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Protein phosphatase 1 is a molecular constraint on learning and memory

Genoux, David, Haditsch, Ursula, Knobloch, Marlen, Michalon, Aubin, Storm, Daniel, Mansuy, Isabelle M.·2002·Nature

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Abstract

Repetition in learning is a prerequisite for the formation of accurate and long-lasting memory. Practice is most effective when widely distributed over time, rather than when closely spaced or massed. But even after efficient learning, most memories dissipate with time unless frequently used. The molecular mechanisms of these time-dependent constraints on learning and memory are unknown. Here we show that protein phosphatase 1 (PP1) determines the efficacy of learning and memory by limiting acquisition and favouring memory decline. When PP1 is genetically inhibited during learning, short intervals between training episodes are sufficient for optimal performance. The enhanced learning correlates with increased phosphorylation of cyclic AMP-dependent response element binding (CREB) protein, of Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) and of the GluR1 subunit of the AMPA receptor; it also correlates with CREB-dependent gene expression that, in control mice, occurs only with widely distributed training. Inhibition of PP1 prolongs memory when induced after learning, suggesting that PP1 also promotes forgetting. This property may account for ageing-related cognitive decay, as old mutant animals had preserved memory. Our findings emphasize the physiological importance of PP1 as a suppressor of learning and memory, and as a potential mediator of cognitive decline during ageing.

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Place navigation impaired in rats with hippocampal lesions
Morris, R. G. M., Garrud, P., Rawlins, J. N. P., & O'Keefe, J. (1982) · Nature · doi:10.1038/297681a0 · Cited by 6,340
Transcriptional Activation by Tetracyclines in Mammalian Cells
Gossen, M., Freundlieb, S., Bender, G., Müller, G., Hillen, W., & Bujard, H. (1995) · Science · doi:10.1126/science.7792603 · Cited by 2,488 · cited 1×
“13 ), were generated using the reversible tetracycline-controlled transactivator (rtTA) system under the control of the Ca 2p /calmodulin-dependent protein kinase α (CaMKIIα) promote”
Method
Cyclic AMP stimulates somatostatin gene transcription by phosphorylation of CREB at serine 133
Gonzalez, G. A., & Montminy, M. (1989) · Cell · doi:10.1016/0092-8674(89)90013-5 · Cited by 2,464
Control of memory formation through regulated expression of a CaMKII transgene
Mayford, M., Bach, M. E., Huang, Y.-Y., Wang, L., Hawkins, R. D., & Kandel, E. R. (1996) · Science · doi:10.1126/science.274.5293.1678 · Cited by 1,550
Protein synthesis and memory: A review.
Davis, H. P., & Squire, L. R. (1984) · Psychological Bulletin · doi:10.1037/0033-2909.96.3.518 · Cited by 1,505
CREB AND MEMORY
Silva, A. J., Kogan, J. H., Frankland, P. W., & Kida, S. (1998) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.21.1.127 · Cited by 1,462
A mechanism for the Hebb and the anti-Hebb processes underlying learning and memory.
Lisman, J. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.23.9574 · Cited by 1,127
Retrieval and reconsolidation: Toward a neurobiology of remembering
Sara, S. J. (2000) · Learning & Memory · doi:10.1101/lm.7.2.73 · Cited by 919
Induction of CRE-Mediated Gene Expression by Stimuli That Generate Long-Lasting LTP in Area CA1 of the Hippocampus
Impey, S., Mark, M., Villacres, E. C., Poser, S., Chavkin, C., & Storm, D. R. (1996) · Neuron · doi:10.1016/s0896-6273(00)80120-8 · Cited by 593
Self-citation
Untitled work
Lisman (2001) · doi:10.1016/s0896-6273(01)00364-6 · Cited by 480

