A possible role of Bacteroides fragilis enterotoxin in the aetiology of colorectal cancer

Manual of Clinical Microbiology.

(1980) · Annals of Internal Medicine · doi:10.7326/0003-4819-93-6-939_2 · Cited by 14,435 · see citing works

Tumor Suppressor Genes

Weinberg, R. A. (1991) · Science · doi:10.1126/science.1659741 · Cited by 1,765 · see citing works

Manual of Clinical Microbiology

(1991) · Annals of Internal Medicine · doi:10.7326/0003-4819-115-3-239_2 · Cited by 987 · see citing works

The Genetic Basis of Human Cancer

Michels, V. V. (1999) · Mayo Clinic Proceedings · doi:10.4065/74.1.107-a · Cited by 734 · see citing works

Bacteroides fragilis enterotoxin cleaves the zonula adherens protein, E-cadherin

Wu, S., Lim, K.-C., Huang, J. H. Y., Saidi, R. F., & Sears, C. L. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.25.14979 · Cited by 410 · see citing works

Bacteroides fragilis enterotoxin induces c-Myc expression and cellular proliferation

Wu, S., Morin, P. J., Maouyo, D., & Sears, C. L. (2003) · Gastroenterology · doi:10.1053/gast.2003.50047 · Cited by 396 · see citing works

Bacteroides fragilis Enterotoxin Induces Intestinal Epithelial Cell Secretion of Interleukin-8 through Mitogen-Activated Protein Kinases and a Tyrosine Kinase-Regulated Nuclear Factor-κB Pathway

Wu, S., Powell, J., Mathioudakis, N. N., Kane, S., Fernandez, E., & Sears, C. L. (2004) · Infection and Immunity · doi:10.1128/iai.72.10.5832-5839.2004 · Cited by 203 · see citing works

Bacteroides fragilis Enterotoxin Gene Sequences in Patients with Inflammatory Bowel Disease

Prindiville, T. P., Sheikh, R. A., Cohen, S. H., Tang, Y. J., Cantrell, M. C., & Silva, J. (2000) · Emerging infectious diseases · doi:10.3201/eid0602.000210 · Cited by 199 · see citing works

The enterotoxin of Bacteroides fragilis is a metalloprotease

Moncrief, J. S., Obiso, R. J., Barroso, L. A., Kling, J. J., Wright, R. L., Tassell, R. L. V., Lyerly, D. M., & Wilkins, T. D. (1995) · Infection and Immunity · doi:10.1128/iai.63.1.175-181.1995 · Cited by 183 · see citing works

Bacteroides fragilis: a possible cause of acute diarrheal disease in newborn lambs

Myers, L. L., Firehammer, B. D., Shoop, D. S., & Border, M. Μ. (1984) · Infection and Immunity · doi:10.1128/iai.44.2.241-244.1984 · Cited by 155 · see citing works

Isolation of enterotoxigenic Bacteroides fragilis from humans with diarrhea

Myers, L. L., Shoop, D. S., Stackhouse, L. L., Newman, F. S., Flaherty, R. J., Letson, G. W., & Sack, R. B. (1987) · Journal of Clinical Microbiology · doi:10.1128/jcm.25.12.2330-2333.1987 · Cited by 154 · see citing works

The toxins of Bacteroides fragilis

Sears, C. L. (2001) · Toxicon · doi:10.1016/s0041-0101(01)00160-x · Cited by 130 · see citing works

ABC of colorectal cancer: Molecular basis for risk factors

Hardy, R. G. (2000) · BMJ · doi:10.1136/bmj.321.7265.886 · Cited by 123 · see citing works

Are Helicobacter Species and Enterotoxigenic Bacteroides fragilis Involved in Inflammatory Bowel Disease?

Basset, C., Holton, J., Bazeos, A., Vaira, D., & Bloom, S. L. (2004) · Digestive Diseases and Sciences · doi:10.1023/b:ddas.0000042241.13489.88 · Cited by 121 · see citing works

Isolation of enterotoxigenic Bacteroides fragilis from Bangladeshi children with diarrhea: a controlled study

Sack, R. B., Albert, M. J., Alam, K., Neogi, P. K., & Akbar, M. S. (1994) · Journal of Clinical Microbiology · doi:10.1128/jcm.32.4.960-963.1994 · Cited by 117 · see citing works

Recognition of Fusobacterium nucleatum subgroups Fn-1, Fn-2 and Fn-3 by ribosomal RNA gene restriction patterns

Lawson, P. A., Gharbia, S. E., Shah, H. N., & Clark, D. R. (1989) · FEMS Microbiology Letters · doi:10.1111/j.1574-6968.1989.tb03594.x · Cited by 116 · see citing works

Bacteroides fragilisenterotoxin induces the expression of IL-8 and transforming growth factor-beta (TGF-β) by human colonic epithelial cells

