The DOI matches its Crossref record; 46 of the 46 references it cites were found in a registry or an index.
IL-17 disrupts corneal barrier following desiccating stress
Open accessAbstract
T helper (Th)-17 is a recently identified subtype of Th response that has been implicated in host defense and autoimmunity. We investigated whether there is evidence for a Th-17 response in human and experimental murine dry eye (DE). Gene expression in the human DE conjunctiva showed increased levels of the Th-17 inducers, interleukin (IL)-23, IL-17A, and interferon-gamma (IFN-γ). In the murine model, we found that desiccating stress increased matrix metalloproteinase-9, Th-17-associated genes (IL-6, IL-23, transforming growth factor-β1 and -2, IL-23R, IL-17R, IL-17A, retinoid-related orphan receptor-γt, and CC chemokine attractant ligand-20) and IFN-γ in cornea and conjunctiva. Furthermore, we found a significantly increased concentration of IL-17 in tears and number of IL-17-producing cells on the ocular surface. Antibody neutralization of IL-17 ameliorated experimental DE-induced corneal epithelial barrier dysfunction and decreased the expression of matrix metalloproteinases 3 and 9. Taken together, these findings suggest that IL-17 has a role in corneal epithelial barrier disruption in DE.
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Cites
Bettelli, E., Carrier, Y., Gao, W., Korn, T., Strom, T. B., Oukka, M., Weiner, H. L., & Kuchroo, V. K. (2006) · Nature · doi:10.1038/nature04753 · Cited by 6,992
Ivanov, I. I., McKenzie, B. S., Zhou, L., Tadokoro, C. E., Lepelley, A., Lafaille, J. J., Cua, D. J., & Littman, D. R. (2006) · Cell · doi:10.1016/j.cell.2006.07.035 · Cited by 5,145
A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17
Park, H., Li, Z., Yang, X. O., Chang, S. H., Nurieva, R., Wang, Y.-H., Wang, Y., Hood, L., Zhu, Z., Tian, Q., et al. (2005) · Nature Immunology · doi:10.1038/ni1261 · Cited by 4,265
Veldhoen, M., Hocking, R. J., Atkins, C. J., Locksley, R. M., & Stockinger, B. (2006) · Immunity · doi:10.1016/j.immuni.2006.01.001 · Cited by 3,605
Transforming growth factor-β induces development of the TH17 lineage
Mangan, P. R., Harrington, L. E., O'Quinn, D. B., Helms, W. S., Bullard, D. C., Elson, C. O., Hatton, R. D., Wahl, S. M., Schoeb, T. R., & Weaver, C. T. (2006) · Nature · doi:10.1038/nature04754 · Cited by 3,087
Liang, S. C., Tan, X.-Y., Luxenberg, D. P., Karim, R., Dunussi-Joannopoulos, K., Collins, M., & Fouser, L. A. (2006) · The Journal of Experimental Medicine · doi:10.1084/jem.20061308 · Cited by 2,330
Development, cytokine profile and function of human interleukin 17-producing helper T cells
Wilson, N. J., Boniface, K., Chan, J. R., McKenzie, B. S., Blumenschein, W. M., Mattson, J. D., Basham, B., Smith, K., Chen, T., Morel, F., et al. (2007) · Nature Immunology · doi:10.1038/ni1497 · Cited by 2,035
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IL-23 is essential for T cell–mediated colitis and promotes inflammation via IL-17 and IL-6
Yen, D., Cheung, J., Scheerens, H., Poulet, F., McClanahan, T., Mckenzie, B., Kleinschek, M. A., Owyang, A., Mattson, J., Blumenschein, W., et al. (2006) · Journal of Clinical Investigation · doi:10.1172/jci21404 · Cited by 1,542
IL-17 plays an important role in the development of experimental autoimmune encephalomyelitis
Komiyama, Y., Nakae, S., Matsuki, T., Nambu, A., Ishigame, H., Kakuta, S., Sudo, K., & Iwakura, Y. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.177.1.566 · Cited by 1,536
Cited by
Harrell, C. R., Jovicic, N., Djonov, V., Arsenijevic, N., & Volarevic, V. (2019) · Cells · doi:10.3390/cells8121605 · Cited by 795
The Pathophysiology of Dry Eye Disease
Pflugfelder, S. C., & de Paiva, C. S. (2017) · Ophthalmology · doi:10.1016/j.ophtha.2017.07.010 · Cited by 533
Self-citationDry Eye as a Mucosal Autoimmune Disease
Stern, M. E., Schaumburg, C. S., & Pflugfelder, S. C. (2013) · International Reviews of Immunology · doi:10.3109/08830185.2012.748052 · Cited by 346
Self-citationDry Eye Management: Targeting the Ocular Surface Microenvironment
Zhang, X., M, V. J., Qu, Y., He, X., Ou, S., Bu, J., Jia, C., Wang, J., Wu, H., Liu, Z., et al. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18071398 · Cited by 267
Deinema, L. A., Vingrys, A. J., Wong, C. Y., Jackson, D. C., Chinnery, H. R., & Downie, L. E. (2017) · Ophthalmology · doi:10.1016/j.ophtha.2016.09.023 · Cited by 160
Metadata
- Authors
- De Paiva, C. S., Chotikavanich, S., Pangelinan, S. B., Pitcher, J. D., Fang, B., Zheng, X., Ma, P., Farley, W. J., Siemasko, K. F., Niederkorn, J. Y., Stern, M. E., Li, D.-Q., & Pflugfelder, S. C.
- Venue
- Mucosal Immunology
- Publisher
- Elsevier BV
- Published
- 2009-05
- Volume
- 2
- Issue
- 3
- Pages
- 243-253
- ISSN
- 1933-0219 (ISSN-L)
- OpenAlex
- W2002180108
- Cited by
- 422
- References
- 46
- FWCI
- 18.53
- Type
- journal article
- Language
- en
- Open access
- bronze
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- De Paiva, C. S., Chotikavanich, S., Pangelinan, S. B., Pitcher, J. D., Fang, B., Zheng, X., Ma, P., Farley, W. J., Siemasko, K. F., Niederkorn, J. Y., Stern, M. E., Li, D.-Q., & Pflugfelder, S. C. (2009). IL-17 disrupts corneal barrier following desiccating stress. Mucosal Immunology. https://doi.org/10.1038/mi.2009.5
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
