A Tumor-specific MicroRNA Recognition System Facilitates the Accurate Targeting to Tumor Cells by Magnetic Nanoparticles
Open accessAbstract
Targeted therapy for cancer is a research area of great interest, and magnetic nanoparticles (MNPs) show great potential as targeted carriers for therapeutics. One important class of cancer biomarkers is microRNAs (miRNAs), which play a significant role in tumor initiation and progression. In this study, a cascade recognition system containing multiple plasmids, including a Tet activator, a lacI repressor gene driven by the TetOn promoter, and a reporter gene repressed by the lacI repressor and influenced by multiple endogenous miRNAs, was used to recognize cells that display miRNA signals that are characteristic of cancer. For this purpose, three types of signal miRNAs with high proliferation and metastasis abilities were chosen (miR-21, miR-145, and miR-9). The response of this system to the human breast cancer MCF-7 cell line was 3.2-fold higher than that to the human breast epithelial HBL100 cell line and almost 7.5-fold higher than that to human embryonic kidney HEK293T cells. In combination with polyethyleneimine-modified MNPs, this recognition system targeted the tumor location in situ in an animal model, and an ~42% repression of tumor growth was achieved. Our study provides a new combination of magnetic nanocarrier and gene therapy based on miRNAs that are active in vivo, which has potential for use in future cancer therapies.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The magnetic response intelligent nano system has two treatment procedures: the first uses magnetic fields to assist drug targeting, and the second uses magnetic fields to cause hyperthermia.
“As a result, the magnetic response intelligent nano system has two treatment procedures. The first technique uses magnetic fields to assist drug targeting, whereas the second uses magnetic fields to cause hyperthermia.186–188”
From Smart nanoparticles for cancer therapy (2023) · cites this paper as [188]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Golub, T. R., Slonim, D. K., Tamayo, P., Huard, C., Gaasenbeek, M., Mesirov, J. P., Coller, H., Loh, M. L., Downing, J. R., Caligiuri, M. A., et al. (1999) · Science · doi:10.1126/science.286.5439.531 · Cited by 11,516 · see citing works
Siegel, R., Naishadham, D., & Jemal, A. (2012) · CA: A Cancer Journal for Clinicians · doi:10.3322/caac.20138 · Cited by 10,679 · see citing works
Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling
Alizadeh, A. A., Eisen, M. B., Davis, R. E., Ma, C., Lossos, I. S., Rosenwald, A., Boldrick, J. C., Sabet, H., Tran, T., Yu, X., et al. (2000) · Nature · doi:10.1038/35000501 · Cited by 9,925 · see citing works
MicroRNA expression profiles classify human cancers
Lü, J., Getz, G. A., Miska, E. A., Alvarez-Saavedra, E., Lamb, J., Peck, D., Sweet-Cordero, A., Ebert, B. L., Mak, R. H., Ferrando, A. A., et al. (2005) · Nature · doi:10.1038/nature03702 · Cited by 9,557 · see citing works
p53, the cellular gatekeeper for growth and division
Levine, A. J. (1997) · Cell · doi:10.1016/s0092-8674(00)81871-1 · Cited by 7,693 · see citing works
MicroRNA signatures in human cancers
