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Cited by 131

The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.

Differential Functions of Members of the Low Density Lipoprotein Receptor Family Suggested by Their Distinct Endocytosis Rates

Li, Yonghe, Lu, Wenyan, Marzolo, Maria Paz, Bu, Guojun·2001·Journal of Biological Chemistry
DOI 10.1074/jbc.m101589200
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Crossref · 10.1074/jbc.m101589200

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  • LRP1 has an endocytosis rate up to 16 times faster than that of other Aβ receptors such as VDLDR or LDLR.

    “Moreover, with an endocytosis rate up to 16 times faster than that of other Aβ receptors, such as VDLDR or LDLR (12,35), LRP1 may outperform other receptors in Aβ clearance, especially at higher concentrations.”

    From Endothelial LRP1 transports amyloid-β1–42 across the blood-brain barrier (2015) · cites this paper as [35]

    The Results report LRP internalization half-times below 30 seconds, versus over 8 minutes for VLDLR, supporting a substantial rate difference of at least 16-fold. The LDLR comparison used a receptor bearing the LDLR tail, not full-length LDLR, and our copy does not test Aβ internalization. The cited paper therefore does not establish the stated rate comparison for Aβ receptors specifically. (LLM, conf=0.86)

    Experimental — accuracy not yet measured

  • LRP1 may outperform other receptors in Aβ clearance, especially at higher concentrations.

    “Moreover, with an endocytosis rate up to 16 times faster than that of other Aβ receptors, such as VDLDR or LDLR (12,35), LRP1 may outperform other receptors in Aβ clearance, especially at higher concentrations.”

    From Endothelial LRP1 transports amyloid-β1–42 across the blood-brain barrier (2015) · cites this paper as [35]

    The Results (page unavailable) show that LRP internalizes the tested ligands much faster than VLDLR and an LDLR-tail chimera; the paper also describes LRP as a clearance receptor. It does not test Aβ clearance or compare receptor performance at higher Aβ concentrations, so those parts of the claim remain unsupported. (LLM, conf=0.87)

    Experimental — accuracy not yet measured

  • LRP1 has a major function as an Aβ clearance receptor in endothelial cells.

    “This demonstrated that LRP1, with an extremely fast endocytosis rate (35), has a major function as an Aβ clearance receptor in endothelial cells.”

    From Endothelial LRP1 transports amyloid-β1–42 across the blood-brain barrier (2015) · cites this paper as [35]

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Citations

Cites

Flagged first, then by citations

Research works printed but not linked: 37

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Metadata

Authors
Li, Y., Lu, W., Marzolo, M. P., & Bu, G.
Venue
Journal of Biological Chemistry
Publisher
Elsevier BV
Published
2001-05
Volume
276
Issue
21
Pages
18000-18006
ISSN
0021-9258
DOI
10.1074/jbc.m101589200
Cited by
131
References
4
Language
en
Licence

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