Intracellular colon cancer-associated Escherichia coli promote protumoral activities of human macrophages by inducing sustained COX-2 expression
Open accessAbstract
Intestinal dysbiosis has been reported in patients with colorectal cancer, and there is a high prevalence of Escherichia coli belonging to B2 phylogroup and producing a genotoxin, termed colibactin. Macrophages are one of the predominant tumor-infiltrating immune cells supporting key processes in tumor progression by producing protumoral factors such as cyclooxygenase-2 (COX-2). Here, we investigated whether B2 E. coli colonizing colon tumors could influence protumoral activities of macrophages. In contrast to commensal or nonpathogenic E. coli strains that were efficiently and rapidly degraded by macrophages at 24 h after infection, colon cancer-associated E. coli were able to resist killing by human THP-1 macrophages, to replicate intracellularly, and to persist inside host cells until at least 72 h after infection. Significant increases in COX-2 expression were observed in macrophages infected with colon cancer E. coli compared with macrophages infected with commensal and nonpathogenic E. coli strains or uninfected cells at 72 h after infection. Induction of COX-2 expression required live bacteria and was not due to colibactin production, as similar COX-2 levels were observed in macrophages infected with the wild-type colon cancer-associated E. coli 11G5 strain or a clbQ mutant unable to produce colibactin. Treatment of macrophages with ofloxacin, an antibiotic with intracellular tropism, efficiently decreased the number of intracellular bacteria and suppressed bacteria-induced COX-2 expression. This study provides new insights into the understanding of how tumor- infiltrating bacteria could influence cancer progression through their interaction with immune cells. Manipulation of microbes associated with tumors could have a deep influence on the secretion of protumoral molecules by infiltrating macrophages.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In colorectal cancer patients, microbiota composition is one factor favoring carcinogenic lesions, notably through genotoxic bacteria such as Fusobacterium nucleatum or colibactin-producing Escherichia coli.
“In CRC patients, it is known that the composition of the microbiota is one of the factors favoring the development of carcinogenic lesions, notably by the presence of genotoxic bacteria such as Fusobacterium nucleatum or colibactin-producing Escherichia coli (124, 125).”
From Bifidobacteria and Their Health-Promoting Effects (2017) · cites this paper as [124]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008
Ferlay, J., Shin, H.-R., Bray, F., Forman, D., Mathers, C., & Parkin, D. M. (2010) · International Journal of Cancer · doi:10.1002/ijc.25516 · Cited by 22,207 · see citing works
Macrophage Diversity Enhances Tumor Progression and Metastasis
Qian, B., & Pollard, J. W. (2010) · Cell · doi:10.1016/j.cell.2010.03.014 · Cited by 5,208 · see citing works
Kostic, A. D., Chun, E., Robertson, L., Glickman, J. N., Gallini, C. A., Michaud, M., Clancy, T. E., Chung, D. C., Lochhead, P., Hold, G. L., et al. (2013) · Cell Host & Microbe · doi:10.1016/j.chom.2013.07.007 · Cited by 2,718 · see citing works
Up-regulation of cyclooxygenase 2 gene expression in human colorectal adenomas and adenocarcinomas
Eberhart, C. E., Coffey, R. J., Aramandla, R., Giardiello, F. M., Ferrenbach, S., & DuBois, R. N. (1994) · Gastroenterology · doi:10.1016/0016-5085(94)90246-1 · Cited by 2,512 · see citing works
Intestinal inflammation targets cancer-inducing activity of the microbiota
Arthur, J. C., Perez-Chanona, E., Mühlbauer, M., Tomkovich, S., Uronis, J. M., Fan, T.-J., Campbell, B. J., Abujamel, T., Dogan, B., Rogers, A. B., et al. (2012) · Science · doi:10.1126/science.1224820 · Cited by 2,263 · see citing works
<i>Fusobacterium nucleatum</i> infection is prevalent in human colorectal carcinoma
Castellarin, M., Warren, R. L., Freeman, J. D., Dreolini, L., Krzywinski, M., Strauss, J., Barnes, R., Watson, P., Allen-Vercoe, E., Moore, R. A., et al. (2012) · Genome Research · doi:10.1101/gr.126516.111 · Cited by 2,043 · see citing works
Genomic analysis identifies association of <i>Fusobacterium</i> with colorectal carcinoma
Kostic, A. D., Gevers, D., Pedamallu, C. S., Michaud, M., Duke, F., Earl, A. M., Ojesina, A. I., Jung, J., Bass, A. J., Tabernero, J., et al. (2012) · Genome Research · doi:10.1101/gr.126573.111 · Cited by 1,960 · see citing works
Wu, S., Rhee, K.-J., Albesiano, E., Rabizadeh, S., Wu, X., Yen, H.-R., Huso, D. L., Brancati, F. L., Wick, E., McAllister, F., et al. (2009) · Nature Medicine · doi:10.1038/nm.2015 · Cited by 1,812 · see citing works
Macrophage polarization in tumour progression
Sica, A., Larghi, P., Mancino, A., Rubino, L., Porta, C., Totaro, M. G., Rimoldi, M., Biswas, S. K., Allavena, P., & Mantovani, A. (2008) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2008.03.004 · Cited by 1,241 · see citing works
<i>Escherichia coli</i> Induces DNA Double-Strand Breaks in Eukaryotic Cells
Nougayrède, J.-P., Homburg, S., Taieb, F., Boury, M., Brzuszkiewicz, E., Gottschalk, G., Buchrieser, C., Hacker, J., Dobrindt, U., & Oswald, E. (2006) · Science · doi:10.1126/science.1127059 · Cited by 1,188 · see citing works
The role of COX-2 in intestinal inflammation and colorectal cancer
Wang, D., & DuBois, R. N. (2009) · Oncogene · doi:10.1038/onc.2009.421 · Cited by 893 · see citing works
Microbial Dysbiosis in Colorectal Cancer (CRC) Patients