Calin, G. A., & Croce, C. M. (2006) · Nature reviews. Cancer · doi:10.1038/nrc1997 · Cited by 7,592 · see citing works
Oncomirs — microRNAs with a role in cancer
Esquela‐Kerscher, A., & Slack, F. J. (2006) · Nature reviews. Cancer · doi:10.1038/nrc1840 · Cited by 7,038 · see citing works
MicroRNAs: small RNAs with a big role in gene regulation
He, L., & Hannon, G. J. (2004) · Nature Reviews Genetics · doi:10.1038/nrg1379 · Cited by 6,992 · see citing works
Matsumura, Y., & Maeda, H. (1986) · PubMed · Cited by 6,771 · see citing works
MicroRNA Gene Expression Deregulation in Human Breast Cancer
Iorio, M. V., Ferracin, M., Liu, C.-G., Veronese, A., Spizzo, R., Sabbioni, S., Magri, E., Pedriali, M., Fabbri, M., Campiglio, M., et al. (2005) · Cancer Research · doi:10.1158/0008-5472.can-05-1783 · Cited by 4,053 · see citing works
Factors affecting the clearance and biodistribution of polymeric nanoparticles
Alexis, F., Pridgen, E., Molnar, L. K., & Farokhzad, O. C. (2008) · Molecular Pharmaceutics · doi:10.1021/mp800051m · Cited by 3,699 · see citing works
The Versatile Role of microRNA-30a in Human Cancer
Wang, C., Yang, X., Chen, Y., & Chen, L. (2017) · Cellular Physiology and Biochemistry · doi:10.1159/000471111 · Cited by 3,409 · see citing works
Unique microRNA molecular profiles in lung cancer diagnosis and prognosis
Yanaihara, N., Caplen, N., Bowman, E., Seike, M., Kumamoto, K., Yi, M., Stephens, R. M., Okamoto, A., Yokota, J., Tanaka, T., et al. (2006) · Cancer Cell · doi:10.1016/j.ccr.2006.01.025 · Cited by 3,023 · see citing works
MicroRNA-21 Regulates Expression of the PTEN Tumor Suppressor Gene in Human Hepatocellular Cancer
Meng, F., Henson, R., Wehbe–Janek, H., Ghoshal, K., Jacob, S. T., & Patel, T. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.05.022 · Cited by 2,773 · see citing works
microRNAs as oncogenes and tumor suppressors
Zhang, B., Pan, X., Cobb, G. P., & Anderson, T. A. (2006) · Developmental Biology · doi:10.1016/j.ydbio.2006.08.028 · Cited by 2,755 · see citing works
Nanoparticle PEGylation for Imaging and Therapy
Jokerst, J. V., Lobovkina, T., Zare, R. N., & Gambhir, S. S. (2011) · Nanomedicine · doi:10.2217/nnm.11.19 · Cited by 2,054 · see citing works
Si, M.-L., Zhu, S., Wu, H., Lu, Z., Wu, F., & Mo, Y.-Y. (2007) · Oncogene · doi:10.1038/sj.onc.1210083 · Cited by 1,600 · see citing works
Schetter, A. J., Leung, S. Y., Sohn, J. J., Zanetti, K. A., Bowman, E. D., Yanaihara, N., Yuen, S. T., Chan, T. L., Kwong, D. L. �., Au, G. K. �., et al. (2008) · JAMA · doi:10.1001/jama.299.4.425 · Cited by 1,578 · see citing works
miR-9, a MYC/MYCN-activated microRNA, regulates E-cadherin and cancer metastasis
Ma, L., Young, J. J., Prabhala, H. K., Pan, E., Mestdagh, P., Muth, D., Teruya‐Feldstein, J., Reinhardt, F., Önder, T. T., Valastyan, S., et al. (2010) · Nature Cell Biology · doi:10.1038/ncb2024 · Cited by 1,336 · see citing works
Biological applications of magnetic nanoparticles
Colombo, M., Carregal‐Romero, S., Casula, M. F., Gutiérrez, L., Morales, M. P., Böhm, I., Heverhagen, J. T., Prosperi, D., & Parak, W. J. (2012) · Chemical Society Reviews · doi:10.1039/c2cs15337h · Cited by 1,314 · see citing works
