Adaptive immunity affects learning behavior in mice

From inflammation to sickness and depression: when the immune system subjugates the brain

Dantzer, R., O'Connor, J. C., Freund, G. G., Johnson, R. W., & Kelley, K. W. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2297 · Cited by 7,395 · see citing works

Immune cells contribute to the maintenance of neurogenesis and spatial learning abilities in adulthood

Ziv, Y., Ron, N., Butovsky, O., Landa, G., Sudai, E., Greenberg, N., Cohen, H., Kipnis, J., & Schwartz, M. (2006) · Nature Neuroscience · doi:10.1038/nn1629 · Cited by 1,209 · see citing works

Autoimmune T cells protect neurons from secondary degeneration after central nervous system axotomy

Moalem‐Taylor, G., Leibowitz‐Amit, R., Yoles, E., Mor, F., Cohen, I. R., & Schwartz, M. (1999) · Nature Medicine · doi:10.1038/4734 · Cited by 882 · see citing works

CNS immune privilege: hiding in plain sight

Carson, M. J., Doose, J. M., Melchior, B., Schmid, C. D., & Ploix, C. C. (2006) · Immunological Reviews · doi:10.1111/j.1600-065x.2006.00441.x · Cited by 797 · see citing works

Cytokine-induced sickness behavior

Kelley, K. W., Bluthé, R.-M., Dantzer, R., Zhou, J.-H., Shen, W.-H., Johnson, R. W., & Broussard, S. R. (2003) · Brain, Behavior, and Immunity · doi:10.1016/s0889-1591(02)00077-6 · Cited by 716 · see citing works

T cell deficiency leads to cognitive dysfunction: Implications for therapeutic vaccination for schizophrenia and other psychiatric conditions

Kipnis, J., Cohen, H., Cardon, M., Ziv, Y., & Schwartz, M. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0402268101 · Cited by 510 · see citing works

Migratory Activity and Functional Changes of Green Fluorescent Effector Cells before and during Experimental Autoimmune Encephalomyelitis

Flügel, A., Berkowicz, T., Ritter, T., Labeur, M. S., Jenne, D. E., Li, Z., Ellwart, J. W., Willem, M., Lassmann, H., & Wekerle, H. (2001) · Immunity · doi:10.1016/s1074-7613(01)00143-1 · Cited by 431 · see citing works

Neuroinflammation and disruption in working memory in aged mice after acute stimulation of the peripheral innate immune system

Chen, J., Buchanan, J. B., Sparkman, N. L., Godbout, J. P., Freund, G. G., & Johnson, R. W. (2007) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2007.08.014 · Cited by 396 · see citing works

Glatiramer acetate fights against Alzheimer’s disease by inducing dendritic-like microglia expressing insulin-like growth factor 1

Butovsky, O., Koronyo-Hamaoui, M., Kunis, G., Ophir, E., Landa, G., Cohen, H., & Schwartz, M. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0604681103 · Cited by 388 · see citing works

Neuroprotection by Encephalomyelitis: Rescue of Mechanically Injured Neurons and Neurotrophin Production by CNS-Infiltrating T and Natural Killer Cells

Hammarberg, H., Lidman, O., Lundberg, C., Eltayeb, S., Gielen, A. W., Muhallab, S., Svenningsson, A., Lindå, H., van der Meide, P. H., Cullheim, S., et al. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-14-05283.2000 · Cited by 311 · see citing works

Interleukin-6 Facilitates Lipopolysaccharide-Induced Disruption in Working Memory and Expression of Other Proinflammatory Cytokines in Hippocampal Neuronal Cell Layers

Sparkman, N. L., Buchanan, J. B., Heyen, J. R. R., Chen, J., Beverly, J. L., & Johnson, R. W. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.3376-06.2006 · Cited by 307 · see citing works

Aging Exacerbates Depressive-like Behavior in Mice in Response to Activation of the Peripheral Innate Immune System