Sanfilippo, L., Li, C. K. F., Seth, R., Balwin, T. J., Menozzi, M. G., & Mahida, Y. R. (2000) · Clinical & Experimental Immunology · doi:10.1046/j.1365-2249.2000.01155.x · Cited by 99 · see citing works

Polarized secretion of CXC chemokines by human intestinal epithelial cells in response to Bacteroides fragilis enterotoxin: NF- κ B plays a major role in the regulation of IL-8 expression

Kim, J. M., Oh, Y., Kim, Y. J., Oh, H.-B., & Cho, Y. J. (2001) · Clinical & Experimental Immunology · doi:10.1046/j.1365-2249.2001.01462.x · Cited by 93 · see citing works

Enterotoxigenic Bacteroides fragilis

Sears, C. L., Myers, L. L., Lazenby, A. J., & Tassell, R. L. V. (1995) · Clinical Infectious Diseases · doi:10.1093/clinids/20.supplement_2.s142 · Cited by 79 · see citing works

Human intestinal epithelial cells swell and demonstrate actin rearrangement in response to the metalloprotease toxin of Bacteroides fragilis

Koshy, S. S., Montrose, M. H., & Sears, C. L. (1996) · Infection and Immunity · doi:10.1128/iai.64.12.5022-5028.1996 · Cited by 72 · see citing works

Detection of Enterotoxigenic Bacteroides fragilis and Its Toxin in Stool Samples from Adults and Children in Italy

Pantosti, A., Menozzi, M. G., Frate, A., Sanfilippo, L., D’Ambrosio, F., & Malpeli, M. (1997) · Clinical Infectious Diseases · doi:10.1093/clinids/24.1.12 · Cited by 52 · see citing works

Detection of enterotoxigenic Bacteroides fragilis by PCR

Pantosti, A., Malpeli, M., Wilks, M., Menozzi, M. G., & D’Ambrosio, F. (1997) · Journal of Clinical Microbiology · doi:10.1128/jcm.35.10.2482-2486.1997 · Cited by 48 · see citing works

Comparison of three dispersion procedures for quantitative recovery of cultivable species of subgingival spirochetes

Salvador, S. L. D. S., Syed, S. A., & Loesche, W. J. (1987) · Journal of Clinical Microbiology · doi:10.1128/jcm.25.11.2230-2232.1987 · Cited by 34 · see citing works

Prevalence of Enterotoxigenic Bacteroides fragilis in Children with Diarrhea in Japan

Kato, N., Liu, C., Kato, H., Watanabe, K., Nakamura, H., Iwai, N., & Ueno, K. (1999) · Journal of Clinical Microbiology · doi:10.1128/jcm.37.3.801-803.1999 · Cited by 29 · see citing works

The gut microbiota--masters of host development and physiology

Sommer, F., & Bäckhed, F. (2013) · Nature Reviews Microbiology · doi:10.1038/nrmicro2974 · Cited by 3,681 · see citing works

Bacteroides : the Good, the Bad, and the Nitty-Gritty

Wexler, H. M. (2007) · Clinical Microbiology Reviews · doi:10.1128/cmr.00008-07 · Cited by 2,316 · see citing works

A human colonic commensal promotes colon tumorigenesis via activation of T helper type 17 T cell responses

Wu, S., Rhee, K.-J., Albesiano, E., Rabizadeh, S., Wu, X., Yen, H.-R., Huso, D. L., Brancati, F. L., Wick, E., McAllister, F., et al. (2009) · Nature Medicine · doi:10.1038/nm.2015 · Cited by 1,812 · see citing works

The keystone-pathogen hypothesis

Hajishengallis, G., Darveau, R. P., & Curtis, M. A. (2012) · Nature Reviews Microbiology · doi:10.1038/nrmicro2873 · Cited by 1,790 · see citing works

Metagenomic analysis of faecal microbiome as a tool towards targeted non-invasive biomarkers for colorectal cancer

Yu, J. Q., Feng, Q., Wong, S. H., Zhang, D., Liang, Q. Y., Qin, Y., Tang, L., Zhao, H., Stenvang, J., Li, Y., et al. (2015) · Gut · doi:10.1136/gutjnl-2015-309800 · Cited by 1,259 · see citing works

Gut Bacteroides species in health and disease

Zafar, H., & Saier, M. H. (2021) · Gut Microbes · doi:10.1080/19490976.2020.1848158 · Cited by 1,258 · see citing works

The Human Gut Microbiome – A Potential Controller of Wellness and Disease

Kho, Z. Y., & Lal, S. K. (2018) · Frontiers in Microbiology · doi:10.3389/fmicb.2018.01835 · Cited by 948 · see citing works

Diet, microorganisms and their metabolites, and colon cancer

O'Keefe, S. J. D. (2016) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2016.165 · Cited by 1,100 · see citing works

A bacterial driver–passenger model for colorectal cancer: beyond the usual suspects

Tjalsma, H., Boleij, A., Marchesi, J. R., & Dutilh, B. E. (2012) · Nature Reviews Microbiology · doi:10.1038/nrmicro2819 · Cited by 903 · see citing works

