Cited by 299T-cell and B-cell ImmunologyCancer Immunotherapy and BiomarkersImmunotherapy and Immune Responses

The DOI matches its Crossref record; 196 of the 211 references it cites were found in a registry or an index.

Tumor-infiltrating T lymphocytes: friends or foes?

Open access

Yu, Ping, Fu, Yang-Xin·2006·Laboratory Investigation

Open this paper in CoChat — free account Open PDF

Abstract

The prognostic significance of tumor-infiltrating lymphocytes (TILs) has been a longstanding topic of debate. In cases where TILs have improved patient outcome, T lymphocytes are recognized as the main effectors of antitumor immune responses. However, recent studies have revealed that a subset of CD4(+) T cells, referred to as CD4(+)CD25(+) regulatory T cells (Treg), may accumulate in the tumor environment and suppress tumor-specific T-cell responses, thereby hindering tumor rejection. Hence, predicting tumor behavior on the basis of an indiscriminate evaluation of tumor-infiltrating T cells may result in inconsistent prognostic accuracy. The presence of infiltrating CD4(+)CD25(+) Treg may be detrimental to the host defense against the tumor, while the presence of effector T lymphocytes, including CD8(+) T cells and non-regulatory CD4(+) helper T cells may be beneficial. Enhanced recruitment of antitumor effector T lymphocytes to tumor tissue in addition to inhibition of local Treg, may therefore be an ideal target for improving cancer immunotherapy. This article reviews the antitumor functions of T-lymphocytes, with special attention given to CD4(+) regulatory T-cells within the tumor environment.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1038/labinvest.3700389

Cites

196 of 196 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Control of Regulatory T Cell Development by the Transcription Factor Foxp3
Hori, S., Nomura, T., & Sakaguchi, S. (2003) · Science · doi:10.1126/science.1079490 · Cited by 8,187
Foxp3 programs the development and function of CD4+CD25+ regulatory T cells
Fontenot, J. D., Gavin, M. A., & Rudensky, A. Y. (2003) · Nature Immunology · doi:10.1038/ni904 · Cited by 7,745
Signaling by intrathymic cytokines, not T cell antigen receptors, specifies CD8 lineage choice and promotes the differentiation of cytotoxic-lineage T cells
Park, J., Adoro, S., Guinter, T. I., Erman, B., Alag, A., Catálfamo, M., Kimura, M. Y., Cui, Y., Lucas, P. J., Gress, R. E., et al. (2010) · Nature Immunology · doi:10.1038/ni.1840 · Cited by 5,835
Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor α-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases
Sakaguchi, S., Sakaguchi, N., Asano, M., Itoh, M., & Toda, M. (1995) · The Journal of Immunology · doi:10.4049/jimmunol.155.3.1151 · Cited by 5,608
Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival
Curiel, T. J., Coukos, G., Zou, L., Alvarez, X., Cheng, P., Mottram, P., Evdemon-Hogan, M., Conejo-Garcia, J. R., Zhang, L., Burow, M., et al. (2004) · Nature Medicine · doi:10.1038/nm1093 · Cited by 5,151
Conversion of Peripheral CD4+CD25− Naive T Cells to CD4+CD25+ Regulatory T Cells by TGF-β Induction of Transcription Factor Foxp3
Chen, W., Jin, W., Hardegen, N. J., Lei, K.-J., Li, L., Marinos, N. J., McGrady, G., & Wahl, S. M. (2003) · The Journal of Experimental Medicine · doi:10.1084/jem.20030152 · Cited by 4,678
The expanding universe of T-cell subsets: Th1, Th2 and more
Mosmann, T. R., & Sad, S. (1996) · Immunology Today · doi:10.1016/0167-5699(96)80606-2 · Cited by 3,603
The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3
Bennett, C. L., Christie, J., Ramsdell, F., Brunkow, M., Ferguson, P., Whitesell, L., Kelly, T., Saulsbury, F., Chance, P., & Ochs, H. (2001) · Nature Genetics · doi:10.1038/83713 · Cited by 3,576
Intratumoral T Cells, Recurrence, and Survival in Epithelial Ovarian Cancer
Zhang, L., Conejo-Garcia, J. R., Katsaros, D., Gimotty, P. A., Massobrio, M., Regnani, G., Makrigiannakis, A., Gray, H., Schlienger, K., Liebman, M. N., et al. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa020177 · Cited by 3,397
N aturally A rising CD4+R egulatory T C ells for I mmunologic S elf -T olerance and N egative C ontrol of I mmune R esponses
Sakaguchi, S. (2003) · Annual Review of Immunology · doi:10.1146/annurev.immunol.21.120601.141122 · Cited by 3,315