Frankel, L. B., Christoffersen, N. R., Jacobsen, A., Lindow, M., Krogh, A., & Lund, A. H. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m707224200 · Cited by 1,141 · see citing works
MicroRNA-21 Targets the Tumor Suppressor Gene Tropomyosin 1 (TPM1)
Zhu, S., Si, M.-L., Wu, H., & Mo, Y.-Y. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m611393200 · Cited by 1,090 · see citing works
OncomiR addiction in an in vivo model of microRNA-21-induced pre-B-cell lymphoma
Medina, P. P., Nolde, M., & Slack, F. J. (2010) · Nature · doi:10.1038/nature09284 · Cited by 971 · see citing works
Xia, T., Kovochich, M., Liong, M., Meng, H., Kabehie, S., George, S., Zink, J. I., & Nel, A. E. (2009) · ACS Nano · doi:10.1021/nn900918w · Cited by 933 · see citing works
Iron Oxide Nanoparticles for Sustained Delivery of Anticancer Agents
Jain, T. K., Morales, M. A., Sahoo, S. K., Leslie‐Pelecky, D. L., & Labhasetwar, V. D. (2005) · Molecular Pharmaceutics · doi:10.1021/mp0500014 · Cited by 904 · see citing works
Progress in developing cationic vectors for non-viral systemic gene therapy against cancer
Morille, M., Passirani, C., Vonarbourg, A., Clavreul, A., & Benoît, J. (2008) · Biomaterials · doi:10.1016/j.biomaterials.2008.04.036 · Cited by 769 · see citing works
Magnetic nanoparticles for gene and drug delivery
Dobson, J. (2008) · International Journal of Nanomedicine · doi:10.2147/ijn.s1608 · Cited by 759 · see citing works
Multi-Input RNAi-Based Logic Circuit for Identification of Specific Cancer Cells
Xie, Z., Wróblewska, L., Prochazka, L., Weiss, R., & Benenson, Y. (2011) · Science · doi:10.1126/science.1205527 · Cited by 741 · see citing works
Self-citationSlabý, O., Svoboda, M., Fabián, P., Šmerdová, T., Knoflíčková, D., Bednaříková, M., Nenutil, R., & Vyzula, R. (2007) · Oncology · doi:10.1159/000113489 · Cited by 682 · see citing works
Brown, B. D., Gentner, B., Cantore, A., Colleoni, S., Amendola, M., Zingale, A., Baccarini, A., Lazzari, G., Galli, C., & Naldini, L. (2007) · Nature Biotechnology · doi:10.1038/nbt1372 · Cited by 556 · see citing works
Synthetic lethal metabolic targeting of cellular senescence in cancer therapy
Dörr, J. R., Yu, Y., Milanovic, M., Beuster, G., Zasada, C., Däbritz, J. H. M., Lisec, J., Lenze, D., Gerhardt, A., Schleicher, K., et al. (2013) · Nature · doi:10.1038/nature12437 · Cited by 541 · see citing works
Self-citationMiR-21 is an EGFR-regulated anti-apoptotic factor in lung cancer in never-smokers
Seike, M., Goto, A., Okano, T., Bowman, E. D., Schetter, A. J., Horikawa, I., Mathe, E. A., Jen, J., Yang, P., Sugimura, H., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0905234106 · Cited by 500 · see citing works
A universal RNAi-based logic evaluator that operates in mammalian cells
Rinaudo, K., Bleris, L. G., Maddamsetti, R., Subramanian, S., Weiss, R., & Benenson, Y. (2007) · Nature Biotechnology · doi:10.1038/nbt1307 · Cited by 483 · see citing works
miR-21 plays a pivotal role in gastric cancer pathogenesis and progression
Zhang, Z., Li, Z., Gao, C., Chen, P., Chen, J., Liu, W., Xiao, S., & Lu, H. (2008) · Laboratory Investigation · doi:10.1038/labinvest.2008.94 · Cited by 477 · see citing works
Self-citationMansfield, J., Harfe, B., Nissen, R., Obenauer, J., Srineel, J., Chaudhuri, A., Farzan-Kashani, R., Zuker, M., Pasquinelli, A., Ruvkun, G., et al. (2004) · Nature Genetics · doi:10.1038/ng1421 · Cited by 464 · see citing works