Gut microbiota imbalance and colorectal cancer

Gagnière, J. (2016) · World Journal of Gastroenterology · doi:10.3748/wjg.v22.i2.501 · Cited by 856 · see citing works

Polyamine metabolism and cancer: treatments, challenges and opportunities

Casero, R. A., Stewart, T. M., & Pegg, A. E. (2018) · Nature reviews. Cancer · doi:10.1038/s41568-018-0050-3 · Cited by 824 · see citing works

Microbes, Microbiota, and Colon Cancer

Sears, C. L., & Garrett, W. S. (2014) · Cell Host & Microbe · doi:10.1016/j.chom.2014.02.007 · Cited by 820 · see citing works

Influence of the Gut Microbiome, Diet, and Environment on Risk of Colorectal Cancer

Song, M., Chan, A. T., & Sun, J. (2020) · Gastroenterology · doi:10.1053/j.gastro.2019.06.048 · Cited by 752 · see citing works

The Bacteroides fragilis toxin gene is prevalent in the colon mucosa of colorectal cancer patients

Boleij, A., Hechenbleikner, E. M., Goodwin, A. C., Badani, R., Stein, E. M., Lazarev, M. G., Ellis, B., Carroll, K. C., Albesiano, E., Wick, E. C., et al. (2015) · Clinical Infectious Diseases · doi:10.1093/cid/ciu787 · Cited by 625 · see citing works

Gut Microbiota, Inflammation, and Colorectal Cancer

Brennan, C. A., & Garrett, W. S. (2016) · Annual Review of Microbiology · doi:10.1146/annurev-micro-102215-095513 · Cited by 572 · see citing works

Towards the Human Colorectal Cancer Microbiome

Marchesi, J. R., Dutilh, B. E., Hall, N., Peters, W. H. M., Roelofs, R., Boleij, A., & Tjalsma, H. (2011) · PLoS ONE · doi:10.1371/journal.pone.0020447 · Cited by 552 · see citing works

Microbiota disbiosis is associated with colorectal cancer

Gao, Z., Guo, B., Gao, R., Zhu, Q., & Qin, H. (2015) · Frontiers in Microbiology · doi:10.3389/fmicb.2015.00020 · Cited by 537 · see citing works

Dysbiosis Signature of Fecal Microbiota in Colorectal Cancer Patients

Wu, N., Yang, X., Zhang, R., Li, J., Xiao, X., Hu, Y., Chen, Y., Yang, F., Lu, N., Wang, Z., et al. (2013) · Microbial Ecology · doi:10.1007/s00248-013-0245-9 · Cited by 454 · see citing works

Variations in oral microbiota associated with oral cancer

Zhao, H., Chu, M., Huang, Z., Yang, X., Ran, S., Hu, B., Zhang, C., & Liang, J. (2017) · Scientific Reports · doi:10.1038/s41598-017-11779-9 · Cited by 438 · see citing works

Enterotoxigenic Bacteroides fragilis : a Rogue among Symbiotes

Sears, C. L. (2009) · Clinical Microbiology Reviews · doi:10.1128/cmr.00053-08 · Cited by 412 · see citing works

Tumor initiation and early tumorigenesis: molecular mechanisms and interventional targets

Zhang, S., Xiao, X., Yi, Y., Wang, X., Zhu, L., Shen, Y., Lin, D., & Wu, C. H. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01848-7 · Cited by 440 · see citing works

The impact of the microbiota on the pathogenesis of IBD: lessons from mouse infection models

Nell, S., Suerbaum, S., & Josenhans, C. (2010) · Nature Reviews Microbiology · doi:10.1038/nrmicro2403 · Cited by 396 · see citing works

Microbiota dysbiosis and barrier dysfunction in inflammatory bowel disease and colorectal cancers: exploring a common ground hypothesis

Yu, L. C. (2018) · Journal of Biomedical Science · doi:10.1186/s12929-018-0483-8 · Cited by 404 · see citing works

Polyamine catabolism and disease

Casero, R. A., & Pegg, A. E. (2009) · Biochemical Journal · doi:10.1042/bj20090598 · Cited by 380 · see citing works

Right Versus Left Colon Cancer Biology: Integrating the Consensus Molecular Subtypes

Lee, M. S., Menter, D. G., & Kopetz, S. (2017) · Journal of the National Comprehensive Cancer Network · doi:10.6004/jnccn.2017.0038 · Cited by 386 · see citing works

Bacteroides fragilis subverts mucosal biology: from symbiont to colon carcinogenesis

Sears, C. L., Geis, A. L., & Housseau, F. (2014) · Journal of Clinical Investigation · doi:10.1172/jci72334 · Cited by 354 · see citing works

High-resolution bacterial 16S rRNA gene profile meta-analysis and biofilm status reveal common colorectal cancer consortia