Godbout, J. P., Moreau, M., Lestage, J., Chen, J., Sparkman, N. L., Connor, J. O., Castanon, N., Kelley, K. W., Dantzer, R., & Johnson, R. W. (2008) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301649 · Cited by 299 · see citing works

The Blood-Brain Barrier and Its Role in Immune Privilege in the Central Nervous System

Pachter, J. S., de Vries, H. E., & Fábry, Z. (2003) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/62.6.593 · Cited by 293 · see citing works

Neurotrophic cross‐talk between the nervous and immune systems: Implications for neurological diseases

Kerschensteiner, M., Stadelmann, C., Dechant, G., Wekerle, H., & Hohlfeld, R. (2003) · Annals of Neurology · doi:10.1002/ana.10446 · Cited by 273 · see citing works

Neuronal Survival after CNS Insult Is Determined by a Genetically Encoded Autoimmune Response

Kipnis, J., Yoles, E., Schori, H., Hauben, E., Shaked, I., & Schwartz, M. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-13-04564.2001 · Cited by 230 · see citing works

Autoimmune T cells as potential neuroprotective therapy for spinal cord injury

Hauben, E., Nevo, U., Yoles, E., Moalem‐Taylor, G., Agranov, E., Mor, F., AKSELROD, S., Neeman, M., Cohen, I., & Schwartz, M. (2000) · The Lancet · doi:10.1016/s0140-6736(99)05140-5 · Cited by 213 · see citing works

Correlation between cognitive deficits and Aβ deposits in transgenic APP+PS1 mice

Gordon, M. N., King, D. L., Diamond, D. M., Jantzen, P. T., Boyett, K. W., Hope, C. E., Hatcher-Martin, J. M., DiCarlo, G., Gottschall, W. P. E., Morgan, D., et al. (2001) · Neurobiology of Aging · doi:10.1016/s0197-4580(00)00249-9 · Cited by 199 · see citing works

Nasal vaccination with a proteosome-based adjuvant and glatiramer acetate clears β-amyloid in a mouse model of Alzheimer disease

Frenkel, D., Maron, R., Burt, D. S., & Weiner, H. L. (2005) · Journal of Clinical Investigation · doi:10.1172/jci23241 · Cited by 186 · see citing works

Innate and Adaptive Immune Responses of the Central Nervous System

Bailey, S. L., Carpentier, P. A., McMahon, E., Begolka, W. S., & Miller, S. D. (2006) · Critical Reviews in Immunology · doi:10.1615/critrevimmunol.v26.i2.40 · Cited by 182 · see citing works

Innate Immunity in Multiple Sclerosis: Myeloid Dendritic Cells in Secondary Progressive Multiple Sclerosis Are Activated and Drive a Proinflammatory Immune Response

Karni, A., Abraham, M., Monsonego, A., Cai, G., Freeman, G. J., Hafler, D. A., Khoury, S. J., & Weiner, H. L. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.177.6.4196 · Cited by 177 · see citing works

Deglycosylated Anti-Amyloid-β Antibodies Eliminate Cognitive Deficits and Reduce Parenchymal Amyloid with Minimal Vascular Consequences in Aged Amyloid Precursor Protein Transgenic Mice

Wilcock, D. M., Alamed, J., Gottschall, P. E., Grimm, J., Rosenthal, A., Pons, J., Ronan, V., Symmonds, K., Gordon, M. N., & Morgan, D. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.0695-06.2006 · Cited by 154 · see citing works

Butovsky, O. et al. Glatiramer acetate fights against Alzheimer's disease by inducing dendritic-like microglia expressing insulin-like growth factor 1. Proc. Natl Acad. Sci. USA 103, 11784-11789

Butovsky, O., Koronyo‐Hamaoui, M., Kunis, G., Ophir, E., Landa, G., Cohen, H., & Schwartz, M. (2006) · Cited by 144 · see citing works

Subcutaneous Nogo Receptor Removes Brain Amyloid-β and Improves Spatial Memory in Alzheimer's Transgenic Mice

