Dynamic Properties of Regulatory Motifs Associated with Induction of Three Temporal Domains of Memory in Aplysia

Memory - A century of consolidation

McGaugh, J. L. (2000) · Science · doi:10.1126/science.287.5451.248 · Cited by 4,250 · see citing works

Synaptic Plasticity and Memory: An Evaluation of the Hypothesis

Martin, S. J., Grimwood, P. D., & Morris, R. G. M. (2000) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.23.1.649 · Cited by 2,794 · see citing works

Function and regulation of CREB family transcription factors in the nervous system

Lonze, B. E., & Ginty, D. D. (2002) · Neuron · doi:10.1016/s0896-6273(02)00828-0 · Cited by 2,127 · see citing works

Protein synthesis and memory: A review.

Davis, H. P., & Squire, L. R. (1984) · Psychological Bulletin · doi:10.1037/0033-2909.96.3.518 · Cited by 1,505 · see citing works

Ultrasensitivity in the mitogen-activated protein kinase cascade.

Huang, C. Y., & Ferrell, J. E. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.19.10078 · Cited by 1,186 · see citing works

Genetic dissection of consolidated memory in Drosophila

Tully, T., Preat, T., Boynton, S. C., & Del Vecchio, M. (1994) · Cell · doi:10.1016/0092-8674(94)90398-0 · Cited by 924 · see citing works

A Requirement for the Mitogen-activated Protein Kinase Cascade in Hippocampal Long Term Potentiation

English, J. D., & Sweatt, J. D. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.31.19103 · Cited by 860 · see citing works

A Critical Period for Macromolecular Synthesis in Long-Term Heterosynaptic Facilitation in <i>Aplysia</i>

Montarolo, P. G., Goelet, P., Castellucci, V. F., Morgan, J., Kandel, E. R., & Schacher, S. (1986) · Science · doi:10.1126/science.3775383 · Cited by 769 · see citing works

Synapse-specific, long-term facilitation of aplysia sensory to motor synapses: a function for local protein synthesis in memory storage.

Martin, K. C., Casadio, A., Zhu, H.-X., Yaping, E., Rose, J. C., Chen, M. C., Bailey, C. H., & Kandel, E. R. (1997) · Cell · doi:10.1016/s0092-8674(00)80484-5 · Cited by 752 · see citing works

Injection of the cAMP-responsive element into the nucleus of Aplysia sensory neurons blocks long-term facilitation

Dash, P. K., Hochner, B., & Kandel, E. R. (1990) · Nature · doi:10.1038/345718a0 · Cited by 747 · see citing works

Toward a molecular definition of long-term memory storage

Bailey, C. H., Bartsch, D., & Kandel, E. R. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.24.13445 · Cited by 691 · see citing works

CREB required for the stability of new and reactivated fear memories

Kida, S., Josselyn, S. A., de Ortı́z, S. P., Kogan, J. H., Chévere-Torres, I., Masushige, S., & Silva, A. J. (2002) · Nature Neuroscience · doi:10.1038/nn819 · Cited by 624 · see citing works

Long-Term Sensitization of a Defensive Withdrawal Reflex in <i>Aplysia</i>

Pinsker, H. M., Hening, W. A., Carew, T. J., & Kandel, E. R. (1973) · Science · doi:10.1126/science.182.4116.1039 · Cited by 606 · see citing works

Tripping the switch fantastic: how a protein kinase cascade can convert graded inputs into switch-like outputs

Ferrell, J. E. (1996) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(96)20026-x · Cited by 591 · see citing works

Aplysia CREB2 represses long-term facilitation: Relief of repression converts transient facilitation into long-term functional and structural change

Bartsch, D., Ghirardi, M., Skehel, P. A., Karl, K. A., Herder, S. P., Chen, M., Bailey, C. H., & Kandel, E. R. (1995) · Cell · doi:10.1016/0092-8674(95)90213-9 · Cited by 572 · see citing works

Presynaptic facilitation revisited: state and time dependence

Byrne, J., & Kandel, E. R. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-02-00425.1996 · Cited by 549 · see citing works