Drewes, J. L., White, J. R., Dejea, C. M., Fathi, P., Iyadorai, T., Vadivelu, J., Roslani, A. C., Wick, E. C., Mongodin, E. F., Loke, M. F., et al. (2017) · npj Biofilms and Microbiomes · doi:10.1038/s41522-017-0040-3 · Cited by 335 · see citing works

Bacteria in cancer initiation, promotion and progression

Tekle, G. E., & Garrett, W. S. (2023) · Nature reviews. Cancer · doi:10.1038/s41568-023-00594-2 · Cited by 349 · see citing works

Fecal microbiota transplantation in cancer management: Current status and perspectives

Chen, D., Wu, J., Jin, D., Wang, B., & Cao, H. (2018) · International Journal of Cancer · doi:10.1002/ijc.32003 · Cited by 330 · see citing works

Alterations of gastric mucosal microbiota across different stomach microhabitats in a cohort of 276 patients with gastric cancer

Liu, X., Shao, L., Liu, X., Ji, F., Mei, Y., Cheng, Y., Liu, F., Yan, C., Li, L., & Ling, Z. (2018) · EBioMedicine · doi:10.1016/j.ebiom.2018.12.034 · Cited by 322 · see citing works

Microbiota, Inflammation and Colorectal Cancer

Lucas, C., Barnich, N., & Nguyen, H. T. T. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18061310 · Cited by 318 · see citing works

Structure of the gut microbiome following colonization with human feces determines colonic tumor burden

Baxter, N. T., Zackular, J. P., Chen, G. Y., & Schloss, P. D. (2014) · Microbiome · doi:10.1186/2049-2618-2-20 · Cited by 299 · see citing works

Induction of Persistent Colitis by a Human Commensal, EnterotoxigenicBacteroides fragilis, in Wild-Type C57BL/6 Mice

Rhee, K., Wu, S., Wu, X., Huso, D. L., Karim, B. O., Franco, A. A., Rabizadeh, S., Golub, J. E., Mathews, L. E., Shin, J. W., et al. (2009) · Infection and Immunity · doi:10.1128/iai.00814-08 · Cited by 297 · see citing works

Emerging role of bacteria in oral carcinogenesis: a review with special reference to perio-pathogenic bacteria

Perera, M. L., Al-Hebshi, N. N., Speicher, D. J., Perera, I. R., & Johnson, N. W. (2016) · Journal of Oral Microbiology · doi:10.3402/jom.v8.32762 · Cited by 283 · see citing works

Microbiota, Disease, and Back to Health: A Metastable Journey

Blumberg, R. S., & Powrie, F. M. (2012) · Science Translational Medicine · doi:10.1126/scitranslmed.3004184 · Cited by 279 · see citing works

The association of diet, gut microbiota and colorectal cancer: what we eat may imply what we get

Yang, J., & Yu, J. Q. (2018) · Protein & Cell · doi:10.1007/s13238-018-0543-6 · Cited by 280 · see citing works

Quantitative profiling of colorectal cancer-associated bacteria reveals associations between Fusobacterium spp., enterotoxigenic Bacteroides fragilis (ETBF) and clinicopathological features of colorectal cancer

Viljoen, K. S., Dakshinamurthy, A., Goldberg, P., & Blackburn, J. M. (2015) · PLoS ONE · doi:10.1371/journal.pone.0119462 · Cited by 256 · see citing works

Gut microbiota, inflammation and colorectal cancer

Sun, J., & Kato, I. (2016) · Genes & Diseases · doi:10.1016/j.gendis.2016.03.004 · Cited by 257 · see citing works

Dysbiosis of the Gut Microbiome in Lung Cancer

Zhuang, H., Cheng, L., Wang, Y., Zhang, Y.-K., Zhao, M.-F., Liang, G.-D., Zhang, M.-C., Li, Y.-G., Zhao, J.-B., Gao, Y.-N., et al. (2019) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2019.00112 · Cited by 235 · see citing works

Intestinal Microbiota Was Assessed in Cirrhotic Patients with Hepatitis B Virus Infection

Lu, H., Wu, Z., Xu, W., Yang, J., Chen, Y., & Li, L. (2011) · Microbial Ecology · doi:10.1007/s00248-010-9801-8 · Cited by 225 · see citing works

The myeloid immune signature of enterotoxigenic Bacteroides fragilis-induced murine colon tumorigenesis

Orberg, E. T., Fan, H., Tam, A. J., Dejea, C. M., Shields, C. E. D., Wu, S., Chung, L., Finard, B. B., Wu, X., Fathi, P., et al. (2016) · Mucosal Immunology · doi:10.1038/mi.2016.53 · Cited by 222 · see citing works

Bacterial infections and cancer

van Elsland, D. M., & Neefjes, J. (2018) · EMBO Reports · doi:10.15252/embr.201846632 · Cited by 216 · see citing works