Park, J. H., Widi, G. A., Gimbel, D. A., Harel, N. Y., Lee, D. H. S., & Strittmatter, S. M. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.4504-06.2006 · Cited by 107 · see citing works

Aging sensitizes mice to behavioral deficits induced by central HIV-1 gp120

Abraham, J., Jang, S., Godbout, J. P., Chen, J., Kelley, K. W., Dantzer, R., & Johnson, R. W. (2006) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2006.11.002 · Cited by 72 · see citing works

Traumatic Injury and the Presence of Antigen Differentially Contribute to T-Cell Recruitment in the CNS

Ling, C., Sándor, M., Suresh, M., & Fábry, Z. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.3502-05.2006 · Cited by 62 · see citing works

Immune Protection of the Brain—Efficient and Delicate

Wekerle, H. (2002) · The Journal of Infectious Diseases · doi:10.1086/344937 · Cited by 60 · see citing works

Intra-hippocampal microinjections of anisomycin did not block glucocorticoid-induced impairment of memory retrieval in rats: An evidence for non-genomic effects of glucocorticoids

Sajadi, A., Samaei, A., & Rashidy‐Pour, A. (2006) · Behavioural Brain Research · doi:10.1016/j.bbr.2006.06.018 · Cited by 54 · see citing works

Breaking Ignorance: The Case of the Brain

Wekerle, H. (2006) · Springer eBooks · doi:10.1007/3-540-29714-6_2 · Cited by 49 · see citing works

Intracerebral regulation of immune responses

Aloisi, F., Ambrosini, E., Cabezas, S. C., Magliozzi, R., & Serafini, B. (2001) · Annals of Medicine · doi:10.3109/07853890108995960 · Cited by 46 · see citing works

Interleukin-1β-converting enzyme-deficient mice resist central but not systemic endotoxin-induced anorexia

Burgess, W., Gheusi, G., Yao, J. S., Johnson, R. W., Dantzer, R., & Kelley, K. W. (1998) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1998.274.6.r1829 · Cited by 43 · see citing works

Selective improvement of aged rat short-term spatial memory by 3,4-diaminopyridine

Barnes, C. A., Eppich, C., & RAO, G. R. (1989) · Neurobiology of Aging · doi:10.1016/0197-4580(89)90045-6 · Cited by 33 · see citing works

Breaking or making immunological privilege in the central nervous system: The regulation of immunity by neuropeptides

Reinke, E. K., & Fábry, Z. (2005) · Immunology Letters · doi:10.1016/j.imlet.2005.11.009 · Cited by 32 · see citing works

IL-1β Suppresses Prolonged Akt Activation and Expression of E2F-1 and Cyclin A in Breast Cancer Cells

Shen, W. H., Jackson, S. T., Broussard, S. R., McCusker, R. H., Strle, K., Freund, G. G., Johnson, R. W., Dantzer, R., & Kelley, K. W. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.172.12.7272 · Cited by 21 · see citing works

Lethally irradiated normal strains of mice radioprotected with SCID bone marrow develop sensitivity to low doses of staphylococcal enterotoxin B

Aboud-Pirak, E., Lubin, I., Pirak, M., Canaan, A., Lowell, G. H., & Reisner, Y. (1995) · Immunology Letters · doi:10.1016/0165-2478(94)00005-c · Cited by 7 · see citing works

Immune modulation of learning, memory, neural plasticity and neurogenesis

Yirmiya, R., & Goshen, I. (2011) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2010.10.015 · Cited by 1,483 · see citing works

Psychoneuroimmunology Meets Neuropsychopharmacology: Translational Implications of the Impact of Inflammation on Behavior

Haroon, E., Raison, C. L., & Miller, A. H. (2012) · Neuropsychopharmacology · doi:10.1038/npp.2011.205 · Cited by 1,000 · see citing works

