Ontogeny of the serotonergic projection to rat neocortex: transient expression of a dense innervation to primary sensory areas.
Open accessAbstract
The development of serotonergic innervation to rat cerebral cortex was characterized by immunohistochemical localization of serotonin combined with autoradiographic imaging of serotonin-uptake sites. In neonatal rat, a transient, dense, serotonergic innervation appears in all primary sensory areas of cortex. In somatosensory cortex, dense patches of serotonergic innervation are aligned with specialized cellular aggregates called barrels. The dense patches are not apparent after 3 weeks of age, and the serotonergic innervation becomes more uniform in adult neocortex. This precocious neonatal serotonergic innervation may play a transient physiologic role in sensory areas of cortex or may exert a trophic influence on the development of cortical circuitry and thalamocortical connections.
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These neurotransmitter projections initially innervate prefrontal regions via two parallel paths: one via the subplate and one via the marginal zone where the Cajal Retzius cells reside.
“These neurotransmitter projections initially innervate prefrontal regions via two parallel paths; one via the subplate and one via the marginal zone where the Cajal Retzius cells reside [235].”
From Development of prefrontal cortex (2022) · cites this paper as [235]
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- Authors
- D'Amato, R. J., Blue, M. E., Largent, B. L., Lynch, D. R., Ledbetter, D. J., Molliver, M. E., & Snyder, S. H.
- Affiliations
- Johns Hopkins University (US)
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 1987-06
- Volume
- 84
- Issue
- 12
- Pages
- 4322-4326
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC305077
- OpenAlex
- W2024503687
- Cited by
- 275
- References
- 28
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 1 · 2023: 2 · 2022: 1 · 2021: 7 · 2020: 5 · 2019: 3 · 2018: 6 · 2017: 1 · 2016: 1 · 2015: 5 · 2014: 2 · 2013: 5 · 2012: 4
- FWCI
- 2.64
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Mental Health (MH-18501)
- National Institute on Drug Abuse (DA.00266)
- National Institute of Neurological Disorders and Stroke (NS16375)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- serotonergic innervation, neocortex development, ontogeny, primary sensory areas, somatosensory cortex, barrel cortex, serotonin, serotonin uptake, neonatal rats, thalamocortical connections, trophic influence
- MeSH terms
- Aging, Animals, Autoradiography, Cerebral Cortex, Male, Propylamines, Rats, Inbred Strains, Receptors, Serotonin, Serotonin, Serotonin Antagonists, Tritium, Citalopram, Rats
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