The role of gut microbiota in the pathogenesis of colorectal cancer

Zhu, Q., Gao, R., Wu, W., & Qin, H. (2013) · Tumor Biology · doi:10.1007/s13277-013-0684-4 · Cited by 210 · see citing works

Impact of the gut microbiome on the genome and epigenome of colon epithelial cells: contributions to colorectal cancer development

Allen, J., & Sears, C. L. (2019) · Genome Medicine · doi:10.1186/s13073-019-0621-2 · Cited by 205 · see citing works

Role of Bacteria in Oncogenesis

Chang, A. H., & Parsonnet, J. (2010) · Clinical Microbiology Reviews · doi:10.1128/cmr.00012-10 · Cited by 194 · see citing works

Regulatory T-cell Response to Enterotoxigenic Bacteroides fragilis Colonization Triggers IL17-Dependent Colon Carcinogenesis

Geis, A. L., Fan, H., Wu, X., Wu, S., Huso, D. L., Wolfe, J. L., Sears, C. L., Pardoll, D. M., & Housseau, F. (2015) · Cancer Discovery · doi:10.1158/2159-8290.cd-15-0447 · Cited by 195 · see citing works

The association between fecal enterotoxigenic B. fragilis with colorectal cancer

Haghi, F., Goli, E., Mirzaei, B., & Zeighami, H. (2019) · BMC Cancer · doi:10.1186/s12885-019-6115-1 · Cited by 195 · see citing works

Collateral damage: Insights into bacterial mechanisms that predispose host cells to cancer

Gagnaire, A., Nadel, B., Raoult, D., Neefjes, J., & Gorvel, J.-P. (2017) · Nature Reviews Microbiology · doi:10.1038/nrmicro.2016.171 · Cited by 189 · see citing works

Simulated Digestion and Fermentation in Vitro by Human Gut Microbiota of Polysaccharides from Bee Collected Pollen of Chinese Wolfberry

Zhou, W., Yan, Y., Mi, J., Zhang, H., Lu, L., Luo, Q., Li, X., Zeng, X., & Cao, Y. (2018) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.7b05546 · Cited by 183 · see citing works

The gut microbiome and colorectal cancer: a review of bacterial pathogenesis

Dahmus, J., Kotler, D. L., Kastenberg, D. M., & Kistler, C. A. (2018) · Journal of Gastrointestinal Oncology · doi:10.21037/jgo.2018.04.07 · Cited by 177 · see citing works

Colon cancer-associated B2Escherichia colicolonize gut mucosa and promote cell proliferation

Raisch, J. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i21.6560 · Cited by 174 · see citing works

Pathogenic role of the gut microbiota in gastrointestinal diseases

Nagao‐Kitamoto, H., Kitamoto, S., Kuffa, P., & Kamada, N. (2016) · Intestinal Research · doi:10.5217/ir.2016.14.2.127 · Cited by 174 · see citing works

Microbial and viral pathogens in colorectal cancer

Collins, D., Hogan, A. M., & Winter, D. C. (2010) · The Lancet Oncology · doi:10.1016/s1470-2045(10)70186-8 · Cited by 172 · see citing works

Colorectal cancer: the facts in the case of the microbiota

Clay, S. L., Fonseca-Pereira, D., & Garrett, W. S. (2022) · Journal of Clinical Investigation · doi:10.1172/jci155101 · Cited by 166 · see citing works

Identification of shared and disease-specific host gene–microbiome associations across human diseases using multi-omic integration

Priya, S., Burns, M. B., Ward, T., Mars, R. A. T., Adamowicz, E. M., Lock, E. F., Kashyap, P., Knights, D., & Blekhman, R. (2022) · Nature Microbiology · doi:10.1038/s41564-022-01121-z · Cited by 171 · see citing works

Long noncoding RNA BFAL1 mediates enterotoxigenic Bacteroides fragilis-related carcinogenesis in colorectal cancer via the RHEB/mTOR pathway

Bao, Y.-J., Tang, J., Qian, Y., Sun, T., Chen, H., Chen, Z., Sun, D., Zhong, M., Chen, H., Hong, J., et al. (2019) · Cell Death and Disease · doi:10.1038/s41419-019-1925-2 · Cited by 164 · see citing works

Altered Gut Archaea Composition and Interaction With Bacteria Are Associated With Colorectal Cancer

Coker, O. O., Wu, W. K. K., Wong, S. H., Sung, J. J. �., & Yu, J. Q. (2020) · Gastroenterology · doi:10.1053/j.gastro.2020.06.042 · Cited by 160 · see citing works

Crypt- and Mucosa-Associated Core Microbiotas in Humans and Their Alteration in Colon Cancer Patients

Saffarian, A., Mulet, C., Regnault, B., Amiot, A., Nhieu, J. T. V., Ravel, J., Sobhani, I., Sansonetti, P. J., & Pédron, T. (2019) · mBio · doi:10.1128/mbio.01315-19 · Cited by 160 · see citing works

Gut Microbiota in Colorectal Cancer: Biological Role and Therapeutic Opportunities

