H. J. G., Gotthardt, M., Adema, G. J., Bussink, J., Raavé, R., & Heskamp, S. (2019) · EJNMMI Radiopharmacy and Chemistry · doi:10.1186/s41181-019-0078-z · Cited by 38 · see citing works

Efficacy of B7-H3-Redirected BiTE and CAR-T Immunotherapies Against Extranodal Nasal Natural Killer/T Cell Lymphoma

Zheng, M., Yu, L., Hu, J., Zhang, Z., Wang, H., Lu, D., Tang, X., Huang, J., Zhong, K., Wang, Z., et al. (2020) · Translational Oncology · doi:10.1016/j.tranon.2020.100770 · Cited by 37 · see citing works

B7-H3/CD276 and small-cell lung cancer: What's new?

Fabrizio, F. P., Muscarella, L. A., & Rossi, A. (2023) · Translational Oncology · doi:10.1016/j.tranon.2023.101801 · Cited by 36 · see citing works

A Comprehensive Analysis of Baseline Clinical Characteristics and Biomarkers Associated with Outcome in Advanced Melanoma Patients Treated with Pembrolizumab

Awada, G., Jansen, Y. J. L., Schwarze, J. K., Tijtgat, J., Hellinckx, L., Gondry, O., Vermeulen, S., Warren, S. E., Schats, K., van Dam, P., et al. (2021) · Cancers · doi:10.3390/cancers13020168 · Cited by 36 · see citing works

Update of early phase clinical trials in cancer immunotherapy

Lee, D. H. (2021) · BMB Reports · doi:10.5483/bmbrep.2021.54.1.242 · Cited by 36 · see citing works

Epigenetic Regulation of Immunotherapy Response in Triple-Negative Breast Cancer

Llinàs‐Arias, P., Íñiguez-Muñoz, S., McCann, K. E., Voorwerk, L., Orozco, J. I. J., Ensenyat-Méndez, M., Sesé, B., DiNome, M. L., & Marzese, D. M. (2021) · Cancers · doi:10.3390/cancers13164139 · Cited by 35 · see citing works

Abstract 494: Novel human B7-H3 knock-in mice demonstrate efficacy of anti-B7-H3 immunotherapy in vivo

Zhao, L., Li, H., Liu, Y., Yu, Z.-X., & Lin, E. (2021) · Cancer Research · doi:10.1158/1538-7445.am2021-494

Inhibition of the B7-H3 immune checkpoint limits hepatocellular carcinoma progression by enhancing T lymphocyte-mediated immune cytotoxicity in vitro and in vivo

Zhou, Z., Yu, X., Chen, Y., Tan, X., Liu, W., Hua, W., Chen, L., & Zhang, W. (2022) · Clinical & Translational Oncology · doi:10.1007/s12094-022-03013-4 · Cited by 12 · see citing works

New checkpoints in cancer immunotherapy

Ni, L., & Dong, C. (2017) · Immunological Reviews · doi:10.1111/imr.12524 · Cited by 143 · see citing works

To kill a cancer: Targeting the immune inhibitory checkpoint molecule, B7-H3

Kanchan, R. K., Doss, D., Κhan, P., Nasser, M. W., & Mahapatra, S. (2022) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2022.188783 · Cited by 43 · see citing works

Mouse B7-H3 induces antitumor immunity

Sun, X., Vale, M., Leung, E. Y., Kanwar, J. R., Gupta, R., & Krissansen, G. W. (2003) · Gene Therapy · doi:10.1038/sj.gt.3302070 · Cited by 132 · see citing works