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OCRL controls trafficking through early endosomes via PtdIns4,5P2‐dependent regulation of endosomal actin

Vicinanza, Mariella, Di Campli, Antonella, Polishchuk, Elena, Santoro, Michele, Di Tullio, Giuseppe, Godi, Anna, Levtchenko, Elena, De Leo, Maria Giovanna, Polishchuk, Roman, Sandoval, Lisette, Marzolo, Maria‐Paz, De Matteis, Maria Antonietta·2011·The EMBO Journal
DOI 10.1038/emboj.2011.354PMC PMC3242071
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Crossref · 10.1038/emboj.2011.354

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  • Other PI(4,5)P2 phosphatases and kinases impact trafficking and degradation of the epidermal growth factor receptor and the transferrin receptor.

    “Notably, other PI(4,5)P2 phosphatases (e.g. Lowe oculocerebrorenal syndrome protein (OCRL), also known as INPP5F) and kinases have been reported to impact trafficking and degradation of the epidermal growth factor receptor and the transferrin receptor, which are recycled and degraded in a manner similar to LDLR11–13.”

    From Phosphatidylinositol-(4,5)-Bisphosphate Regulates Plasma Cholesterol Through LDL (Low-Density Lipoprotein) Receptor Lysosomal Degradation (2020) · cites this paper as [11]

    The Results section reports that OCRL depletion slows transferrin-receptor recycling and delays EGFR degradation. It also reports that reducing PIP5K levels affects transferrin uptake, but does not show a kinase effect on EGFR degradation or transferrin-receptor degradation. The cited paper therefore supports the trafficking claim, not all of its stated degradation effects. (LLM, conf=0.84)

    Experimental — accuracy not yet measured

  • OCRL is a phosphatase that converts PI(4,5)P2 to PI4P.

    “OCRL is a phosphatase that converts PI(4,5)P2 to PI4P11, 36.”

    From Phosphatidylinositol-(4,5)-Bisphosphate Regulates Plasma Cholesterol Through LDL (Low-Density Lipoprotein) Receptor Lysosomal Degradation (2020) · cites this paper as [11]

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Research works printed but not linked: 77

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Metadata

Authors
Vicinanza, M., Di Campli, A., Polishchuk, E., Santoro, M., Di Tullio, G., Godi, A., Levtchenko, E., De Leo, M. G., Polishchuk, R., Sandoval, L., Marzolo, M., & De Matteis, M. A.
Venue
The EMBO Journal
Publisher
Springer Science and Business Media LLC
Published
2011-10-04
Volume
30
Issue
24
Pages
4970-4985
ISSN
  • 0261-4189
  • 1460-2075
DOI
10.1038/emboj.2011.354
PMC
PMC3242071
Cited by
196
References
3
Language
en
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