Regulation of learning and memory by meningeal immunity: a key role for IL-4

Derecki, N. C., Cardani, A. N., Yang, C. H., Quinnies, K. M., Crihfield, A., Lynch, K. R., & Kipnis, J. (2010) · Journal of Experimental Medicine · doi:10.1084/jem.20091419 · Cited by 800 · see citing works

Unexpected role of interferon-γ in regulating neuronal connectivity and social behaviour

Filiano, A. J., Xu, Y., Tustison, N. J., Marsh, R. L., Baker, W., Smirnov, I., Overall, C. C., Gadani, S. P., Turner, S. D., Weng, Z., et al. (2016) · Nature · doi:10.1038/nature18626 · Cited by 697 · see citing works

Revisiting the Mechanisms of CNS Immune Privilege

Louveau, A., Harris, T. H., & Kipnis, J. (2015) · Trends in Immunology · doi:10.1016/j.it.2015.08.006 · Cited by 682 · see citing works

IL-4 in the brain: a cytokine to remember

Gadani, S. P., Cronk, J. C., Norris, G. T., & Kipnis, J. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1202246 · Cited by 549 · see citing works

Immune mediators in the brain and peripheral tissues in autism spectrum disorder

Estes, M. L., & McAllister, A. K. (2015) · Nature Reviews Neuroscience · doi:10.1038/nrn3978 · Cited by 514 · see citing works

Human immunodeficiency virus‐associated neurocognitive disorders: Mind the gap

McArthur, J. C., Steiner, J. P., Sacktor, N. C., & Nath, A. (2010) · Annals of Neurology · doi:10.1002/ana.22053 · Cited by 445 · see citing works

Neuromodulation by the immune system: a focus on cytokines

Salvador, A. F., de Lima, K. A., & Kipnis, J. (2021) · Nature Reviews Immunology · doi:10.1038/s41577-021-00508-z · Cited by 389 · see citing works

Multifaceted interactions between adaptive immunity and the central nervous system

Kipnis, J. (2016) · Science · doi:10.1126/science.aag2638 · Cited by 376 · see citing works

Meningeal Immunity and Its Function in Maintenance of the Central Nervous System in Health and Disease

Alves de Lima, K., Rustenhoven, J., & Kipnis, J. (2020) · Annual Review of Immunology · doi:10.1146/annurev-immunol-102319-103410 · Cited by 348 · see citing works

Modeling an autism risk factor in mice leads to permanent immune dysregulation

Hsiao, E. Y., McBride, S. W., Chow, J., Mazmanian, S. K., & Patterson, P. H. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1202556109 · Cited by 340 · see citing works

Depression and immunity: A role for T cells?

Miller, A. H. (2009) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2009.09.009 · Cited by 340 · see citing works

CD4-positive T lymphocytes provide a neuroimmunological link in the control of adult hippocampal neurogenesis

Wolf, S. A., Steiner, B., Akpinarli, A., Kammertoens, T., Nassenstein, C., Braun, A., Blankenstein, T., & Kempermann, G. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0801218 · Cited by 329 · see citing works

Advances in Meningeal Immunity

Rua, R., & McGavern, D. B. (2018) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2018.04.003 · Cited by 326 · see citing works

Neuroplastic changes in depression: A role for the immune system

Eyre, H., & Baune, B. T. (2012) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2012.03.019 · Cited by 319 · see citing works

Contribution of neuroinflammation and immunity to brain aging and the mitigating effects of physical and cognitive interventions

Benedetto, S. D., Müller, L., Wenger, E., Düzel, S., & Pawelec, G. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.01.044 · Cited by 280 · see citing works

Inflammatory T helper 17 cells promote depression-like behavior in mice

Beurel, E., Harrington, L. E., & Jope, R. S. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2012.09.021 · Cited by 254 · see citing works

Pro-cognitive properties of T cells

Kipnis, J., Gadani, S., & Derecki, N. C. (2012) · Nature Reviews Immunology · doi:10.1038/nri3280 · Cited by 246 · see citing works

