Risk variants and polygenic architecture of disruptive behavior disorders in the context of attention-deficit/hyperactivity disorder
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Attention-Deficit/Hyperactivity Disorder (ADHD) is a childhood psychiatric disorder often comorbid with disruptive behavior disorders (DBDs). Here, we report a GWAS meta-analysis of ADHD comorbid with DBDs (ADHD + DBDs) including 3802 cases and 31,305 controls. We identify three genome-wide significant loci on chromosomes 1, 7, and 11. A meta-analysis including a Chinese cohort supports that the locus on chromosome 11 is a strong risk locus for ADHD + DBDs across European and Chinese ancestries (rs7118422, P = 3.15×10−10, OR = 1.17). We find a higher SNP heritability for ADHD + DBDs (h 2SNP = 0.34) when compared to ADHD without DBDs (h 2SNP = 0.20), high genetic correlations between ADHD + DBDs and aggressive (r g = 0.81) and anti-social behaviors (r g = 0.82), and an increased burden (polygenic score) of variants associated with ADHD and aggression in ADHD + DBDs compared to ADHD without DBDs. Our results suggest an increased load of common risk variants in ADHD + DBDs compared to ADHD without DBDs, which in part can be explained by variants associated with aggressive behavior.
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One study noted an increased contribution of common genetic variants to ADHD with disruptive behavior disorder compared to ADHD without disruptive behavior disorder, with a portion of that increase attributed to genetic variants associated with aggression.
“with one study noting an increased contribution of common genetic variants to ADHD with disruptive behavior disorder compared to ADHD without disruptive behavior disorder, with a portion of that increase attributed to genetic variants associated with aggression [152].”
From Genetics of child aggression, a systematic review (2024) · cites this paper as [152]
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PLINK: a tool set for whole-genome association and population-based linkage analyses.
Purcell, S., Neale, B., Todd-Brown, K., Thomas, L., Ferreira, M. A. R., Bender, D., Maller, J., Sklar, P., de Bakker, P. I. W., Daly, M. J., et al. (2007) · The American Journal of Human Genetics · doi:10.1086/519795 · Cited by 34,089 · see citing works
Self-citationA global reference for human genetic variation
The 1000 Genomes Project Consortium, authors, C., Auton, A., Abecasis, G. R., Steering committee, Altshuler, D. M., Durbin, R. M., Abecasis, G. R., Bentley, D. R., Chakravarti, A., et al. (2015) · Nature · doi:10.1038/nature15393 · Cited by 18,247 · see citing works
Self-citationSecond-generation PLINK: rising to the challenge of larger and richer datasets
Chang, C. C., Chow, C. C., Tellier, L. C., Vattikuti, S., Purcell, S. M., & Lee, J. J. (2015) · Gigascience · doi:10.1186/s13742-015-0047-8 · Cited by 12,709 · see citing works
Principal components analysis corrects for stratification in genome-wide association studies
Price, A. L., Patterson, N. J., Plenge, R. M., Weinblatt, M. E., Shadick, N. A., & Reich, D. (2006) · Nature Genetics · doi:10.1038/ng1847 · Cited by 10,248 · see citing works
GCTA: a tool for genome-wide complex trait analysis
Yang, J., Lee, S. H., Goddard, M. E., & Visscher, P. M. (2011) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2010.11.011 · Cited by 8,279 · see citing works
An integrated map of genetic variation from 1,092 human genomes
The 1000 Genomes Project Consortium (2012) · Nature · doi:10.1038/nature11632 · Cited by 7,711 · see citing works
Biological insights from 108 schizophrenia-associated genetic loci
Schizophrenia Working Group of the Psychiatric Genomics Consortium (2014) · Nature · doi:10.1038/nature13595 · Cited by 7,577 · see citing works
LD Score regression distinguishes confounding from polygenicity in genome-wide association studies
