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Combinatorial Control of Suicide Gene Expression by Tissue-specific Promoter and microRNA Regulation for Cancer Therapy
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“Similar approaches have been used to selectively prevent transgene expression in hematopoetic cells and other cell types [28]–[31].”
From Reduced Expression of Brain-Enriched microRNAs in Glioblastomas Permits Targeted Regulation of a Cell Death Gene (2011) · cites this paper as [31]
In the citing paper
“This vector showed the same therapeutic efficacy in glioblastoma U87 cells as a control HSV-TK vector lacking artificial miRNA target sites, but when introduced into human astrocytes, which express the three selected miRNAs, showed restricted HSV-TK expression, leading to an increase in cell viability.”
From Reduced Expression of Brain-Enriched microRNAs in Glioblastomas Permits Targeted Regulation of a Cell Death Gene (2011) · cites this paper as [31]
In the citing paper
“The use of tissue-specific miRNAs to regulate transgene expression for therapeutic applications has been investigated in multiple cell types, including lymphoid and myeloid cells, muscle cells, liver cells, and brain cells [28]–[31].”
From Reduced Expression of Brain-Enriched microRNAs in Glioblastomas Permits Targeted Regulation of a Cell Death Gene (2011) · cites this paper as [31]
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Cites
A Mammalian microRNA Expression Atlas Based on Small RNA Library Sequencing
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Cited by
Sorted by citations
Skalsky, R. L., & Cullen, B. R. (2011) · PLoS ONE · doi:10.1371/journal.pone.0024248 · Cited by 170
Yu, Y., Yao, Y., Yan, H., Wang, R., Zhang, Z., Sun, X., Zhao, L., Ao, X., Xie, Z., & Wu, Q. (2016) · Molecular Therapy - Nucleic Acids · doi:10.1038/mtna.2016.28 · Cited by 31
Metadata
- Authors
- Wu, C., Lin, J., Hong, M., Choudhury, Y., Balani, P., Leung, D., Dang, L. H., Zhao, Y., Zeng, J., & Wang, S.
- Venue
- Molecular Therapy
- Publisher
- Elsevier BV
- Published
- 2009-12
- Volume
- 17
- Issue
- 12
- Pages
- 2058-2066
- ISSN
- 1525-0016
- Cited by
- 61
- References
- 3
- Language
- en
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- Wu, C., Lin, J., Hong, M., Choudhury, Y., Balani, P., Leung, D., Dang, L. H., Zhao, Y., Zeng, J., & Wang, S. (2009). Combinatorial Control of Suicide Gene Expression by Tissue-specific Promoter and microRNA Regulation for Cancer Therapy. Molecular Therapy. https://doi.org/10.1038/mt.2009.225