Sobhani, I., Tap, J., Roudot‐Thoraval, F., Roperch, J. P., Letulle, S., Langella, P., Corthier, G., Nhieu, J. T. V., & Furet, J. (2011) · PLoS ONE · doi:10.1371/journal.pone.0016393 · Cited by 842 · see citing works
Microbes, Microbiota, and Colon Cancer
Sears, C. L., & Garrett, W. S. (2014) · Cell Host & Microbe · doi:10.1016/j.chom.2014.02.007 · Cited by 820 · see citing works
Internalization of Salmonella by Macrophages Induces Formation of Nonreplicating Persisters
Hélaine, S., Cheverton, A. M., Watson, K. G., Faure, L. M., Matthews, S. A., & Holden, D. W. (2014) · Science · doi:10.1126/science.1244705 · Cited by 744 · see citing works
Martin, H., Campbell, B. J., Hart, C. A., Mpofu, C., Nayar, M. K., Singh, R., Englyst, H. N., Williams, H. F., & Rhodes, J. M. (2004) · Gastroenterology · doi:10.1053/j.gastro.2004.03.054 · Cited by 719 · see citing works
The Gut Microbiome Modulates Colon Tumorigenesis
Zackular, J. P., Baxter, N. T., Iverson, K. D., Sadler, W. D., Petrosino, J. F., Chen, G., & Schloss, P. D. (2013) · mBio · doi:10.1128/mbio.00692-13 · Cited by 717 · see citing works
Huxley, R., Ansari‐Moghaddam, A., Clifton, P. M., Czernichow, S., Parr, C. L., & Woodward, M. (2009) · International Journal of Cancer · doi:10.1002/ijc.24343 · Cited by 650 · see citing works
High Prevalence of Mucosa-Associated E. coli Producing Cyclomodulin and Genotoxin in Colon Cancer
Buc, E., Dubois, D., Sauvanet, P., Raisch, J., Delmas, J., Darfeuille-Michaud, A., Pezet, D., & Bonnet, R. (2013) · PLoS ONE · doi:10.1371/journal.pone.0056964 · Cited by 535 · see citing works
Self-citationCOX-2: A Molecular Target for Colorectal Cancer Prevention
Brown, J. R., & DuBois, R. N. (2005) · Journal of Clinical Oncology · doi:10.1200/jco.2005.09.051 · Cited by 529 · see citing works
Cougnoux, A., Dalmasso, G., Martinez, R., Buc, E., Delmas, J., Gibold, L., Sauvanet, P., Darcha, C., Déchelotte, P., Bonnet, M., et al. (2014) · Gut · doi:10.1136/gutjnl-2013-305257 · Cited by 486 · see citing works
Self-citationGlasser, A.-L., Boudeau, J., Barnich, N., Perruchot, M.-H., Colombel, J., & Darfeuille–Michaud, A. (2001) · Infection and Immunity · doi:10.1128/iai.69.9.5529-5537.2001 · Cited by 465 · see citing works
Self-citationA possible role of Bacteroides fragilis enterotoxin in the aetiology of colorectal cancer
Ulger Toprak, N., Yagci, A., Gulluoglu, B. M., Akin, M. L., Demirkalem, P., Celenk, T., & Soyletir, G. (2006) · Clinical Microbiology and Infection · doi:10.1111/j.1469-0691.2006.01494.x · Cited by 454 · see citing works
A rapid method for efficient gene replacement in the filamentous fungus Aspergillus nidulans
Chaveroche, M. (2000) · Nucleic Acids Research · doi:10.1093/nar/28.22.e97 · Cited by 430 · see citing works
Chun, K., & Surh, Y. (2004) · Biochemical Pharmacology · doi:10.1016/j.bcp.2004.05.031 · Cited by 402 · see citing works
The Multifaceted Role of the Intestinal Microbiota in Colon Cancer
Irrazábal, T., Belcheva, A., Girardin, S. E., Martín, A., & Philpott, D. J. (2014) · Molecular Cell · doi:10.1016/j.molcel.2014.03.039 · Cited by 345 · see citing works
Starr, T., Child, R., Wehrly, T. D., Hansen, B. T., Hwang, S., López-Otı́n, C., Virgin, H. W., & Celli, J. (2012) · Cell Host & Microbe · doi:10.1016/j.chom.2011.12.002 · Cited by 341 · see citing works
Dynamics of intracellular bacterial replication at the single cell level
Hélaine, S., Thompson, J. A., Watson, K. G., Liu, M., Boyle, C., & Holden, D. W. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1000041107 · Cited by 309 · see citing works
Association between intraepithelial Escherichia coli and colorectal cancer
Swidsinski, A. V., Khilkin, M., Kerjaschki, D., Schreiber, S., Ortner, M., Weber, J., & Lochs, H. (1998) · Gastroenterology · doi:10.1016/s0016-5085(98)70194-5 · Cited by 302 · see citing works
The Stress-Induced MAP Kinase p38 Regulates Endocytic Trafficking via the GDI:Rab5 Complex
Cavalli, V., Vilbois, F., Felberbaum‐Corti, M., Marcote, M. J., Tamura, K., Karin, M., Arkinstall, S., & Gruenberg, J. E. (2001) · Molecular Cell · doi:10.1016/s1097-2765(01)00189-7 · Cited by 288 · see citing works
Coordinated regulation of autophagy by p38α MAPK through mAtg9 and p38IP
Webber, J. L., & Tooze, S. A. (2009) · The EMBO Journal · doi:10.1038/emboj.2009.321 · Cited by 251 · see citing works
The role of gut microbiota in the pathogenesis of colorectal cancer
Zhu, Q., Gao, R., Wu, W., & Qin, H. (2013) · Tumor Biology · doi:10.1007/s13277-013-0684-4 · Cited by 210 · see citing works
Cyclooxygenase-2 Expression is an Independent Predictor of Poor Prognosis in Colon Cancer
Ogino, S., Kirkner, G., Nosho, K., Irahara, N., Kure, S., Shima, K., Hazra, A., Chan, A., Dehari, R., Giovannucci, E., et al. (2008) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-08-1841 · Cited by 206 · see citing works
Corcelle–Termeau, E., Djerbi, N., Mari, M., Nebout, M., Fiorini, C., Fénichel, P., Hofman, P. M., Poujeol, P., & Mograbi, B. (2007) · Autophagy · doi:10.4161/auto.3424 · Cited by 184 · see citing works
Colon cancer-associated B2Escherichia colicolonize gut mucosa and promote cell proliferation
Raisch, J. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i21.6560 · Cited by 174 · see citing works
Self-citationCyclooxygenase-2 in tumorigenesis of gastrointestinal cancers: An update on the molecular mechanisms
Wu, W. K. K., Sung, J. J. �., Lee, C. W., Yu, J. Q., & Cho, C. H. (2010) · Cancer Letters · doi:10.1016/j.canlet.2010.03.015 · Cited by 153 · see citing works