Schizophrenia Working Group of the Psychiatric Genomics Consortium, Bulik-Sullivan, B. K., Loh, P.-R., Finucane, H. K., Ripke, S., Yang, J., Patterson, N., Daly, M. J., Price, A. L., & Neale, B. M. (2015) · Nature Genetics · doi:10.1038/ng.3211 · Cited by 5,559 · see citing works
Self-citationMETAL: fast and efficient meta-analysis of genomewide association scans
Willer, C. J., Li, Y., & Abecasis, G. R. (2010) · Bioinformatics · doi:10.1093/bioinformatics/btq340 · Cited by 5,205 · see citing works
The Genotype-Tissue Expression (GTEx) pilot analysis: Multitissue gene regulation in humans
The GTEx Consortium, Ardlie, K. G., Deluca, D. S., Segrè, A. V., Sullivan, T. J., Young, T. R., Gelfand, E. T., Trowbridge, C. A., Maller, J. B., Tukiainen, T., et al. (2015) · Science · doi:10.1126/science.1262110 · Cited by 5,062 · see citing works
An atlas of genetic correlations across human diseases and traits
ReproGen Consortium, Bulik-Sullivan, B., Psychiatric Genomics Consortium, Genetic Consortium for Anorexia Nervosa of the Wellcome Trust Case Control Consortium 3, Finucane, H. K., Anttila, V., Gusev, A., Day, F. R., Loh, P.-R., Duncan, L., et al. (2015) · Nature Genetics · doi:10.1038/ng.3406 · Cited by 4,255 · see citing works
Self-citationMAGMA: Generalized Gene-Set Analysis of GWAS Data
de Leeuw, C. A., Mooij, J. M., Heskes, T., & Posthuma, D. (2015) · PLOS Computational Biology · doi:10.1371/journal.pcbi.1004219 · Cited by 3,653 · see citing works
(2013) · The Lancet · doi:10.1016/s0140-6736(12)62129-1 · Cited by 3,010 · see citing works
ADHD Working Group of the Psychiatric Genomics Consortium (PGC), Demontis, D., Early Lifecourse & Genetic Epidemiology (EAGLE) Consortium, 23andMe Research Team, Walters, R. K., Martin, J., Mattheisen, M., Als, T. D., Agerbo, E., Baldursson, G., et al. (2019) · Nature Genetics · doi:10.1038/s41588-018-0269-7 · Cited by 2,203 · see citing works
Self-citationA linear complexity phasing method for thousands of genomes
Delaneau, O., Marchini, J., & Zagury, J.-F. (2012) · Nature Methods · doi:10.1038/nmeth.1785 · Cited by 1,850 · see citing works
A gene-based association method for mapping traits using reference transcriptome data
Gamazon, E. R., Wheeler, H. E., Shah, K. P., Mozaffari, S. V., Aquino-Michaels, K., Carroll, R. J., Eyler, A. E., Denny, J. C., Nicolae, D. L., Cox, N. J., et al. (2015) · Nature Genetics · doi:10.1038/ng.3367 · Cited by 1,762 · see citing works
The Danish Psychiatric Central Research Register
Mors, O., Perto, G. P., & Mortensen, P. B. (2011) · Scandinavian Journal of Public Health · doi:10.1177/1403494810395825 · Cited by 1,589 · see citing works
Self-citationAttention-deficit/hyperactivity disorder
Faraone, S. V., Asherson, P., Banaschewski, T., Biederman, J., Buitelaar, J. K., Ramos-Quiroga, J. A., Rohde, L. A., Sonuga-Barke, E. J. S., Tannock, R., & Franke, B. (2015) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2015.20 · Cited by 1,479 · see citing works
Self-citationGenomic Relationships, Novel Loci, and Pleiotropic Mechanisms across Eight Psychiatric Disorders
Lee, P. H., Anttila, V., Won, H., Feng, Y.-C. A., Rosenthal, J., Zhu, Z., Tucker-Drob, E. M., Nivard, M. G., Grotzinger, A. D., Posthuma, D., et al. (2019) · Cell · doi:10.1016/j.cell.2019.11.020 · Cited by 1,381 · see citing works
Self-citationZhang, S. L., Yu, Y., Roos, J., Kozak, J. A., Deerinck, T. J., Ellisman, M. H., Stauderman, K. A., & Cahalan, M. D. (2005) · Nature · doi:10.1038/nature04147 · Cited by 1,374 · see citing works
Genetics of attention deficit hyperactivity disorder
Faraone, S. V., & Larsson, H. (2019) · Molecular Psychiatry · doi:10.1038/s41380-018-0070-0 · Cited by 1,338 · see citing works
Self-citationGenome-wide association study identifies 74 loci associated with educational attainment
Okbay, A., Beauchamp, J. P., Fontana, M. A., Lee, J. J., Pers, T. H., Rietveld, C. A., Turley, P., Chen, G.-B., Emilsson, V., Meddens, S. F. W., et al. (2016) · Nature · doi:10.1038/nature17671 · Cited by 1,297 · see citing works
Self-citationStability of aggression over time and generations.