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Zusman, M. (2004) · Physical Therapy Reviews · doi:10.1179/108331904225003973 · Cited by 73
β-Adrenergic receptor activation during distinct patterns of stimulation critically modulates the PKA-dependence of LTP in the mouse hippocampusPreprint
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Philips, G. T., Tzvetkova, E. I., & Carew, T. J. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.4262-07.2007 · Cited by 67
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Bickle, J., & Hardcastle, V. G. (2012) · Wiley eBooks · doi:10.1002/9780470015902.a0024144 · Cited by 66
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Seoane, A., Massey, P. V., Keen, H., Bashir, Z. I., & Brown, M. W. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.5199-08.2009 · Cited by 62
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Inoue, A., Sawatari, E., Hisamoto, N., Kitazono, T., Teramoto, T., Fujiwara, M., Matsumoto, K., & Ishihara, T. (2013) · Cell Reports · doi:10.1016/j.celrep.2013.02.019 · Cited by 59
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Self-citation
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Rajan, K. E., Jayakumar, P., & Singh, H. K. (2015) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2015/945217 · Cited by 55
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Sama, D. M., Abdul, H. M., Furman, J. L., Artiushin, I. A., Szymkowski, D. E., Scheff, S. W., & Norris, C. M. (2012) · PLoS ONE · doi:10.1371/journal.pone.0038170 · Cited by 54
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Bibb, J. A. (2003) · Neurosignals · doi:10.1159/000074620 · Cited by 54
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Structural and functional analysis of the apoptosis-associated tyrosine kinase (AATYK) family
Tomomura, M., Morita, N., Yoshikawa, F., Konishi, A., Akiyama, H., Furuichi, T., & Kamiguchi, H. (2007) · Neuroscience · doi:10.1016/j.neuroscience.2007.05.048 · Cited by 49
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Weber, W. (2003) · Nucleic Acids Research · doi:10.1093/nar/gng069 · Cited by 49
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Cooke, S. F., & Bliss, T. (2003) · Cellular and Molecular Life Sciences · doi:10.1007/s000180300000 · Cited by 48
Dynamic Properties of Regulatory Motifs Associated with Induction of Three Temporal Domains of Memory in Aplysia
Pettigrew, D. B., Smolen, P., Baxter, D. A., & Byrne, J. H. (2005) · Journal of Computational Neuroscience · doi:10.1007/s10827-005-6557-0 · Cited by 48
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Self-citation
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Schiapparelli, L., Rı́o, J. D., & Frechilla, D. (2005) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2005.03193.x · Cited by 48
Reversible blockade of experience-dependent plasticity by calcineurin in mouse visual cortex
Yang, Y., Fischer, Q. S., Zhang, Y., Baumgärtel, K., Mansuy, I. M., & Daw, N. W. (2005) · Nature Neuroscience · doi:10.1038/nn1464 · Cited by 47
Self-citation
Memory extinction entails the inhibition of the transcription factor NF-κB
Merlo, E., & Romano, A. (2008) · PLoS ONE · doi:10.1371/journal.pone.0003687 · Cited by 47
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Sharma, S. K. (2010) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2010.02.009 · Cited by 50
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Poon, C. H., Tse, L. S. R., & Lim, L. W. (2020) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.14373 · Cited by 47
Role of Hippocampal CaMKII in Serotonin 5-HT1A Receptor-Mediated Learning Deficit in Rats
Moyano, S., Rı́o, J. D., & Frechilla, D. (2004) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300504 · Cited by 46
Opposing effects of AMPA and 5-HT1A receptor blockade on passive avoidance and object recognition performance: Correlation with AMPA receptor subunit expression in rat hippocampus
Schiapparelli, L., Simón, A. M., del Rı́o, J. A., & Frechilla, D. (2006) · Neuropharmacology · doi:10.1016/j.neuropharm.2006.02.005 · Cited by 48
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Nordeen, K. W., & Nordeen, E. J. (2004) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1298.018 · Cited by 46
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Carpenter, S. K. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-809324-5.21054-7 · Cited by 52
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Kumar, A., & Foster, T. C. (2007) · CRC Press eBooks · doi:10.1201/9781420005523-10 · Cited by 46
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Moyano, S., Frechilla, D., & R�o, J. D. (2004) · Psychopharmacology · doi:10.1007/s00213-004-1816-8 · Cited by 45
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El‐Armouche, A., Wittköpper, K., Fuller, W., Howie, J., Shattock, M. J., & Pavlović, D. (2011) · The FASEB Journal · doi:10.1096/fj.11-184903 · Cited by 44
PP1 inhibition by Aβ peptide as a potential pathological mechanism in Alzheimer's disease
Vintém, A. P. B., Henriques, A. G., Silva, O. A. B. D. C. E., & Silva, E. F. D. C. E. (2008) · Neurotoxicology and Teratology · doi:10.1016/j.ntt.2008.11.001 · Cited by 45
