Genome‐wide analyses of aggressiveness in attention‐deficit hyperactivity disorder
Open accessAbstract
Aggressiveness is a behavioral trait that has the potential to be harmful to individuals and society. With an estimated heritability of about 40%, genetics is important in its development. We performed an exploratory genome‐wide association (GWA) analysis of childhood aggressiveness in attention deficit hyperactivity disorder (ADHD) to gain insight into the underlying biological processes associated with this trait. Our primary sample consisted of 1,060 adult ADHD patients (aADHD). To further explore the genetic architecture of childhood aggressiveness, we performed enrichment analyses of suggestive genome‐wide associations observed in aADHD among GWA signals of dimensions of oppositionality (defiant/vindictive and irritable dimensions) in childhood ADHD (cADHD). No single polymorphism reached genome‐wide significance (P < 5.00E‐08). The strongest signal in aADHD was observed at rs10826548, within a long noncoding RNA gene (beta = −1.66, standard error (SE) = 0.34, P = 1.07E‐06), closely followed by rs35974940 in the neurotrimin gene (beta = 3.23, SE = 0.67, P = 1.26E‐06). The top GWA SNPs observed in aADHD showed significant enrichment of signals from both the defiant/vindictive dimension (Fisher's P‐value = 2.28E‐06) and the irritable dimension in cADHD (Fisher's P‐value = 0.0061). In sum, our results identify a number of biologically interesting markers possibly underlying childhood aggressiveness and provide targets for further genetic exploration of aggressiveness across psychiatric disorders. © 2016 The Authors. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics Published by Wiley Periodicals, Inc.
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There were no genome-wide significant SNPs for either individual samples or meta-analysis.
“NS genome-wide SNPs for either individual samples or meta-analysis.”
From Genetics of child aggression, a systematic review (2024) · cites this paper as Brevik [112]
Top gene was WD repeat domain 62 (WDR62; p = 4.84e-5).
“Top gene WD repeat domain 62 (WDR62; p = 4.84e–5).”
From Genetics of child aggression, a systematic review (2024) · cites this paper as Brevik [112]
Top SNPs were rs10826548 in long noncoding RNA in chr 10 (beta = -1.66, se=0.34, p = 1.07e-6) and rs35974940 in neurotrimin (NTM) gene (beta=3.23, se=0.67, p = 1.26e-6).
“Top SNPs rs10826548 in long noncoding RNA in chr 10 (beta = –1.66, se=0.34, p = 1.07e–6), rs35974940 in neurotrimin (NTM) gene (beta=3.23, se=0.67, p = 1.26e–6).”
From Genetics of child aggression, a systematic review (2024) · cites this paper as Brevik [112]
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PLINK: a tool set for whole-genome association and population-based linkage analyses.
Purcell, S., Neale, B., Todd-Brown, K., Thomas, L., Ferreira, M. A. R., Bender, D., Maller, J., Sklar, P., de Bakker, P. I. W., Daly, M. J., et al. (2007) · The American Journal of Human Genetics · doi:10.1086/519795 · Cited by 34,089 · see citing works
GCTA: a tool for genome-wide complex trait analysis
Yang, J., Lee, S. H., Goddard, M. E., & Visscher, P. M. (2011) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2010.11.011 · Cited by 8,279 · see citing works
An integrated map of genetic variation from 1,092 human genomes
The 1000 Genomes Project Consortium (2012) · Nature · doi:10.1038/nature11632 · Cited by 7,711 · see citing works
Biological insights from 108 schizophrenia-associated genetic loci
Schizophrenia Working Group of the Psychiatric Genomics Consortium (2014) · Nature · doi:10.1038/nature13595 · Cited by 7,577 · see citing works
LD Score regression distinguishes confounding from polygenicity in genome-wide association studies
Schizophrenia Working Group of the Psychiatric Genomics Consortium, Bulik-Sullivan, B. K., Loh, P.-R., Finucane, H. K., Ripke, S., Yang, J., Patterson, N., Daly, M. J., Price, A. L., & Neale, B. M. (2015) · Nature Genetics · doi:10.1038/ng.3211 · Cited by 5,559 · see citing works
Achenbach, T. M., McConaughy, S. H., & Howell, C. T. (1987) · Psychological Bulletin · doi:10.1037/0033-2909.101.2.213 · Cited by 5,436 · see citing works
METAL: fast and efficient meta-analysis of genomewide association scans
Willer, C. J., Li, Y., & Abecasis, G. R. (2010) · Bioinformatics · doi:10.1093/bioinformatics/btq340 · Cited by 5,205 · see citing works
An atlas of genetic correlations across human diseases and traits