Huesmann, L. R., Eron, L. D., Lefkowitz, M. M., & Walder, L. O. (1984) · Developmental Psychology · doi:10.1037/0012-1649.20.6.1120 · Cited by 1,290 · see citing works
Wellcome Trust Case Control Consortium, Ferreira, M. A. R., O'Donovan, M. C., Meng, Y. A., Jones, I. R., Ruderfer, D. M., Jones, L., Fan, J., Kirov, G., Perlis, R. H., et al. (2008) · Nature Genetics · doi:10.1038/ng.209 · Cited by 1,237 · see citing works
Genotype Imputation with Thousands of Genomes
Howie, B., Marchini, J., & Stephens, M. (2011) · G3 Genes|Genomes|Genetics · doi:10.1534/g3.111.001198 · Cited by 966 · see citing works
Causal associations between risk factors and common diseases inferred from GWAS summary data
Zhu, Z., Zheng, Z., Zhang, F., Wu, Y., Trzaskowski, M., Maier, R., Robinson, M. R., McGrath, J. J., Visscher, P. M., Wray, N. R., et al. (2018) · Nature Communications · doi:10.1038/s41467-017-02317-2 · Cited by 951 · see citing works
Conduct disorder and oppositional defiant disorder in a national sample: developmental epidemiology
Maughan, B., Rowe, R., Messer, J., Goodman, R., & Meltzer, H. (2004) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.2004.00250.x · Cited by 743 · see citing works
Dalsgaard, S., Østergaard, S. D., Leckman, J. F., Mortensen, P. B., & Pedersen, M. G. (2015) · The Lancet · doi:10.1016/s0140-6736(14)61684-6 · Cited by 681 · see citing works
Self-citationLive fast, die young? A review on the developmental trajectories of ADHD across the lifespan
Franke, B., Michelini, G., Asherson, P., Banaschewski, T., Bilbow, A., Buitelaar, J. K., Cormand, B., Faraone, S. V., Ginsberg, Y., Haavik, J., et al. (2018) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2018.08.001 · Cited by 643 · see citing works
Self-citationPatterns of Comorbidity, Functioning, and Service Use for US Children With ADHD, 2007
Larson, K., Russ, S. A., Kahn, R. S., & Halfon, N. (2011) · Pediatrics · doi:10.1542/peds.2010-0165 · Cited by 580 · see citing works
Nock, M. K., Kazdin, A. E., Hiripi, E., & Kessler, R. C. (2007) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.2007.01733.x · Cited by 559 · see citing works
Erskine, H. E., Norman, R. E., Ferrari, A. J., Chan, G. C. K., Copeland, W. E., Whiteford, H. A., & Scott, J. G. (2016) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1016/j.jaac.2016.06.016 · Cited by 555 · see citing works
Dalsgaard, S., Thorsteinsson, E., Trabjerg, B. B., Schullehner, J., Plana-Ripoll, O., Brikell, I., Wimberley, T., Thygesen, M., Madsen, K. B., Timmerman, A., et al. (2020) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2019.3523 · Cited by 510 · see citing works
Self-citationSniekers, S., Stringer, S., Watanabe, K., Jansen, P. R., Coleman, J. R. I., Krapohl, E., Taskesen, E., Hammerschlag, A. R., Okbay, A., Zabaneh, D., et al. (2017) · Nature Genetics · doi:10.1038/ng.3869 · Cited by 490 · see citing works
BIEDERMAN, J., WILENS, T., MICK, E., FARAONE, S. V., WEBER, W., CURTIS, S., THORNELL, A., PFISTER, K., JETTON, J. G., & SORIANO, J. (1997) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/00004583-199701000-00013 · Cited by 476 · see citing works
Self-citationCalcium Channels, Synaptic Plasticity, and Neuropsychiatric Disease
Nanou, E., & Catterall, W. A. (2018) · Neuron · doi:10.1016/j.neuron.2018.03.017 · Cited by 476 · see citing works
Long-Range LD Can Confound Genome Scans in Admixed Populations
Price, A. L., Weale, M. E., Patterson, N., Myers, S. R., Need, A. C., Shianna, K. V., Ge, D., Rotter, J. I., Torres, E., Taylor, K. D., et al. (2008) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2008.06.005 · Cited by 443 · see citing works
Fairchild, G. F., Hawes, D. J., Frick, P. J., Copeland, W., Odgers, C. L., Franke, B., Freitag, C. M., & Brito, S. A. D. (2019) · Nature Reviews Disease Primers · doi:10.1038/s41572-019-0095-y · Cited by 426 · see citing works
Self-citationDavies, G., Marioni, R. E., Liewald, D. C., Hill, W. D., Hagenaars, S. P., Harris, S. E., Ritchie, S. J., Luciano, M., Fawns-Ritchie, C., Lyall, D., et al. (2016) · Molecular Psychiatry · doi:10.1038/mp.2016.45 · Cited by 373 · see citing works
Genetic risk for autism spectrum disorders and neuropsychiatric variation in the general population
iPSYCH-SSI-Broad Autism Group, Robinson, E. B., St Pourcain, B., Anttila, V., Kosmicki, J. A., Bulik-Sullivan, B., Grove, J., Maller, J., Samocha, K. E., Sanders, S. J., et al. (2016) · Nature Genetics · doi:10.1038/ng.3529 · Cited by 367 · see citing works
Self-citationPolygenic dissection of diagnosis and clinical dimensions of bipolar disorder and schizophrenia
