Cited by 254Effects and risks of endocrine disrupting chemicalsPharmaceutical and Antibiotic Environmental ImpactsPesticide Exposure and Toxicity

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Parabens in urine, serum and seminal plasma from healthy Danish men determined by liquid chromatography–tandem mass spectrometry (LC–MS/MS)

Frederiksen, Hanne, Jørgensen, Niels, Andersson, Anna-Maria·2011·Journal of Exposure Science & Environmental Epidemiology

DOI 10.1038/jes.2010.6

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Abstract

Parabens are used as anti-microbial preservatives in a range of consumer products, especially in cosmetics. In vitro and animal studies have shown weak estrogenic and other endocrine disrupting effects of parabens, including reduced testosterone levels in exposed male rats. The knowledge of paraben exposure, distribution and excretion in humans is limited. In this study we determined the concentration of five parabens; methyl-, ethyl-, n-propyl-, n-butyl- and benzylparaben in urine, serum and seminal plasma samples from 60 healthy Danish men. To conduct the study a sensitive and specific method using LC-MS/MS for simultaneous determination of the five parabens was developed for all three different matrices. Highest concentrations of the parabens were found in urine, wherein methyl-, ethyl-, n-propyl- and n-butyl parabens were measurable in 98%, 80%, 98% and 83% of the men, respectively. Benzyl paraben was only measurable in urine from 7% of the men. Methyl- and n-propyl parabens were also measurable in the majority of serum and seminal plasma samples, whereas the other parabens could only be detected in some of the samples. In all the three matrices significant correlations between the parabens were seen. Furthermore, urinary paraben concentrations correlate to the paraben concentrations in both serum and seminal plasma.

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Authors: Frederiksen, H., Jørgensen, N., & Andersson, A.-M.
Affiliations: Copenhagen University Hospital (DK)
Corresponding author: Frederiksen, Hanne
ORCID: Frederiksen, Hanne
Jørgensen, Niels
Andersson, Anna-Maria
Venue: Journal of Exposure Science & Environmental Epidemiology
Publisher: Springer Science and Business Media LLC
Published: 2010-03-10
Volume: 21
Issue: 3
Pages: 262-271
ISSN: 1559-0631 (ISSN-L)
1559-064X
DOI: 10.1038/jes.2010.6
OpenAlex: W2022438662
Cited by: 254
References: 27
Citations by year: 2026: 7 · 2025: 7 · 2024: 10 · 2023: 12 · 2022: 24 · 2021: 26 · 2020: 19 · 2019: 20 · 2018: 23 · 2017: 18 · 2016: 17 · 2015: 20 · 2014: 21 · 2013: 17 · 2012: 11
FWCI: 7.09
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Journal of Exposure Science & Environmental Epidemiology (publishedVersion)
PubMed (publishedVersion)
Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
Funders: Velux Fonden
Topics: Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Effects and risks of endocrine disrupting chemicals
Physical Sciences › Environmental Science › Pollution › Pharmaceutical and Antibiotic Environmental Impacts
Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Toxicology › Pesticide Exposure and Toxicity
Keywords: parabens, methylparaben, ethylparaben, benzylparaben, human exposure, urinary biomonitoring, serum, seminal plasma, endocrine disruptors, cosmetics, preservatives, healthy men
MeSH terms: Adolescent, Adult, Chromatography, Liquid, Humans, Hydrolysis, Male, Parabens, Quality Control, Reference Standards, Reference Values, Semen, Reproducibility of Results, Solid Phase Extraction, Tandem Mass Spectrometry, Young Adult, Limit of Detection

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Parabens in urine, serum and seminal plasma from healthy Danish men determined by liquid chromatography–tandem mass spectrometry (LC–MS/MS)

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