Ectopic lipids and organ function.
Abstract
PURPOSE OF REVIEW: To summarize recent studies that shed more light on possible mechanisms by which ectopic lipid storage affects organ function. RECENT FINDINGS: Although ectopic lipids have been considered as biomarkers of lipotoxicity, adaptation of metabolic fluxes and of mitochondrial function seem to be more important than actual cellular fat contents in liver and muscle. Diabetic and obese humans have elevated myocardial lipid contents, which are associated with mitochondrial and contractile dysfunction and could even precede the development of heart failure. Although pancreatic fat content is negatively associated with insulin secretion, [beta]-cell triglycerides are not easily accessible to measurement in humans rendering their role for [beta]-cell function unclear. New approaches to quantify energy metabolism in various organs could help to identify novel biomarkers of organ function in humans. SUMMARY: Dietary intake of high-caloric high-fat diets and sedentary lifestyle lead to increased storage of triglycerides not only in adipose tissue but also ectopically in other tissues. Intracellular lipid contents in skeletal muscle and liver have been related to insulin resistance and inflammatory processes. Myocardial fat is increased in heart failure, whereas pancreatic fat could relate to insulin secretion.
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Hepatic steatosis is often associated with increased intraabdominal fat and fat accumulation in other tissues such as skeletal muscle, heart, and perhaps pancreas, and may lead to insulin resistance associated with type 2 diabetes and metabolic syndrome.
“Hepatic steatosis is often associated with increased intraabdominal fat and fat accumulation in other tissues such as skeletal muscle, heart, and perhaps pancreas, and may lead to insulin resistance associated with type 2 diabetes and metabolic syndrome (130).”
From Evaluation and Treatment of Hypertriglyceridemia: An Endocrine Society Clinical Practice Guideline (2012) · cites this paper as [130]
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Abnormal Hepatic Energy Homeostasis in Type 2 Diabetes†
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Self-citationLefort, N., Glancy, B., Bowen, B., Willis, W. T., Bailowitz, Z., De Filippis, E. A., Brophy, C., Meyer, C., Højlund, K., Yi, Z., et al. (2010) · Diabetes · doi:10.2337/db10-0174 · Cited by 174 · see citing works
Tsatsoulis, A., Mantzaris, M. D., Bellou, S., & Andrikoula, M. (2013) · Metabolism · doi:10.1016/j.metabol.2012.11.004 · Cited by 174 · see citing works
Sobrecases, H., Lê, K.-A., Bortolotti, M., Schneiter, P., Ith, M., Kreis, R., Boesch, C., & Tappy, L. (2010) · Diabetes & Metabolism · doi:10.1016/j.diabet.2010.03.003 · Cited by 161 · see citing works
Gaborit, B., Kober, F., Jacquier, A., Moro, P. J., Cuisset, T., Boullu, S., Dadoun, F., Alessi, M.-C., Morange, P., Clément, K., et al. (2012) · International Journal of Obesity · doi:10.1038/ijo.2011.117 · Cited by 116 · see citing works
Cimini, F. A., Barchetta, I., Carotti, S., Bertoccini, L., Baroni, M. G., Vespasiani-Gentilucci, U., Cavallo, M.-G., & Morini, S. (2017) · World Journal of Gastroenterology · doi:10.3748/wjg.v23.i19.3407 · Cited by 101 · see citing works
Insulin Resistance in Type 1 Diabetes: Pathophysiological, Clinical, and Therapeutic Relevance
Apostolopoulou, M., Lambadiari, V., Roden, M., & Dimitriadis, G. D. (2025) · Endocrine Reviews · doi:10.1210/endrev/bnae032 · Cited by 90 · see citing works
Self-citationEffects of Intranasal Insulin on Hepatic Fat Accumulation and Energy Metabolism in Humans
Gancheva, S., Koliaki, C., Bierwagen, A., Nowotny, P., Heni, M., Fritsche, A., Häring, H.-U., Szendroedi, J., & Roden, M. (2015) · Diabetes · doi:10.2337/db14-0892 · Cited by 81 · see citing works
Self-citationLipid-mediated muscle insulin resistance: different fat, different pathways?
Ritter, O., Jelenik, T., & Roden, M. (2015) · Journal of Molecular Medicine · doi:10.1007/s00109-015-1310-2 · Cited by 74 · see citing works
Self-citationRole of lipid-derived mediators in skeletal muscle insulin resistance
Taube, A., Eckardt, K., & Eckel, J. (2009) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00241.2009 · Cited by 40 · see citing works
Franko, A., von Kleist-Retzow, J. C., Böse, M., Sanchez-Lasheras, C., Brodesser, S., Krut, O., Kunz, W. S., Wiedermann, D., Hoehn, M., Stöhr, O., et al. (2012) · Journal of Molecular Medicine · doi:10.1007/s00109-012-0887-y · Cited by 39 · see citing works
- Authors
- Szendroedi, J., & Roden, M.
- Affiliations
- Deutsches Diabetes-Zentrum e.V. (DE)
- Corresponding author
- Roden, Michael
- Venue
- Current Opinion in Lipidology
- Published
- 2009-02
- Volume
- 20
- Issue
- 1
- Pages
- 50-56
- ISSN
- 0957-9672 (ISSN-L)
- OpenAlex
- W2090335621
- Cited by
- 200
- References
- 83
- Citations by year
- 2025: 3 · 2024: 8 · 2023: 8 · 2022: 5 · 2021: 6 · 2020: 10 · 2019: 10 · 2018: 9 · 2017: 12 · 2016: 12 · 2015: 12 · 2014: 22 · 2013: 19 · 2012: 17
- FWCI
- 1.11
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Current Opinion in Lipidology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Science Foundation
- Oesterreichische Nationalbank
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Keywords
- lipotoxicity, heart failure, mitochondrial dysfunction, insulin secretion, pancreatic fat, liver lipids, insulin resistance, inflammation, energy metabolism, high-fat diet, obesity, diabetes mellitus
- MeSH terms
- Animals, Choristoma, Heart, Humans, Lipids, Liver, Myocardium, Pancreas, Lipid Metabolism
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