Maddocks, O. D. K., Short, A., Donnenberg, M. S., Bader, S. A., & Harrison, D. J. (2009) · PLoS ONE · doi:10.1371/journal.pone.0005517 · Cited by 150 · see citing works
Leading a Sheltered Life: Intracellular Pathogens and Maintenance of Vacuolar Compartments
Kumar, Y., & Valdivia, R. H. (2009) · Cell Host & Microbe · doi:10.1016/j.chom.2009.05.014 · Cited by 148 · see citing works
Chang, Y., Wu, M., Lin, J.-T., Sheu, B., Muta, T., Inoue, H., & Chen, C. (2004) · Molecular Pharmacology · doi:10.1124/mol.104.005199 · Cited by 145 · see citing works
Bringer, M.-A., Glasser, A.-L., Tung, C., Méresse, S., & Darfeuille–Michaud, A. (2005) · Cellular Microbiology · doi:10.1111/j.1462-5822.2005.00639.x · Cited by 143 · see citing works
Self-citationCyclooxygenase 2 is up-regulated and localized to macrophages in the intestine of Min mice
Hull, M. A., Booth, J., Tisbury, A., Scott, N., Bonifer, C., Markham, A. F., & Coletta, P. L. (1999) · British Journal of Cancer · doi:10.1038/sj.bjc.6690224 · Cited by 135 · see citing works
Sécher, T., Samba‐Louaka, A., Oswald, É., & Nougayrède, J. (2013) · PLoS ONE · doi:10.1371/journal.pone.0077157 · Cited by 134 · see citing works
Marjuki, H., Gornitzky, A. L., Marathe, B. M., Ilyushina, N. A., Aldridge, J. R., Desai, G., Webby, R. J., & Webster, R. G. (2010) · Cellular Microbiology · doi:10.1111/j.1462-5822.2010.01556.x · Cited by 120 · see citing works
Pro-inflammatory prostaglandins and progression of colorectal cancer
Wang, D., & DuBois, R. N. (2008) · Cancer Letters · doi:10.1016/j.canlet.2008.03.004 · Cited by 112 · see citing works
Fratti, R. A., Chua, J., & Deretic, V. P. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m305225200 · Cited by 108 · see citing works
Hardwick, J. C. H., BRINK, G. R. V. D., Offerhaus, G. J. A., van Deventer, S. J. H., & Peppelenbosch, M. P. (2001) · Oncogene · doi:10.1038/sj.onc.1204162 · Cited by 106 · see citing works
A comparative overview of general risk factors associated with the incidence of colorectal cancer
Rasool, S., Kadla, S. A., Rasool, V., & Ganai, B. A. (2013) · Tumor Biology · doi:10.1007/s13277-013-0876-y · Cited by 106 · see citing works
Bringer, M.-A., Barnich, N., Glasser, A.-L., Bardot, O., & Darfeuille–Michaud, A. (2005) · Infection and Immunity · doi:10.1128/iai.73.2.712-721.2005 · Cited by 104 · see citing works
Self-citationMechanistic Aspects of COX-2 Expression in Colorectal Neoplasia
Dixon, D. A., Blanco, F. F., Bruno, A., & Patrignani, P. (2012) · Recent results in cancer research/Recent Results in Cancer Research · doi:10.1007/978-3-642-30331-9_2 · Cited by 99 · see citing works
Sleeping with the Enemy: How Intracellular Pathogens Cope with a Macrophage Lifestyle
Thi, E. P., Lambertz, U., & Reiner, N. E. (2012) · PLoS Pathogens · doi:10.1371/journal.ppat.1002551 · Cited by 96 · see citing works
Prison Break: Pathogens' Strategies To Egress from Host Cells
Friedrich, N., Hagedorn, M., Soldati‐Favre, D., & Soldati, T. (2012) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00024-12 · Cited by 96 · see citing works
Bacterial Pathogens Commandeer Rab GTPases to Establish Intracellular Niches
Stein, M., Müller, M. P., & Wandinger‐Ness, A. (2012) · Traffic · doi:10.1111/tra.12000 · Cited by 93 · see citing works
Autophagosomes can support Yersinia pseudotuberculosis replication in macrophages
Moreau, K., Lacas‐Gervais, S., Fujita, N., Sebbane, F., Yoshimori, T., Simonet, M., & Lafont, F. (2010) · Cellular Microbiology · doi:10.1111/j.1462-5822.2010.01456.x · Cited by 90 · see citing works
Bacterial Oncogenesis in the Colon
Dejea, C. M., Wick, E., & Sears, C. L. (2013) · Future Microbiology · doi:10.2217/fmb.13.17 · Cited by 90 · see citing works
Posttranscriptional Regulation of Cyclooxygenase 2 Expression in Colorectal Cancer
Young, L. E., & Dixon, D. A. (2010) · Current Colorectal Cancer Reports · doi:10.1007/s11888-010-0044-3 · Cited by 57 · see citing works
Kim, J. M., Lee, J., Yoon, Y. M., Oh, Y., Kang, J., Kim, Y., & Kim, K. (2006) · European Journal of Immunology · doi:10.1002/eji.200535808 · Cited by 50 · see citing works
Thomas, W., Ascott, Z. K., Harmey, D., Slice, L. W., Rozengurt, E., & Lax, A. J. (2001) · Infection and Immunity · doi:10.1128/iai.69.11.6839-6845.2001 · Cited by 43 · see citing works
Hisatsune, J., Yamasaki, E., Nakayama, M., Shirasaka, D., Kurazono, H., Katagata, Y., Inoue, H., Han, J., Sap, J., Yahiro, K., et al. (2007) · Infection and Immunity · doi:10.1128/iai.00500-07 · Cited by 43 · see citing works
Regulation of stromal cell cyclooxygenase-2 in the Apc Min/+ mouse model of intestinal tumorigenesis
Hull, M. A., Faluyi, O. O., Ko, C. W. S., Holwell, S. E., Scott, D. J., Cuthbert, R. J., Poulsom, R., Goodlad, R. A., Bonifer, C., Markham, A. F., et al. (2005) · Carcinogenesis · doi:10.1093/carcin/bgi236 · Cited by 29 · see citing works
Chen, T., Tsai, J., Huang, H.-J., Teng, C., Chien, S., Kuo, H., Huang, W., & Chen, C. (2011) · Cellular Microbiology · doi:10.1111/j.1462-5822.2011.01650.x · Cited by 19 · see citing works
Klug, K., Ehlers, S., Uhlig, S., & Reiling, N. (2010) · Innate Immunity · doi:10.1177/1753425910377799 · Cited by 19 · see citing works
Dimitrakopoulos, O., Liopeta, K., Dimitracopoulos, G., & Paliogianni, F. (2013) · Microbes and Infection · doi:10.1016/j.micinf.2013.04.007 · Cited by 10 · see citing works
Flagged first, then by citations
Research works printed but not linked: 3
- Martin HM, Campbell BJ, Hart CA, et al. Enhanced Escherichia coli adherence and invasion in Crohn's disease and colon cancer. Gastroenterology 2004;127:80-93.