Show all 211 references

Research works printed but not linked: 1

Allione, 1994, Cancer Res, 54, 6022

Sorted by citations

Items 201–299 of 299

Elucidating cuproptosis-related gene SLC31A1 diagnostic and prognostic values in cancer.
Mi, J., Luo, J., Zeng, H., Zhang, H., Jamil, M., Abdel-Maksoud, M. A., Zakri, A. M., Alfuraydi, A. A., Zhang, N., & Xiao, M. (2023) · PubMed Central · Cited by 10
Explainable cancer factors discovery: Shapley additive explanation for machine learning models demonstrates the best practices in the case of pancreatic cancer
Su, L., Hounye, A. H., Pan, Q. A., Miao, K., Wang, J., Hou, M., & Li, X. (2024) · Pancreatology · doi:10.1016/j.pan.2024.02.002 · Cited by 10
Immune checkpoint inhibitors in gynecologic cancers with lessons learned from non-gynecologic cancers
Menderes, G., Hicks, C., Black, J. D., Schwab, C. L., & Santin, A. D. (2016) · Expert Opinion on Biological Therapy · doi:10.1080/14712598.2016.1177018 · Cited by 9
Evidence that the viral oncoproteins E6 and E7 of HPV induce the expression of a functional IL-2R on cervical cancer cells
Trujillo-Cirilo, L., Torres-Corioriles, E. I., Rangel-Corona, R., Corona-Ortega, M. T., & Weiss‐Steider, B. (2021) · Cytokine · doi:10.1016/j.cyto.2021.155592 · Cited by 10
Role of Rho guanine nucleotide exchange factors in non-small cell lung cancer
Zeng, R., Xie, W., Zheng, C., Chen, W., Wang, S.-M., Li, Z., Cheng, C.-B., Zou, H., Xu, L., & Li, E. (2021) · Bioengineered · doi:10.1080/21655979.2021.2006519 · Cited by 10
Immune Compartmentalization of T cell Subsets in Chemically‐induced Breast Cancer
Fahmi, T., Esendağlı, G., Yilmaz, G., Kansu, E., & Guc, D. (2010) · Scandinavian Journal of Immunology · doi:10.1111/j.1365-3083.2010.02447.x · Cited by 10
A high ratio of IL-12Rβ2-positive tumor-infiltrating lymphocytes indicates favorable prognosis in laryngeal cancer
Tao, Y., Gross, N. D., Liu, Y., Zhang, L., Li, G., Huang, Z., & Yang, J. (2017) · Oral Oncology · doi:10.1016/j.oraloncology.2017.10.006 · Cited by 10
Role of cytokine in malignant T-cell metabolism and subsequent alternation in T-cell tumor microenvironment
Yadav, M., Uikey, B. N., Rathore, S. S., Gupta, P. S., Kashyap, D., Kumar, C., Shukla, D., Vijayamahantesh, V., Chandel, A. K. S., Ahirwar, B., et al. (2023) · Frontiers in Oncology · doi:10.3389/fonc.2023.1235711 · Cited by 9
Combination of Adoptive Cell Transfer and Antibody Injection Can Eradicate Established Tumors in Mice–Anin vivostudy using anti-OX40mAb, anti-CD25mAb and anti-CTLA4mAb–
Watanabe, A., Hara, M., Chosa, E., Nakamura, K., Sekiya, R., Shimizu, T. M., & Onitsuka, T. (2009) · Immunopharmacology and Immunotoxicology · doi:10.3109/08923970903222355 · Cited by 9
Increased expression of IL-21 reduces tumor growth by modulating the status of tumor-infiltrated lymphocytes
Hsieh, C.-L., Hsu, S.-C., Shen, C., Chen, M., Liu, S., Chong, P. C.-S., & Chen, H. (2010) · Immunobiology · doi:10.1016/j.imbio.2010.09.002 · Cited by 9
Overview of Autophagy
Hayat, M. A. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-812146-7.00001-9 · Cited by 10
A Multi-Element Expression Score Is A Prognostic Factor In Glioblastoma Multiforme
Li, J.-Q., Wang, Q.-T., Nie, Y., Xiao, Y.-P., Lin, T., Han, R.-J., Li, Z., Fan, Y., Yuan, X., Wang, Y., et al. (2019) · Cancer Management and Research · doi:10.2147/cmar.s228174 · Cited by 8
A Functional Food Inhibits Azoxymethane/Dextran Sulfate Sodium-Induced Inflammatory Colorectal Cancer in Mice
Zhang, J., Chen, Z., Lu, Y., Tu, D., Zou, F., Lin, S., Yu, W., Miao, M., & Shi, H. (2021) · OncoTargets and Therapy · doi:10.2147/ott.s283465 · Cited by 8
IL-6-transfected tumor cells modulate the status of CD8+ and CD4+ T cells to control tumor growth
Hsieh, C.-L., Liu, S., Shen, C., Chen, M., Hsu, S.-C., Tsai, J.-P., Li, Y.-S., Yang, C., Chong, P. C.-S., & Chen, H. (2009) · Immunobiology · doi:10.1016/j.imbio.2009.07.003 · Cited by 8
