Decreased Cortical Serotonin in Neonatal Rabbits Exposed to Endotoxin in Utero
Open accessAbstract
Maternal intrauterine inflammation is implicated in neurodevelopmental disorders in the offspring. Serotonin is crucial for regulating maturation in the developing brain, and maternal inflammation may result in disruption of the serotonergic system in the perinatal period. Saline or endotoxin was injected intrauterine in pregnant rabbits term. Newborn rabbits underwent positron emission tomography (PET) imaging with α[(11)C]methyl-L-tryptophan (AMT) to evaluate tryptophan metabolism in vivo. Decrease in standard uptake value for AMT and decrease in serotonin concentration was noted in the frontal and parietal cortices of endotoxin kits when compared with controls. In addition, a significant decrease in serotonin-immunoreactive fibers and decreased expression of serotonin transporter (5HTT) was measured in the somatosensory cortex. There was a three-fold increase in the number of apoptotic cells in the ventrobasal (VB) thalamus without loss of raphe serotonergic cell bodies in endotoxin kits when compared with controls. Glutamateric VB neurons projecting to somatosensory cortex transiently express 5HTT and store serotonin, regulating development of the somatosensory cortex. Intrauterine inflammation results in alterations in cortical serotonin and disruption of serotonin-regulated thalamocortical development in the newborn brain. This may be a common link in neurodevelopmental disorders resulting in impairment of the somatosensory system, such as cerebral palsy and autism.
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The 5-HT system plays a critical role in brain development, including neurogenesis, neuronal migration, and synaptogenesis.
“The 5-HT system plays a critical role in brain development, including neurogenesis, neuronal migration and synaptogenesis (Daws and Gould, 2011; Kannan et al., 2011).”
From Neuroinflammation as a risk factor for attention deficit hyperactivity disorder (2019) · cites this paper as Kannan et al., 2011
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Modeling cerebral palsy in animals
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Gestational kynurenine metabolites mediate effects of pregnancy adiposity on child negative affect
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Fetal and Maternal Responses to Intraamniotic Infection
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- Authors
- Kannan, S., Saadani-Makki, F., Balakrishnan, B., Dai, H., Chakraborty, P. K., Janisse, J., Muzik, O., Romero, R., & Chugani, D. C.
- Affiliations
- Wayne State University (US)
- Department of Pediatrics, Children's Hospital of Michigan, Wayne State University School of Medicine, Detroit, Michigan, USA
- Department of Family Medicine and Public Health Sciences, Detroit, Michigan, USA
- United States Department of Health and Human Services (US)
- Corresponding author
- Kannan, Sujatha
- ORCID
- Venue
- Journal of Cerebral Blood Flow & Metabolism
- Publisher
- SAGE Publications
- Published
- 2010-09-08
- Volume
- 31
- Issue
- 2
- Pages
- 738-749
- ISSN
- 0271-678X (ISSN-L)
- 1559-7016
- PMC
- PMC3049527
- OpenAlex
- W1996553169
- Cited by
- 58
- References
- 40
- Citations by year
- 2025: 3 · 2024: 2 · 2023: 6 · 2022: 1 · 2021: 4 · 2020: 5 · 2019: 5 · 2018: 2 · 2017: 3 · 2016: 4 · 2015: 6 · 2014: 2 · 2013: 4 · 2012: 6
- FWCI
- 4.37
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Cerebral Blood Flow & Metabolism (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (K08HD050652)
- Topics
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Neonatal and fetal brain pathology
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- endotoxin, serotonin, serotonergic system, tryptophan metabolism, somatosensory cortex, ventrobasal thalamus, serotonin transporter, thalamocortical development, neurodevelopmental disorders, cerebral palsy, autism spectrum disorder, neonatal brain
- MeSH terms
- Algorithms, Animals, Animals, Newborn, Cell Count, Cerebral Cortex, Endotoxins, Female, Image Processing, Computer-Assisted, Immunohistochemistry, Magnetic Resonance Imaging, Nerve Fibers, Pregnancy, Rabbits, Raphe Nuclei, Serotonin, Somatosensory Cortex, Tryptophan, Tryptophan Hydroxylase, Apoptosis, In Situ Nick-End Labeling, Positron-Emission Tomography, Serotonin Plasma Membrane Transport Proteins
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