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Epigenetics and gene expression
Open accessAbstract
Transcription, translation and subsequent protein modification represent the transfer of genetic information from the archival copy of DNA to the short-lived messenger RNA, usually with subsequent production of protein. Although all cells in an organism contain essentially the same DNA, cell types and functions differ because of qualitative and quantitative differences in their gene expression. Thus, control of gene expression is at the heart of differentiation and development. Epigenetic processes, including DNA methylation, histone modification and various RNA-mediated processes, are thought to influence gene expression chiefly at the level of transcription; however, other steps in the process (for example, translation) may also be regulated epigenetically. The following paper will outline the role epigenetics is believed to have in influencing gene expression.
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“There are three main types of epigenetic modifications: DNA methylation, histone modifications, and various RNA-mediated processes (39, 40).”
From Epigenetic Modifications in Stress Response Genes Associated With Childhood Trauma (2019) · cites this paper as [40]
In the citing paper
“As these modifications accumulate and interact with one-another to produce tightly regulated changes in gene expression, it is not sufficient to only study differences in single DNA methylation loci.9”
From The role of epigenetics in psychological resilience (2021) · cites this paper as [9]
In the citing paper
“As these modifications accumulate and interact with one-another to produce tightly regulated changes in gene expression, it is not sufficient to only study differences in single DNA methylation loci.9”
From The role of epigenetics in psychological resilience (2021) · cites this paper as [9]
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Cites
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“Epi-genetics refers to molecular processes that influence gene expression without modifying the underlying DNA sequence [18].”
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“These modi fi cations, including methylation, acetylation, phosphorylation, ubiquitination, and SUMOylation, in fl uence gene expression either by altering chromatin compaction or by serving as docking platforms for regulatory protein complexes (31 – 33).”
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Molecular Strategies to Distinguish Key Subphenotypes in Sarcoidosis
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Sinopoli, V. M. (2019) · TSpace (University of Toronto)
Tanner, J. (2017) · TSpace (University of Toronto)
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Metadata
- Authors
- Gibney, E. R., & Nolan, C. M.
- Affiliations
- University College Dublin (IE)
- Corresponding author
- Nolan, C M
- Venue
- Heredity
- Published
- 2010-05-12
- Volume
- 105
- Issue
- 1
- Pages
- 4-13
- ISSN
- 0018-067X (ISSN-L)
- 1365-2540
- OpenAlex
- W1974450480
- Cited by
- 1,109
- References
- 119
- Citations by year
- 2026: 68 · 2025: 148 · 2024: 175 · 2023: 147 · 2022: 115 · 2021: 102 · 2020: 70 · 2019: 33 · 2018: 42 · 2017: 28 · 2016: 32 · 2015: 22 · 2014: 29 · 2013: 32 · 2012: 31
- FWCI
- 2.72
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Heredity (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Science Foundation Ireland (RFP06)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Syndromes and Imprinting
- Keywords
- epigenetics, gene expression regulation, transcriptional regulation, DNA methylation, histone modifications, RNA-mediated gene regulation, cell differentiation, development (biology), translational regulation, protein modification
- MeSH terms
- Animals, Cell Differentiation, Humans, DNA Modification Methylases, Gene Expression, Cell Lineage, Heredity, Epigenesis, Genetic
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