- Bamba H, Ota S, Kato A, et al. High expression of cyclooxygenase-2 in macrophages of human colonic adenoma. Int J Cancer 1999; 83:470-475.
- Hull MA, Faluyi OO, Ko CW, et al. Regulation of stromal cell cyclo- oxygenase-2 in the ApcMin/ þ mouse model of intestinal tumori- genesis. Carcinogenesis 2006;27:382-391.
Cited by
Sorted by citations
Gut microbiota imbalance and colorectal cancer
Gagnière, J. (2016) · World Journal of Gastroenterology · doi:10.3748/wjg.v22.i2.501 · Cited by 856 · see citing works
The gut microbiota influences anticancer immunosurveillance and general health
Routy, B., Gopalakrishnan, V., Daillère, R., Zitvogel, L., Wargo, J. A., & Kroemer, G. (2018) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-018-0006-2 · Cited by 523 · see citing works
Bifidobacteria and Their Health-Promoting Effects
Hidalgo-Cantabrana, C., Delgado, S., Ruiz, L., Ruas-Madiedo, P., Sánchez, B., & Margolles, A. (2017) · Microbiology Spectrum · doi:10.1128/microbiolspec.bad-0010-2016 · Cited by 490 · see citing works
Yu, L. C. (2018) · Journal of Biomedical Science · doi:10.1186/s12929-018-0483-8 · Cited by 404 · see citing works
Wang, H., Tian, T., & Zhang, J. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22168470 · Cited by 364 · see citing works
Lam, M. M. C., Wyres, K. L., Duchêne, S., Wick, R. R., Judd, L. M., Gan, Y., Hoh, C.-H., Archuleta, S., Molton, J. S., Kalimuddin, S., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-05114-7 · Cited by 349 · see citing works
Microbiota, Inflammation and Colorectal Cancer
Lucas, C., Barnich, N., & Nguyen, H. T. T. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18061310 · Cited by 318 · see citing works
Colonic macrophage polarization in homeostasis, inflammation, and cancer
Isidro, R. A., & Appleyard, C. B. (2016) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00123.2016 · Cited by 229 · see citing works
Cancer‐associated fecal microbial markers in colorectal cancer detection
Eklöf, V., Löfgren‐Burström, A., Zingmark, C., Edin, S., Larsson, P. G., Karling, P., Alexeyev, O. A., Rutegård, M., Wikberg, M. L., & Palmqvist, R. (2017) · International Journal of Cancer · doi:10.1002/ijc.31011 · Cited by 209 · see citing works
High fat diet, gut microbiome and gastrointestinal cancer
Tong, Y., Gao, H., Qi, Q., Liu, X., Li, J., Gao, J., Li, P., Wang, Y., Du, L., & Wang, C. (2021) · Theranostics · doi:10.7150/thno.56157 · Cited by 205 · see citing works
Gut microbiota and colorectal cancer
Gao, R., Gao, Z., Huang, L., & Qin, H. (2017) · European Journal of Clinical Microbiology & Infectious Diseases · doi:10.1007/s10096-016-2881-8 · Cited by 205 · see citing works
Das, U. N. (2021) · Biomolecules · doi:10.3390/biom11020241 · Cited by 142 · see citing works
Colon Carcinogenesis: The Interplay Between Diet and Gut Microbiota
Loke, Y. L., Chew, M. T., Ngeow, Y. F., Lim, W. W.-D., & Peh, S. C. (2020) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2020.603086 · Cited by 129 · see citing works
Zhu, W., Miyata, N., Winter, M. G., Arenales, A., Hughes, E. R., Spiga, L., Kim, J., Sifuentes-Dominguez, L., Starokadomskyy, P., Gopal, P., et al. (2019) · The Journal of Experimental Medicine · doi:10.1084/jem.20181939 · Cited by 124 · see citing works
Role of Gut Microbiota in the Development and Treatment of Colorectal Cancer
Lin, C., Cai, X., Zhang, J., Wang, W., Sheng, Q., Hua, H., & Zhou, X. (2018) · Digestion · doi:10.1159/000494052 · Cited by 121 · see citing works
Sheppe, A. E. F., & Edelmann, M. J. (2021) · Infection and Immunity · doi:10.1128/iai.00095-21 · Cited by 121 · see citing works
Lopès, A., Billard, E., Casse, A. H., Villéger, R., Véziant, J., Roche, G., Carrier, G., Sauvanet, P., Briat, A., Pagès, F., et al. (2020) · International Journal of Cancer · doi:10.1002/ijc.32920 · Cited by 119 · see citing works
Comparative genomics of Crohn's disease-associated adherent-invasiveEscherichia coli