Pandey, H., Tang, D. W. T., Wong, S. H., & Lal, D. (2023) · Cancers · doi:10.3390/cancers15030866 · Cited by 165 · see citing works

Dissecting the interplay between intestinal microbiota and host immunity in health and disease: Lessons learned from germfree and gnotobiotic animal models

Fiebiger, U., Bereswill, S., & Heimesaat, M. M. (2016) · European Journal of Microbiology and Immunology · doi:10.1556/1886.2016.00036 · Cited by 160 · see citing works

Metaproteomics characterizes human gut microbiome function in colorectal cancer

Long, S., Yang, Y., Shen, C., Wang, Y., Deng, A., Qin, Q., & Qiao, L. (2020) · npj Biofilms and Microbiomes · doi:10.1038/s41522-020-0123-4 · Cited by 156 · see citing works

Bacterial Biofilms in Colorectal Cancer Initiation and Progression

Li, S., Konstantinov, S. R., Smits, R., & Peppelenbosch, M. P. (2016) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2016.11.004 · Cited by 154 · see citing works

Association of EnterotoxigenicBacteroides fragilisInfection with Inflammatory Diarrhea

Sears, C. L., Islam, S., Saha, A., Jamil, M., Alam, N. H., Faruque, S. M., Salam, M. A., Shin, J. W., Hecht, D. W., Weintraub, A., et al. (2008) · Clinical Infectious Diseases · doi:10.1086/591130 · Cited by 152 · see citing works

Enterotoxigenic Bacteroides fragilis: A Possible Etiological Candidate for Bacterially-Induced Colorectal Precancerous and Cancerous Lesions

Zamani, S., Taslimi, R., Asiabar, A. S., Jasemi, S., Sechi, L. A., & Feizabadi, M. M. (2020) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2019.00449 · Cited by 151 · see citing works

Gut bacteria in health and disease: a survey on the interface between intestinal microbiology and colorectal cancer

Boleij, A., & Tjalsma, H. (2012) · Biological reviews/Biological reviews of the Cambridge Philosophical Society · doi:10.1111/j.1469-185x.2012.00218.x · Cited by 145 · see citing works

Enterotoxigenic Bacteroides fragilis: A potential instigator of colitis

Rabizadeh, S., Rhee, K., Wu, S., Huso, D. L., Gan, C. M., Golub, J. E., Wu, X., Zhang, M., & Sears, C. L. (2007) · Inflammatory Bowel Diseases · doi:10.1002/ibd.20265 · Cited by 147 · see citing works

Gut dysbiosis: Ecological causes and causative effects on human disease

Winter, S., & Bäumler, A. J. (2023) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2316579120 · Cited by 150 · see citing works

Noninvasive, microbiome-based diagnosis of inflammatory bowel disease

Zheng, J., Sun, Q., Zhang, M., Liu, C., Su, Q., Zhang, L., Xu, Z., Lu, W., Ching, J. Y. L., Tang, W., et al. (2024) · Nature Medicine · doi:10.1038/s41591-024-03280-4 · Cited by 144 · see citing works

Role of gut microbiota in the pathogenesis of colorectal cancer; a review article.

Jahani‐Sherafat, S., Alebouyeh, M., Moghim, S., Amoli, H. A., & Ghasemian-Safaei, H. (2018) · Europe PMC (PubMed Central) · Cited by 143 · see citing works

Good Gone Bad: One Toxin Away From Disease for Bacteroides fragilis

Valguarnera, E., & Wardenburg, J. B. (2019) · Journal of Molecular Biology · doi:10.1016/j.jmb.2019.12.003 · Cited by 140 · see citing works

Outer membrane vesicles secreted by pathogenic and nonpathogenic Bacteroides fragilis represent different metabolic activities

Zakharzhevskaya, N. B., Vanyushkina, A., Altukhov, I. A., Shavarda, A. L., Butenko, I., Rakitina, D. V., Nikitina, A. S., Manolov, A. I., Egorova, A. N., Kulikov, E. E., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-05264-6 · Cited by 137 · see citing works

Longitudinal Analysis of the Prevalence, Maintenance, and IgA Response to Species of the Order Bacteroidales in the Human Gut

Zitomersky, N. L., Coyne, M. J., & Comstock, L. E. (2011) · Infection and Immunity · doi:10.1128/iai.01348-10 · Cited by 135 · see citing works

Periodontal pathogens promote cancer aggressivity via TLR/MyD88 triggered activation of Integrin/FAK signaling that is therapeutically reversible by a probiotic bacteriocin

Kamarajan, P., Ateia, I., Shin, J. M., Fenno, J. C., Le, C., Zhan, L., Chang, A., Darveau, R., & Kapila, Y. L. (2020) · PLOS Pathogens · doi:10.1371/journal.ppat.1008881 · Cited by 134 · see citing works