ReproGen Consortium, Bulik-Sullivan, B., Psychiatric Genomics Consortium, Genetic Consortium for Anorexia Nervosa of the Wellcome Trust Case Control Consortium 3, Finucane, H. K., Anttila, V., Gusev, A., Day, F. R., Loh, P.-R., Duncan, L., et al. (2015) · Nature Genetics · doi:10.1038/ng.3406 · Cited by 4,255 · see citing works
Howie, B. N., Donnelly, P., & Marchini, J. (2009) · PLoS Genetics · doi:10.1371/journal.pgen.1000529 · Cited by 3,928 · see citing works
Anderson, C. A., & Bushman, B. J. (2002) · Annual Review of Psychology · doi:10.1146/annurev.psych.53.100901.135231 · Cited by 3,915 · see citing works
MAGMA: Generalized Gene-Set Analysis of GWAS Data
de Leeuw, C. A., Mooij, J. M., Heskes, T., & Posthuma, D. (2015) · PLOS Computational Biology · doi:10.1371/journal.pcbi.1004219 · Cited by 3,653 · see citing works
Genomic Control for Association Studies
Devlin, B., & Roeder, K. (1999) · Biometrics · doi:10.1111/j.0006-341x.1999.00997.x · Cited by 3,162 · see citing works
Browning, S. R., & Browning, B. L. (2007) · The American Journal of Human Genetics · doi:10.1086/521987 · Cited by 3,138 · see citing works
(2013) · The Lancet · doi:10.1016/s0140-6736(12)62129-1 · Cited by 3,010 · see citing works
A new multipoint method for genome-wide association studies by imputation of genotypes
Marchini, J., Howie, B., Myers, S., McVean, G., & Donnelly, P. (2007) · Nature Genetics · doi:10.1038/ng2088 · Cited by 2,609 · see citing works
FARAONE, S. V., BIEDERMAN, J., & MICK, E. (2006) · Psychological Medicine · doi:10.1017/s003329170500471x · Cited by 2,267 · see citing works
Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs
Cross-Disorder Group of the Psychiatric Genomics Consortium (2013) · Nature Genetics · doi:10.1038/ng.2711 · Cited by 2,263 · see citing works
MaCH: using sequence and genotype data to estimate haplotypes and unobserved genotypes
Li, Y., Willer, C. J., Ding, J., Scheet, P., & Abecasis, G. R. (2010) · Genetic Epidemiology · doi:10.1002/gepi.20533 · Cited by 1,843 · see citing works
Conners, C. K., Sitarenios, G., Parker, J. D. A., & Epstein, J. N. (1998) · Journal of Abnormal Child Psychology · doi:10.1023/a:1022602400621 · Cited by 1,772 · see citing works
Attention-deficit/hyperactivity disorder
Faraone, S. V., Asherson, P., Banaschewski, T., Biederman, J., Buitelaar, J. K., Ramos-Quiroga, J. A., Rohde, L. A., Sonuga-Barke, E. J. S., Tannock, R., & Franke, B. (2015) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2015.20 · Cited by 1,479 · see citing works
Self-citation(1993) · American Journal of Psychiatry · doi:10.1176/ajp.150.6.885 · Cited by 1,421 · see citing works
Candidate gene studies of ADHD: a meta-analytic review
Gizer, I. R., Ficks, C., & Waldman, I. D. (2009) · Human Genetics · doi:10.1007/s00439-009-0694-x · Cited by 1,020 · see citing works
Genetic Heterogeneity in Human Disease
McClellan, J., & King, M.-C. (2010) · Cell · doi:10.1016/j.cell.2010.03.032 · Cited by 981 · see citing works
Common variants associated with plasma triglycerides and risk for coronary artery disease
Do, R., Willer, C. J., Schmidt, E. M., Sengupta, S., Gao, C., Peloso, G. M., Gustafsson, S., Kanoni, S., Ganna, A., Chen, J., et al. (2013) · Nature Genetics · doi:10.1038/ng.2795 · Cited by 862 · see citing works
Moffitt, T. E. (2005) · Psychological Bulletin · doi:10.1037/0033-2909.131.4.533 · Cited by 785 · see citing works
Biederman, J. (1992) · Archives of General Psychiatry · doi:10.1001/archpsyc.1992.01820090056010 · Cited by 771 · see citing works
Lindgren, C. M., Heid, I. M., Randall, J. C., Lamina, C., Steinthórsdóttir, V., Qi, L., Speliotes, E. K., Þorleifsson, G., Willer, C. J., Herrera, B. M., et al. (2009) · PLoS Genetics · doi:10.1371/journal.pgen.1000508 · Cited by 701 · see citing works
Hunter, D. J., Peltonen, L., Guiducci, C., Crawford, G., Hirschhorn, J. N., Lyon, H. N., & Speliotes, E. K. (2009) · DSpace@MIT (Massachusetts Institute of Technology) · Cited by 687 · see citing works
Moffitt, T. E., Houts, R., Asherson, P., Belsky, D. W., Corcoran, D. L., Hammerle, M., Harrington, H., Hogan, S., Meier, M. H., Polanczyk, G. V., et al. (2015) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2015.14101266 · Cited by 618 · see citing works
Brookes, K., Xu, X., Chen, W., Zhou, K., Neale, B., Lowe, N., Aneey, R., Franke, B., Gill, M., Ebstein, R., et al. (2006) · Molecular Psychiatry · doi:10.1038/sj.mp.4001869 · Cited by 533 · see citing works
Self-citationGenetic and environmental architecture on human aggression.
Miles, D. R., & Carey, G. (1997) · Journal of Personality and Social Psychology · doi:10.1037//0022-3514.72.1.207 · Cited by 490 · see citing works
Genetic and environmental architecture on human aggression.