Qualitative analysis of connective tissue stroma in different grades of oral squamous cell carcinoma: A histochemical study
Shanbhag, V. K. L., Kullage, S., Jose, M., & Abdulla, R. (2017) · Indian Journal of Dental Research · doi:10.4103/ijdr.ijdr_683_16 · Cited by 8
Tumor-Localized Ligation of CD3 and CD28 with Systemic Regulatory T-Cell Depletion Induces Potent Innate and Adaptive Antitumor Responses
Lee, C.-H., Chiang, Y., Chang, S., Chong, C.-L., Cheng, B.-M., & Roffler, S. R. (2009) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-08-2311 · Cited by 8
Synergistic upregulation of PD‑L1 in tumor cells and CD39 in tumor‑infiltrating CD8+ T cells leads to poor prognosis in patients with hepatocellular carcinoma
Kang, X., Zhao, S., Lin, S., Li, J., & Wang, S. (2024) · Oncology Letters · doi:10.3892/ol.2024.14501 · Cited by 7
Does the immune reaction cause malignant transformation by disrupting cell-to-cell or cell-to-matrix communications?
Prehn, R. T. (2007) · Theoretical Biology and Medical Modelling · doi:10.1186/1742-4682-4-16 · Cited by 7
The Construction of a Nomogram Using the Pan-Immune-Inflammation Value Combined with a PILE Score for Immunotherapy Prediction Prognosis in Advanced NSCLC
Ma, S., Li, F., & Wang, L. (2024) · Cancer Management and Research · doi:10.2147/cmar.s461964 · Cited by 6
The Expression of Forkhead Box P3 T Regulatory Lymphocytes as a Prognostic Factor in Malignant Melanomas
Gâta, V. A., Paşca, A., Roman, A., Muntean, M. V., Morariu, D. Ș., Bonci, E.-A., Dina, C., & Ungureanu, L. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25126377 · Cited by 6
A combined antitumor strategy of separately transduced mesenchymal stem cells with soluble TRAIL and IFNβ produces a synergistic activity in the reduction of lymphoma and mice survival enlargement
Quiroz-Reyes, A. G., González-Villarreal, C. A., Martínez-Rodríguez, H. G., Said‐Fernández, S., Salinas-Carmona, M. C., Limón-Flores, A. Y., Soto‐Domínguez, A., Padilla-Rivas, G. R., Montes‐de‐Oca‐Luna, R., Islas, J. F., et al. (2022) · Molecular Medicine Reports · doi:10.3892/mmr.2022.12722 · Cited by 6
Association between CD8+ Tumor Infiltrating Lymphocytes and the Clinical Outcome of Patients with Operable Breast Cancer Treated with Adjuvant Dose-Dense Chemotherapy—A 10 Year Follow-Up Report of a Hellenic Cooperative Oncology Group Observational Study
Spathas, N., GOUSSIA, A. C., Koliou, G.-A., Gogas, H. J., Zagouri, F., Batistatou, A. K., Charchanti, A. V., Papoudou‐Bai, A., Bobos, M., Chrisafi, S., et al. (2022) · Cancers · doi:10.3390/cancers14225635 · Cited by 6
Immune Response Modulation by Tumor-Secreted Glycosphingolipids
Lardone, R. D., & Cely, I. (2015) · Journal of Glycobiology · doi:10.4172/2168-958x.1000107 · Cited by 6
Reduced numbers of regulatory T cells in breast carcinoma with medullary features
Vong, J. S. L., Yu, A. M. C., Ng, D. C. H., Lui, P. C. W., Law, B. K. B., Chau, H. H. L., Tan, P. H., & Tse, G. M.-K. (2011) · Histopathology · doi:10.1111/j.1365-2559.2011.03903.x · Cited by 5
Overview of Hematopoietic Stem Cells in Systemic Cancer Treatment, Aging, Pregnancy, and Radiation Hormesis
Shoutko, A. N. (2019) · Advances in Molecular Imaging · doi:10.4236/ami.2019.92003 · Cited by 5
Topical Application of Houttuynia cordata Thunb Ethanol Extracts Increases Tumor Infiltrating CD8+ /Treg Cells Ratio and Inhibits Cutaneous Squamous Cell Carcinoma in vivo
Gao, L., Gui, R.-Y., Zheng, X., Wang, Y., Gong, Y., Wang, T. H., Wang, J., Huang, J., & Liao, X.-H. (2022) · ONCOLOGIE · doi:10.32604/oncologie.2022.022454 · Cited by 5
Targeting Ibrutinib to Tumor-Infiltrating T Cells with a Sialic Acid Conjugate-Modified Phospholipid Complex for Improved Tumor Immunotherapy
Li, C., Fan, C., Lü, S., Qiu, Q., Gao, X., Yan, X., Wang, S., Zhao, B., Liu, X., Song, Y., et al. (2022) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.2c00709 · Cited by 5
