Cited by 140Retinal Diseases and TreatmentsRetinal and Macular SurgeryOcular Diseases and Behçet’s Syndrome

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Morphology of early choroidal neovascularisation in age-related macular degeneration: Correlation with activity

Sarks, J P, Sarks, S H, Killingsworth, M C·1997·Eye

DOI 10.1038/eye.1997.137

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Abstract

The purpose of this study was to describe the morphology of early choroidal neovascularisation (CNV) and compare the findings in two patients, in the first of whom the vessels appeared inactive and in the second progressive. Changes common to both included a diffuse deposition of membrane coils external to the basement membrane (BsM) of the retinal pigment epithelium (RPE), and macrophages and foreign body giant cells beneath thinned segments of Bruch's membrane (BrM). In the first patient small activated vessels surrounded by enlarged pericytes were found in the choroid beneath these areas and pursued a convoluted course, bulging into or through BrM, but without spreading in the sub-RPE space. This choroidal phase of CNV may be common and unrecognised. In the second patient there was spread of CNV in the sub-RPE space with extravasation of red cells and fibrin. The tips leaking fibrin were covered by a thick BsM-like material and naked endothelial cells were not seen. Pericytes were absent here but were observed at the non-leaking edge. The difference in activity of CNV in the two patients appeared to correlate with the quantity of membranous debris present.

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Authors: Sarks, J. P., Sarks, S. H., & Killingsworth, M. C.
Affiliations: UNSW Sydney (AU)
ORCID: Killingsworth, M C
Venue: Eye
Publisher: Springer Science and Business Media LLC
Published: 1997-07
Volume: 11
Issue: 4
Pages: 515-522
ISSN: 0078-5334 (ISSN-L)
0950-222X
1476-5454
DOI: 10.1038/eye.1997.137
OpenAlex: W1976540988
Cited by: 140
References: 33
Citations by year: 2026: 3 · 2025: 5 · 2024: 9 · 2023: 2 · 2022: 9 · 2021: 10 · 2020: 12 · 2019: 1 · 2018: 3 · 2017: 5 · 2016: 4 · 2015: 12 · 2014: 3 · 2013: 4 · 2012: 4
FWCI: 4.47
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Eye (publishedVersion)
PubMed (publishedVersion)
Funders: Retina Research Foundation
Topics: Health Sciences › Medicine › Ophthalmology › Retinal Diseases and Treatments
Health Sciences › Medicine › Ophthalmology › Retinal and Macular Surgery
Health Sciences › Medicine › Ophthalmology › Ocular Diseases and Behçet’s Syndrome
Keywords: choroidal neovascularization, age-related macular degeneration, choroid, Bruch's membrane, retinal pigment epithelium, basement membrane, pericytes, macrophages, foreign body giant cells, choroidal morphology
MeSH terms: Aged, Aged, 80 and over, Choroid, Humans, Macular Degeneration, Male, Microscopy, Electron, Neovascularization, Pathologic, Pigment Epithelium of Eye, Bruch Membrane, Disease Progression

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Morphology of early choroidal neovascularisation in age-related macular degeneration: Correlation with activity

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