Calcineurin contributes to spatial memory impairment induced by rapid eye movement sleep deprivation
Wang, G.-P., Huang, L., Wu, H., Zhang, L., You, Z.-D., & Zhao, Z. (2009) · Neuroreport · doi:10.1097/wnr.0b013e32832f0772 · Cited by 44
The Large Isoforms of A-Kinase Anchoring Protein 18 Mediate the Phosphorylation of Inhibitor-1 by Protein Kinase A and the Inhibition of Protein Phosphatase 1 Activity
Singh, A., Redden, J. M., Kapiloff, M. S., & Dodge‐Kafka, K. L. (2010) · Molecular Pharmacology · doi:10.1124/mol.110.065425 · Cited by 43
Actin‐associated neurabin–protein phosphatase‐1 complex regulates hippocampal plasticity
Hu, X. D., Huang, Q., Roadcap, D. W., Shenolikar, S., & Xia, H. (2006) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.04070.x · Cited by 43
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Wass, C., Pizzo, A., Sauce, B., Kawasumi, Y., Sturzoiu, T., Ree, F., Otto, T., & Matzel, L. D. (2013) · Learning & Memory · doi:10.1101/lm.031971.113 · Cited by 43
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McDonald, C. R., Cahill, L. S., Ho, K. T., Yang, J., Kim, H., Silver, K., Ward, P. A., Mount, H. T. J., Liles, W. C., Sled, J. G., et al. (2015) · PLoS Pathogens · doi:10.1371/journal.ppat.1005140 · Cited by 42
Cognitive performance and age-related changes in the hippocampal proteome
Freeman, W. M., VanGuilder, H. D., Bennett, C., & Sonntag, W. E. (2008) · Neuroscience · doi:10.1016/j.neuroscience.2008.12.004 · Cited by 42
LTP‐ and LTD‐inducing stimulations cause opposite changes in arc/arg3.1 mRNA level in hippocampal area CA1 in vivo
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Kang-Park, M.-H., Sarda, M. A., Jones, K. H., Moore, S. D., Shenolikar, S., Clark, S., & Wilson, W. A. (2003) · Journal of Neurophysiology · doi:10.1152/jn.01041.2001 · Cited by 41
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Yu, H., Lin, X., Wang, D., Zhang, Z., Guo, Y. M., Ren, X., Xu, B., Yuan, J., Liu, J., Spencer, P. S., et al. (2018) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2018.00074 · Cited by 40
Early dysregulation of hippocampal proteins in transgenic rats with Alzheimer's disease-linked mutations in amyloid precursor protein and presenilin 1
Vercauteren, F., Clerens, S., Roy, L., Hamel, N., Arckens, L., Vandesande, F., Alhonen, L. I., Jänne, J., Szyf, M., & Cuello, A. C. (2004) · Molecular Brain Research · doi:10.1016/j.molbrainres.2004.10.012 · Cited by 40
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Dunning, J., & During, M. J. (2003) · Expert Reviews in Molecular Medicine · doi:10.1017/s1462399403006707 · Cited by 39
Impairment of spatial learning and memory in ELKL Motif Kinase1 (EMK1/MARK2) knockout mice
Ségu, L., Pascaud, A., Costet, P., Darmon, M. Y., & Buhot, M.-C. (2006) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2006.10.014 · Cited by 39
Activation of septal 5‐HT1A receptors alters spatial memory encoding, interferes with consolidation, but does not affect retrieval in rats subjected to a water‐maze task
Koenig, J., Cosquer, B., & Cassel, J. (2007) · Hippocampus · doi:10.1002/hipo.20368 · Cited by 38
Localization of myosin phosphatase target subunit 1 in rat brain and in primary cultures of neuronal cells
Lontay, B., Serfözö, Z., Gergely, P., Ito, M., Hartshorne, D. J., & Erdődi, F. (2004) · The Journal of Comparative Neurology · doi:10.1002/cne.20273 · Cited by 38
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Authors: Genoux, D., Haditsch, U., Knobloch, M., Michalon, A., Storm, D., & Mansuy, I. M.
Affiliations: ETH Zurich (CH)
University of Washington (US)
Corresponding author: Mansuy, Isabelle M.
ORCID: Haditsch, Ursula
Knobloch, Marlen
Michalon, Aubin
Storm, Daniel
Mansuy, Isabelle M.
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 2002-08
Volume: 418
Issue: 6901
Pages: 970-975
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/nature00928
OpenAlex: W1992020799
Cited by: 472
References: 30
Citations by year: 2026: 4 · 2025: 9 · 2024: 18 · 2023: 7 · 2022: 16 · 2021: 17 · 2020: 15 · 2019: 16 · 2018: 15 · 2017: 10 · 2016: 22 · 2015: 21 · 2014: 24 · 2013: 26 · 2012: 21
FWCI: 15.36
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
RePEc: Research Papers in Economics (submittedVersion)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
Keywords: protein phosphatase 1, learning and memory, forgetting, memory consolidation, CREB phosphorylation, CaMKII, GluR1, AMPA receptors, cognitive decline, protein dephosphorylation
MeSH terms: Aging, Animals, Cognition, Discrimination, Psychological, Gene Expression Regulation, Hippocampus, Learning, Memory, Mice, Transgenic, Mutation, Phosphoprotein Phosphatases, Phosphorylation, Space Perception, Time Factors, Cyclic AMP Response Element-Binding Protein, Calcium-Calmodulin-Dependent Protein Kinases, Receptors, AMPA, Protein Subunits, Mice, Protein Phosphatase 1, Calcium-Calmodulin-Dependent Protein Kinase Type 2

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Protein phosphatase 1 is a molecular constraint on learning and memory

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