Ruderfer, D. M., Fanous, A. H., Ripke, S., McQuillin, A., Amdur, R. L., Schizophrenia Working Group of the Psychiatric Genomics Consortium, Bipolar Disorder Working Group of the Psychiatric Genomics Consortium, Cross-Disorder Working Group of the Psychiatric Genomics Consortium, Gejman, P. V., O'Donovan, M. C., et al. (2014) · Molecular Psychiatry · doi:10.1038/mp.2013.138 · Cited by 364 · see citing works
Self-citationFast Principal-Component Analysis Reveals Convergent Evolution of ADH1B in Europe and East Asia
Galinsky, K. J., Bhatia, G., Loh, P., Georgiev, S., Mukherjee, S., Patterson, N. J., & Price, A. L. (2016) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2015.12.022 · Cited by 357 · see citing works
Zoccolillo, M., Pickles, A. R., Quinton, D., & Rutter, M. L. (1992) · Psychological Medicine · doi:10.1017/s003329170003854x · Cited by 346 · see citing works
A Better Coefficient of Determination for Genetic Profile Analysis
Lee, S., Goddard, M. E., Wray, N. R., & Visscher, P. M. (2012) · Genetic Epidemiology · doi:10.1002/gepi.21614 · Cited by 338 · see citing works
Pedersen, C. B., Bybjerg-Grauholm, J., Pedersen, M. G., Grove, J., Agerbo, E., Bækvad-Hansen, M., Poulsen, J. B., Hansen, C. S., McGrath, J. J., Als, T. D., et al. (2018) · Molecular Psychiatry · doi:10.1038/mp.2017.196 · Cited by 338 · see citing works
Self-citationSniekers, S., Stringer, S., Watanabe, K., Jansen, P. R., Coleman, J. R. I., Krapohl, E. M. L., Taskesen, E., Hammerschlag, A. R., Okbay, A., Zabaneh, D., et al. (2017) · Nature Genetics · doi:10.1038/ng1017-1558c · Cited by 333 · see citing works
RICOPILI: Rapid Imputation for COnsortias PIpeLIne
Lam, M., Awasthi, S., Watson, H. J., Goldstein, J., Panagiotaropoulou, G., Trubetskoy, V., Karlsson, R., Frei, O., Fan, C.-C., De Witte, W., et al. (2020) · Bioinformatics · doi:10.1093/bioinformatics/btz633 · Cited by 315 · see citing works
Self-citationA General Theory for Jackknife Variance Estimation
Shao, J., & Wu, C. (1989) · The Annals of Statistics · doi:10.1214/aos/1176347263 · Cited by 308 · see citing works
Hyperactive Boys Almost Grown Up
Mannuzza, S. (1989) · Archives of General Psychiatry · doi:10.1001/archpsyc.1989.01810120015004 · Cited by 286 · see citing works
Examining the comorbidity of ADHD-related behaviours and conduct problems using a twin study design
Thapar, A., Harrington, R., & McGuffin, P. (2001) · The British Journal of Psychiatry · doi:10.1192/bjp.179.3.224 · Cited by 266 · see citing works
Self-citationThe Genotype-Tissue Expression (GTEx) project
Lonsdale, J., Thomas, J., Salvatore, M., Phillips, R., Lo, E., Shad, S., Hasz, R., Walters, G., Garcia, F., Young, N., et al. (2013) · Nature Genetics · doi:10.1038/ng.2653 · Cited by 263 · see citing works
Faraone, S. V., Biederman, J., Keenan, K. E., & Tsuang, M. T. (1991) · Psychological Medicine · doi:10.1017/s0033291700014707 · Cited by 228 · see citing works
Self-citationSlutske, W. S., Heath, A. C., Dinwiddie, S. H., Madden, P. A. F., Bucholz, K. K., Dunne, M. P., Statham, D. J., & Martin, N. G. (1997) · Journal of Abnormal Psychology · doi:10.1037/0021-843x.106.2.266 · Cited by 213 · see citing works
Self-citationDick, D. M., Viken, R. J., Kaprio, J., Pulkkinen, L., & Rose, R. J. (2005) · Journal of Abnormal Child Psychology · doi:10.1007/s10802-005-1829-8 · Cited by 206 · see citing works
A genome‐wide approach to children's aggressive behavior: <i>The EAGLE consortium</i>
Pappa, I., St Pourcain, B., Benke, K., Cavadino, A., Hakulinen, C., Nivard, M. G., Nolte, I. M., Tiesler, C. M. T., Bakermans‐Kranenburg, M. J., Davies, G. E., et al. (2016) · American Journal of Medical Genetics Part B: Neuropsychiatric Genetics · doi:10.1002/ajmg.b.32333 · Cited by 195 · see citing works
Genome-Wide Association Studies of a Broad Spectrum of Antisocial Behavior
Tielbeek, J. J., Johansson, A., Polderman, T. J. C., Rautiainen, M.-R., Jansen, P., Taylor, M., Tong, X., Lu, Q., Burt, A. S., Tiemeier, H., et al. (2017) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2017.3069 · Cited by 194 · see citing works
Self-citationfor the advanced Collaborative Study of Mood Disorder (COSMO) team, Ikeda, M., Takahashi, A., Kamatani, Y., Okahisa, Y., Kunugi, H., Mori, N., Sasaki, T., Ohmori, T., Okamoto, Y., et al. (2017) · Molecular Psychiatry · doi:10.1038/mp.2016.259 · Cited by 190 · see citing works
GROUP investigators, Børglum, A. D., Demontis, D., Grove, J., Pallesen, J., Hollegaard, M. V., Pedersen, C. B., Hedemand, A., Mattheisen, M., Uitterlinden, A., et al. (2014) · Molecular Psychiatry · doi:10.1038/mp.2013.2 · Cited by 186 · see citing works
Self-citationDoes the prevalence of CD and ODD vary across cultures?