The role of T cells in age-related diseases

Carrasco, E., Heras, M. M. G. D. L., Gabandé‐Rodríguez, E., Desdín-Micó, G., Aranda, J. F., & Mittelbrunn, M. (2021) · Nature reviews. Immunology · doi:10.1038/s41577-021-00557-4 · Cited by 244 · see citing works

Cytokines as emerging regulators of central nervous system synapses

Zipp, F., Bittner, S., & Schafer, D. P. (2023) · Immunity · doi:10.1016/j.immuni.2023.04.011 · Cited by 239 · see citing works

Microglia: A new frontier for synaptic plasticity, learning and memory, and neurodegenerative disease research

Morris, G. P., Clark, I. A., Zinn, R., & Vissel, B. (2013) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2013.07.002 · Cited by 236 · see citing works

Peripheral immune system in aging and Alzheimer’s disease

Cao, W., & Zheng, H. (2018) · Molecular Neurodegeneration · doi:10.1186/s13024-018-0284-2 · Cited by 214 · see citing works

Novel roles for immune molecules in neural development: implications for neurodevelopmental disorders

Garay, P. (2010) · Frontiers in Synaptic Neuroscience · doi:10.3389/fnsyn.2010.00136 · Cited by 217 · see citing works

Interactions of innate and adaptive immunity in brain development and function

Filiano, A. J., Gadani, S. P., & Kipnis, J. (2014) · Brain Research · doi:10.1016/j.brainres.2014.07.050 · Cited by 217 · see citing works

Microglial Activation – Tuning and Pruning Adult Neurogenesis

Ekdahl, C. T. (2012) · Frontiers in Pharmacology · doi:10.3389/fphar.2012.00041 · Cited by 211 · see citing works

Active, phosphorylated fingolimod inhibits histone deacetylases and facilitates fear extinction memory

Hait, N. C., Wise, L. E., Allegood, J. C., O'Brien, M., Avni, D., Reeves, T. M., Knapp, P. E., Lu, J., Luo, C., Miles, M. F., et al. (2014) · Nature Neuroscience · doi:10.1038/nn.3728 · Cited by 209 · see citing works

How and why do T cells and their derived cytokines affect the injured and healthy brain?

Filiano, A. J., Gadani, S. P., & Kipnis, J. (2017) · Nature Reviews Neuroscience · doi:10.1038/nrn.2017.39 · Cited by 199 · see citing works

Reduced levels of immunoglobulin in children with autism correlates with behavioral symptoms

Heuer, L., Ashwood, P., Schauer, J., Goines, P., Krakowiak, P., Hertz‐Picciotto, I., Hansen, R., Croen, L. A., Pessah, I. N., & Van de Water, J. (2008) · Autism Research · doi:10.1002/aur.42 · Cited by 190 · see citing works

Neuroimmunological effects of physical exercise in depression

Eyre, H. A., & Baune, B. T. (2011) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2011.09.015 · Cited by 188 · see citing works

Learning and memory … and the immune system

Marin, I., & Kipnis, J. (2013) · Learning & Memory · doi:10.1101/lm.028357.112 · Cited by 166 · see citing works

Aging and Neurodegenerative Disease: Is the Adaptive Immune System a Friend or Foe?

Mayne, K., White, J. A., McMurran, C. E., Rivera, F. J., & de la Fuente, A. G. (2020) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2020.572090 · Cited by 167 · see citing works

Altered Cytokine and BDNF Levels in Autism Spectrum Disorder

Ricci, S., Businaro, R., Ippoliti, F., Vasco, V. R. L., Massoni, F., Onofri, E., Troili, G. M., Pontecorvi, V., Morelli, M., Ricciardi, M. R., et al. (2013) · Neurotoxicity Research · doi:10.1007/s12640-013-9393-4 · Cited by 165 · see citing works

Evidence supporting an altered immune response in ASD

Mead, J., & Ashwood, P. (2015) · Immunology Letters · doi:10.1016/j.imlet.2014.11.006 · Cited by 165 · see citing works

