The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Saliva microbiomes distinguish caries-active from healthy human populations
Open accessAbstract
The etiology of dental caries remains elusive because of our limited understanding of the complex oral microbiomes. The current methodologies have been limited by insufficient depth and breadth of microbial sampling, paucity of data for diseased hosts particularly at the population level, inconsistency of sampled sites and the inability to distinguish the underlying microbial factors. By cross-validating 16S rRNA gene amplicon-based and whole-genome-based deep-sequencing technologies, we report the most in-depth, comprehensive and collaborated view to date of the adult saliva microbiomes in pilot populations of 19 caries-active and 26 healthy human hosts. We found that: first, saliva microbiomes in human population were featured by a vast phylogenetic diversity yet a minimal organismal core; second, caries microbiomes were significantly more variable in community structure whereas the healthy ones were relatively conserved; third, abundance changes of certain taxa such as overabundance of Prevotella Genus distinguished caries microbiota from healthy ones, and furthermore, caries-active and normal individuals carried different arrays of Prevotella species; and finally, no ‘caries-specific’ operational taxonomic units (OTUs) were detected, yet 147 OTUs were ‘caries associated’, that is, differentially distributed yet present in both healthy and caries-active populations. These findings underscored the necessity of species- and strain-level resolution for caries prognosis, and were consistent with the ecological hypothesis where the shifts in community structure, instead of the presence or absence of particular groups of microbes, underlie the cariogenesis.
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Cites
UniFrac: a New Phylogenetic Method for Comparing Microbial Communities
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Bacterial Community Variation in Human Body Habitats Across Space and Time
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Defining the normal bacterial flora of the oral cavity
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Defining the healthy “core microbiome” of oral microbial communities
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Are dental diseases examples of ecological catastrophes?
Marsh, P. D. (2003) · Microbiology · doi:10.1099/mic.0.26082-0 · Cited by 1,256
Dental plaque as a biofilm and a microbial community—Implications for health and disease
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Bacteria of Dental Caries in Primary and Permanent Teeth in Children and Young Adults
Aas, J. A., Griffen, A. L., Dardis, S. R., Lee, A. M., Olsen, I., Dewhirst, F. E., Leys, E. J., & Paster, B. J. (2008) · Journal of Clinical Microbiology · doi:10.1128/jcm.01410-07 · Cited by 952 · cited 4×
“, 2005) or only a partial, biased and a prior determined list of microorganisms in DNA chip (Corby et al., 2005; Aas et al., 2008; Kanasi et al., 2010).”
BackgroundMethodInfluentialPyrosequencing analysis of the oral microflora of healthy adults
Keijser, B. J. F., Zaura, E., Huse, S. M., van der Vossen, J. M. B. M., Schuren, F. H. J., Montijn, R. C., ten Cate, J. M., & Crielaard, W. (2008) · Journal of Dental Research · doi:10.1177/154405910808701104 · Cited by 669 · cited 6×
“For example, Proteobacteria were more abundant in our data sets when in silico pooled (healthy Chinese adults), wherever Firmicutes were more abundant at a sample pooled from 91 healthy adult individuals in Amsterdam (Keijser et al., 2008).”
BackgroundResultInfluentialThe complex oral microflora of high‐risk individuals and groups and its role in the caries process
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Cited by
The oral microbiome in health and disease
Wade, W. G. (2013) · Pharmacological Research · doi:10.1016/j.phrs.2012.11.006 · Cited by 1,347
Comparison of the Respiratory Microbiome in Healthy Nonsmokers and Smokers
Morris, A., Beck, J. M., Schloss, P. D., Campbell, T. B., Crothers, K., Curtis, J. L., Flores, S. C., Fontenot, A. P., Ghedin, E., Huang, L., et al. (2013) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201210-1913oc · Cited by 822
Rodríguez, J. M. (2014) · Advances in Nutrition · doi:10.3945/an.114.007229 · Cited by 454
The Microbiome and Human Biology
Knight, R., Callewaert, C., Marotz, C., Hyde, E. R., Debelius, J. W., McDonald, D., & Sogin, M. L. (2017) · Annual Review of Genomics and Human Genetics · doi:10.1146/annurev-genom-083115-022438 · Cited by 373
Oral cavity contains distinct niches with dynamic microbial communities
Xu, X., He, J., Xue, J., Wang, Y., Li, K., Zhang, K., Guo, Q., Liu, X., Zhou, Y., Cheng, L., et al. (2015) · Environmental Microbiology · doi:10.1111/1462-2920.12502 · Cited by 335
Metadata
- Authors
- Yang, F., Zeng, X., Ning, K., Liu, K.-L., Lo, C.-C., Wang, W., Chen, J., Wang, D., Huang, R., Chang, X., Chain, P. S., Xie, G., Ling, J., & Xu, J.
- Venue
- The ISME Journal
- Publisher
- Oxford University Press (OUP)
- Published
- 2011-06-30
- Volume
- 6
- Issue
- 1
- Pages
- 1-10
- ISSN
- 1751-7362 (ISSN-L)
- 1751-7370
- OpenAlex
- W2017727472
- Cited by
- 369
- References
- 9
- FWCI
- 27.25
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Yang, F., Zeng, X., Ning, K., Liu, K.-L., Lo, C.-C., Wang, W., Chen, J., Wang, D., Huang, R., Chang, X., Chain, P. S., Xie, G., Ling, J., & Xu, J. (2012). Saliva microbiomes distinguish caries-active from healthy human populations. The ISME Journal. https://doi.org/10.1038/ismej.2011.71
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