O'Brien, C. L., Bringer, M.-A., Holt, K. E., Gordon, D. M., Dubois, A. L., Barnich, N., Darfeuille–Michaud, A., & Pavli, P. (2016) · Gut · doi:10.1136/gutjnl-2015-311059 · Cited by 110 · see citing works
Self-citationIntracellular bacteria in cancer—prospects and debates
Schorr, L., Mathies, M., Elinav, E., & Puschhof, J. (2023) · npj Biofilms and Microbiomes · doi:10.1038/s41522-023-00446-9 · Cited by 113 · see citing works
Unexpected therapeutic effects of cisplatin
Raudenská, M., Balvan, J., Fojtů, M., Gumulec, J., & Masařík, M. (2019) · Metallomics · doi:10.1039/c9mt00049f · Cited by 104 · see citing works
Tumor Microenvironment Shapes Colorectal Cancer Progression, Metastasis, and Treatment Responses
Li, J., Chen, D., & Shen, M. (2022) · Frontiers in Medicine · doi:10.3389/fmed.2022.869010 · Cited by 94 · see citing works
Lucas, C., Salesse, L., Hoang, M. H. T., Bonnet, M., Sauvanet, P., Larabi, A. B., Godfraind, C., Gagnière, J., Pezet, D., Rosenstiel, P. C., et al. (2020) · Gastroenterology · doi:10.1053/j.gastro.2019.12.026 · Cited by 89 · see citing works
Tumor immune microenvironment and nano-immunotherapeutics in colorectal cancer
Xiong, Y., Wang, Y., & Tiruthani, K. (2019) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2019.102034 · Cited by 88 · see citing works
Colorectal cancer-inflammatory bowel disease nexus and felony of Escherichia coli
Khan, A. A., Khan, Z., Malik, A., Kalam, M. A., Cash, P., Ashraf, M. T., & Alshamsan, A. (2017) · Life Sciences · doi:10.1016/j.lfs.2017.05.016 · Cited by 85 · see citing works
Microbiome-driven carcinogenesis in colorectal cancer: Models and mechanisms
Wang, X., Yang, Y., & Huycke, M. M. (2016) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2016.10.504 · Cited by 82 · see citing works
Barrett's esophagus is associated with a distinct oral microbiome
Snider, E. J., Compres, G., Freedberg, D. E., Giddins, M. J., Khiabanian, H., Lightdale, C. J., Nobel, Y. R., Toussaint, N. C., Uhlemann, A.-C., & Abrams, J. A. (2018) · Clinical and Translational Gastroenterology · doi:10.1038/s41424-018-0005-8 · Cited by 72 · see citing works
Tumor-Associated Macrophage (TAM) and Angiogenesis in Human Colon Carcinoma
Badawi, M., Abouelfadl, D. M., El-Sharkawy, S. L., AbdEl-Aal, W. E., & Abbas, N. F. (2015) · Open Access Macedonian Journal of Medical Sciences · doi:10.3889/oamjms.2015.044 · Cited by 65 · see citing works
Shaping functional gut microbiota using dietary bioactives to reduce colon cancer risk
Seidel, D., Azcárate-Peril, M. A., Chapkin, R. S., & Turner, N. D. (2017) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2017.06.009 · Cited by 65 · see citing works
Véziant, J., Gagnière, J., Jouberton, E., Bonnin, V., Sauvanet, P., Pezet, D., Barnich, N., Miot‐Noirault, E., & Bonnet, M. (2016) · World Journal of Clinical Oncology · doi:10.5306/wjco.v7.i3.293 · Cited by 64 · see citing works
Impact of microbiota in colorectal carcinogenesis: lessons from experimental models
Yu, L. C., Wei, S., & Ni, Y. (2018) · Intestinal Research · doi:10.5217/ir.2018.16.3.346 · Cited by 62 · see citing works
Bacteria as a double-action sword in cancer
Yaghoubi, A., Khazaei, M., Jalili, S., Hasanian, S. M., Avan, A., Soleimanpour, S., & Cho, W. C. S. (2020) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2020.188388 · Cited by 55 · see citing works
Cao, C., Yue, S., Lü, A., & Liang, C. (2024) · Pharmacological Research · doi:10.1016/j.phrs.2024.107321 · Cited by 59 · see citing works
Gagnière, J., Bonnin, V., Jarrousse, A., Cardamone, E., Agus, A., Uhrhammer, N. A., Sauvanet, P., Déchelotte, P., Barnich, N., Bonnet, R., et al. (2017) · Clinical Science · doi:10.1042/cs20160876 · Cited by 55 · see citing works
Gut microbiota modulation: a tool for the management of colorectal cancer
Wang, Y., & Li, H. (2022) · Journal of Translational Medicine · doi:10.1186/s12967-022-03378-8 · Cited by 57 · see citing works
Colorectal Cancer and Probiotics: Are Bugs Really Drugs?
