Autism recurrence in half siblings: strong support for genetic mechanisms of transmission in ASD
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Only few earlier studies have had the possibility to calculate the relative recurrence risk.
“Only few earlier studies have had the possibility to calculate the RR8,27,28.”
From The Familial Risk of Autism (2014) · cites this paper as [8]
Two earlier studies presented self-selected samples and limited family data.
“Two studies are presenting self-selected samples8,28 and with limited family data.”
From The Familial Risk of Autism (2014) · cites this paper as [8]
The overrepresentation of high-risk siblings in latent classes with subtly disturbed functioning is consonant with genetic models of autism spectrum disorder that encompass transmission of subclinical manifestations in a subset of first-degree relatives.
“The overrepresentation of HR siblings among latent classes characterized by subtly disturbed levels of functioning is consonant with genetic models of ASD that encompass the transmission of subclinical manifestations of the autistic syndrome in a subset of first-degree relatives, on the basis of either incomplete penetrance or additive (multigenic) models of inheritance.39–41”
From Beyond Autism: A Baby Siblings Research Consortium Study of High-Risk Children at Three Years of Age (2013) · cites this paper as [41]
Earlier population studies indicated importance of shared maternal bloodline in sibling risk.
“Earlier population studies have indicated the importance of a shared maternal bloodline in sibling risk (19,20).”
From Low load for disruptive mutations in autism genes and their biased transmission (2015) · cites this paper as [19]
Enhanced anandamide signaling can curb the effects of chronic stress, possibly by maintaining normal amygdala function via extinction-driven reductions in fear resulting in improved stress-reactivity in humans.
“as emerging data have revealed that enhanced anandamide signaling can curb the effects of chronic stress, possibly by maintaining normal amygdala function64 via extinction-driven reductions in fear resulting in improved stress-reactivity in humans10.”
From Elevated brain cannabinoid CB1 receptor availability in post-traumatic stress disorder: A positron emission tomography study (2013) · cites this paper as [64]
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- Authors
- Constantino, J. N., Todorov, A., Hilton, C., Law, P., Zhang, Y., Molloy, E., Fitzgerald, R., & Geschwind, D.
- Affiliations
- Washington University in St. Louis (US)
- Kennedy Krieger Institute (US)
- University of California, Los Angeles (US)
- Corresponding author
- Constantino, J N
- Venue
- Molecular Psychiatry
- Published
- 2012-02-28
- Volume
- 18
- Issue
- 2
- Pages
- 137-138
- ISSN
- 1359-4184 (ISSN-L)
- 1476-5578
- OpenAlex
- W2069515082
- Cited by
- 134
- References
- 8
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 1 · 2023: 4 · 2022: 9 · 2021: 8 · 2020: 12 · 2019: 11 · 2018: 11 · 2017: 8 · 2016: 16 · 2015: 20 · 2014: 14 · 2013: 9 · 2012: 6
- FWCI
- 8.03
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Molecular Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Autism Speaks (AS2306)
- National Institute of Neurological Disorders and Stroke (R01NS073871)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Keywords
- autism spectrum disorder, half-siblings, genetic transmission, heritability, genetic susceptibility, pleiotropy, maternal genetics, fetal brain development
- MeSH terms
- Adolescent, Autistic Disorder, Child, Child Development Disorders, Pervasive, Child, Preschool, Female, Humans, Male, Recurrence, Registries, Prevalence, Siblings
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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