Cited by 367Gut microbiota and healthOral microbiology and periodontitis researchInfant Nutrition and Health

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Microbiota conservation and BMI signatures in adult monozygotic twins

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Tims, Sebastian, Derom, Catherine, Jonkers, Daisy M, Vlietinck, Robert, Saris, Wim H, Kleerebezem, Michiel, de Vos, Willem M, Zoetendal, Erwin G·2013·The ISME Journal

DOI 10.1038/ismej.2012.146PMC PMC3603393

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Abstract

The human gastrointestinal (GI) tract microbiota acts like a virtual organ and is suggested to be of great importance in human energy balance and weight control. This study included 40 monozygotic (MZ) twin pairs to investigate the influence of the human genotype on GI microbiota structure as well as microbial signatures for differences in body mass index (BMI). Phylogenetic microarraying based on 16S rRNA genes demonstrated that MZ twins have more similar microbiotas compared with unrelated subjects (P<0.001), which allowed the identification of 35 genus-like microbial groups that are more conserved between MZ twins. Half of the twin pairs were selected on discordance in terms of BMI, which revealed an inverse correlation between Clostridium cluster IV diversity and BMI. Furthermore, relatives of Eubacterium ventriosum and Roseburia intestinalis were positively correlated to BMI differences, and relatives of Oscillospira guillermondii were negatively correlated to BMI differences. Lower BMI was associated with a more abundant network of primary fiber degraders, while a network of butyrate producers was more prominent in subjects with higher BMI. Combined with higher butyrate and valerate contents in the fecal matter of higher BMI subjects, the difference in microbial networks suggests a shift in fermentation patterns at the end of the colon, which could affect human energy homeostasis.

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Authors: Tims, S., Derom, C., Jonkers, D. M., Vlietinck, R., Saris, W. H., Kleerebezem, M., de Vos, W. M., & Zoetendal, E. G.
Affiliations: TiFN (NL)
KU Leuven (BE)
Maastricht University Medical Centre (NL)
Laboratory of Microbiology, Wageningen University and TI Food and Nutrition , Wageningen, The Netherlands
Corresponding author: Zoetendal, Erwin G
ORCID: Tims, Sebastian
Derom, Catherine
Jonkers, Daisy M
Vlietinck, Robert
Saris, Wim H
Kleerebezem, Michiel
Zoetendal, Erwin G
Venue: The ISME Journal
Publisher: Oxford University Press (OUP)
Published: 2012-11-29
Volume: 7
Issue: 4
Pages: 707-717
ISSN: 1751-7362 (ISSN-L)
1751-7370
DOI: 10.1038/ismej.2012.146
PMC: PMC3603393
OpenAlex: W2158341557
Cited by: 367
References: 69
Citations by year: 2026: 12 · 2025: 12 · 2024: 29 · 2023: 35 · 2022: 48 · 2021: 41 · 2020: 26 · 2019: 25 · 2018: 28 · 2017: 20 · 2016: 28 · 2015: 26 · 2014: 24 · 2013: 9 · 2012: 1
FWCI: 7.72
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: academic.oup.com/pages/standard-publication-reuse-rights (vor)
Locations: The ISME Journal (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Research Publications (Maastricht University) (publishedVersion, other-oa)
Socio-Environmental Systems Modeling (submittedVersion)
Lirias (KU Leuven) (submittedVersion)
Research Publications (Maastricht University) (submittedVersion, other-oa)
Data Archiving and Networked Services (DANS) (submittedVersion)
Funders: European Commission (201052)
Institut National de la Recherche Agronomique
Vlaamse regering
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
Health Sciences › Nursing › Nutrition and Dietetics › Infant Nutrition and Health
Keywords: gut microbiota, monozygotic twins, body mass index, obesity, microbial conservation, Clostridium cluster IV, Eubacterium ventriosum, Roseburia intestinalis, fiber-degrading bacteria, butyrate-producing bacteria, microbial fermentation, energy homeostasis
MeSH terms: Adult, Dietary Fiber, DNA, Bacterial, Feces, Humans, Phylogeny, RNA, Ribosomal, 16S, Twins, Monozygotic, Body Mass Index, Gram-Positive Endospore-Forming Rods, Gastrointestinal Tract, Metagenome

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Microbiota conservation and BMI signatures in adult monozygotic twins

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