Lamichhane, P., Maiolini, M., Alnafoosi, O., Hussein, S., Alnafoosi, H., Umbela, S., Richardson, T., Alla, N., Lamichhane, N., Subhadra, B. G., et al. (2020) · Cancers · doi:10.3390/cancers12051162 · Cited by 50 · see citing works
Mola, S., Pandolfo, C., Sica, A., & Porta, C. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21186866 · Cited by 48 · see citing works
Microbial sensing in the intestine
Wan, T., Wang, Y., He, K., & Zhu, S. (2023) · Protein & Cell · doi:10.1093/procel/pwad028 · Cited by 48 · see citing works
Bacterial signatures and their inflammatory potentials associated with prostate cancer
Brüggemann, H., & Al‐Zeer, M. A. (2020) · Apmis · doi:10.1111/apm.13021 · Cited by 47 · see citing works
Escherichia coli and Colorectal Cancer: Unfolding the Enigmatic Relationship
Rezaee, M. A., Nouri, R., Hasani, A., Shirazi, K. M., Alivand, M. R., Sepehri, B., Sotoodeh, S., & Hemmati, F. (2021) · Current Pharmaceutical Biotechnology · doi:10.2174/1389201022666210910094827 · Cited by 45 · see citing works
Yu, L. C., Wei, S., Li, Y.-H., Lin, P.-Y., Chang, X., Weng, J.-P., Shue, Y.-W., Lai, L., Wang, J., Jeng, Y., et al. (2021) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2021.08.007 · Cited by 40 · see citing works
Oral and intestinal bacterial exotoxins: Potential linked to carcinogenesis
Silbergleit, M., Vasquez, A. A., Miller, C. J., Sun, J., & Kato, I. (2020) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2020.02.004 · Cited by 39 · see citing works
Guntaka, N. S., Healy, A. R., Crawford, J. M., Herzon, S. B., & Bruner, S. D. (2017) · ACS Chemical Biology · doi:10.1021/acschembio.7b00479 · Cited by 38 · see citing works
Ma, S., Yao, H., Si, X., Huang, Z., Wang, R., Wan, R., Tang, Z., Wang, G., & Song, W. (2024) · Journal of Controlled Release · doi:10.1016/j.jconrel.2024.05.002 · Cited by 39 · see citing works
Gut microbiota, an emergent target to shape the efficiency of cancer therapy
Kouidhi, S., Zidi, O., Belkhiria, Z., Raïs, H., Ayadi, A., Ayed, F. B., Mosbah, A., Cherif, A., & Gaaied, A. B. A. E. (2023) · Exploration of Targeted Anti-tumor Therapy · doi:10.37349/etat.2023.00132 · Cited by 37 · see citing works
Exploring the microbiota to better understand gastrointestinal cancers physiology
Panebianco, C., Potenza, A., Andriulli, A., & Pazienza, V. (2018) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm-2017-1163 · Cited by 45 · see citing works
Nouri, R., Hasani, A., Shirazi, K. M., Alivand, M. R., Sepehri, B., Sotoudeh, S., Hemmati, F., Fattahzadeh, A., Abdinia, B., & Rezaee, M. A. (2021) · Canadian Journal of Infectious Diseases and Medical Microbiology · doi:10.1155/2021/2131787 · Cited by 35 · see citing works
From Colitis to Cancer: An Evolutionary Trajectory That Merges Maths and Biology
Bakir, I. A., Curtius, K., & Graham, T. A. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02368 · Cited by 33 · see citing works
Progress in Research on Colorectal Cancer-Related Microorganisms and Metabolites
Han, S., Jing, Z., Wu, Y., Wu, W., & Yang, X. (2020) · Cancer Management and Research · doi:10.2147/cmar.s268943 · Cited by 34 · see citing works
Zhuang, Y.-P., Zhou, H., Chen, H., Zheng, M.-Y., Liang, Y., Gu, Y.-T., Li, W., Qiu, W., & Zhou, H. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.115040 · Cited by 33 · see citing works
A perspective review on impact and molecular mechanism of environmental carcinogens on human health
Malik, S., Prasad, S., Kishore, S., Kumar, A., & Upadhyay, V. (2021) · Biotechnology and Genetic Engineering Reviews · doi:10.1080/02648725.2021.1991715 · Cited by 31 · see citing works
A Special Network Comprised of Macrophages, Epithelial Cells, and Gut Microbiota for Gut Homeostasis
Chen, W., Liu, D., Ren, C., Su, L., Wong, C. K., & Yang, R. (2022) · Cells · doi:10.3390/cells11020307 · Cited by 32 · see citing works
Bifidobacteria and Their Health-Promoting Effects
Hidalgo-Cantabrana, C., Delgado, S., Ruíz, L., Ruas‐Madiedo, P., Sánchez, B., & Margollés, A. (2018) · ASM Press eBooks · doi:10.1128/9781555819705.ch3 · Cited by 31 · see citing works
Hull, M. A., Cuthbert, R. J., Ko, C. W. S., Scott, D. J., Cartwright, E. J., Hawcroft, G., Perry, S., Ingram, N., Carr, I., Markham, A. F., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-06253-5 · Cited by 27 · see citing works
Ahmad, A., Mahmood, N., Raza, M. A., Mushtaq, Z., Saeed, F., Afzaal, M., Hussain, M., Amjad, H., & Al-Awadi, H. M. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e29495 · Cited by 30 · see citing works
The role of the gut microbiome in gastrointestinal cancers
Mishra, Y., Ranjan, A., Mishra, V. K., Chattaraj, A., Aljabali, A. A. A., El‐Tanani, M., Hromić‐Jahjefendić, A., Uversky, V. N., & Tambuwala, M. M. (2023) · Cellular Signalling · doi:10.1016/j.cellsig.2023.111013 · Cited by 25 · see citing works
Microbiome in drug resistance to colon cancer
Pandey, K. R., & Umar, S. (2021) · Current Opinion in Physiology · doi:10.1016/j.cophys.2021.100472 · Cited by 24 · see citing works
Liu, F., Su, D., Zhang, H., Lin, H., Zhou, Q., Cao, B., & Ren, D. (2022) · Oncology Reports · doi:10.3892/or.2022.8407 · Cited by 23 · see citing works
The crosstalk of the human microbiome in breast and colon cancer: A metabolomics analysis
Mukherjee, A. G., Wanjari, U. R., Bradu, P., Murali, R., Kannampuzha, S., Loganathan, T., Doss, C. G. P., Arun Prakash, B. P., Renu, K., Dey, A., et al. (2022) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2022.103757 · Cited by 22 · see citing works
Transforming bacterial pathogens into wonder tools in cancer immunotherapy
Senevirathne, A., Lloren, K. K. S., Aganja, R. P., Kwon, J., & Lee, J. H. (2025) · Molecular Therapy · doi:10.1016/j.ymthe.2025.01.029 · Cited by 20 · see citing works
Progress of tumor-resident intracellular bacteria for cancer therapy
Bao, P., & Zhang, X. (2024) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2024.115458 · Cited by 19 · see citing works
E. coli diversity: low in colorectal cancer
Tang, L., Zhou, Y.-J., Zhu, S.-L., Liang, G.-D., Zhuang, H., Zhao, M.-F., Chang, X., Li, H.-N., Liu, Z., Guo, Z.-R., et al. (2020) · BMC Medical Genomics · doi:10.1186/s12920-020-0704-3 · Cited by 18 · see citing works
Genomic, Microbial and Immunological Microenvironment of Colorectal Polyps
Tse, B. C. Y., Welham, Z., Engel, A. F., & Molloy, M. P. (2021) · Cancers · doi:10.3390/cancers13143382 · Cited by 18 · see citing works
Bacterial infections in cancer: A bilateral relationship
Basu, A., Singh, R., & Gupta, S. (2022) · Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology · doi:10.1002/wnan.1771 · Cited by 19 · see citing works
Certaines bactéries de la flore commensale exacerberaient-elles la carcinogenèse colorectale ?