Canino, G., Polanczyk, G., Bauermeister, J. J., Rohde, L. A., & Frick, P. J. (2010) · Social Psychiatry and Psychiatric Epidemiology · doi:10.1007/s00127-010-0242-y · Cited by 185 · see citing works
Self-citationAutism spectrum disorders and autistic traits share genetics and biology
Bralten, J., van Hulzen, K. J. E., Martens, M. B., Galesloot, T. E., Vásquez, A. A., Kiemeney, L. A. L. M., Buitelaar, J. K., Muntjewerff, J.-W., Franke, B., & Poelmans, G. (2017) · Molecular Psychiatry · doi:10.1038/mp.2017.98 · Cited by 183 · see citing works
Self-citationvan Beijsterveldt, C. E. M., Bartels, M., Hudziak, J. J., & Boomsma, D. I. (2003) · Behavior Genetics · doi:10.1023/a:1025735002864 · Cited by 173 · see citing works
Dalsgaard, S., Mortensen, P. B., Frydenberg, M., & Thomsen, P. H. (2002) · British Journal of Psychiatry · doi:10.1192/bjp.181.5.416 · Cited by 172 · see citing works
Self-citationSmalley, S. L., McGough, J. J., Moilanen, I. K., Loo, S. K., Taanila, A. M., Ebeling, H. E., Hurtig, T. M., Kaakinen, M., Humphrey, L. A., McCracken, J. T., et al. (2007) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/chi.0b013e3181573137 · Cited by 170 · see citing works
Self-citationCausal associations between risk factors and common diseases inferred from GWAS summary dataPreprint
Zhu, Z., Zheng, Z., Zhang, F., et al. (2017) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/168674 · Cited by 160 · see citing works
High Loading of Polygenic Risk for ADHD in Children With Comorbid Aggression
Hamshere, M. L., Langley, K., Martin, J., Agha, S. S., Stergiakouli, E., Anney, R. J. L., Buitelaar, J., Faraone, S. V., Lesch, K.-P., Neale, B. M., et al. (2013) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2013.12081129 · Cited by 144 · see citing works
Self-citationGroenman, A. P., Oosterlaan, J., Rommelse, N., Franke, B., Roeyers, H., Oades, R. D., Sergeant, J. A., Buitelaar, J. K., & Faraone, S. V. (2013) · Addiction · doi:10.1111/add.12188 · Cited by 138 · see citing works
Self-citationEstévez, E., Jiménez, T. I., & Ruiz, D. M. (2018) · Psicothema · doi:10.7334/psicothema2016.294 · Cited by 137 · see citing works
Anney, R., Lasky-Su, J., O'Dushlaine, C., Kenny, E., Neale, B., Mulligan, A., Franke, B., Zhou, K., Chen, W., Christiansen, H., et al. (2008) · American Journal of Medical Genetics Part B: Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30871 · Cited by 135 · see citing works
Self-citationRisky decision making in attention-deficit/hyperactivity disorder: a meta-regression analysis
Dekkers, T. J., Popma, A., Agelink van Rentergem, J. A., Bexkens, A., & Huizenga, H. M. (2016) · Clinical Psychology Review · doi:10.1016/j.cpr.2016.03.001 · Cited by 119 · see citing works
Genome-wide association study of conduct disorder symptomatology
Dick, D. M., Aliev, F., Krueger, R. F., Edwards, A., Agrawal, A., Lynskey, M., Lin, P., Schuckit, M., Hesselbrock, V, Nurnberger, J., et al. (2011) · Molecular Psychiatry · doi:10.1038/mp.2010.73 · Cited by 111 · see citing works
Genomics of body fat percentage may contribute to sex bias in anorexia nervosa
Hübel, C., Gaspar, H., Coleman, J., Finucane, H., Purves, K., Hanscombe, K. B., Prokopenko, I., Graff, M., Ngwa, J., Workalemahu, T., et al. (2018) · American Journal of Medical Genetics Part B: Neuropsychiatric Genetics · doi:10.1002/ajmg.b.32709 · Cited by 110 · see citing works
Faraone, S. V., Biederman, J., Mennin, D. S., Russell, R. L., & Tsuang, M. T. (1998) · Journal of Child Psychology and Psychiatry · doi:10.1111/1469-7610.00407 · Cited by 108 · see citing works
Self-citationLongitudinal heritability of childhood aggression