Role of neuro-immunological factors in the pathophysiology of mood disorders

Bhattacharya, A., Derecki, N. C., Lovenberg, T. W., & Drevets, W. C. (2016) · Psychopharmacology · doi:10.1007/s00213-016-4214-0 · Cited by 149 · see citing works

Treating Depression and Depression-Like Behavior with Physical Activity: An Immune Perspective

Eyre, H. A., Papps, E., & Baune, B. T. (2013) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2013.00003 · Cited by 144 · see citing works

Alterations in Immune Cells and Mediators in the Brain: It's Not Always Neuroinflammation!

Estes, M. L., & McAllister, A. K. (2014) · Brain Pathology · doi:10.1111/bpa.12198 · Cited by 145 · see citing works

Probiotics normalize the gut-brain-microbiota axis in immunodeficient mice

Smith, C. J., Emge, J. R., Berzins, K., Lung, L., Khamishon, R., Shah, P., Rodrigues, D. M., Sousa, A. J., Reardon, C., Sherman, P. M., et al. (2014) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00238.2014 · Cited by 143 · see citing works

Fingolimod for the treatment of neurological diseases—state of play and future perspectives

Brunkhorst, R., Vutukuri, R., & Pfeilschifter, W. (2014) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2014.00283 · Cited by 142 · see citing works

Brain antigen-reactive CD4+ T cells are sufficient to support learning behavior in mice with limited T cell repertoire

Radjavi, A., Smirnov, I., & Kipnis, J. (2013) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2013.08.013 · Cited by 137 · see citing works

Lymphocytes from Chronically Stressed Mice Confer Antidepressant-Like Effects to Naive Mice

Brachman, R. A., Lehmann, M. L., Maric, D., & Herkenham, M. (2015) · The Journal of Neuroscience · doi:10.1523/jneurosci.2278-14.2015 · Cited by 130 · see citing works

Dual Induction of TREM2 and Tolerance-Related Transcript, Tmem176b, in Amyloid Transgenic Mice: Implications for Vaccine-Based Therapies for Alzheimer’s Disease

Melchior, B., Garcia, A., Hsiung, B., Lo, K. M., Doose, J. M., Thrash, J. C., Stalder, A. K., Staufenbiel, M., Neumann, H., & Carson, M. J. (2010) · ASN NEURO · doi:10.1042/an20100010 · Cited by 133 · see citing works

IL-13–Mediated Regulation of Learning and Memory

Brombacher, T. M., Nono, J. K., Gouveia, K. S. D., Makena, N., Darby, M., Womersley, J. S., Tamgue, O., & Brombacher, F. (2017) · The Journal of Immunology · doi:10.4049/jimmunol.1601546 · Cited by 134 · see citing works

Protective autoimmunity functions by intracranial immunosurveillance to support the mind: The missing link between health and disease

Schwartz, M., & Shechter, R. (2010) · Molecular Psychiatry · doi:10.1038/mp.2010.31 · Cited by 129 · see citing works

Cognitive Function and the Microbiome

Gareau, M. G. (2016) · International review of neurobiology · doi:10.1016/bs.irn.2016.08.001 · Cited by 131 · see citing works

Immune Abnormalities in Autism Spectrum Disorder—Could They Hold Promise for Causative Treatment?

Gładysz, D., Krzywdzińska, A., & Hozyasz, K. K. (2018) · Molecular Neurobiology · doi:10.1007/s12035-017-0822-x · Cited by 130 · see citing works

Absence of IFNγ promotes hippocampal plasticity and enhances cognitive performance

Monteiro, S., Ferreira, F. M., Pinto, V., Roque, S., Morais, M., Calçada, D. D. S., Mota, C., Correia‐Neves, M., & Cerqueira, J. (2016) · Translational Psychiatry · doi:10.1038/tp.2015.194 · Cited by 124 · see citing works