Huang, J., Bu, L., Xie, J., Chen, K., Cheng, Z., Li, X., & Chen, X. S. (2010) · ACS Nano · doi:10.1021/nn101643u · Cited by 463 · see citing works
Antonia, S. J., Mirza, N., Fricke, I., Chiappori, A., Thompson, P., Williams, N., Bepler, G., Simon, G., Janssen, W., Lee, J.-H., et al. (2006) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-05-2013 · Cited by 444 · see citing works
Kievit, F. M., Omid Veiseh, A., Bhattarai, N., Fang, C., Gunn, J., Lee, D., Ellenbogen, R. G., Olson, J. M., & Zhang, M. (2009) · Advanced Functional Materials · doi:10.1002/adfm.200801844 · Cited by 381 · see citing works
A review of nanocarriers for the delivery of small interfering RNA
Kesharwani, P., Gajbhiye, V., & Jain, N. K. (2012) · Biomaterials · doi:10.1016/j.biomaterials.2012.06.068 · Cited by 368 · see citing works
Micro RNA 145 Targets the Insulin Receptor Substrate-1 and Inhibits the Growth of Colon Cancer Cells
Shi, B., Sepp‐Lorenzino, L., di Prisco, M., Linsley, P. S., DeAngelis, T., & Baserga, R. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m702806200 · Cited by 349 · see citing works
Programmable and Multiparameter DNA-Based Logic Platform For Cancer Recognition and Targeted Therapy
You, M., Zhu, G., Chen, T., Donovan, M. J., & Tan, W. (2014) · Journal of the American Chemical Society · doi:10.1021/ja509263k · Cited by 281 · see citing works
Micromarkers: miRNAs in cancer diagnosis and prognosis
Ferracin, M., Veronese, A., & Negrini, M. (2010) · Expert Review of Molecular Diagnostics · doi:10.1586/erm.10.11 · Cited by 268 · see citing works
An optimized isolation and labeling platform for accurate microRNA expression profiling
Shingara, J., Keiger, K., Shelton, J., Laosinchai-Wolf, W., POWERS, P., Conrad, R. C., Brown, D., & Labourier, E. (2005) · RNA · doi:10.1261/rna.2610405 · Cited by 259 · see citing works
p53 and its isoforms in cancer
Bourdon, J. (2007) · British Journal of Cancer · doi:10.1038/sj.bjc.6603886 · Cited by 245 · see citing works
Zhu, L., Ma, J., Jia, N., Zhao, Y., & Shen, H. (2008) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2008.07.020 · Cited by 211 · see citing works
Real-Time Polymerase Chain Reaction MicroRNA Detection Based on Enzymatic Stem-Loop Probes Ligation
Li, J., Yao, B., Huang, H., Wang, Z., Sun, C., Fan, Y., Chang, Q., Li, S., Wang, X., & Xi, J. (2009) · Analytical Chemistry · doi:10.1021/ac900598d · Cited by 203 · see citing works
Recent Advances in p53 Research and Cancer Treatment
Suzuki, K., & Matsubara, H. (2011) · BioMed Research International · doi:10.1155/2011/978312 · Cited by 187 · see citing works
Liu, C., Liu, F., Feng, L., Li, M., Zhang, J., & Zhang, N. (2013) · Biomaterials · doi:10.1016/j.biomaterials.2012.12.038 · Cited by 168 · see citing works
Oh, I.-H., Min, H. S., Li, L., Tran, T. H., Lee, Y.-K., Kwon, I. C., Choi, K., Kim, K., & Huh, K. M. (2013) · Biomaterials · doi:10.1016/j.biomaterials.2013.05.017 · Cited by 148 · see citing works
Ostenfeld, M. S., Bramsen, J. B., Lamy, P., Villadsen, S. B., Fristrup, N., Sørensen, K. D., Ulhøi, B. P., Borre, M., Kjems, J., Dyrskjøt, L., et al. (2009) · Oncogene · doi:10.1038/onc.2009.395 · Cited by 141 · see citing works