Miles, D. R., & Carey, G. (1997) · Journal of Personality and Social Psychology · doi:10.1037/0022-3514.72.1.207 · Cited by 414 · see citing works
Ramírez, J. M., & Andreu, J. M. (2005) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2005.04.015 · Cited by 371 · see citing works
Larsson, H., Chang, Z., D'Onofrio, B. M., & Lichtenstein, P. (2014) · Psychological Medicine · doi:10.1017/s0033291713002493 · Cited by 364 · see citing works
Differential Heritability of Adult and Juvenile Antisocial Traits
Lyons, M. J. (1995) · Archives of General Psychiatry · doi:10.1001/archpsyc.1995.03950230020005 · Cited by 333 · see citing works
Halmøy, A., Fasmer, O. B., Gillberg, C., & Haavik, J. (2009) · Journal of Attention Disorders · doi:10.1177/1087054708329777 · Cited by 317 · see citing works
Self-citationYoung, S., Moss, D., Sedgwick, O., Fridman, M., & Hodgkins, P. (2015) · Psychological Medicine · doi:10.1017/s0033291714000762 · Cited by 291 · see citing works
Genome-wide Association Scan of Attention Deficit Hyperactivity Disorder
Neale, B., Su, J., Anney, R., Franke, B., Zhou, K., Maller, J., Vásquez, A., Asherson, P., Chen, W., Banaschewski, T., et al. (2008) · American Journal of Medical Genetics Part B: Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30866 · Cited by 288 · see citing works
Self-citationAdolescent Irritability: Phenotypic Associations and Genetic Links With Depressed Mood
Stringaris, A. K., Zavos, H. M. S., Leibenluft, E., Maughan, B., & Eley, T. C. (2011) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2011.10101549 · Cited by 273 · see citing works
A review of effective interventions for reducing aggression and violence
McGuire, J. (2008) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2008.0035 · Cited by 234 · see citing works
Vassos, E., Collier, D. A., & Fazel, S. (2014) · Molecular Psychiatry · doi:10.1038/mp.2013.31 · Cited by 234 · cited 2× · see citing works
“Thus, the overall genetic architecture of ADHD and/or aggression remains largely unknown and warrants studies using a hypothesis-free approach [Vassos et al., 2014].”
Genetic background of extreme violent behavior
Tiihonen, J., Rautiainen, M.-R., Ollila, H. M., Repo‐Tiihonen, E., Virkkunen, M. E., Palotie, A. V., Pietiläinen, O. P. H., Kristiansson, K., Joukamaa, M. I., Lauerma, H., et al. (2014) · Molecular Psychiatry · doi:10.1038/mp.2014.130 · Cited by 220 · see citing works
Adult ADHD and its comorbidities, with a focus on bipolar disorder
Klassen, L. J., Katzman, M. A., & Chokka, P. (2010) · Journal of Affective Disorders · doi:10.1016/j.jad.2009.06.036 · Cited by 205 · see citing works
Etiology of the impulsivity/aggression relationship: Genes or environment?
Seroczynski, A. D., Bergeman, C. S., & Coccaro, E. F. (1999) · Psychiatry Research · doi:10.1016/s0165-1781(99)00013-x · Cited by 195 · see citing works
Franke, B., Vasquez, A. A., Johansson, S., Hoogman, M., Romanos, J., Boreatti-Hümmer, A., Heine, M., Jacob, C. P., Lesch, K.-P., Casas, M., et al. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2009.170 · Cited by 183 · see citing works
Self-citationDalsgaard, S., Mortensen, P. B., Frydenberg, M., & Thomsen, P. H. (2002) · British Journal of Psychiatry · doi:10.1192/bjp.181.5.416 · Cited by 172 · see citing works
Influence of Functional Variant of Neuronal Nitric Oxide Synthase on Impulsive Behaviors in Humans
Reif, A., Jacob, C., Rujescu, D., Herterich, S., Lang, S., Gutknecht, L., Baehne, C. G., Strobel, A., Freitag, C. M., Giegling, I., et al. (2009) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2008.510 · Cited by 149 · see citing works
Self-citationGenetics of aggressive behavior: An overview
Veroude, K., Zhang‐James, Y., Fernàndez‐Castillo, N., Bakker, M. J., Cormand, B., & Faraone, S. V. (2016) · American Journal of Medical Genetics Part B: Neuropsychiatric Genetics · doi:10.1002/ajmg.b.32364 · Cited by 147 · see citing works
Self-citationLesch, K., Araragi, N., Waider, J., van den Hove, D., & Gutknecht, L. (2012) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2012.0039 · Cited by 147 · see citing works
Self-citationHigh Loading of Polygenic Risk for ADHD in Children With Comorbid Aggression
Hamshere, M. L., Langley, K., Martin, J., Agha, S. S., Stergiakouli, E., Anney, R. J. L., Buitelaar, J., Faraone, S. V., Lesch, K.-P., Neale, B. M., et al. (2013) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2013.12081129 · Cited by 144 · see citing works
Self-citationA family-genetic study of girls with DSM-III attention deficit disorder
Faraone, S. V., Biederman, J., Keenan, K. E., & Tsuang, M. T. (1991) · American Journal of Psychiatry · doi:10.1176/ajp.148.1.112 · Cited by 142 · see citing works
Struyk, A., Canoll, P., Wolfgang, M., Rosen, C., D'Eustachio, P., & Salzer, J. (1995) · The Journal of Neuroscience · doi:10.1523/jneurosci.15-03-02141.1995 · Cited by 142 · see citing works
Human Aggression Across the Lifespan
Tuvblad, C., & Baker, L. A. (2011) · Advances in Genetics · doi:10.1016/b978-0-12-380858-5.00007-1 · Cited by 139 · cited 1× · see citing works
“Th Att and cite Gra Gra He Sev Gra 602 643 Gra Gr Az. Spa SAF RESEARCH ARTICLE Neuropsychiatric Genetics”
Anney, R., Lasky-Su, J., O'Dushlaine, C., Kenny, E., Neale, B., Mulligan, A., Franke, B., Zhou, K., Chen, W., Christiansen, H., et al. (2008) · American Journal of Medical Genetics Part B: Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30871 · Cited by 135 · see citing works
Self-citationTuvblad, C., Zheng, M., Raine, A., & Baker, L. A. (2009) · Journal of Abnormal Child Psychology · doi:10.1007/s10802-008-9278-9 · Cited by 134 · see citing works
Examining genetic and environmental effects on reactive versus proactive aggression.