Spatially Resolved Dynamics of cAMP and Protein Kinase A Subunits in Aplysia Sensory Neurons

Bacskai, B. J., Hochner, B., Mahaut‐Smith, M. P., Adams, S., Kaang, B., Kandel, E. R., & Tsien, R. Y. (1993) · Science · doi:10.1126/science.7682336 · Cited by 546 · see citing works

MAP Kinase Translocates into the Nucleus of the Presynaptic Cell and Is Required for Long-Term Facilitation in Aplysia

Martin, K. C., Michael, D., Rose, J. C., Barad, M., Casadio, A., Zhu, H., & Kandel, E. R. (1997) · Neuron · doi:10.1016/s0896-6273(00)80330-x · Cited by 545 · see citing works

Antisense oligodeoxynucleotide-mediated disruption of hippocampal cAMP response element binding protein levels impairs consolidation of memory for water maze training

Guzowski, J. F., & McGaugh, J. L. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.6.2693 · Cited by 481 · see citing works

Protein phosphatase 1 is a molecular constraint on learning and memory

Genoux, D., Haditsch, U., Knobloch, M., Michalon, A., Storm, D., & Mansuy, I. M. (2002) · Nature · doi:10.1038/nature00928 · Cited by 472 · see citing works

Reversible Inhibition of CREB/ATF Transcription Factors in Region CA1 of the Dorsal Hippocampus Disrupts Hippocampus-Dependent Spatial Memory

Pittenger, C., Huang, Y. Y., Paletzki, R. F., Bourtchouladze, R., Scanlin, H., Vronskaya, S., & Kandel, E. R. (2002) · Neuron · doi:10.1016/s0896-6273(02)00684-0 · Cited by 464 · see citing works

Long-Term Memory Is Facilitated by cAMP Response Element-Binding Protein Overexpression in the Amygdala

Josselyn, S. A., Shi, C., Carlezon, W. A., Neve, R. L., Nestler, E. J., & Davis, M. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-07-02404.2001 · Cited by 451 · see citing works

New life in an old idea: The synaptic plasticity and memory hypothesis revisited

Martin, S. J., & Morris, R. (2002) · Hippocampus · doi:10.1002/hipo.10107 · Cited by 440 · see citing works

A Neuronal Isoform of CPEB Regulates Local Protein Synthesis and Stabilizes Synapse-Specific Long-Term Facilitation in Aplysia

Si, K., Giustetto, M., Etkin, A., Hsu, R., Janisiewicz, A. M., Miniaci, M. C., Kim, J., Zhu, H., & Kandel, E. R. (2003) · Cell · doi:10.1016/s0092-8674(03)01021-3 · Cited by 432 · see citing works

CREB1 Encodes a Nuclear Activator, a Repressor, and a Cytoplasmic Modulator that Form a Regulatory Unit Critical for Long-Term Facilitation

Bartsch, D., Casadio, A., Karl, K. A., Serodio, P., & Kandel, E. R. (1998) · Cell · doi:10.1016/s0092-8674(00)81752-3 · Cited by 373 · see citing works

Ubiquitin C-Terminal Hydrolase Is an Immediate-Early Gene Essential for Long-Term Facilitation in Aplysia

Hegde, A. N., Inokuchi, K., Pei, W., Casadio, A., Ghirardi, M., Chain, D. G., Martin, K. C., Kandel, E. R., & Schwartz, J. H. (1997) · Cell · doi:10.1016/s0092-8674(00)80188-9 · Cited by 359 · see citing works

Monosynaptic connections made by the sensory neurons of the gill- and siphon-withdrawal reflex in <i>Aplysia</i> participate in the storage of long-term memory for sensitization

Frost, W. N., Castellucci, V. F., Hawkins, R. D., & Kandel, E. R. (1985) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.82.23.8266 · Cited by 334 · see citing works

A Model for Circadian Rhythms in Drosophila Incorporating the Formation of a Complex between the PER and TIM Proteins

Leloup, J., & Goldbeter, A. (1998) · Journal of Biological Rhythms · doi:10.1177/074873098128999934 · Cited by 316 · see citing works