Comparison of human gut microbiota in control subjects and patients with colorectal carcinoma in adenoma: Terminal restriction fragment length polymorphism and next-generation sequencing analyses

Kasai, C., Sugimoto, K., Moritani, I., Tanaka, J., Oya, Y., Inoue, H., Tameda, M., Shiraki, K., Ito, M., Takei, Y., et al. (2015) · Oncology Reports · doi:10.3892/or.2015.4398 · Cited by 130 · see citing works

Gut microbiome compositional and functional differences between tumor and non-tumor adjacent tissues from cohorts from the US and Spain

Allali, I., Delgado, S., Marrón, P. I., Astudillo, A., Yeh, J. J., Ghazal, H., Amzazi, S., Keku, T. O., & Azcárate-Peril, M. A. (2015) · Gut Microbes · doi:10.1080/19490976.2015.1039223 · Cited by 124 · see citing works

Emerging role of human microbiome in cancer development and response to therapy: special focus on intestinal microflora

Sadrekarimi, H., Gardanova, Z. R., Bakhshesh, M., Ebrahimzadeh, F., Yaseri, A. F., Thangavelu, L. P., Hasanpoor, Z., Zadeh, F. A., & Kahrizi, M. S. (2022) · Journal of Translational Medicine · doi:10.1186/s12967-022-03492-7 · Cited by 125 · see citing works

The struggle within: Microbial influences on colorectal cancer

Arthur, J. C., & Jobin, C. (2010) · Inflammatory Bowel Diseases · doi:10.1002/ibd.21354 · Cited by 121 · see citing works

Robust species taxonomy assignment algorithm for 16S rRNA NGS reads: application to oral carcinoma samples

Al-Hebshi, N. N., Nasher, A. T., Idris, A. M., & Chen, T. (2015) · Journal of Oral Microbiology · doi:10.3402/jom.v7.28934 · Cited by 123 · see citing works

Enterotoxigenic Bacteroides fragilis induces the stemness in colorectal cancer via upregulating histone demethylase JMJD2B

Liu, Q., Li, C., Fu, L., Wang, H.-L., Tan, J., Wang, Y.-Q., Sun, D., Gao, Q., Chen, Y., & Fang, J. (2020) · Gut Microbes · doi:10.1080/19490976.2020.1788900 · Cited by 123 · see citing works

DNA Damage Repair and Bacterial Pathogens

Žgur-Bertok, D. (2013) · PLoS Pathogens · doi:10.1371/journal.ppat.1003711 · Cited by 117 · see citing works

The Complex Interplay between Chronic Inflammation, the Microbiome, and Cancer: Understanding Disease Progression and What We Can Do to Prevent It

Armstrong, H., Bording‐Jorgensen, M., Dijk, S., & Wine, E. (2018) · Cancers · doi:10.3390/cancers10030083 · Cited by 117 · see citing works

Increased Enterococcus faecalis infection is associated with clinically active Crohn disease

Zhou, Y., Chen, H., He, H., Du, Y., Hu, J., Li, Y., Li, Y., Zhou, Y., Wang, H., Chen, Y., et al. (2016) · Medicine · doi:10.1097/md.0000000000005019 · Cited by 116 · see citing works

Review article: colorectal neoplasia in patients with primary sclerosing cholangitis and inflammatory bowel disease

Torres, J., de Chambrun, G. P., Itzkowitz, S. H., Sachar, D. B., & Colombel, J. F. (2011) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2011.04753.x · Cited by 116 · see citing works

Human intestinal microbiota: cross-talk with the host and its potential role in colorectal cancer

Candela, M., Guidotti, M., Fabbri, A., Brigidi, P., Franceschi, C., & Fiorentini, C. (2010) · Critical Reviews in Microbiology · doi:10.3109/1040841x.2010.501760 · Cited by 115 · see citing works

Pathogenesis of intestinal Pseudomonas aeruginosa infection in patients with cancer

Markou, P., & Apidianakis, Y. (2014) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2013.00115 · Cited by 114 · see citing works

Infection, immunoregulation, and cancer

Rook, G., & Dalgleish, A. (2011) · Immunological Reviews · doi:10.1111/j.1600-065x.2010.00987.x · Cited by 115 · see citing works

Stat3 Activation in Murine Colitis Induced by Enterotoxigenic Bacteroides fragilis

Wick, E. C., Rabizadeh, S., Albesiano, E., Wu, X., Wu, S., Chan, J. L., Rhee, K., Ortega, G., Huso, D. L., Pardoll, D. M., et al. (2014) · Inflammatory Bowel Diseases · doi:10.1097/mib.0000000000000019 · Cited by 112 · see citing works

Enterotoxigenic Bacteroides fragilis (ETBF)-mediated colitis in Min ( Apc +/- ) mice: a human commensal-based murine model of colon carcinogenesis

Housseau, F., & Sears, C. L. (2010) · Cell Cycle · doi:10.4161/cc.9.1.10352 · Cited by 110 · see citing works

Clinical applications of gut microbiota in cancer biology

Wong, S. H., Kwong, T. N. Y., Wu, C., & Yu, J. Q. (2018) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2018.05.003 · Cited by 100 · see citing works

Intracellular colon cancer-associated Escherichia coli promote protumoral activities of human macrophages by inducing sustained COX-2 expression

Raisch, J., Rolhion, N., Dubois, A., Darfeuille-Michaud, A., & Bringer, M.-A. (2015) · Laboratory Investigation · doi:10.1038/labinvest.2014.161 · Cited by 100 · see citing works

Do bacterial genotoxins contribute to chronic inflammation, genomic instability and tumor progression?