Brendgen, M. R., Vitaro, F., Boivin, M., Dionne, G., & Pérusse, D. (2006) · Developmental Psychology · doi:10.1037/0012-1649.42.6.1299 · Cited by 112 · see citing works
Genome-wide association study of conduct disorder symptomatology
Dick, D. M., Aliev, F., Krueger, R. F., Edwards, A., Agrawal, A., Lynskey, M., Lin, P., Schuckit, M., Hesselbrock, V, Nurnberger, J., et al. (2011) · Molecular Psychiatry · doi:10.1038/mp.2010.73 · Cited by 111 · see citing works
Müller, U., Asherson, P., Banaschewski, T., Buitelaar, J., Ebstein, R., Eisenberg, J., Gill, M., Manor, I., Miranda, A., Oades, R., et al. (2011) · BMC Psychiatry · doi:10.1186/1471-244x-11-54 · Cited by 111 · see citing works
Long ncRNA expression associates with tissue-specific enhancers
Vučićević, D., Corradin, O., Ntini, E., Scacheri, P. C., & Ørom, U. A. (2015) · Cell Cycle · doi:10.4161/15384101.2014.977641 · Cited by 110 · see citing works
Tsuchida, A., Okajima, T., Furukawa, K., Ando, T., Ishida, H., Yoshida, A., Nakamura, Y., Kannagi, R., Kiso, M., & Furukawa, K. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m211034200 · Cited by 107 · see citing works
Perkins, D. O., Jeffries, C. D., & Sullivan, P. (2004) · Molecular Psychiatry · doi:10.1038/sj.mp.4001577 · Cited by 103 · see citing works
The Association Between ADHD and Antisocial Personality Disorder (ASPD)
Storebø, O. J., & Simonsen, E. (2016) · Journal of Attention Disorders · doi:10.1177/1087054713512150 · Cited by 100 · see citing works
Hofvander, B., Ossowski, D., Lundström, S., & Anckarsäter, H. (2009) · International Journal of Law and Psychiatry · doi:10.1016/j.ijlp.2009.04.004 · Cited by 97 · see citing works
Unraveling the Genetic Etiology of Adult Antisocial Behavior: A Genome-Wide Association Study
Tielbeek, J. J., Medland, S. E., Benyamin, B., Byrne, E. M., Heath, A. C., Madden, P. A. F., Martin, N. G., Wray, N. R., & Verweij, K. J. H. (2012) · PLoS ONE · doi:10.1371/journal.pone.0045086 · Cited by 86 · see citing works
Rahmioglu, N., Macgregor, S., Drong, A. W., Hedman, A. K., Harris, H. R., Randall, J. C., Prokopenko, I., The International Endogene Consortium (IEC), T. G. C., Nyholt, D. R., Morris, A. P., et al. (2015) · Human Molecular Genetics · doi:10.1093/hmg/ddu516 · Cited by 85 · see citing works
Genome-wide analysis of attention deficit hyperactivity disorder in Norway
Zayats, T., Athanasiu, L., Sonderby, I., Djurovic, S., Westlye, L. T., Tamnes, C. K., Fladby, T., Aase, H., Zeiner, P., Reichborn-Kjennerud, T., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0122501 · Cited by 83 · see citing works
Self-citationAebi, M., Plattner, B., Metzke, C. W., Bessler, C., & Steinhausen, H. (2013) · Journal of Child Psychology and Psychiatry · doi:10.1111/jcpp.12039 · Cited by 79 · see citing works
Self-citationJain, M., Palacio, L. G., Castellanos, F. X., Palacio, J. D., Pineda, D. A., Restrepo, M. I., Muñoz, J. F., Lopera, F. J., WALLIS, D. E., Berg, K. A., et al. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.06.026 · Cited by 77 · see citing works
Sánchez-Mora, C., Ramos-Quiroga, J., Bosch, R., Corrales, M., Garcia-Martínez, I., Nogueira, M., Pagerols, M., Palomar, G., Richarte, V., Vidal, R., et al. (2015) · Neuropsychopharmacology · doi:10.1038/npp.2014.267 · Cited by 69 · see citing works
Self-citationGuldberg-Kjär, T., & Johansson, B. (2009) · Nordic Journal of Psychiatry · doi:10.1080/08039480902818238 · Cited by 66 · see citing works
LincSNP: a database of linking disease-associated SNPs to human large intergenic non-coding RNAs
Ning, S., Zhao, Z., Ye, J., Wang, P., Zhi, H., Li, R., Wang, T., & Li, X. (2014) · BMC Bioinformatics · doi:10.1186/1471-2105-15-152 · Cited by 61 · see citing works
Aggression proneness: Transdiagnostic processes involving negative valence and cognitive systems
Verona, E., & Bresin, K. (2015) · International Journal of Psychophysiology · doi:10.1016/j.ijpsycho.2015.03.008 · Cited by 57 · see citing works
Halmøy, A., Johansson, S., Winge, I., McKinney, J. A., Knappskog, P. M., & Haavik, J. (2010) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2010.124 · Cited by 56 · see citing works