Porsch, R. M., Middeldorp, C. M., Cherny, S. S., Krapohl, E. M. L., van Beijsterveldt, C. E. M., Loukola, A., Korhonen, T., Pulkkinen, L., Corley, R. P., Rhee, S. H., et al. (2016) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.32420 · Cited by 102 · see citing works
Klejman, M. E., Gruszczynska‐Biegala, J., Skibinska-Kijek, A., et al. (2008) · Neurochemistry International · doi:10.1016/j.neuint.2008.10.005 · Cited by 100 · see citing works
Bierman, K. L., Coie, J. D., Dodge, K. A., Greenberg, M. T., Lochman, J. E., McMahon, R. J., & Pinderhughes, E. E. (2013) · Aggressive Behavior · doi:10.1002/ab.21467 · Cited by 96 · see citing works
Goldstein, R. B., Prescott, C. A., & Kendler, K. S. (2001) · The Journal of Nervous and Mental Disease · doi:10.1097/00005053-200104000-00001 · Cited by 91 · see citing works
Rose, R. J., Dick, D. M., Viken, R. J., Pulkkinen, L., & Kaprio, J. A. (2004) · Alcoholism Clinical and Experimental Research · doi:10.1097/01.alc.0000141822.36776.55 · Cited by 88 · see citing works
Robustness of genome-wide scanning using archived dried blood spot samples as a DNA source
Hollegaard, M. V., Grove, J., Grauholm, J., Kreiner-Møller, E., Bønnelykke, K., Nørgaard, M., Benfield, T. L., Nørgaard-Pedersen, B., Mortensen, P. B., Mors, O., et al. (2011) · BMC Genetics · doi:10.1186/1471-2156-12-58 · Cited by 83 · see citing works
Self-citationPingault, J., Côté, S. M., Lacourse, É., Galéra, C., Vitaro, F., & Tremblay, R. E. (2013) · PLoS ONE · doi:10.1371/journal.pone.0062594 · Cited by 81 · see citing works
Christiansen, H., Chen, W., Oades, R. D., Asherson, P., Taylor, E. A., Lasky-Su, J., Zhou, K., Banaschewski, T., Buschgens, C., Franke, B., et al. (2008) · Journal of Neural Transmission · doi:10.1007/s00702-007-0837-y · Cited by 79 · see citing works
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Lee, P. H., Anttila, V., Won, H., Feng, Y. A., Rosenthal, J., Zhu, Z., Tucker–Drob, E. M., Nivard, M. G., Grotzinger, A. D., Posthuma, D., et al. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/528117 · Cited by 51 · see citing works
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Scott, J. G., Pedersen, M. G., Erskine, H. E., Bikic, A., Demontis, D., McGrath, J. J., & Dalsgaard, S. (2017) · Psychiatry Research · doi:10.1016/j.psychres.2017.02.029 · Cited by 36 · see citing works
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Research works printed but not linked: 1
- [74]Demontis, D. et al. Discovery of the first genome-wide significant risk loci for attention deficit/hyperactivity disorder. Nat. Genet.51, 63–75 (2018). PMC6481311 30478444
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- Authors
- Demontis, D., Walters, R. K., Rajagopal, V. M., Waldman, I. D., Grove, J., Als, T. D., Dalsgaard, S., Ribasés, M., Bybjerg-Grauholm, J., Bækvad-Hansen, M., Werge, T., Nordentoft, M., Mors, O., Mortensen, P. B., ADHD Working Group of the Psychiatric Genomics Consortium (PGC), Andreassen, O. A., Arranz, M. J., Banaschewski, T., Bau, C., Bellgrove, M., Biederman, J., Brikell, I., Buitelaar, J. K., Burton, C. L., Casas, M., Crosbie, J., Doyle, A. E., Ebstein, R. P., Elia, J., Elizabeth, C. C., Grevet, E., Grizenko, N., Havdahl, A., Hawi, Z., Hebebrand, J., Hervas, A., Hohmann, S., Haavik, J., Joober, R., Kent, L., Kuntsi, J., Langley, K., Larsson, H., Lesch, K.-P., Leung, P. W. L., Liao, C., Loo, S. K., Martin, J., Martin, N. G., Medland, S. E., Miranda, A., Mota, N. R., Oades, R. D., Ramos-Quiroga, J. A., Reif, A., Rietschel, M., Roeyers, H., Rohde, L. A., Rothenberger, A., Rovira, P., Sánchez-Mora, C., Schachar, R. J., Sengupta, S., Artigas, M. S., Steinhausen, H.-C., Thapar, A., Witt, S. H., Yang, L., Zayats, T., Zhang-James, Y., Cormand, B., Hougaard, D. M., Neale, B. M., Franke, B., Faraone, S. V., & Børglum, A. D.
