Cited by 299T-cell and B-cell ImmunologyCancer Immunotherapy and BiomarkersImmunotherapy and Immune Responses

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Tumor-infiltrating T lymphocytes: friends or foes?

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Yu, Ping, Fu, Yang-Xin·2006·Laboratory Investigation

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Abstract

The prognostic significance of tumor-infiltrating lymphocytes (TILs) has been a longstanding topic of debate. In cases where TILs have improved patient outcome, T lymphocytes are recognized as the main effectors of antitumor immune responses. However, recent studies have revealed that a subset of CD4(+) T cells, referred to as CD4(+)CD25(+) regulatory T cells (Treg), may accumulate in the tumor environment and suppress tumor-specific T-cell responses, thereby hindering tumor rejection. Hence, predicting tumor behavior on the basis of an indiscriminate evaluation of tumor-infiltrating T cells may result in inconsistent prognostic accuracy. The presence of infiltrating CD4(+)CD25(+) Treg may be detrimental to the host defense against the tumor, while the presence of effector T lymphocytes, including CD8(+) T cells and non-regulatory CD4(+) helper T cells may be beneficial. Enhanced recruitment of antitumor effector T lymphocytes to tumor tissue in addition to inhibition of local Treg, may therefore be an ideal target for improving cancer immunotherapy. This article reviews the antitumor functions of T-lymphocytes, with special attention given to CD4(+) regulatory T-cells within the tumor environment.

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Authors: Yu, P., & Fu, Y.-X.
Affiliations: University of Chicago (US)
Corresponding author: Yu, Ping
Fu, Yang-Xin
ORCID: Fu, Yang-Xin
Venue: Laboratory Investigation
Publisher: Elsevier BV
Published: 2006-03
Volume: 86
Issue: 3
Pages: 231-245
ISSN: 0023-6837 (ISSN-L)
DOI: 10.1038/labinvest.3700389
OpenAlex: W2061590134
Cited by: 299
References: 211
Citations by year: 2026: 3 · 2025: 9 · 2024: 14 · 2023: 13 · 2022: 15 · 2021: 20 · 2020: 13 · 2019: 15 · 2018: 8 · 2017: 18 · 2016: 12 · 2015: 14 · 2014: 16 · 2013: 11 · 2012: 17
FWCI: 1.35
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 6160 d)
Locations: Laboratory Investigation (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Health Sciences › Medicine › Oncology › Cancer Immunotherapy and Biomarkers
Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
Keywords: tumor-infiltrating lymphocytes, regulatory T cells, CD4+CD25+ T cells, CD8+ T cells, CD4+ T helper cells, antitumor immunity, tumor immunosuppression, prognostic value, cancer immunotherapy
MeSH terms: Humans, Neoplasms, Prognosis, CD4-Positive T-Lymphocytes, T-Lymphocyte Subsets, Lymphocytes, Tumor-Infiltrating, T-Lymphocytes, Regulatory

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Tumor-infiltrating T lymphocytes: friends or foes?

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