The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.
Mesenchymal Stem Cell-derived Extracellular Vesicles: Toward Cell-free Therapeutic Applications
Open accessAbstract
Mesenchymal stem (stromal) cells (MSCs) are multipotent cells with the ability to differentiate into several cell types, thus serving as a cell reservoir for regenerative medicine. Much of the current interest in therapeutic application of MSCs to various disease settings can be linked to their immunosuppressive and anti-inflammatory properties. One of the key mechanisms of MSC anti-inflammatory effects is the secretion of soluble factors with paracrine actions. Recently it has emerged that the paracrine functions of MSCs could, at least in part, be mediated by extracellular vesicles (EVs). EVs are predominantly released from the endosomal compartment and contain a cargo that includes miRNA, mRNA, and proteins from their cells of origin. Recent animal model-based studies suggest that EVs have significant potential as a novel alternative to whole cell therapies. Compared to their parent cells, EVs may have a superior safety profile and can be safely stored without losing function. In this article, we review current knowledge related to the potential use of MSC-derived EVs in various diseases and discuss the promising future for EVs as an alternative, cell-free therapy.
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Cites
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Cited by
Exosomes: biogenesis, biologic function and clinical potential
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Mesenchymal stem cell-derived extracellular vesicles: novel frontiers in regenerative medicine
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Metadata
- Authors
- Rani, S., Ryan, A. E., Griffin, M. D., & Ritter, T.
- Venue
- Molecular Therapy
- Publisher
- Elsevier BV
- Published
- 2015-05
- Volume
- 23
- Issue
- 5
- Pages
- 812-823
- ISSN
- 1525-0016 (ISSN-L)
- OpenAlex
- W1967270924
- Cited by
- 1,227
- References
- 14
- FWCI
- 25.99
- Type
- journal article
- Language
- en
- Open access
- hybrid
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Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