- Affiliations
- Aarhus University (DK)
- Broad Institute (US)
- Emory University (US)
- Universitat Autònoma de Barcelona (ES)
- Statens Serum Institut (DK)
- University of Copenhagen (DK)
- Aarhus University Hospital (DK)
- Oslo University Hospital (NO)
- University Hospital Mútua de Terrassa (ES)
- Heidelberg University (DE)
- Universidade Federal do Rio Grande do Sul (BR)
- Monash University (AU)
- Harvard University (US)
- Karolinska Institutet (SE)
- Radboud University Medical Center (NL)
- University of Toronto (CA)
- Southwestern University of Finance and Economics (CN)
- Alfred I. duPont Hospital for Children (US)
- Douglas Mental Health University Institute (CA)
- Norwegian Institute of Public Health (NO)
- Essen University Hospital (DE)
- Haukeland University Hospital (NO)
- University of St Andrews (GB)
- King's College London (GB)
- Cardiff University (GB)
- Örebro University (SE)
- Sechenov University (RU)
- Chinese University of Hong Kong (HK)
- McGill University (CA)
- University of California, Los Angeles (US)
- QIMR Berghofer Medical Research Institute (AU)
- Universitat de València (ES)
- University of Duisburg-Essen (DE)
- University Hospital Frankfurt (DE)
- Ghent University (BE)
- Universitätsmedizin Göttingen (DE)
- Vall d'Hebron Hospital Universitari (ES)
- University of Southern Denmark (DK)
- Peking University Sixth Hospital (CN)
- University of Oslo (NO)
- Instituto de Salud Carlos III (ES)
- Radboud University Nijmegen (NL)
- SUNY Upstate Medical University (US)
- Corresponding author
- Demontis, Ditte
- Faraone, Stephen V.
- Børglum, Anders D.
- ORCID
- Demontis, Ditte
- Walters, Raymond K.
- Rajagopal, Veera M.
- Waldman, Irwin D.
- Grove, Jakob
- Als, Thomas D.
- Dalsgaard, Søren
- Ribasés, Marta
- Bybjerg-Grauholm, Jonas
- Werge, Thomas
- Nordentoft, Merete
- Mors, Ole
- Mortensen, Preben Bo
- Andreassen, Ole A.
- Arranz, Maria Jesús
- Banaschewski, Tobias
- Bau, Claiton
- Bellgrove, Mark
- Biederman, Joseph
- Brikell, Isabell
- Buitelaar, Jan K.
- Burton, Christie L.
- Casas, Miguel
- Crosbie, Jennifer
- Doyle, Alysa E.
- Ebstein, Richard P.
- Elia, Josephine
- Grevet, Eugenio
- Havdahl, Alexandra
- Hawi, Ziarih
- Hebebrand, Johannes
- Hohmann, Sarah
- Haavik, Jan
- Joober, Ridha
- Kent, Lindsey
- Kuntsi, Jonna
- Langley, Kate
- Larsson, Henrik
- Lesch, Klaus-Peter
- Leung, Patrick W. L.
- Liao, Calwing
- Loo, Sandra K.
- Martin, Joanna
- Martin, Nicholas G.
- Medland, Sarah E.
- Miranda, Ana
- Mota, Nina Roth
- Reif, Andreas
- Rietschel, Marcella
- Roeyers, Herbert
- Rothenberger, Aribert
- Rovira, Paula
- Schachar, Russell James
- Thapar, Anita
- Witt, Stephanie H.
- Yang, Li
- Zayats, Tetyana
- Cormand, Bru
- Hougaard, David M.
- Neale, Benjamin M.
- Franke, Barbara
- Faraone, Stephen V.
- Børglum, Anders D.
