Student or educator? Sign up with your school email and get 6 months of Pro free.
CoChat
Sign Up
Cited by 359

The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.

Repeated Negative DC Deflections in Rat Cortex following Middle Cerebral Artery Occlusion are Abolished by MK-801: Effect on Volume of Ischemic Injury

Open access
Iijima, T., Mies, G., Hossmann, K.-A.·1992·Journal of Cerebral Blood Flow & Metabolism
DOI 10.1038/jcbfm.1992.103
Open this paper in CoChat — free account

Abstract

Following permanent occlusion of the left middle cerebral artery (MCA) in rats, electrophysiological and hemodynamic characteristics of the periinfarct border zone were investigated in sham-operated (n = 6), untreated (n = 6), and MK-801-treated (3.0 mg/kg; n = 6) animals. For this purpose, direct current potential (DC), EEG, and blood flow (laser-Doppler flowmetry) were recorded from the cortex in the periphery of the MCA territory. In sham-operated rats, a single negative cortical DC deflection was observed after electrocoagulation of the cortex, whereas in untreated MCA-occluded animals, three to eight transient DC deflections were monitored during the initial 3 h of ischemia. The duration of these cortical DC shifts gradually increased from 1.2 ± 0.3 to 3.7 ± 2.7 min (mean ± SD; p < 0.05) during this time. In animals treated intraperitoneally with MK-801 (3.0 mg/kg) immediately after MCA occlusion, the number of cortical DC shifts significantly declined to one to three deflections (p < 0.005). The EEG of the treated animals revealed low-amplitude burst-suppression activity. In the untreated and treated experimental group, the reduction of cortical blood flow amounted to 69 ± 25 and 49 ± 13% of control, respectively. Despite the more pronounced cortical oligemia, MK-801 treatment resulted in a significant decrease of the volume of the ischemically injured tissue from 108 ± 38.5 (untreated group) to 58 ± 11.5 (p < 0.05) mm 3. Our results suggest that repetitive cortical DC deflections in the periinfarct border zone contribute to the expansion of ischemic brain infarcts.

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1038/jcbfm.1992.103

Cites

1 of 1 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Research works printed but not linked: 32

  1. 10.1161/01.STR.8.1.51 · DOI · Paper page
  2. 10.1111/j.1471-4159.1973.tb00053.x · doi:10.1111/j.1471-4159.1973.tb00053.x
  3. 10.1523/JNEUROSCI.10-01-00311.1990 · DOI · Paper page
  4. 10.1016/0006-8993(90)91424-F · DOI · Paper page
  5. 10.1016/0006-8993(90)91060-T · DOI
  6. 10.1016/0306-4522(88)90040-1 · DOI · Paper page
  7. 10.1007/BF03160362 · DOI
  8. 10.1002/ana.410140307 · DOI · Paper page
  9. 10.1007/BF00596178 · DOI
  10. Hossmann K-A, (1992) Disturbances of cerebral protein synthesis and ischemic cell death. Prog Brain Res (in press) · DOI
  11. 10.1016/0014-4886(89)90072-1 · doi:10.1016/0014-4886(89)90072-1
  12. 10.1038/jcbfm.1990.99 · DOI
  13. Krivanek J, 1978, Physiol Bohemoslov, 27, 117
  14. Marquis KL, 1989, J Pharmacol Exp Ther, 251, 1104, 10.1016/S0022-3565(25)21060-6 · doi:10.1016/s0022-3565(25)21060-6
  15. 10.1016/0006-8993(88)90690-7 · DOI · Paper page
  16. 10.1038/jcbfm.1991.142 · DOI
  17. 10.1016/0014-4886(84)90222-X · DOI
  18. 10.1038/jcbfm.1991.132 · DOI · Paper page
  19. 10.1038/jcbfm.1986.108 · DOI · Paper page
  20. 10.1016/0006-8993(88)91062-1 · DOI · Paper page
  21. 10.1038/jcbfm.1988.18 · DOI · Paper page
  22. 10.1038/jcbfm.1990.44 · DOI
  23. 10.1002/ana.410240411 · DOI · Paper page
  24. 10.1038/jcbfm.1989.88 · DOI
  25. 10.1161/01.STR.21.10.1445 · DOI
  26. 10.1126/science.758688 · DOI
  27. 10.1111/j.1469-8749.1982.tb08807.x · doi:10.1111/j.1469-8749.1982.tb08807.x
  28. 10.1038/jcbfm.1990.63 · DOI
  29. 10.1038/jcbfm.1991.135 · DOI
  30. 10.1002/neu.480040406 · doi:10.1002/neu.480040406
  31. 10.1161/01.STR.20.5.620 · DOI
  32. 10.1016/0006-8993(88)90036-4 · DOI

Cited by

See all 359

Metadata

Authors
Iijima, T., Mies, G., & Hossmann, K.-A.
Venue
Journal of Cerebral Blood Flow & Metabolism
Publisher
SAGE Publications
Published
1992-09
Volume
12
Issue
5
Pages
727-733
ISSN
  • 0271-678X (ISSN-L)
  • 1559-7016
DOI
10.1038/jcbfm.1992.103
OpenAlex
W2079609158
Cited by
359
References
1
FWCI
14.10
Type
journal article
Language
en
Open access
bronze
Licence
journals.sagepub.com/page/policies/text-and-data-mining-license (tdm)

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.