Kasturi, S. P., Sachaphibulkij, K., & Roy, K. (2005) · Biomaterials · doi:10.1016/j.biomaterials.2005.03.043 · Cited by 138 · see citing works
Yang, H., Hui, A., Pampalakis, G., Soleymani, L., Liu, F.-F., Sargent, E., & Kelley, S. (2009) · Angewandte Chemie · doi:10.1002/anie.200902577 · Cited by 130 · see citing works
Yang, H. Y., Hui, A. B., Pampalakis, G., Soleymani, L., Liu, F., Sargent, E. H., & Kelley, S. O. (2009) · Angewandte Chemie · doi:10.1002/ange.200902577 · Cited by 127 · see citing works
Construction of Nonbiofouling Surfaces by Polymeric Self-Assembled Monolayers
Jon, S., Seong, J., Khademhosseini, A., Tran, T.-N., Laibinis, P. E., & Langer, R. (2003) · Langmuir · doi:10.1021/la034839e · Cited by 125 · see citing works
Yoshizaki, Y., Yuba, E., Sakaguchi, N., Koiwai, K., Harada, A., & Kono, K. (2014) · Biomaterials · doi:10.1016/j.biomaterials.2014.05.077 · Cited by 121 · see citing works
Lee, C., Rennie, P. S., & Jia, W. W.-G. (2009) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-09-0051 · Cited by 110 · see citing works
Myc-modulated miR-9 makes more metastases
Khew‐Goodall, Y., & Goodall, G. J. (2010) · Nature Cell Biology · doi:10.1038/ncb0310-209 · Cited by 104 · see citing works
Long-term efficient gene delivery using polyethylenimine with modified Tat peptide
Yamano, S., Dai, J., Hanatani, S., Haku, K., Yamanaka, T., Ishioka, M., Takayama, T., Yuvienco, C., Khapli, S., Moursi, A. M., et al. (2013) · Biomaterials · doi:10.1016/j.biomaterials.2013.11.012 · Cited by 100 · see citing works
MicroRNA-9 up-regulation is involved in colorectal cancer metastasis via promoting cell motility
Zhu, L. W., Chen, H., Zhou, D., Li, D., Bai, R., Zheng, S. S., & Ge, W. (2011) · Medical Oncology · doi:10.1007/s12032-011-9975-z · Cited by 95 · see citing works
Electrostatic Self-Assembly of PEG Copolymers onto Porous Silica Nanoparticles
Thierry, B., Zimmer, L., McNiven, S. J., Finnie, K. S., Barbe, C., & Griesser, H. J. (2008) · Langmuir · doi:10.1021/la8007206 · Cited by 92 · see citing works
Tumor targeting RGD conjugated bio-reducible polymer for VEGF siRNA expressing plasmid delivery
Kim, H., Nam, K., & Kim, S. W. (2014) · Biomaterials · doi:10.1016/j.biomaterials.2014.05.021 · Cited by 87 · see citing works
Chen, B., Ren, Y., & Chen, B. (2012) · International Journal of Nanomedicine · doi:10.2147/ijn.s29357 · Cited by 85 · see citing works
Value of Current Chemotherapy and Surgery in Advanced and Metastatic Bladder Cancer
Racioppi, M., D’Agostino, D., Totaro, A., Pinto, F., Sacco, E., D’Addessi, A., Marangi, F., Palermo, G., & Bassi, P. (2012) · Urologia Internationalis · doi:10.1159/000335556 · Cited by 82 · see citing works
MicroRNA-21 accelerates hepatocyte proliferation in vitro via PI3K/Akt signaling by targeting PTEN
Bai, Y.-N., Yu, Z., Luo, L.-X., jiang, Y., Xia, Q., & Yong, Z. (2013) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2013.12.047 · Cited by 78 · see citing works
Lin, G., Zhu, W., Yang, L., Wu, J., Lin, B., Xu, Y., Cheng, Z., Xia, C., Gong, Q., Song, B., et al. (2014) · Biomaterials · doi:10.1016/j.biomaterials.2014.07.049 · Cited by 76 · see citing works