Self-citationMüller, U. C., Asherson, P. J., Banaschewski, T., Buitelaar, J. K., Ebstein, R. P., Eisenberg, J., Gill, M., Manor, I., Miranda, A., Oades, R. D., et al. (2011) · BMC Psychiatry · doi:10.1186/1471-244x-11-55 · Cited by 49 · see citing works
Genome-Wide Association Study of Proneness to Anger
Mick, E. O., McGough, J. J., Deutsch, C. K., Frazier, J. A., Kennedy, D. N., & Goldberg, R. J. (2014) · PLoS ONE · doi:10.1371/journal.pone.0087257 · Cited by 46 · see citing works
Aebi, M., van Donkelaar, M. M. J., Poelmans, G., Buitelaar, J. K., Sonuga-Barke, E. J. S., Stringaris, A. K., Faraone, S. V., Franke, B., Steinhausen, H., & van Hulzen, K. J. E. (2015) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.32346 · Cited by 45 · see citing works
Self-citationMcKinney, J. A., Johansson, S., Halmøy, A., Dramsdahl, M., Winge, I., Knappskog, P. M., & Haavik, J. (2008) · Molecular Psychiatry · doi:10.1038/sj.mp.4002152 · Cited by 43 · see citing works
Self-citationSalvatore, J. E., Edwards, A. C., McClintick, J. N., Bigdeli, T. B., Adkins, A., Aliev, F., Edenberg, H. J., Foroud, T., Hesselbrock, V, Kramer, J., et al. (2015) · Translational Psychiatry · doi:10.1038/tp.2015.36 · Cited by 42 · see citing works
LocusTrack: Integrated visualization of GWAS results and genomic annotation
Cuéllar-Partida, G., Rentería, M. E., & MacGregor, S. (2015) · Source Code for Biology and Medicine · doi:10.1186/s13029-015-0032-8 · Cited by 39 · see citing works
González‐Giraldo, Y., Camargo, A., López‐León, S., Adán, A., & Forero, D. A. (2015) · European Psychiatry · doi:10.1016/j.eurpsy.2015.03.002 · Cited by 20 · see citing works
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Fairchild, G. F., Hawes, D. J., Frick, P. J., Copeland, W., Odgers, C. L., Franke, B., Freitag, C. M., & Brito, S. A. D. (2019) · Nature Reviews Disease Primers · doi:10.1038/s41572-019-0095-y · Cited by 426 · see citing works
Self-citationReduced microbiome alpha diversity in young patients with ADHD
Prehn‐Kristensen, A., Zimmermann, A., Tittmann, L., Lieb, W., Schreiber, S., Baving, L., & Fischer, A. (2018) · PLoS ONE · doi:10.1371/journal.pone.0200728 · Cited by 295 · see citing works
An integrated analysis of genes and functional pathways for aggression in human and rodent models
Zhang-James, Y., Fernàndez-Castillo, N., Hess, J. L., Malki, K., Glatt, S. J., Cormand, B., & Faraone, S. V. (2019) · Molecular Psychiatry · doi:10.1038/s41380-018-0068-7 · Cited by 98 · see citing works
Self-citationNeural Glycosylphosphatidylinositol-Anchored Proteins in Synaptic Specification
Um, J. W., & Ko, J. (2017) · Trends in Cell Biology · doi:10.1016/j.tcb.2017.06.007 · Cited by 92 · see citing works
Ranaivoson, F. M., Turk, L. S., Ozgul, S., Kakehi, S., von Daake, S., Lopez, N., Trobiani, L., Jaco, A. D., Denissova, N. G., Demeler, B., et al. (2019) · Structure · doi:10.1016/j.str.2019.03.004 · Cited by 59 · see citing works
Pothion, H., Jehan, C., Tostivint, H., Cartier, D., Bucharles, C., Falluel‐Morel, A., Boukhzar, L., Anouar, Y., & Lihrmann, I. (2020) · Antioxidants and Redox Signaling · doi:10.1089/ars.2019.7931 · Cited by 57 · see citing works
Demontis, D., Walters, R. K., Rajagopal, V. M., Waldman, I. D., Grove, J., Als, T. D., Dalsgaard, S., Ribasés, M., Bybjerg-Grauholm, J., Bækvad-Hansen, M., et al. (2021) · Nature Communications · doi:10.1038/s41467-020-20443-2 · Cited by 50 · see citing works
Self-citationOdintsova, V. V., Roetman, P. J., Ip, H. F., Pool, R., van der Laan, C. M., Tona, K., Vermeiren, R. R. J. M., & Boomsma, D. I. (2019) · Psychiatric Genetics · doi:10.1097/ypg.0000000000000239 · Cited by 44 · see citing works
Tan, R., Leshchyns’ka, I., & Sytnyk, V. (2017) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2017.00378 · Cited by 42 · see citing works
Manchia, M., & Fanos, V. (2017) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2017.03.024 · Cited by 42 · see citing works
Common protein-coding variants influence the racing phenotype in galloping racehorse breeds
