Maintained exercise‐enhanced brain executive function related to cerebral lactate metabolism in men
Open accessAbstract
High‐intensity interval exercise (HIIE) improves cerebral executive function (EF), but the improvement in EF is attenuated after reρeated HIIE, perhaρs because of lower lactate availability for the brain. This investigation examined whether imρroved EF after exercise relates to brain lactate uρtake. Fourteen healthy, male subjects performed 2 HIIE protocols separated by 60 min of rest. Blood samples were obtained from the right internal jugular venous bulb and from the brachial artery to determine arterial‐venous differences across the brain for lactate (a‐v diff lactate ), glucose (a‐v diff glucose ), oxygen (a‐v diff oxygen ), and brain‐derived neurotrophic factor (BDNF; a‐v diff BDNF ). EF was evaluated by the color‐word Stroop task. The first HIIE improved EF for 40 min, whereas the second HIIE improved EF only immediately after exercise. The a‐v diff glucose was unchanged, whereas the a‐v diff BDNF increased similarly after both HIIEs, and the a‐v diff lactate increased, but the increase was attenuated after the second HIIE, compared with the first HIIE (P <0.05). The EF after HIIE correlated with the a‐v diff lactate ( r 2 = 0.62; P < 0.01). We propose that attenuated improvement in EF after repeated HIIE relates to reduced cerebral lactate metabolism and is, thereby, linked to systemic metabolism as an example of the lactate shuttle mechanism.— Hashimoto, T., Tsukamoto, H., Takenaka, S., Olesen, N. D., Petersen, L. G., Sørensen, H., Nielsen, H. B., Secher, N. H., Ogoh, S. Maintained exercise‐enhanced brain executive function related to cerebral lactate metabolism in men. FASEB J. 32, 1417‐1427 (2018). www.fasebj.org
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Relative changes in peripheral levels of blood lactate are correlated significantly with cognitive performance levels after high-intensity interval endurance exercises.
“relative changes in peripheral levels of blood lactate are correlated significantly with cognitive performance levels after high-intensity interval endurance exercises (Lee et al., 2014; Tsukamoto et al., 2016; Hashimoto et al., 2017)”
From Dose-Response Matters! - A Perspective on the Exercise Prescription in Exercise-Cognition Research (2019) · cites this paper as Hashimoto et al., 2017
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BackgroundAstrocyte-Neuron Lactate Transport Is Required for Long-Term Memory Formation
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- Authors
- Hashimoto, T., Tsukamoto, H., Takenaka, S., Olesen, N. D., Petersen, L. G., Sørensen, H., Nielsen, H. B., Secher, N. H., & Ogoh, S.
- Affiliations
- Ritsumeikan University (JP)
- University of Copenhagen (DK)
- Toyo University (JP)
- Corresponding author
- Hashimoto, Takeshi
- ORCID
- Venue
- The FASEB Journal
- Publisher
- Wiley
- Published
- 2018-01-03
- Volume
- 32
- Issue
- 3
- Pages
- 1417-1427
- ISSN
- 0892-6638 (ISSN-L)
- 1530-6860
- OpenAlex
- W2767798800
- Semantic Scholar
- a664402a8306a8eb878cedc7815347666fc8accd
- Cited by
- 156
- References
- 13
- Citations by year
- 2026: 16 · 2025: 28 · 2024: 20 · 2023: 17 · 2022: 18 · 2021: 20 · 2020: 20 · 2019: 7 · 2018: 9 · 2017: 1
- FWCI
- 15.00
- Type
- journal article
- Language
- en
- Open access
- Licence
- Locations
- The FASEB Journal (publishedVersion)
- PubMed (publishedVersion)
- Institutional Repositories DataBase (IRDB) (submittedVersion, cc-by-nc-nd)
- Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
- Funders
- Novo Nordisk Fonden (NNF16OC0019196)
- Japan Society for the Promotion of Science (15KK0358, 17H07244, 18H03156, 26702029, 15H03098)
- Topics
- Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
- Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
- Health Sciences › Medicine › Physiology › Physical Activity and Health
- Keywords
- high-intensity interval exercise, brain-derived neurotrophic factor, lactate shuttle, repeated exercise, Stroop task, brain glucose metabolism, cerebral oxygen consumption
- MeSH terms
- Adult, Brain, Humans, Male, Time Factors, Exercise, Brain-Derived Neurotrophic Factor, Lactic Acid
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