- Venue
- Nature Communications
- Published
- 2021-01-25
- Volume
- 12
- Issue
- 1
- Pages
- 1166-1166
- ISSN
- 2041-1723 (ISSN-L)
- PMC
- PMC7835232
- OpenAlex
- W3122992840
- Cited by
- 50
- References
- 93
- Citations by year
- 2026: 6 · 2025: 10 · 2024: 7 · 2023: 13 · 2022: 11 · 2021: 3
- FWCI
- 6.05
- Type
- journal article
- Language
- en
- Update notices
- correction (2021-02-15)
- Open access
- gold
- doi.org
- Locations
- Nature Communications (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Research at the University of Copenhagen (University of Copenhagen) (publishedVersion, cc-by)
- University of Southern Denmark Research Portal (University of Southern Denmark) (publishedVersion, cc-by)
- ORCA Online Research @Cardiff (Cardiff University) (acceptedVersion)
- Zurich Open Repository and Archive (University of Zurich) (acceptedVersion, cc-by)
- Radboud Repository (Radboud University) (submittedVersion)
- Lume (Universidade Federal do Rio Grande do Sul) (submittedVersion, cc-by-nc-sa)
- Radboud Repository (Radboud University) (submittedVersion, other-oa)
- RePEc: Research Papers in Economics (submittedVersion)
- Research Publications (Maastricht University) (submittedVersion, cc-by)
- Dipòsit Digital de Documents de la UAB (Universitat Autònoma de Barcelona) (submittedVersion, cc-by)
- Dipòsit Digital de la Universitat de Barcelona (Universitat de Barcelona) (submittedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- eScholarship (California Digital Library) (submittedVersion)
- eScholarship (California Digital Library) (submittedVersion, cc-by)
- Research Portal (King's College London) (submittedVersion, other-oa)
- GoeScholar The Publication Server of the Georg-August-Universität Göttingen (Georg-August-Universität Göttingen) (submittedVersion, cc-by)
- St Andrews Research Repository (St Andrews Research Repository) (submittedVersion, cc-by)
- SUNY Digital Repository Support (State University of New York System) (submittedVersion, cc-by-nc)
- SUNY Digital Repository Support (State University of New York System) (submittedVersion, cc-by-nc-nd)
- Zurich Open Repository and Archive (University of Zurich) (submittedVersion, cc-by)
- Zurich Open Repository and Archive (University of Zurich)
- Funders
- Eli Lilly and Company
- Pfizer
- American Academy of Child and Adolescent Psychiatry
- Sunovion
- National Alliance for Research on Schizophrenia and Depression (667302, 728018, 602805)
- University of St Andrews
- European Commission (2014‐2020, H2020 Program, EU-FP7, 728018, H2020/2014-2020, 667302, 092330/31, 602805)
- Generalitat de Catalunya (SLT006/17/287, 2017-SGR, PERIS SLT006, 2017/SGR738, 2017SGR1461)
- Ministerio de Economía y Competitividad (PI17/00289, PI16/, SAF2015-68341-R, PI15/01789, PI16/01505, RTI2018)
- Lundbeckfonden (R155-2014-1724, R302-2018-2155, R102‐A9118, R248‐2017‐2003, R165–2013–15320, R102-A9118, R155-2014-1724, and R248-2017-2003, R102-A9118, R155-2014-1724, and R248-2017-2003)
- Novo Nordisk
- Shire
- Helsefonden (19-8-0260)
- TrygFonden
- European College of Neuropsychopharmacology
- Novo Nordisk Fonden
- H. Lundbeck A/S (R102-A9118, R155-2014-1724, R248-2017-2003)
- National Institutes of Health (2014-2020)
- Genentech
- Horizon 2020 Framework Programme (H2020/2014–2020, 667302, 728018, R155-2014-1724, R248-2017-2003)
- Pfizer Pharmaceuticals
- Agència de Gestió d'Ajuts Universitaris i de Recerca (2017SGR1461, 2014-2020, 2017-SGR-738)
- Instituto de Salud Carlos III (PI16/, PI15/01789, 00023, PI17/00289, SLT006/17/287, PI16/01505, 728018, CP09/00119, CPII15/00023)
- European Regional Development Fund (2014-2020’, 667302, SLT006/17/287, RTI2018, 728018)
- National Institute of Mental Health (U01MH109539, U01MH109514)
- National Institute on Drug Abuse
- National Institute of Environmental Health Sciences (R01ES026993)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Keywords
- attention deficit hyperactivity disorder, disruptive behavior disorders, comorbidities, genetic risk variants, polygenic architecture, polygenic risk score, aggression, antisocial behavior, SNP heritability, genetic correlation, Chinese cohort
- MeSH terms
- Attention Deficit Disorder with Hyperactivity, Child, China, Europe, Female, Humans, Male, Risk Factors, Cohort Studies, Comorbidity, Attention Deficit and Disruptive Behavior Disorders, Genetic Predisposition to Disease, Multifactorial Inheritance, Polymorphism, Single Nucleotide, Genome-Wide Association Study
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