Wu, C., Lin, J., Hong, M. L. W., Choudhury, Y., Balani, P., Leung, D. S. Y., Dang, L. H., Zhao, Y. H., Zeng, J., & Wang, S. (2009) · Molecular Therapy · doi:10.1038/mt.2009.225 · Cited by 69 · see citing works
Gene Therapy Used in Cancer Treatment
Wirth, T. C., & Ylä‐Herttuala, S. (2014) · Biomedicines · doi:10.3390/biomedicines2020149 · Cited by 67 · see citing works
Prediction of individual response to anticancer therapy: historical and future perspectives
Unger, F. T., Witte, I., & David, K. A. (2014) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-014-1772-3 · Cited by 66 · see citing works
Yiu, H. H. P., Pickard, M. R., Olariu, C. I., Williams, S. R., Chari, D. M., & Rosseinsky, M. J. (2011) · Pharmaceutical Research · doi:10.1007/s11095-011-0632-1 · Cited by 62 · see citing works
Park, H., Tsutsumi, H., & Mihara, H. (2013) · Biomaterials · doi:10.1016/j.biomaterials.2013.03.049 · Cited by 54 · see citing works
Yiu, H. H. P., McBain, S. C., Haj, A. J. E., & Dobson, J. (2007) · Nanotechnology · doi:10.1088/0957-4484/18/43/435601 · Cited by 40 · see citing works
Yao, Y., Jin, S., Long, H., Yu, Y., Zhang, Z., Cheng, G., Xu, C., Ding, Y., Guan, Q., Li, N., et al. (2015) · Nucleic Acids Research · doi:10.1093/nar/gkv125 · Cited by 37 · see citing works
Self-citationThe role of radiotherapy in urinary bladder cancer: current status
Marta, G. N., Hanna, S. A., Gadia, R., Corrêa, S. F. M., da Silva, J. L. F., & Carvalho, H. D. A. (2012) · International braz j urol · doi:10.1590/s1677-55382012000200002 · Cited by 34 · see citing works
Yang, Huang, Horng, H.-E., Hong, & Yang (2012) · International Journal of Nanomedicine · doi:10.2147/ijn.s30061 · Cited by 27 · see citing works
A tetracycline expression system in combination with Sox9 for cartilage tissue engineering
Yao, Y., He, Y., Guan, Q., & Wu, Q. (2013) · Biomaterials · doi:10.1016/j.biomaterials.2013.11.043 · Cited by 22 · see citing works
Self-citationZhang, L., Fan, Y., & Wu, Y. (2013) · Biomaterials · doi:10.1016/j.biomaterials.2013.11.034 · Cited by 10 · see citing works
Flagged first, then by citations
2 of the 78 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Smart nanoparticles for cancer therapy
Sun, L., Liu, H., Ye, Y., Lei, Y., Islam, R., Tan, S., Tong, R., Miao, Y.-B., & Cai, L. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01642-x · Cited by 1,073 · see citing works
miRNA nanotherapeutics for cancer
Ganju, A., Khan, S., Hafeez, B. B., Behrman, S. W., Yallapu, M. M., Chauhan, S. C., & Jaggi, M. (2016) · Drug Discovery Today · doi:10.1016/j.drudis.2016.10.014 · Cited by 299 · see citing works
MicroRNA Therapeutics in Cancer: Current Advances and Challenges
Sayed, S. R. E., Cristante, J., Guyon, L., Denis, J., Chabre, O., & Cherradi, N. (2021) · Cancers · doi:10.3390/cancers13112680 · Cited by 211 · see citing works
Role of MicroRNA in Endothelial Dysfunction and Hypertension
Nemecz, M., Alexandru, N., Tanko, G., & Georgescu, A. (2016) · Current Hypertension Reports · doi:10.1007/s11906-016-0696-8 · Cited by 119 · see citing works
Chen, T., Yang, Z., Liu, C., Wang, L., Yang, J. H., Chen, L., & Li, W. (2018) · Cell Proliferation · doi:10.1111/cpr.12548 · Cited by 118 · see citing works
Li, G., Wu, F., Yang, H., Deng, X., & Yuan, Y. (2017) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2017.11.105 · Cited by 103 · see citing works