The role of regulatory T cells in the modulation of anti-tumor immune response
Radosavljevic, G. D., Jovanović, I., Kanjevac, T., & Arsenijević, N. (2013) · Srpski arhiv za celokupno lekarstvo · doi:10.2298/sarh1304262r · Cited by 5
Peptide and Protein-Based Cancer Vaccines
Braun, M., Perret, R., Scholz, G., & Romero, P. J. (2012) · Springer eBooks · doi:10.1007/978-1-4614-4732-0_5 · Cited by 5
Dendritic cell immunotherapy has its antitumor action improved by the LPS in the maturation process
Lopes, A. M. M., Vieira, J. F., da Silva, S. F. M., Murta, E., & Michelin, M. (2025) · Clinical and Translational Oncology · doi:10.1007/s12094-025-03858-5 · Cited by 4
A new marker for predicting sentinel lymph node metastasis in early (cT1-2N0) breast cancer: Tumor-infiltrating lymphocytes (TILs)
Ni, X., Wang, W., Sun, H., An, R., Lei, Y., & Wang, C.-L. (2025) · PLoS ONE · doi:10.1371/journal.pone.0320487 · Cited by 4
Abundance of Tumor-Infiltrating B Cells in Human Epithelial Malignancies
Petrov, E. A., Malabuiok, D. M., Zheng, H., Mokrushina, Y. A., Abrikosova, V. A., Kuzmin, Y. B., Tzarapaev, P. V., Kochkina, S. O., Eltsov, I. V., Knorre, V. D., et al. (2024) · Acta Naturae · doi:10.32607/actanaturae.27353 · Cited by 4
The Prognostic Role of Tumor-Infiltrating Lymphocytes CD8 and Foxp3 and their Impact on Recurrence in Breast Cancer Patients
Khedr, R. A. E.-G., & Ghannam, A. A. E.-A. (2016) · Journal of Cancer Science & Therapy · doi:10.4172/1948-5956.1000414 · Cited by 4
Tumor microenvironment genesis and implications on cancer immune response
Baronzio, G., & Freitas, I. (2008) · Springer eBooks · doi:10.1007/978-1-4020-6931-4_2 · Cited by 4
The capacity of the immune system to control cancer
Håkansson, L. (2009) · European Journal of Cancer · doi:10.1016/j.ejca.2009.06.002 · Cited by 4
Vaccination with in vitro grown whole tumor cells induces strong immune responses and retards tumor growth in a murine model of colorectal liver metastases
Fifis, T., Lam, I., Lin, D., Malcontenti‐Wilson, C., Christophi, C., & Loveland, B. E. (2007) · Vaccine · doi:10.1016/j.vaccine.2007.10.068 · Cited by 4
Tumor-infiltrating lymphocytes and their role in breast carcinoma
Diana, D., & Kusmardi, K. (2020) · Majalah Patologi Indonesia · doi:10.55816/mpi.v29i1.405 · Cited by 3
The Cellular Microenvironment of Head and Neck Squamous Cell Carcinoma
Mathew, M., & Mary, S. (2012) · InTech eBooks · doi:10.5772/25652 · Cited by 3
New Era of Regulatory T Cells in Tumor Immunity: Insights in Cancer Immunotherapy
Sheu, B., Chang, W., & Huang, S. (2010) · Journal of the Formosan Medical Association · doi:10.1016/s0929-6646(10)60016-2 · Cited by 3
Fatores de risco não habituais para metástase linfonodal no câncer do colo do útero
Fregnani, J. H. T. G., Soares, F. A., Novik, P. R., Lopes, A., & Latorre, M. D. R. D. D. O. (2007) · Revista da Associação Médica Brasileira · doi:10.1590/s0104-42302007000400020 · Cited by 3
Immunity or morphogenesis in cancer development and treatment
Shoutko, A. N. (2019) · Integrative Cancer Science and Therapeutics · doi:10.15761/icst.1000317 · Cited by 3
Exploring the role of readthrough-inducing molecule 2,6-diaminopurine to increase immune response against cancer cells
Pacheco, C. M. S., Leroy, A. M., Derhourhi, M., Cardon, T., Leroy, C., Jouy, N., Com, E., Guével, B., Bourette, R. P., Carrard, J., et al. (2025) · Molecular Therapy · doi:10.1016/j.ymthe.2025.09.024 · Cited by 2
Prognostic and clinicopathological value of prognostic nutritional index in patients with multiple myeloma: a meta-analysis
Nie, Y., Zhang, Z., & Tang, X. (2025) · Frontiers in Oncology · doi:10.3389/fonc.2025.1545096 · Cited by 2
Prognostic value of the tumor immune microenvironment, PD-L1 and p16INK4A in penile squamous cell carcinoma