Han, H., McGivney, B. A., Allen, L., Bai, D., Corduff, L. R., Davaakhuu, G., Davaasambuu, J., Dorjgotov, D., Hall, T. J., Hemmings, A., et al. (2022) · Communications Biology · doi:10.1038/s42003-022-04206-x · Cited by 37 · see citing works
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Koyama, E., Kant, T., Takata, A., Kennedy, J. L., & Zai, C. C. (2024) · Translational Psychiatry · doi:10.1038/s41398-024-02870-7 · Cited by 33 · see citing works
Liau, W., Samaddar, S., Banerjee, S., & Bredy, T. W. (2021) · RNA Biology · doi:10.1080/15476286.2020.1868165 · Cited by 27 · see citing works
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McGivney, B. A., Hernández, B., Katz, L. M., MacHugh, D. E., McGovern, S. P., Parnell, A. C., Wiencko, H. L., & Hill, E. W. (2019) · Animal Genetics · doi:10.1111/age.12798 · Cited by 31 · see citing works
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Koyama, E., Zai, C. C. H., Bryushkova, L., Kennedy, J. L., & Beitchman, J. H. (2019) · Psychiatry Research · doi:10.1016/j.psychres.2019.112726 · Cited by 32 · see citing works
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Salluzzo, M., Vianello, C., Abdullatef, S., Rimondini, R., Piccoli, G., & Carboni, L. (2023) · Genes · doi:10.3390/genes14101886 · Cited by 29 · see citing works
Varlamova, E. G., Goltyaev, M. V., & Turovsky, E. A. (2022) · Biology · doi:10.3390/biology11060811 · Cited by 28 · see citing works
Deep learning model reveals potential risk genes for ADHD, especially Ephrin receptor gene EPHA5
Liu, L., Feng, X., Li, H., Li, S. C., Qian, Q., & Wang, Y. (2021) · Briefings in Bioinformatics · doi:10.1093/bib/bbab207 · Cited by 27 · see citing works
Gonda, X., Eszlári, N., Török, D., Gál, Z., Bokor, J., Millinghoffer, A., Baksa, D., Petschner, P., Antal, P., Breen, G. D., et al. (2021) · Translational Psychiatry · doi:10.1038/s41398-021-01436-1 · Cited by 19 · see citing works
The genetics of aggression: Where are we now?
Asherson, P. J., & Cormand, B. (2016) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.32450 · Cited by 17 · see citing works
Self-citationRare copy number variation in extremely impulsively violent males
Vevera, J., Zarrei, M., Hartmannová, H., Jedličková, I., Mušálková, D., Přistoupilová, A., Oliveriusová, P., Trešlová, H., Nosková, L., Hodaňová, K., et al. (2019) · Genes, Brain and Behavior · doi:10.1111/gbb.12536 · Cited by 15 · see citing works
Bogari, N. M., Al-Allaf, F. A., Aljohani, A., Taher, M. M., Qutub, N. A., Alhelfawi, S., Alobaidi, A., Alqudah, D., Banni, H., Dairi, G., et al. (2020) · Frontiers in Genetics · doi:10.3389/fgene.2020.548559 · Cited by 15 · see citing works
Veenstra, J., Kalsbeek, A., Westra, J., Disselkoen, C., Smith, C. E., & Tintle, N. (2017) · Nutrients · doi:10.3390/nu9080900 · Cited by 15 · see citing works
Smeijers, D., Bulten, E., Franke, B., Buitelaar, J. K., & Verkes, R. (2017) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2017.06.016 · Cited by 15 · see citing works
Self-citationIntegrative genomics analysis highlights functionally relevant genes for equine behaviour
Holtby, A. R., Hall, T. J., McGivney, B. A., Han, H., Murphy, K. J., MacHugh, D. E., Katz, L. M., & Hill, E. W. (2023) · Animal Genetics · doi:10.1111/age.13320 · Cited by 13 · see citing works
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Gmel, A. I., Mikko, S., Ricard, A., Velie, B. D., Gerber, V., Hamilton, N. A., & Neuditschko, M. (2024) · Genetics Selection Evolution · doi:10.1186/s12711-024-00922-6 · Cited by 12 · see citing works
O’Leary, A., Laas, K., Vaht, M., Kiive, E., Veidebaum, T., Reif, A., & Harro, J. (2019) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2019.07.241 · Cited by 10 · see citing works
Self-citationGenome-wide DNA methylation profiles of autism spectrum disorder
Sun, L., Wang, X., Wang, X., Cui, X., Li, G., Wang, L., Wang, L., Song, M., & Yu, L. (2022) · Psychiatric Genetics · doi:10.1097/ypg.0000000000000314 · Cited by 9 · see citing works
Aggressiveness in Italian Children with ADHD: MAOA Gene Polymorphism Involvement
Neri, L., Marziani, B., Sebastiani, P., Beato, T. D., Colanardi, A., Legge, M. P., & Aureli, A. (2024) · Diseases · doi:10.3390/diseases12040070 · Cited by 7 · see citing works
