The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.
Postprandial remodeling of the gut microbiota in Burmese pythons
Open accessAbstract
The vertebrate gut microbiota evolved in an environment typified by periodic fluctuations in nutrient availability, yet little is known about its responses to host feeding and fasting. As many model species (for example, mice) are adapted to lifestyles of frequent small meals, we turned to the Burmese python, a sit-and-wait foraging snake that consumes large prey at long intervals (>1 month), to examine the effects of a dynamic nutrient milieu on the gut microbiota. We used multiplexed 16S rRNA gene pyrosequencing to characterize bacterial communities harvested from the intestines of fasted and digesting snakes, and from their rodent meal. In this unprecedented survey of a reptilian host, we found that Bacteroidetes and Firmicutes numerically dominated the python gut. In the large intestine, fasting was associated with increased abundances of the genera Bacteroides, Rikenella, Synergistes and Akkermansia, and with reduced overall diversity. A marked postprandial shift in bacterial community configuration occurred. Between 12 h and 3 days after feeding, Firmicutes, including the taxa Clostridium, Lactobacillus and Peptostreptococcaceae, gradually outnumbered the fasting-dominant Bacteroidetes, and overall ‘species’-level diversity increased significantly. Most lineages seemed to be indigenous to the python rather than ingested with the meal, but a dietary source of Lactobacillus could not be ruled out. Thus, the observed large-scale alterations of the gut microbiota that accompany the Burmese python's own dramatic physiological and morphological changes during feeding and fasting emphasize the need to consider both microbial and host cellular responses to nutrient flux. The Burmese python may provide a unique model for dissecting these interrelationships.
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“E-mail: rob.knight@colorado.edu The ISME Journal (2010) 4, 1375–1385 & 2010 International Society for Microbial Ecology All rights reserved 1751-7362/10 www.nature.com/ismej intermittently available (Backhed et al., 2004; Ley et al., 2005; Turnbaugh et al., 2006, 2009a; Samuel et al., 2008).”
InfluentialSelf-citationAkkermansia muciniphila gen. nov., sp. nov., a human intestinal mucin-degrading bacterium
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Self-citationGreenblum, S., Turnbaugh, P. J., & Borenstein, E. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1116053109 · Cited by 821
Rhythmicity of the intestinal microbiota is regulated by gender and the host circadian clock
Liang, X., Bushman, F. D., & FitzGerald, G. A. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1501305112 · Cited by 578
Microbial regulation of organismal energy homeostasis
Cani, P. D., Van Hul, M., Lefort, C., Depommier, C., Rastelli, M., & Everard, A. (2019) · Nature Metabolism · doi:10.1038/s42255-018-0017-4 · Cited by 569
Metadata
- Authors
- Costello, E. K., Gordon, J. I., Secor, S. M., & Knight, R.
- Venue
- The ISME Journal
- Publisher
- Oxford University Press (OUP)
- Published
- 2010-06-03
- Volume
- 4
- Issue
- 11
- Pages
- 1375-1385
- ISSN
- 1751-7362 (ISSN-L)
- 1751-7370
- OpenAlex
- W2046846930
- Cited by
- 269
- References
- 13
- FWCI
- 4.84
- Type
- journal article
- Language
- en
- Open access
- green
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