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Cited by 386

The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.

Extension of a genetic network model by iterative experimentation and mathematical analysis

Open access
Locke, James C W, Southern, Megan M, Kozma‐Bognár, László, Hibberd, Victoria, Brown, Paul E, Turner, Matthew S, Millar, Andrew J·2005·Molecular Systems Biology
DOI 10.1038/msb4100018
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Abstract

Circadian clocks involve feedback loops that generate rhythmic expression of key genes. Molecular genetic studies in the higher plant Arabidopsis thaliana have revealed a complex clock network. The first part of the network to be identified, a transcriptional feedback loop comprising TIMING OF CAB EXPRESSION 1 (TOC1), LATE ELONGATED HYPOCOTYL (LHY) and CIRCADIAN CLOCK ASSOCIATED 1 (CCA1), fails to account for significant experimental data. We develop an extended model that is based upon a wider range of data and accurately predicts additional experimental results. The model comprises interlocking feedback loops comparable to those identified experimentally in other circadian systems. We propose that each loop receives input signals from light, and that each loop includes a hypothetical component that had not been explicitly identified. Analysis of the model predicted the properties of these components, including an acute light induction at dawn that is rapidly repressed by LHY and CCA1. We found this unexpected regulation in RNA levels of the evening‐expressed gene GIGANTEA (GI), supporting our proposed network and making GI a strong candidate for this component.

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Metadata

Authors
Locke, J. C. W., Southern, M. M., Kozma‐Bognár, L., Hibberd, V., Brown, P. E., Turner, M. S., & Millar, A. J.
Venue
Molecular Systems Biology
Publisher
Springer Science and Business Media LLC
Published
2005-01
Volume
1
Issue
1
Pages
2005.0013-2005.0013
ISSN
1744-4292 (ISSN-L)
DOI
10.1038/msb4100018
OpenAlex
W2135007181
Cited by
386
References
1
FWCI
10.62
Type
journal article
Language
en
Open access
green
Licence

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