Cited by 217Birth, Development, and HealthPrenatal Substance Exposure EffectsRegulation of Appetite and Obesity

Maternal high fat diet consumption during the perinatal period programs offspring behavior

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Sullivan, Elinor L., Nousen, Elizabeth K., Chamlou, Katherine A.·2014·Physiology & Behavior

Abstract

The environment that a developing offspring experiences during the perinatal period is markedly influenced by maternal health and diet composition. Evidence from both epidemiological studies and animal models indicates that maternal diet and metabolic status play a critical role in programming the neural circuitry that regulates behavior, resulting in long-term consequences for offspring behavior. Maternal diet and metabolic state influence the behavior of offspring directly by impacting the intrauterine environment and indirectly by modulating maternal behavior. The mechanisms by which maternal diet and metabolic profile shape the perinatal environment remain largely unknown, but recent research has found that increases in inflammatory cytokines, nutrients (glucose and fatty acids), and hormones (insulin and leptin) affect the environment of the developing offspring. Offspring exposed to maternal obesity and high fat diet consumption during development are more susceptible to developing mental health and behavioral disorders such as anxiety, depression, attention deficit hyperactivity disorder, and autism spectrum disorders. Recent evidence suggests that this increased risk for behavioral disorders is driven by modifications in the development of neural pathways involved in behavioral regulation. In particular, research indicates that the development of the serotonergic system is impacted by exposure to maternal obesity and high fat diet consumption, and this disruption may underlie many of the behavioral disturbances observed in these offspring. Given the high rates of obesity and high fat diet consumption in pregnant women, it is vital to examine the influence that maternal nutrition and metabolic profile have on the developing offspring.

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  • In nonhuman primates, an unhealthy diet during pregnancy has been linked to poorer cognitive outcomes, enhanced stress responses, and behavioral disruptions in the offspring.

    “Likewise, in nonhuman primates, an unhealthy diet during pregnancy has been linked to poorer cognitive outcomes, enhanced stress responses, and behavioral disruptions in the offspring (242),”

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Authors
Sullivan, E. L., Nousen, E. K., & Chamlou, K. A.
Affiliations
  • Oregon National Primate Research Center (US)
  • University of Portland (US)
Corresponding author
Sullivan, Elinor L.
Venue
Physiology & Behavior
Publisher
Elsevier BV
Published
2014-01
Volume
123
Pages
236-242
ISSN
0031-9384 (ISSN-L)
OpenAlex
W2050705896
Cited by
217
References
120
Citations by year
2026: 8 · 2025: 12 · 2024: 23 · 2023: 7 · 2022: 11 · 2021: 17 · 2020: 25 · 2019: 14 · 2018: 23 · 2017: 15 · 2016: 19 · 2015: 21 · 2014: 12 · 2013: 10
FWCI
2.15
Type
journal article
Language
en
Open access
Locations
  • Physiology & Behavior (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institute of Diabetes and Digestive and Kidney Diseases (R01DK079194)
  • National Center for Research Resources (P51RR000163)
  • Eunice Kennedy Shriver National Institute of Child Health and Human Development (L40 HD059242)
Topics
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Prenatal Substance Exposure Effects
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Keywords
maternal high-fat diet, maternal obesity, perinatal programming, offspring behavior, developmental programming, intrauterine environment, maternal behavior, inflammatory cytokines, insulin, leptin, glucose, fatty acids, serotonergic system, anxiety, depression, attention deficit hyperactivity disorder, autism spectrum disorder, mental illness
MeSH terms
Child Behavior Disorders, Child, Preschool, Female, Humans, Pregnancy, Prenatal Exposure Delayed Effects, Maternal Nutritional Physiological Phenomena, Diet, High-Fat

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