Smajlagić, D., Jacobsen, K. K., Myrum, C., Haavik, J., Johansson, S., & Zayats, T. (2018) · Brain and Behavior · doi:10.1002/brb3.1144 · Cited by 7 · see citing works
Self-citationDemontis, D., Walters, R., Rajagopal, V., Waldman, I., Grove, J., Als, T., Dalsgaard, S., Ribasés, M., Grauholm, J., Bækvad-Hansen, M., et al. (2019) · bioRxiv · doi:10.1101/791160 · Cited by 6 · see citing works
Self-citationGenetics and epigenetics of human aggression
Odintsova, V. V., Hagenbeek, F. A., van der Laan, C. M., van de Weijer, S. G. A., & Boomsma, D. I. (2023) · Handbook of clinical neurology · doi:10.1016/b978-0-12-821375-9.00005-0 · Cited by 11 · see citing works
Molecular genetic approaches to understanding the comorbidity of psychiatric disorders
Gizer, I. R. (2016) · Development and Psychopathology · doi:10.1017/s0954579416000717 · Cited by 7 · see citing works
Recent advances in genetics of aggressive behavior
Davydova, Y. D., Litvinov, S., Enikeeva, R. F., Malykh, S. B., & Хуснутдинова, Э. К. (2018) · Vavilov Journal of Genetics and Breeding · doi:10.18699/vj18.415 · Cited by 6 · see citing works
Behavioral Genetics of Aggression and Intermittent Explosive Disorder
Tuvblad, C., Sild, M., Frogner, L., & Booij, L. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-813858-8.00002-4 · Cited by 5 · see citing works
Recursive splicing is a rare event in the mouse brain
Moon, S., & Zhao, Y.-T. (2022) · PLoS ONE · doi:10.1371/journal.pone.0263082 · Cited by 4 · see citing works
Genome-wide association study of aggression and violence in schizophrenia
Bani‐Fatemi, A., Roy, A., Dai, N., Dada, O. O., Adanty, C., Kiruparajah, L., Kolla, N. J., Strauss, J., Zai, C. C. H., Graff, A., et al. (2020) · Neuroscience Letters · doi:10.1016/j.neulet.2020.135061 · Cited by 4 · see citing works
Neue Studien zu ADHS im Erwachsenenalter
Roll, S. C., & Hahn, M. (2015) · DNP - Der Neurologe und Psychiater · doi:10.1007/s15202-015-0638-3 · Cited by 3 · see citing works
A case report of microcephaly and refractory West syndrome associated with WDR62 mutation
Zhou, P., Ding, X., Zeng, Q., Zou, H., Liao, J., & Cao, D. (2020) · Acta Epileptologica · doi:10.1186/s42494-020-00012-2 · Cited by 3 · see citing works
Heritability and genetic contribution analysis of structural-functional coupling in human brain
Dai, W., Zhang, Z., Song, P., Heping Zhang, D., & Zhao, Y. (2024) · Imaging Neuroscience · doi:10.1162/imag_a_00346 · Cited by 2 · see citing works
Genetics of impulsivity, anger, and aggression as risk factors for suicidal behavior
Rujescu, D., & Giegling, I. (2019) · Oxford University Press eBooks · doi:10.1093/oso/9780198793014.003.0023
Media violance and how it`s impact on audience
Nazarova, I. V. (2021) · Век информации (сетевое издание) · doi:10.33941/age-info.com54(17)1
Neue Studien zu ADHS im Erwachsenenalter
Roll, S. C., & Hahn, M. (2018) · DNP - Der Neurologe und Psychiater · doi:10.1007/s15202-018-2087-2
Gmel, A. I., Mikko, S., Ricard, A., Velie, B. D., Gerber, V., Hamilton, N. A., & Neuditschko, M. (2024) · Figshare · doi:10.6084/m9.figshare.26747804
Gmel, A. I., Mikko, S., Ricard, A., Velie, B. D., Gerber, V., Hamilton, N. A., & Neuditschko, M. (2024) · Figshare · doi:10.6084/m9.figshare.26747792
Gmel, A. I., Mikko, S., Ricard, A., Velie, B. D., Gerber, V., Hamilton, N. A., & Neuditschko, M. (2024) · Figshare · doi:10.6084/m9.figshare.26747807
Gmel, A. I., Mikko, S., Ricard, A., Velie, B. D., Gerber, V., Hamilton, N. A., & Neuditschko, M. (2024) · Figshare · doi:10.6084/m9.figshare.26747795
Gmel, A. I., Mikko, S., Ricard, A., Velie, B. D., Gerber, V., Hamilton, N. A., & Neuditschko, M. (2024) · Figshare · doi:10.6084/m9.figshare.26747813
Gmel, A. I., Mikko, S., Ricard, A., Velie, B. D., Gerber, V., Hamilton, N. A., & Neuditschko, M. (2024) · Figshare · doi:10.6084/m9.figshare.26747801
Gmel, A. I., Mikko, S., Ricard, A., Velie, B. D., Gerber, V., Hamilton, N. A., & Neuditschko, M. (2024) · Figshare · doi:10.6084/m9.figshare.26747789
Gmel, A. I., Mikko, S., Ricard, A., Velie, B. D., Gerber, V., Hamilton, N. A., & Neuditschko, M. (2024) · Figshare · doi:10.6084/m9.figshare.26747798