Guerra, L., Guidi, R., & Frisan, T. (2011) · The FEBS Journal · doi:10.1111/j.1742-4658.2011.08125.x · Cited by 102 · see citing works

The Microbiome of Oral Squamous Cell Carcinomas: a Functional Perspective

Al-Hebshi, N. N., Borgnakke, W. S., & Johnson, N. W. (2019) · Current Oral Health Reports · doi:10.1007/s40496-019-0215-5 · Cited by 93 · see citing works

Know your neighbor: Microbiota and host epithelial cells interact locally to control intestinal function and physiology

Sommer, F., & Bäckhed, F. (2016) · BioEssays · doi:10.1002/bies.201500151 · Cited by 90 · see citing works

Bacteroides spp. and diarrhea

Wick, E. C., & Sears, C. L. (2010) · Current Opinion in Infectious Diseases · doi:10.1097/qco.0b013e32833da1eb · Cited by 89 · see citing works

Microbiome distinctions between the CRC carcinogenic pathways

DeDecker, L. C., Coppedge, B., Avelar‐Barragan, J., Karnes, W. E., & Whiteson, K. (2021) · Gut Microbes · doi:10.1080/19490976.2020.1854641 · Cited by 90 · see citing works

Bacterial Oncogenesis in the Colon

Dejea, C. M., Wick, E., & Sears, C. L. (2013) · Future Microbiology · doi:10.2217/fmb.13.17 · Cited by 90 · see citing works

Adapting Cancer Immunotherapy Models for the Real World

Klevorn, L. E., & Teague, R. M. (2016) · Trends in Immunology · doi:10.1016/j.it.2016.03.010 · Cited by 87 · see citing works

Changes of digestive and fermentation properties of Sargassum pallidum polysaccharide after ultrasonic degradation and its impacts on gut microbiota

Yuan, D., Li, C., You, L., Dong, H., & Fu, X. (2020) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2020.07.198 · Cited by 88 · see citing works

Spermine oxidase: ten years after

Cervelli, M., Amendola, R., Polticelli, F., & Mariottini, P. (2011) · Amino Acids · doi:10.1007/s00726-011-1014-z · Cited by 88 · see citing works

Reduction of Murine Colon Tumorigenesis Driven by EnterotoxigenicBacteroides fragilisUsing Cefoxitin Treatment

Shields, C. E. D., Meerbeke, S. W. V., Housseau, F., Wang, H., Huso, D. L., Casero, R. A., O’Hagan, H. M., & Sears, C. L. (2016) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiw069 · Cited by 88 · see citing works

The association between fecal enterotoxigenic B. fragilis with colorectal cancer

Haghi, F., Goli, E., Mirzaei, B., & Zeighami, H. (2019) · BMC Cancer · doi:10.1186/s12885-019-6115-1 · Cited by 195 · see citing works

The Bacteroides fragilis toxin gene is prevalent in the colon mucosa of colorectal cancer patients

Boleij, A., Hechenbleikner, E. M., Goodwin, A. C., Badani, R., Stein, E. M., Lazarev, M. G., Ellis, B., Carroll, K. C., Albesiano, E., Wick, E. C., et al. (2015) · Clinical Infectious Diseases · doi:10.1093/cid/ciu787 · Cited by 625 · see citing works

Evaluation of Enterotoxigenic Bacteroides fragilis from Colonic Washings from Patients Undergoing Colonoscopy

Van, N., Ahlberg, N. C., Jung, B. C., Lee, M. H., Ahn, S. J., Lee, I.-S., Kim, Y. S., & Rhee, K. (2012) · Cited by 3 · see citing works

Enterotoxigenic Bacteroides fragilis: A Possible Etiological Candidate for Bacterially-Induced Colorectal Precancerous and Cancerous Lesions

Zamani, S., Taslimi, R., Asiabar, A. S., Jasemi, S., Sechi, L. A., & Feizabadi, M. M. (2020) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2019.00449 · Cited by 151 · see citing works

Screening for enterotoxigenic Bacteroides fragilis in stool samples

Keenan, J. I., Aitchison, A., Purcell, R. V., Greenlees, R., Pearson, J. F., & Frizelle, F. (2016) · Anaerobe · doi:10.1016/j.anaerobe.2016.05.004 · Cited by 43 · see citing works