Fiegl, A., Angeloni, M., Mink, J. N., Pryalukhin, A. E., Khalmurzaev, O., Lohse, S., Lobo, J., Henrique, R., Jerónimo, C., Loertzer, H., et al. (2026) · Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin · doi:10.1007/s00428-026-04498-y · Cited by 2
Electron microscopy of juvenile nasopharyngeal angiofibroma: clinical and histopathological correlates
Ampu, H., Singhai, A., Mishra, A., & Mishra, S. C. (2021) · European Archives of Oto-Rhino-Laryngology · doi:10.1007/s00405-021-06815-4 · Cited by 2
HLA-I and breast cancer prognosis: A systematic review and meta-analysis
de Moraes, F. C. A., Cardoso, J. H. C. O., Kelly, F. A., Kreuz, M., Fernandes, L. R., Magalhães, M. C. F., & Burbano, R. M. R. (2024) · Human Immunology · doi:10.1016/j.humimm.2024.111148 · Cited by 2
In vitro and in vivo antitumor effects of 50 to 100-KDa components from B16 melanoma culture supernatant
Qin, Y.-S., Zhang, X., & ZHANG, X.-Y. (2015) · Oncology Letters · doi:10.3892/ol.2015.3239 · Cited by 2
Optimized adoptive T-cell therapy for the treatment of residual mantle cell lymphoma
Munger, C. M., Hegde, G. V., Weisenburger, D. D., Vose, J. M., & Joshi, S. S. (2012) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-012-1229-1 · Cited by 2
Tumor-Infiltrating Lymphocytes and Breast Cancer: Are Immune Checkpoint Inhibitors Ready for Prime Time in Breast Cancer?
Cvetanović, A., Filipović, S., Živković, N., Kostić, M. S., Vrbić, S., & Pejčić, I. (2015) · AFMN Biomedicine · doi:10.1515/afmnai-2016-0026 · Cited by 2
Evaluation of the Risk Factors for Pelvic Lymph Node Metastasis in Early Stage Cervical Cancer
Ferdous, J., Khatun, S., Akhter, S., Chowdhury, S., Pervin, S., Amir, M., & Goodman, A. (2018) · Journal of Cancer Therapy · doi:10.4236/jct.2018.912083 · Cited by 2
Understanding the complex microenvironment in oral cancer: the contribution of the Faculty of Dentistry, University of Otago over the last 100 years
Rich, A. M., Hussaini, H. M., Seo, B., & Zain, R. B. (2020) · Journal of the Royal Society of New Zealand · doi:10.1080/03036758.2020.1736586 · Cited by 2
Targets and Strategies for Cancer Immunoprevention
Ünver, N., & Mohindroo, C. (2022) · Methods in molecular biology · doi:10.1007/978-1-0716-2014-4_2 · Cited by 2
Tumor Infiltration by Immune Cells: Pathologic Evaluation and a Clinical Significance
Gutkin, D. W. (2013) · Springer eBooks · doi:10.1007/978-94-007-6217-6_3 · Cited by 1
A robust immune-related lncRNA signature for the prognosis of human colorectal cancer
Zhu, G., Pei, L., Yang, F., & Zhang, C. (2022) · Bioscience Reports · doi:10.1042/bsr20220078 · Cited by 2
Immunomodulatory Biopharmaceuticals and Risk of Neoplasia
Bugelski, P. J., Sachs, C. W., Cornacoff, J. B., Martin, P. L., & Treacy, G. (2010) · Pharmaceutical Sciences Encyclopedia · doi:10.1002/9780470571224.pse186 · Cited by 2
CARACTERIZAÇÃO DO INFILTRADO INFLAMATÓRIO E AVALIAÇÃO DOS MARCADORES DE PROGNÓSTICO Ki-67, p53, RECEPTOR DE ESTRÓGENO E PROGESTERONA NO TUMOR MAMÁRIO MALIGNO DE CADELAS.
Silveira, A. C. (2009) · Americanae (AECID Library) · Cited by 2
Immunophenotypic Differences in Tumor-Infiltrating Lymphocytes and Neovascularization Between Primary Cutaneous Melanoma With and Without Metastasis: An Immunohistochemical Study of 80 Cases
Fernández, I. S., Roustan-Gullón, G., Requena, L., Suárez, D., García, D., Redondo, J. I., & Nájera, L. (2021) · American Journal of Dermatopathology · doi:10.1097/dad.0000000000001907 · Cited by 1
Response to Neoadjuvant Chemotherapy in Invasive Breast Cancer Predicted by CD4+, CD8+, and FOXP3+ Tumor-Infiltrating Lymphocytes
Rustamadji, P., Wiyarta, E., Pramono, M., & Maulanisa, S. C. (2024) · Asian Pacific Journal of Cancer Prevention · doi:10.31557/apjcp.2024.25.5.1607 · Cited by 1
Correlation of G protein-coupled receptor and tumor microenvironment with gastric cancer outcomes and therapies
Li, J., Ren, J., Zhang, W., Ren, A., Jiao, B., & Yang, W. (2025) · Chinese Medical Journal · doi:10.1097/cm9.0000000000003605 · Cited by 1