Repeated stress induces a pro-inflammatory state, increases amygdala neuronal and microglial activation, and causes anxiety in adult male rats

Munshi, S., Loh, M. K., Ferrara, N., DeJoseph, M. R., Ritger, A., Padival, M., Record, M. J., Urban, J. H., & Rosenkranz, J. A. (2020) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2019.11.023 · Cited by 117 · see citing works

Correlates of cognitive dysfunction in multiple sclerosis

Heesen, C., Schulz, K., Fiehler, J., Mark, U., Otte, C., Jung, R., Poettgen, J., Krieger, T., & Gold, S. M. (2010) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2010.05.006 · Cited by 116 · see citing works

Meningeal macrophages protect against viral neuroinfection

Rebejac, J., Eme‐Scolan, E., Arnaud, L., Kharbouche, S., Teleman, M., Spinelli, L., Gallo, E., Roussel‐Queval, A., Zarubica, A., Sansoni, A., et al. (2022) · Immunity · doi:10.1016/j.immuni.2022.10.005 · Cited by 115 · see citing works

Dynamics of the meningeal CD4+ T-cell repertoire are defined by the cervical lymph nodes and facilitate cognitive task performance in mice

Radjavi, A., Smirnov, I., Derecki, N., & Kipnis, J. (2014) · Molecular Psychiatry · doi:10.1038/mp.2013.79 · Cited by 112 · see citing works

CD4+ but not CD8+ T cells revert the impaired emotional behavior of immunocompromised RAG-1-deficient mice

Rattazzi, L., Piras, G., Ono, M., Deacon, R. M. J., Pariante, C. M., & D’Acquisto, F. (2013) · Translational Psychiatry · doi:10.1038/tp.2013.54 · Cited by 108 · see citing works

Anti-inflammatory IL-10 administration rescues depression-associated learning and memory deficits in mice

Worthen, R. J., Zighelboim, S. S. G., Jaramillo, C., & Beurel, E. (2020) · Journal of Neuroinflammation · doi:10.1186/s12974-020-01922-1 · Cited by 109 · see citing works

Affective immunology: where emotions and the immune response converge

D’Acquisto, F. (2017) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2017.19.1/fdacquisto · Cited by 108 · see citing works

Ingestion of mycobacterium vaccae decreases anxiety-related behavior and improves learning in mice

Matthews, D. M., & Jenks, S. M. (2013) · Behavioural Processes · doi:10.1016/j.beproc.2013.02.007 · Cited by 105 · see citing works

The immune system as a novel regulator of sex differences in brain and behavioral development

Nelson, L. H., & Lenz, K. M. (2016) · Journal of Neuroscience Research · doi:10.1002/jnr.23821 · Cited by 107 · see citing works

Alternatively activated myeloid (M2) cells enhance cognitive function in immune compromised mice

Derecki, N. C., Quinnies, K. M., & Kipnis, J. (2010) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2010.11.009 · Cited by 97 · see citing works

Immunity and cognition: what do age-related dementia, HIV-dementia and ‘chemo-brain’ have in common?

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Reduced β-amyloid pathology in an APP transgenic mouse model of Alzheimer’s disease lacking functional B and T cells

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Immune Dysregulation in Autism Spectrum Disorder

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Boosting T-cell immunity as a therapeutic approach for neurodegenerative conditions: the role of innate immunity.

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The Cross-Talk Between the Dopaminergic and the Immune System Involved in Schizophrenia

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Cognitive and Behavioral Consequences of Impaired Immunoregulation in Aging

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Unique aspects of IFN ‐γ/ STAT1 signaling in neurons

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Cross-Talk of the CNS With Immune Cells and Functions in Health and Disease

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Neuroimmunology of depression

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Role of Neuro-Immunological Factors in the Pathophysiology of Mood Disorders: Implications for Novel Therapeutics for Treatment Resistant Depression

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Immunity to self and self-maintenance: a unified theory of brain pathologies

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Brain interference: Revisiting the role of IFNγ in the central nervous system