Raisch, J., Dalmasso, G., Bonnet, R., Barnich, N., Bonnet, M., & Bringer, M.-A. (2016) · médecine/sciences · doi:10.1051/medsci/20163202011 · Cited by 17 · see citing works
Self-citationKaźmierczak-Siedlecka, K., Ruszkowski, J., Skonieczna‐Żydecka, K., Jędrzejczak, J., Folwarski, M., & Makarewicz, W. (2021) · Central European Journal of Immunology · doi:10.5114/ceji.2020.103353 · Cited by 18 · see citing works
Tang-Fichaux, M., Branchu, P., Nougayrède, J., & Oswald, É. (2021) · Toxins · doi:10.3390/toxins13120897 · Cited by 16 · see citing works
Escherichia coli on colorectal cancer: A two‐edged sword
Chu, J., Wu, Y., Jing, Z., Zhanbo, Q., Zefeng, W., & Han, S. (2024) · Microbial Biotechnology · doi:10.1111/1751-7915.70029 · Cited by 16 · see citing works
Bioactive lipid-based therapeutic approach to COVID-19 and other similar infections
Das, U. N. (2021) · Archives of Medical Science · doi:10.5114/aoms/135703 · Cited by 15 · see citing works
The Role of Escherichia coli in the Development and Progression of Cancer
(2017) · ARC Journal of Cancer Science · doi:10.20431/2455-6009.0301001 · Cited by 13 · see citing works
Li, Y., Shen, X., Wang, D., & Sun, K. (2026) · Discover Oncology · doi:10.1007/s12672-025-04367-1 · Cited by 12 · see citing works
The role of COX-2 and its use as a therapeutic target in IBD and related colorectal cancer
Yang, L., Akanyibah, F. A., Yao, D., Jin, T., & Mao, F. (2025) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2025.110516 · Cited by 13 · see citing works
Correlation between Colon Polyps and Metabolic Syndrome and HP Infection Status
Huang, L., Wu, L., Qiao, Q., & Fang, L. (2019) · Gastroenterology Research and Practice · doi:10.1155/2019/3916154 · Cited by 12 · see citing works
Gut bacteria, host immunity, and colorectal cancer: From pathogenesis to therapy
Li, Y., Peng, J., & Meng, X. (2024) · European Journal of Immunology · doi:10.1002/eji.202451022 · Cited by 11 · see citing works
Sheppe, A. E. F., Santelices, J., Czyż, D. M., & Edelmann, M. J. (2021) · Microbiology Spectrum · doi:10.1128/spectrum.00496-21 · Cited by 10 · see citing works
Lou, Y., Song, M., Han, M., Zhong, J., Tian, X., Ren, Y., Song, Y., Duan, L., Zhao, P., Song, X., et al. (2022) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-21-0666 · Cited by 10 · see citing works
Microbiota-associated mechanisms in colorectal cancer
González, A., Fullaondo, A., & Odriozola, A. (2024) · Advances in genetics · doi:10.1016/bs.adgen.2024.05.002 · Cited by 8 · see citing works
Nouri, R., Hasani, A., Shirazi, K. M., Sefiadn, F. Y., Mazraeh, F. N., Sattarpour, S., & Rezaee, M. A. (2024) · Diagnostic Microbiology and Infectious Disease · doi:10.1016/j.diagmicrobio.2024.116229 · Cited by 6 · see citing works
Phenotypic characterization and complete genome of a tumorigenic pathobiont Escherichia coli LI60C3
Yu, L. C., Wei, S., Li, Y.-H., Huang, C., Pai, Y.-C., Hung, Y.-M., Lai, L., & Ni, Y. (2025) · Gut Pathogens · doi:10.1186/s13099-025-00732-1 · Cited by 5 · see citing works
Pai, Y.-C., Huang, C., Lin, L.-Y., Li, Y.-H., & Yu, L. C. (2025) · Journal of physiological investigation. · doi:10.4103/ejpi.ejpi-d-25-00045 · Cited by 6 · see citing works
Advancements in Understanding and Preventing Obesity-Related Colon Cancer
Shieh, C., Thompson, H. J., McLaughlin, E. M., Chiang, C., & Hussan, H. (2024) · The Cancer Journal · doi:10.1097/ppo.0000000000000744 · Cited by 5 · see citing works
Huang, J., Yang, K., Gao, L., He, Q., & Ge, S. (2024) · Technology and Health Care · doi:10.3233/thc-240218 · Cited by 3 · see citing works
Advancements in the Pathogenesis, Diagnosis, and Therapeutic Implications of Intestinal Bacteria
Lu, D., Ma, X., Tao, K., & Lei, H. (2025) · Current Issues in Molecular Biology · doi:10.3390/cimb47020106 · Cited by 3 · see citing works
Escherichia coli bloodstream infection preceding the diagnosis of rectal carcinoma
Thoma, R., Haeuptle, P., Degen, L. P., Bassetti, S., & Osthoff, M. F. (2018) · Oxford Medical Case Reports · doi:10.1093/omcr/omy084 · Cited by 3 · see citing works
Li, C., (130768), H. Z., (140791), J. W., Liu, C., He, S., Zhou, J., Li, L., Liu, Y., Wang, Q., Shen, X., et al. (2026) · Cell Reports · doi:10.1016/j.celrep.2026.117079 · Cited by 2 · see citing works
Role of Bacterial Infection (H. pylori) in Colon Carcinogenesis and Therapeutic Approaches
Singh, P., Tiwari, S. P., Mehdi, M. M., & Sharma, R. (2021) · Springer eBooks · doi:10.1007/978-3-030-64668-4_6 · Cited by 2 · see citing works