Immune Cell Responses in Gastric Carcinoma
Ohtani, H. (2011) · InTech eBooks · doi:10.5772/17472 · Cited by 1
Modulation of Cancer Progression by Tumor Microenvironmental Leukocyte-Expressed microRNAs
Sempere, L. F., & Conejo-Garci, J. (2012) · InTech eBooks · doi:10.5772/32026
Tumor Microenvironment: Aspects of Stromal-Parenchymal Interaction
Zalatnai, A. (2009) · Springer eBooks · doi:10.1007/978-1-4020-9576-4_2 · Cited by 1
Poxvirus-Based Strategies for Combined Vaccine and Tumor Microenvironment Manipulation
de Vries, C. R., Poplin, E. A., Weiss, R. E., August, D. A., Gabriel, E. M., DiPaola, R. S., & Lattime, E. C. (2013) · Elsevier eBooks · doi:10.1016/b978-0-12-394295-1.00017-2 · Cited by 1
Modulating the Tumor Microenvironment
Ruby, C. E., & Kaufman, H. L. (2011) · Springer eBooks · doi:10.1007/978-1-61779-407-0_18 · Cited by 1
The role of immune cell subpopulations in the growth and rejection of TC‑1/A9 tumors in novel mouse strains differing in the H2‑D haplotype and NKC domain
⁄, M. I., Rossowska, J., Pajtasz‐Piasecka, E., ⁄, R. M., Richter, J., Rosina, J., Sedláček, R., & ⁄, A. F. (2018) · Oncology Letters · doi:10.3892/ol.2018.7763 · Cited by 1
Spontaneous regression in a primary adenocarcinoma of lung with epidermal growth factor receptor mutation
Ahmad, F. J., Singh, S., & Kumari, N. (2021) · Journal of Cancer Research and Therapeutics · doi:10.4103/jcrt.jcrt_845_20 · Cited by 1
Secondary Alterations of Hepatocellular Carcinoma
Zimmermann, A. (2016) · Springer eBooks · doi:10.1007/978-3-319-26956-6_5 · Cited by 1
Myeloid-derived suppressor-like cells - a potential biomarker for prognosis of colorectal cancer?
Brcerevic, I., Doder, R., Vojvodić, D., Perisic, N., & Petrović, S. (2022) · Vojnosanitetski pregled · doi:10.2298/vsp220117083b · Cited by 1
FoxP3 mRNA splice forms in arthritis patients
Ryder, L. R. (2011) · Cited by 1
SOTIP: a Unified Framework for Microenvironment Modelling with Spatial Omics DataPreprint
Yuan, Z., Li, Y., Shi, M., Yang, F., Gao, J. T., Yao, J., & Zhang, M. Q. (2022) · Research Square · doi:10.21203/rs.3.rs-1263025/v1 · Cited by 1
Tumor cell plasticity: vascularisation beyond angiogenesis
Hillen, F. (2008) · doi:10.26481/dis.20080221fh
Caratterizzazione della risposta immunitaria in biopsie pleuriche di pazienti affetti da mesotelioma epiteliale e sarcomatoso
Lasagna, L. (2012) · DSpaceUnipr (University of Parma)
Atividade da fosfoetanolamina sintética em melanoma murino experimental
Veronez, L. C. (2012) · doi:10.11606/d.17.2012.tde-15122012-123717
Valor predictivo de la infiltración por linfocitos T intraepiteliales (CD3) en el pronóstico del cáncer colorrectal resecado
Borda, F., Martínez-Peñuela, J. M., Borda, A., Muñoz-Navas, M. Á., Jiménez, J., & Carretero, C. (2012) · Gastroenterología y Hepatología · doi:10.1016/j.gastrohep.2012.05.003
Natural Killer Cells in Colon Cancer: A Study in Racial Differences and Immune Coordination
Basa, R. C. B. (2011) · California State University ScholarWorks (system-wide DSpace) · doi:10.13140/rg.2.1.3111.2801
Estudo da incidência, identificação e parâmetrosprognósticos dos hemangiomas e hemangiossarcomas em animais de companhia
Berselli, M. (2011) · Americanae (AECID Library)
SISTEMA IMUNOLÓGICO NO COMBATE AO CÂNCER: EVASÃO DA VIGILÂNCIA IMUNOLÓGICA
Rodrigues, A. F. F. (2013) · FACIDER - Revista Científica
ATIVIDADE DA FOSFOETANOLAMINA SINTÉTICA EM
Experimental, M. M. (2012)
Molecular and Cellular Interplay in SCC Including Immunomodulation and Clinical Implications
Yanofsky, V. R., Carucci, J. A., & Hofbauer, G. F. L. (2016) · Springer eBooks · doi:10.1007/978-3-662-47081-7_4
Secondary Alterations of Hepatocellular Carcinoma
Zimmermann, A. (2016) · Springer eBooks · doi:10.1007/978-3-319-26587-2_5-1
Immune modulation in serous epithelial ovarian cancer : focus on the role of tumor-derived exosomes
