Cerebral Blood Flow Response to Functional Activation

Paulson, Olaf B; Hasselbalch, Steen G; Rostrup, Egill; Knudsen, Gitte Moos; Pelligrino, Dale

doi:10.1038/jcbfm.2009.188

Cited by 264Advanced MRI Techniques and ApplicationsOptical Imaging and Spectroscopy TechniquesTraumatic Brain Injury and Neurovascular Disturbances

Cerebral Blood Flow Response to Functional Activation

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Paulson, Olaf B, Hasselbalch, Steen G, Rostrup, Egill, Knudsen, Gitte Moos, Pelligrino, Dale·2010·Journal of Cerebral Blood Flow & Metabolism

DOI 10.1038/jcbfm.2009.188PMC PMC2872188

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Abstract

Cerebral blood flow (CBF) and cerebral metabolic rate are normally coupled, that is an increase in metabolic demand will lead to an increase in flow. However, during functional activation, CBF and glucose metabolism remain coupled as they increase in proportion, whereas oxygen metabolism only increases to a minor degree—the so-called uncoupling of CBF and oxidative metabolism. Several studies have dealt with these issues, and theories have been forwarded regarding the underlying mechanisms. Some reports have speculated about the existence of a potentially deficient oxygen supply to the tissue most distant from the capillaries, whereas other studies point to a shift toward a higher degree of non-oxidative glucose consumption during activation. In this review, we argue that the key mechanism responsible for the regional CBF (rCBF) increase during functional activation is a tight coupling between rCBF and glucose metabolism. We assert that uncoupling of rCBF and oxidative metabolism is a consequence of a less pronounced increase in oxygen consumption. On the basis of earlier studies, we take into consideration the functional recruitment of capillaries and attempt to accommodate the cerebral tissue's increased demand for glucose supply during neural activation with recent evidence supporting a key function for astrocytes in rCBF regulation.

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Neural activity induces functional hyperemia, which is thought to deliver energy substrates and remove toxic byproducts of brain activity.
“neural activity induces a powerful increase in CBF (functional hyperemia) that is thought to deliver energy substrates and remove toxic byproducts of brain activity.88”
From Vascular Contributions to Cognitive Impairment and Dementia: A Statement for Healthcare Professionals From the American Heart Association/American Stroke Association (2011) · cites this paper as [88]
The Introduction (page not supplied) says regional cerebral blood flow increases during brain activation. The Concluding remarks (page not supplied) link that increase to sufficient glucose supply. The paper does not say that functional hyperemia removes toxic byproducts of brain activity. (LLM, conf=0.86)
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Authors: Paulson, O. B., Hasselbalch, S. G., Rostrup, E., Knudsen, G. M., & Pelligrino, D.
Affiliations: University of Copenhagen (DK)
University of Illinois Chicago (US)
Corresponding author: Paulson, Olaf B
ORCID: Paulson, Olaf B
Hasselbalch, Steen G
Rostrup, Egill
Knudsen, Gitte Moos
Venue: Journal of Cerebral Blood Flow & Metabolism
Publisher: SAGE Publications
Published: 2009-09-09
Volume: 30
Issue: 1
Pages: 2-14
ISSN: 0271-678X (ISSN-L)
1559-7016
DOI: 10.1038/jcbfm.2009.188
PMC: PMC2872188
OpenAlex: W2010746653
Cited by: 264
References: 109
Citations by year: 2026: 12 · 2025: 16 · 2024: 9 · 2023: 10 · 2022: 13 · 2021: 13 · 2020: 17 · 2019: 15 · 2018: 31 · 2017: 12 · 2016: 16 · 2015: 12 · 2014: 18 · 2013: 23 · 2012: 18
FWCI: 2.26
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: journals.sagepub.com/page/policies/text-and-data-mining-license (tdm)
Locations: Journal of Cerebral Blood Flow & Metabolism (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
Funders: Lundbeckfonden (R62-2010-5364)
National Heart, Lung, and Blood Institute (R01HL088259)
National Institute of Neurological Disorders and Stroke (R01NS063279)
Topics: Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Optical Imaging and Spectroscopy Techniques
Health Sciences › Medicine › Neurology › Traumatic Brain Injury and Neurovascular Disturbances
Keywords: cerebral blood flow, functional activation, cerebral metabolic rate, oxygen consumption, glucose metabolism, capillary recruitment, astrocytes
MeSH terms: Animals, Arterioles, Astrocytes, Brain Chemistry, Capillaries, Cerebrovascular Circulation, Glucose, Humans, Magnetic Resonance Imaging, Oxygen, Oxygen Consumption

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Cerebral Blood Flow Response to Functional Activation

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