Li, X., Zeng, Z., Wang, J., Wu, Y., Chen, W., Zheng, L., Xi, T., Wang, A., & Lu, Y. (2019) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2019.109687 · Cited by 93 · see citing works
Non-viral nanocarriers for intracellular delivery of microRNA therapeutics
Bai, Z., Wei, J., Yu, C., Han, X., Qin, X., Zhang, C., Liao, W., Li, L., & Huang, W. (2019) · Journal of Materials Chemistry B · doi:10.1039/c8tb02946f · Cited by 91 · see citing works
Elgqvist, J. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18051102 · Cited by 80 · see citing works
Recent advances in nanotechnology approaches for non-viral gene therapy
Jiang, Y., Fan, M., Yang, Z., Liu, X., Xu, Z., Liu, S., Feng, G., Tang, S., Li, Z., Zhang, Y., et al. (2022) · Biomaterials Science · doi:10.1039/d2bm01001a · Cited by 74 · see citing works
Therapeutic strategies for miRNA delivery to reduce hepatocellular carcinoma
Roy, B., Ghose, S., & Biswas, S. (2021) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2021.04.006 · Cited by 60 · see citing works
Lei, L., Chen, C., Zhao, J., Wang, H., Guo, M., Zhou, Y., Luo, J., Zhang, J., & Xu, L. (2017) · Molecular Therapy — Nucleic Acids · doi:10.1016/j.omtn.2016.12.005 · Cited by 55 · see citing works
MicroRNA therapeutic delivery strategies: A review
Tian, H., Cheng, L., Liang, Y., Lei, H., Qin, M., Li, X., & Ren, Y. (2024) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2024.105430 · Cited by 45 · see citing works
Niazi, S. K., & Magoola, M. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252312883 · Cited by 27 · see citing works
Recent advances in novel miRNA mediated approaches for targeting breast cancer
Ahmadi, S. M., Amirkhanloo, S., Robati, R. Y., Ebrahimi, H., Pirhayati, F. H., Almalki, W. H., Ebrahimnejad, P., & Kesharwani, P. (2023) · Journal of drug targeting · doi:10.1080/1061186x.2023.2240979 · Cited by 20 · see citing works
Fabrication of advanced parenteral drug-delivery systems
Manchanda, S., Das, N., Chandra, A., Bandyopadhyay, S., & Chaurasia, S. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-814487-9.00002-8 · Cited by 17 · see citing works
Triple negative aggressive phenotype controlled by miR-135b and miR-365: new theranostics candidates
Bertoli, G. R., Cava, C., Corsi, F., Piccotti, F., Martelli, C., Ottobrini, L., Vaira, V., & Castiglioni, I. (2021) · Scientific Reports · doi:10.1038/s41598-021-85746-w · Cited by 15 · see citing works
Houri, H., Ghalavand, Z., Faghihloo, E., Fallah, F., & Mohammadi‐Yeganeh, S. (2019) · Journal of Cellular Physiology · doi:10.1002/jcp.29198 · Cited by 12 · see citing works
Orlandella, F. M., Auletta, L., Greco, A., Zannetti, A., & Salvatore, G. (2021) · Cancers · doi:10.3390/cancers13236020 · Cited by 7 · see citing works
Nanoparticle Based Delivery of miRNAs to Overcome Drug Resistance in Breast Cancer
Yalçın, S., & Gündüz, U. (2016) · Journal of Nanomedicine & Nanotechnology · doi:10.4172/2157-7439.1000414 · Cited by 6 · see citing works
Clinical Application of MicroRNAs in Breast Cancer Treatment
Hironaka‐Mitsuhashi, A., Takayama, S., Jimbo, K., Suto, A., Shimomura, A., & Ochiya, T. (2022) · Archives of Breast Cancer · doi:10.32768/abc.20229120-31 · Cited by 5 · see citing works