Labani-Motlagh, A. (2017)
Modulation of Regulatory T Cells by Cytokines
Pillemer, B. B. L. (2007) · D-Scholarship@Pitt (University of Pittsburgh)
Characterization of the inflammatory infiltrates associated with oral epithelial dysplasia and oral squamous cell carcinoma
Mahdi, H. (2017) · TSpace (University of Toronto)
Expressão de indoleamina 2,3-dioxigenase (IDO) e triptofano 2,3-dioxigenase(TDO) no ambiente cervicovaginal normal, na vaginose bacteriana e nas lesões cervicais associadas ao HPV
Venancio, P. A. (2018) · doi:10.11606/d.9.2018.tde-12112018-124550
Avaliação do crosstalk entre os Linfócitos Infiltrantes de Tumor (TILs) e o Fator Regulador de Interferon 8 (IRF-8) no Microambiente Tumoral: estudo em melanoma oral canino
Yasumaru, C. C. (2019) · doi:10.11606/d.10.2019.tde-02072019-114551
Dual effect of autophagy in the regulation of cell-mediated cytotoxicity
Chouaı̈b, S., & Thiery, J. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-819609-0.00001-8
Enhancing Cancer Immunotherapies Using Cell-Based or Viral Vectored Vaccines
Mould, R. C. (2020) · The Atrium (University of Guelph)
Therapeutic strategies
Ribatti, D. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-822803-6.00007-7
Data from Tumor-Localized Ligation of CD3 and CD28 with Systemic Regulatory T-Cell Depletion Induces Potent Innate and Adaptive Antitumor Responses
Lee, C.-H., Chiang, Y.-H., Chang, S., Chong, C.-L., Cheng, B.-M., & Roffler, S. R. (2023) · doi:10.1158/1078-0432.c.6517468
Data from Tumor-Localized Ligation of CD3 and CD28 with Systemic Regulatory T-Cell Depletion Induces Potent Innate and Adaptive Antitumor Responses
Lee, C.-H., Chiang, Y.-H., Chang, S., Chong, C.-L., Cheng, B.-M., & Roffler, S. R. (2023) · doi:10.1158/1078-0432.c.6517468.v1
OPTIMIZATION OF A FLOW CYTOMETRY PROTOCOL FOR PD-1/CTLA-4 IMMUNE CHECKPOINTS RECEPTORS DETECTION IN COLORECTAL CANCER TUMOUR MICROENVIRONMENT
Zamfir, M. (2023) · FARMACIA · doi:10.31925/farmacia.2023.2.17
Microalgae-derived bioactive compounds - A natural ally in cancer immunotherapy
Mittal, D., Thakur, R., Singh, S., Chauhan, A., & Devi, R. (2025) · The Applied Biology & Chemistry Journal · doi:10.52679/tabcj.2025.62002
Additional file 1 of Clinicopathological significance and prognostic role of LAG3 + tumor-infiltrating lymphocytes in colorectal cancer; relationship with sidedness
Tavana, S., Mokhtari, Z., Sanei, M. H., Heidari, Z., Dehghanian, A.-R., Faghih, Z., & Rezaei, M. (2023) · Figshare · doi:10.6084/m9.figshare.22605313
Facteurs pronostiques biopathologiques des lymphomes Hodgkiniens : influence du microenvironnement
Chetaille, B. (2010) · doi:10.70675/3a5b2f21ze6cbz403aza5d1z22d7507d5cf6
Rôle de CD5 dans la potentialisation de la réponse T cytotoxique et dans le contrôle de la progression tumorale dans un modèle in vivo
Tabbekh, M. (2011) · theses.fr (ABES) · doi:10.70675/0117b50bzfdbfz487bzab3fz834502a98c56
Caractérisation moléculaire et fonctionnelle des lymphocytes T CD8+/CD103+ infiltrant les tumeurs pulmonaires humaines
Djenidi, B. F. (2014) · theses.fr (ABES) · doi:10.70675/82393e4dz1433z4905zbff8zb3e7e5008e64
Comprehensive Review of Immunotherapy in Colorectal Cancer: From Mechanisms to Nursing Interventions
Zhu, Q., Lai, Y., Zhao, J., Zhang, Z., Cui, X., & Kou, M. (2026) · ImmunoTargets and Therapy · doi:10.2147/itt.s603959
Advanced Lung Cancer Inflammation Index as a Prognostic Inflammation–Nutrition Marker in Appendiceal High‐Grade Pseudomyxoma Peritonei: A 10‐Year Single‐Center Study
Gao, Y., Ma, R., Feng, Z., Yang, S., & An, G. (2026) · ANZ Journal of Surgery · doi:10.1111/ans.70884
Efeito protetor in vivo de vacinas de células dendríticas sensibilizadas com RNA de células MC-38 pré-tratadas com agentes antineoplásticos em concentrações efetivas minímas
de Camargo, M. R. (2014) · Aleph UCLA Undergraduate Research Journal for the Humanities and Social Sciences

