The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
P-Glycoprotein and Breast Cancer Resistance Protein Restrict Apical-to-Basolateral Permeability of Human Brain Endothelium to Amyloid-β
Abstract
The clearance of amyloid beta (Aβ) from the brain represents a novel therapeutic target for Alzheimer's disease. Conflicting data exist regarding the contribution of adenosine triphosphatebinding cassette transporters to the clearance of Aβ through the blood-brain barrier. Therefore, we investigated whether Aβ could be a substrate for P-glycoprotein (P-gp) and/or for breast cancer resistance protein (BCRP) using a human brain endothelial cell line, hCMEC/D3. Inhibition of P-gp and BCRP increased apical-to-basolateral, but not basolateral-to-apical, permeability of hCMEC/D3 cells to 125 l Aβ 1–40. Our in vitro data suggest that P-gp and BCRP might act to prevent the blood-borne Aβ 1–40 from entering the brain.
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Increased production of NO elicited by statins reduces activity of Pgp/ABCB1 and BCRP/ABCG2 in hCMEC/D3 cells.
“the increased production of NO elicited by the statins reduced the activity of at least two proteins -Pgp/ABCB1 and BCRP/ABCG2 -that are involved in the apical extrusion of drugs in hCMEC/D3 cells (Tai et al., 2009) and in vivo (Declèves et al., 2006;Mercer et al., 2009;Robey et al., 2010).”
From The association of statins plus LDL receptor‐targeted liposome‐encapsulated doxorubicin increases in vitro drug delivery across blood–brain barrier cells (2012) · cites this paper as Tai et al., 2009
Other studies have demonstrated that ABCB1 restricts the re-entry of Aβ peptides into the CNS.
“others have demonstrated that this transporter restricts the re-entry of these peptides into the CNS [34,45].”
ABCB1 is involved in Aβ peptide transport across the BBB.
“but it is now clear that ABCB1 is also involved in A peptide transport across the BBB.”
The bexarotene-induced decrease in apical-to-basolateral Aβ peptide transport across the BBB is ABCB1-mediated.
“The results of our experiments with the specific ABCB1 inhibitor elacridar [34,45] definitively confirmed that the process was ABCB1-mediated, since the compound restored apical-to-basolateral A peptide transport across the BBB.”
Citations
Cites
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Structure and function of the blood–brain barrier
Abbott, N. J., Patabendige, A. A. K., Dolman, D. E. M., Yusof, S. R., & Begley, D. J. (2010) · Neurobiology of Disease · doi:10.1016/j.nbd.2009.07.030 · Cited by 5,185
The hCMEC/D3 cell line as a model of the human blood brain barrier
Weksler, B., Romero, I. A., & Couraud, P.-O. (2013) · Fluids and Barriers of the CNS · doi:10.1186/2045-8118-10-16 · Cited by 753
Self-citationRegulation of ABC efflux transporters at blood-brain barrier in health and neurological disorders
Qosa, H., Miller, D. S., Pasinelli, P., & Trotti, D. (2015) · Brain Research · doi:10.1016/j.brainres.2015.07.005 · Cited by 249
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Qosa, H., Abuasal, B. S., Romero, I. A., Weksler, B., Couraud, P.-O., Keller, J. N., & Kaddoumi, A. (2014) · Neuropharmacology · doi:10.1016/j.neuropharm.2014.01.023 · Cited by 146
Self-citationWilson, H. K., Canfield, S. G., Hjortness, M. K., Palecek, S. P., & Shusta, E. V. (2015) · Fluids and Barriers of the CNS · doi:10.1186/s12987-015-0007-9 · Cited by 130
The barrier and interface mechanisms of the brain barrier, and brain drug delivery
Zhang, S., Gan, L., Cao, F., Wang, H., Gong, P., Ma, C., Ren, L., Lin, Y., & Lin, X. (2022) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2022.09.017 · Cited by 129
Pinzón‐Daza, M., Garzón, R., Couraud, P., Romero, I., Weksler, B., Ghigo, D., Bosia, A., & Riganti, C. (2012) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2012.02103.x · Cited by 84
Self-citationKuntz, M., Candela, P., Saint-Pol, J., Lamartinière, Y., Boucau, M.-C., Sevin, E., Fenart, L., & Gosselet, F. (2015) · Journal of Alzheimer's Disease · doi:10.3233/jad-150469 · Cited by 55
Matsumoto, K., Chiba, Y., Fujihara, R., Kubo, H., Sakamoto, H., & Ueno, M. (2015) · Histochemistry and Cell Biology · doi:10.1007/s00418-015-1366-7 · Cited by 46
Metadata
- Authors
- Tai, L. M., Loughlin, A. J., Male, D. K., & Romero, I. A.
- Affiliations
- Department of Life Sciences, The Open University, Walton Hall, Milton Keynes, UK
- Venue
- Journal of Cerebral Blood Flow & Metabolism
- Publisher
- SAGE Publications
- Published
- 2009-04-15
- Volume
- 29
- Issue
- 6
- Pages
- 1079-1083
- ISSN
- 0271-678X
- 1559-7016
- Cited by
- 108
- References
- 4
- Language
- en
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