Pérez, J. M., Alessi, C., & Grzech-Wojciechowska, M. (2019) · Research in Veterinary Science · doi:10.1016/j.rvsc.2019.12.001 · Cited by 5 · see citing works
Approaches and applications in transdermal and transpulmonary gene drug delivery
Zhang, A., Zhang, X., Chen, J., Shi, X., Yu, X., He, Z., Sun, J., Sun, M., & Liu, Z. (2025) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2024.1519557 · Cited by 4 · see citing works
Moeinafshar, A., Nouri, M., Shokrollahi, N., Masrour, M., Behnam, A., Fateh, S. T., Sadeghi, H., Miryounesi, M., & Ghasemi, M. (2024) · Cancer Cell International · doi:10.1186/s12935-023-03203-2 · Cited by 4 · see citing works
MicroRNA nanoformulation: a promising approach to anti-tumour activity
Badal, A. K., Nayek, A., Dhar, R., & Karmakar, S. (2025) · Investigational New Drugs · doi:10.1007/s10637-025-01534-7 · Cited by 3 · see citing works
Electrochemical and Optical Detection of MicroRNAs as Biomarkers for Cancer Diagnosis
Zayani, R., Hassine, A. B., Rabti, A., Raouafi, A., & Raouafi, N. (2023) · BENTHAM SCIENCE PUBLISHERS eBooks · doi:10.2174/9789815079364123010016 · Cited by 2 · see citing works
Dual-regulatory miRNAs: master regulators and therapeutic targets in bone-metastatic breast cancer
Meng, F., Zhang, M., Pu, D., Shi, G., & Li, J. (2025) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2025.1680908 · Cited by 1 · see citing works
Lei, H., Shi, J., Teng, Y., Song, C., Zou, L., Ye, F., & Zhang, H. (2018) · Pathology - Research and Practice · doi:10.1016/j.prp.2018.11.005
Application of Nanotherapeutics in Cancer Treatment
Johari, A., Chhabra, P., & Tripathy, D. B. (2024) · BENTHAM SCIENCE PUBLISHERS eBooks · doi:10.2174/9789815256505124010008
Stimuli-Responsive Lipid Nanoparticles for Cancer Therapy
Umeyor, C. E., Negi, P., Andrew, E. C., Bairagi, G., & Patravale, V. B. (2026) · Springer eBooks · doi:10.1007/978-981-95-2744-1_7
MicroRNA: role in pathogenesis, problems of microRNA therapy, and future prospects
Kugaevskaya, E. V., Timoshenko, O. S., Gureeva, T. A., & Lisitsa, A. V. (2026) · Biomeditsinskaya Khimiya · doi:10.18097/pbmcr1705
- Authors
- Yu, Y., Yao, Y., Yan, H., Wang, R., Zhang, Z., Sun, X., Zhao, L., Ao, X., Xie, Z., & Wu, Q.
- Affiliations
- Tsinghua University (CN)
- Corresponding author
- Wu, Qiong
- Venue
- Molecular Therapy - Nucleic Acids
- Publisher
- Elsevier BV
- Published
- 2016
- Volume
- 5
- Pages
- e318
- ISSN
- 2162-2531 (ISSN-L)
- PMC
- PMC5014513
- OpenAlex
- W2346752463
- Cited by
- 31
- References
- 78
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 4 · 2023: 3 · 2022: 2 · 2021: 4 · 2019: 5 · 2018: 2 · 2017: 3 · 2016: 3
- FWCI
- 2.25
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Molecular Therapy — Nucleic Acids (publishedVersion, cc-by-nc-nd)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion, cc-by-nc-sa)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Interference and Gene Delivery
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
- Keywords
- microRNA, magnetic nanoparticles, tumor targeting, LacI repressor, reporter genes, miR-21, miR-145, miR-9, breast cancer, MCF-7 cells, polyethyleneimine, gene therapy, tumor markers, tumor growth inhibition
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