Authors: Yu, P., & Fu, Y.-X.
Affiliations: University of Chicago (US)
Corresponding author: Yu, Ping
Fu, Yang-Xin
ORCID: Fu, Yang-Xin
Venue: Laboratory Investigation
Publisher: Elsevier BV
Published: 2006-03
Volume: 86
Issue: 3
Pages: 231-245
ISSN: 0023-6837 (ISSN-L)
DOI: 10.1038/labinvest.3700389
OpenAlex: W2061590134
Cited by: 299
References: 211
Citations by year: 2026: 3 · 2025: 9 · 2024: 14 · 2023: 13 · 2022: 15 · 2021: 20 · 2020: 13 · 2019: 15 · 2018: 8 · 2017: 18 · 2016: 12 · 2015: 14 · 2014: 16 · 2013: 11 · 2012: 17
FWCI: 1.35
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 6160 d)
Locations: Laboratory Investigation (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Health Sciences › Medicine › Oncology › Cancer Immunotherapy and Biomarkers
Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
Keywords: tumor-infiltrating lymphocytes, regulatory T cells, CD4+CD25+ T cells, CD8+ T cells, CD4+ T helper cells, antitumor immunity, tumor immunosuppression, prognostic value, cancer immunotherapy
MeSH terms: Humans, Neoplasms, Prognosis, CD4-Positive T-Lymphocytes, T-Lymphocyte Subsets, Lymphocytes, Tumor-Infiltrating, T-Lymphocytes, Regulatory

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Tumor-infiltrating T lymphocytes: friends or foes?

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks