Dynamics of the meningeal CD4+ T-cell repertoire are defined by the cervical lymph nodes and facilitate cognitive task performance in mice
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CD4+ T cells can traffic into the meninges from circulation and scan the tissue for antigens before departing to the deep cervical lymph nodes.
“CD4+ T cells can traffic into the meninges from circulation and scan the tissue for antigens before departing to the deep cervical lymph nodes (93).”
From The anatomy and immunology of vasculature in the central nervous system (2019) · cites this paper as [93]
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- Authors
- Radjavi, A., Smirnov, I., Derecki, N., & Kipnis, J.
- Affiliations
- University of Virginia (US)
- Corresponding author
- Kipnis, J
- ORCID
- Kipnis, J
- Venue
- Molecular Psychiatry
- Published
- 2013-06-11
- Volume
- 19
- Issue
- 5
- Pages
- 531-532
- ISSN
- 1359-4184 (ISSN-L)
- 1476-5578
- PMC
- PMC3773254
- OpenAlex
- W2068747215
- Cited by
- 112
- References
- 10
- Citations by year
- 2026: 2 · 2025: 14 · 2024: 9 · 2023: 9 · 2022: 12 · 2021: 12 · 2020: 10 · 2019: 5 · 2018: 11 · 2017: 9 · 2016: 9 · 2015: 4 · 2014: 3 · 2013: 3
- FWCI
- 3.51
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Molecular Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Aging (R01AG034113)
- National Institute of Allergy and Infectious Diseases (T32AI007496)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Health Sciences › Medicine › Pathology and Forensic Medicine › Multiple Sclerosis Research Studies
- Keywords
- cervical lymph nodes, meningeal lymphatic vessels, cognitive performance, neuroinflammation, T cell migration
- MeSH terms
- Animals, Cognition, Infant, Premature, Lymph Node Excision, Lymph Nodes, Meninges, Mice, Transgenic, Monocytes, Neck, Spleen, Neuroimmunomodulation, CD4-Positive T-Lymphocytes, Cell Transplantation, Lymphocyte Count, Maze Learning, Mice
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