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Age-dependent spatial memory loss can be partially restored by immune activation

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The microbiota-gut-brain axis in hippocampus-dependent learning and memory: current state and future challenges

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A conceptual revolution in the relationships between the brain and immunity

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Active Immunization with Amyloid-β 1–42 Impairs Memory Performance through TLR2/4-Dependent Activation of the Innate Immune System

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T cells establish and maintain CNS viral infection in HIV-infected humanized mice

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Adaptive Immunity in Schizophrenia: Functional Implications of T Cells in the Etiology, Course and Treatment

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Breaking Boundaries in Neural-Immune Interactions

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Immune senescence and brain aging: can rejuvenation of immunity reverse memory loss?

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CD8+ T cells are essential for the effects of enriched environment on hippocampus-dependent behavior, hippocampal neurogenesis and synaptic plasticity

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Natural killer cells and innate lymphoid cells 1 tune anxiety-like behavior and memory in mice via interferon-γ and acetylcholine

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A Non-inflammatory Role for Microglia in Autism Spectrum Disorders

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Disruption of the Blood-Brain Barrier During Neuroinflammatory and Neuroinfectious Diseases

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Premature Immunosenescence Is Associated with Memory Dysfunction in Rheumatoid Arthritis

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Contributions of monocytes to nervous system disorders

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Rett syndrome and other autism spectrum disorders—brain diseases of immune malfunction?

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Increased circulating regulatory T cells in medicated people with schizophrenia

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The brain cytokine orchestra in multiple sclerosis: from neuroinflammation to synaptopathology

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Senescence-accelerated Mice (SAMs) as a Model for Brain Aging and Immunosenescence.

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Lymphocytes in neuroprotection, cognition and emotion: Is intolerance really the answer?

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Cohorts based on decade of death: No evidence for secular trends favoring later cohorts in cognitive aging and terminal decline in the AHEAD study.

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Astrocytes Modulate the Polarization of CD4+ T Cells to Th1 Cells

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Meningeal immunity: Structure, function and a potential therapeutic target of neurodegenerative diseases

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Th17 Cells in Depression: Are They Crucial for the Antidepressant Effect of Ketamine?

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Dysregulation of kisspeptin and neurogenesis at adolescence link inborn immune deficits to the late onset of abnormal sensorimotor gating in congenital psychological disorders

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Cytokines, synaptic plasticity and network dynamics: a matter of balance

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Loss of T cells influences sex differences in behavior and brain structure

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Brain homeostasis is maintained by “danger” signals stimulating a supportive immune response within the brain’s borders

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Non-canonical alternatives: What a macrophage is 4

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A(H1N1) vaccination recruits T lymphocytes to the choroid plexus for the promotion of hippocampal neurogenesis and working memory in pregnant mice

Qi, F., Yang, J., Xia, Y., Yuan, Q., Guo, K., Zou, J., & Yao, Z. (2015) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2015.11.006 · Cited by 35 · see citing works

Central Nervous System: (Immunological) Ivory Tower or Not?

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Friend or foe: the dichotomous impact of T cells on neuro-de/re-generation during aging

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Adaptive Immune Deficiency Impairs Neural Activity After Training and Retrieval

Li, H., Fu, Z., Hu, M., & Xu, X. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.739580

Alternatively activated myeloid (M2) cells enhance cognitive function in immune compromised mice

Derecki, N. C., Quinnies, K. M., & Kipnis, J. (2010) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2010.11.009 · Cited by 97 · see citing works

Meningeal Immunity, Learning and Memory, and IL-4: Do T cells Make You Smart? (87.35)

Derecki, N. C., Cardani, A. N., Quinnies, K. M., Crihfield, A., Lynch, K., & Kipnis, J. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.184.supp.87.35 · Cited by 3 · see citing works

Can a good immune system reduce ageing?

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Effects of Brain-Derived IL-2 Deficiency and the Development of Autoimmunity on Spatial Learning and Fear Conditioning

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