Saini, R. V., Pal, S., Saini, A. K., Kaushal, A., Gupta, S., Gaur, N. A., Chhillar, A. K., Sharma, A. K., & Gupta, V. K. (2022) · Current Pharmaceutical Design · doi:10.2174/1381612829666221122115906 · Cited by 2 · see citing works
Bacteria-Based Roles in Solid Tumors: Potential for Prevention and Treatment
Huang, J., Zhang, A., Sun, J., Fu, Y., Li, W., & Wang, Y. (2025) · Pathogens · doi:10.3390/pathogens14090874 · Cited by 1 · see citing works
Gut microbiota-driven diseases and intervention strategies – lessons from China
Zhou, Y., Gong, T., Yi, C., Yang, W., Ye, G., Xiao, D., Cao, Y., Xiong, Y., Ibáñez, E., Cifuentes, A., et al. (2025) · npj Science of Food · doi:10.1038/s41538-025-00610-9 · Cited by 1 · see citing works
Bioactive lipids and gut microbiota interact to regulate health and disease
Das, U. N. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-821039-0.00011-3 · Cited by 1 · see citing works
Bacteria and cancer: Advances, perspectives and applications
Rolim, M. S., Montenegro, Y. H. A., & Ceballos, A. M. C. A. B. S. (2019) · Clinical Microbiology and Infectious Diseases · doi:10.15761/cmid.1000147 · Cited by 1 · see citing works
Dysbiosis Promotes Gastric Diseases and Impede Therapies by Hijacking Gut Immune HomeostasisPreprint
Toor, D., Wasson, M. K., Goel, C., Kaushik, N. K., Kumar, P., Singh, S. K., Karthikeyan, G., Kumar, A., & Prakash, H. (2019) · Preprints.org · doi:10.20944/preprints201901.0170.v1 · Cited by 1 · see citing works
Azour, A., Al-Bayssari, C., & Rolain, J. (2024) · SSRN Electronic Journal · doi:10.2139/ssrn.4863297 · Cited by 1 · see citing works
Lou, Y., Song, M., Han, M., Zhong, J., Tian, X., Ren, Y., Song, Y., Duan, L., Zhao, P., Xiangfeng, S., et al. (2023) · doi:10.1158/2326-6066.c.6550773
Liu, S., & Liu, H. (2024) · Elsevier eBooks · doi:10.1016/b978-0-12-818619-0.00030-7
Additional file 1 of E. coli diversity: low in colorectal cancer
Tang, L. M., Zhou, Y., Zhu, S., Liang, G.-D., Zhuang, H., Zhao, M.-F., Chang, X., Li, H., Liu, Z., Guo, Z., et al. (2020) · Figshare · doi:10.6084/m9.figshare.12097164
Additional file 3 of E. coli diversity: low in colorectal cancer
Tang, L., Zhou, Y., Zhu, S., Liang, G.-D., Zhuang, H., Zhao, M.-F., Chang, X., Li, H., Liu, Z., Guo, Z., et al. (2020) · Figshare · doi:10.6084/m9.figshare.12097173
Additional file 2 of E. coli diversity: low in colorectal cancer
Tang, L., Zhou, Y., Zhu, S., Liang, G.-D., Zhuang, H., Zhao, M.-F., Chang, X., Li, H., Liu, Z., Guo, Z., et al. (2020) · Figshare · doi:10.6084/m9.figshare.12097170
Fecal Microbiota Transplantation and Cancer Immunotherapy: Current Evidence and Future Directions
Mokhtarpour, K., Akbarzadehmoallemkolaei, M., & Rezaei, N. (2024) · Interdisciplinary cancer research · doi:10.1007/16833_2024_419
Additional file 4 of E. coli diversity: low in colorectal cancer
Tang, L., Zhou, Y.-J., Zhu, S., Liang, G.-D., Zhuang, H., Zhao, M.-F., Chang, X.-Y., Li, H.-N., Liu, Z., Guo, Z.-R., et al. (2020) · Figshare · doi:10.6084/m9.figshare.12097182
- Authors
- Raisch, J., Rolhion, N., Dubois, A., Darfeuille-Michaud, A., & Bringer, M.-A.
- Affiliations
- Inserm (FR)
- Imperial College London (GB)
- Corresponding author
- Bringer, Marie-Agnès
- Venue
- Laboratory Investigation
- Publisher
- Elsevier BV
- Published
- 2015-03
- Volume
- 95
- Issue
- 3
- Pages
- 296-307
- ISSN
- 0023-6837 (ISSN-L)
- OpenAlex
- W2094274080
- Cited by
- 100
- References
- 62
- Citations by year
- 2026: 4 · 2025: 7 · 2024: 13 · 2023: 6 · 2022: 9 · 2021: 16 · 2020: 11 · 2019: 6 · 2018: 10 · 2017: 10 · 2016: 7 · 2015: 1
- FWCI
- 4.23
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Laboratory Investigation (publishedVersion, other-oa)
- PubMed (publishedVersion)
- HAL (submittedVersion, other-oa)
- Funders
- Imperial College London
- Institut National de la Santé et de la Recherche Médicale (UMR 1071, USC-2018)
- Ligue Contre le Cancer
- Institut National de la Recherche Agronomique (USC-2018)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Escherichia coli research studies
- Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biotechnology › Cancer Research and Treatments
- Keywords
- colorectal cancer, tumor-associated macrophages, COX-2 expression, intracellular bacterial replication, colibactin, ofloxacin, THP-1 macrophages, gut dysbiosis
- MeSH terms
- Colonic Neoplasms, Escherichia coli, Humans, Macrophages, Peptides, Vacuoles, Immunoblotting, Dinoprostone, Microscopy, Confocal, Cell Line, Tumor, Microscopy, Electron, Transmission, p38 Mitogen-Activated Protein Kinases, Microbial Viability, Cyclooxygenase 2, Host-Pathogen Interactions, Polyketides
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review