Gmel, A. I., Mikko, S., Ricard, A., Velie, B. D., Gerber, V., Hamilton, N. A., & Neuditschko, M. (2024) · Figshare · doi:10.6084/m9.figshare.26241345
Gmel, A. I., Mikko, S., Ricard, A., Velie, B. D., Gerber, V., Hamilton, N. A., & Neuditschko, M. (2024) · Figshare · doi:10.6084/m9.figshare.26241154
Gmel, A. I., Mikko, S., Ricard, A., Velie, B. D., Gerber, V., Hamilton, N. A., & Neuditschko, M. (2024) · Figshare · doi:10.6084/m9.figshare.26747786
Gmel, A. I., Mikko, S., Ricard, A., Velie, B. D., Gerber, V., Hamilton, N. A., & Neuditschko, M. (2024) · Figshare · doi:10.6084/m9.figshare.26747810
Palumbo, S., Grassi, G., Mariotti, V., & Pellegrini, S. (2025) · Aggression and Violent Behavior · doi:10.1016/j.avb.2025.102096
Mikheim, K., Nazarova, M., Kuuskmäe, C., Kase, M., Kaare, M., Oja, E.-M., Bregin, A., Mohammadrahimi, N., Mitt, M., Heinla, I., et al. (2026) · SSRN Electronic Journal · doi:10.2139/ssrn.7488951
- Authors
- Brevik, E. J., van Donkelaar, M. M. J., Weber, H., Sánchez‐Mora, C., Jacob, C., Rivero, O., Kittel‐Schneider, S., Garcia‐Martínez, I., Aebi, M., van Hulzen, K., Cormand, B., Ramos‐Quiroga, J. A., IMAGE Consortium, Lesch, K., Reif, A., Ribasés, M., Franke, B., Posserud, M., Johansson, S., Lundervold, A. J., Haavik, J., & Zayats, T.
- Affiliations
- Haukeland University Hospital (NO)
- Department of Human Genetics Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center Nijmegen The Netherlands
- Goethe University Frankfurt (DE)
- Universitat Autònoma de Barcelona (ES)
- Department of Psychiatry and Psychotherapy Klinik Nürtingen Nürtingen Germany
- University of Würzburg (DE)
- Psychiatric Genetics Unit, Vall d'Hebron Research Institute (VHIR) Universitat Autònoma de Barcelona Barcelona Spain
- University of Zurich (CH)
- Centre for Biomedical Network Research on Rare Diseases (ES)
- Maastricht University (NL)
- Radboud University Nijmegen (NL)
- University of Bergen (NO)
- Corresponding author
- Brevik, Erlend J.
- Zayats, Tetyana
- ORCID
- Venue
- American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
- Publisher
- Wiley
- Published
- 2016-03-29
- Volume
- 171
- Issue
- 5
- Pages
- 733-747
- ISSN
- 1552-4841 (ISSN-L)
- 1552-485X
- PMC
- PMC5071721
- OpenAlex
- W2332741616
- Cited by
- 57
- References
- 80
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 16 · 2023: 3 · 2022: 4 · 2021: 5 · 2020: 4 · 2019: 9 · 2018: 6 · 2017: 5 · 2016: 2 · 2015: 1
- FWCI
- 6.52
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- American Journal of Medical Genetics Part B Neuropsychiatric Genetics (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Zurich Open Repository and Archive (University of Zurich) (acceptedVersion, cc-by-nc)
- Dipòsit Digital de Documents de la UAB (Universitat Autònoma de Barcelona) (submittedVersion, cc-by-nc)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (submittedVersion, cc-by-nc)
- Radboud Repository (Radboud University) (submittedVersion)
- NORA - Norwegian Open Research Archives (submittedVersion, cc-by-nc)
- Research Publications (Maastricht University) (submittedVersion, cc-by-nc)
- Online Publication Service of Würzburg University (Würzburg University) (submittedVersion, cc-by-nc)
- Zurich Open Repository and Archive (University of Zurich) (submittedVersion, cc-by-nc)
- Radboud Repository (Radboud University) (submittedVersion, other-oa)
- Research Publications (Maastricht University) (submittedVersion, other-oa)
- Zurich Open Repository and Archive (University of Zurich)
- Funders
- University of Bergen
- Deutsche Forschungsgemeinschaft (DFG: KFO 125, TRR 58/A5, DFG RE1632/5‐1)
- Fritz Thyssen Stiftung (Az.10.13.1185)
- Jacobs Foundation
- AGAUR (2014SGR932)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- attention deficit hyperactivity disorder, adult ADHD, oppositional behavior, long non-coding RNA, genetic architecture
- MeSH terms
- Adolescent, Adult, Aggression, Attention Deficit Disorder with Hyperactivity, Child, Female, Humans, Male, Genetic Predisposition to Disease, Polymorphism, Single Nucleotide, Genome-Wide Association Study
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