N‐methyl‐D‐aspartate receptor signaling results in Aurora kinase‐catalyzed CPEB phosphorylation and αCaMKII mRNA polyadenylation at synapses

Huang, Y.-S., Jung, M.-Y., Sarkissian, M., & Richter, J. (2002) · EMBO Journal · doi:10.1093/emboj/21.9.2139 · Cited by 290 · see citing works

Depletion of serotonin in the nervous system of Aplysia reduces the behavioral enhancement of gill withdrawal as well as the heterosynaptic facilitation produced by tail shock

Glanzman, D. L., Mackey, S. L., Hawkins, R. D., Dyke, A. M., Lloyd, P. E., & Kandel, E. R. (1989) · Journal of Neuroscience · doi:10.1523/jneurosci.09-12-04200.1989 · Cited by 287 · see citing works

Dissection of memory formation: from behavioral pharmacology to molecular genetics

DeZazzo, J., & Tully, T. (1995) · Trends in Neurosciences · doi:10.1016/0166-2236(95)93905-d · Cited by 270 · see citing works

Both Protein Kinase A and Mitogen-Activated Protein Kinase Are Required in the Amygdala for the Macromolecular Synthesis-Dependent Late Phase of Long-Term Potentiation

Huang, Y.-Y., Martin, K. C., & Kandel, E. R. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-17-06317.2000 · Cited by 269 · see citing works

Genetic approaches to memory storage.

Mayford, M., & Kandel, E. (1999) · Trends in Genetics · doi:10.1016/s0168-9525(99)01846-6 · Cited by 260 · see citing works

Inhibitor of protein synthesis blocks longterm behavioral sensitization in the isolated gill‐withdrawal reflex of Aplysia

Castellucci, V. F., Blumenfeld, H., Goelet, P., & Kandel, E. R. (1989) · Journal of Neurobiology · doi:10.1002/neu.480200102 · Cited by 232 · see citing works

Ultrasensitivity in biochemical systems controlled by covalent modification. Interplay between zero-order and multistep effects.

Goldbeter, A., & Koshland, D. E. (1984) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)42619-6 · Cited by 230 · cited 1× · see citing works

A molecular mechanism for long-term sensitization in Aplysia

Greenberg, S. M., Castellucci, V. F., Bayley, H., & Schwartz, J. H. (1987) · Nature · doi:10.1038/329062a0 · Cited by 230 · see citing works

Regulatory subunits of cAMP-dependent protein kinases are degraded after conjugation to ubiquitin: a molecular mechanism underlying long-term synaptic plasticity.

Hegde, A. N., Goldberg, A. L., & Schwartz, J. H. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.16.7436 · Cited by 215 · see citing works

Memory fixation in the goldfish.

Agranoff, B. W., Davis, R. E., & Brink, J. J. (1965) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.54.3.788 · Cited by 214 · see citing works

A novel intermediate stage in the transition between short- and long-term facilitation in the sensory to motor neuron synapse of aplysia

Ghirardi, M., Montarolo, P. G., & Kandel, E. R. (1995) · Neuron · doi:10.1016/0896-6273(95)90297-x · Cited by 198 · see citing works

Two previously undescribed members of the mouse CPEB family of genes and their inducible expression in the principal cell layers of the hippocampus

Theis, M., Si, K., & Kandel, E. R. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1133424100 · Cited by 194 · see citing works

Long-Term Synaptic Facilitation in the Absence of Short-Term Facilitation in Aplysia Neurons

Emptage, N. J., & Carew, T. J. (1993) · Science · doi:10.1126/science.8211146 · Cited by 193 · see citing works

Short-term, intermediate-term, and long-term memories

Rosenzweig, M. R., Bennett, E. L., Colombo, P. J., Lee, D. W., & Serrano, P. A. (1993) · Behavioural Brain Research · doi:10.1016/0166-4328(93)90135-d · Cited by 189 · see citing works

Role of Transforming Growth Factor-β in Long-Term Synaptic Facilitation in Aplysia

Zhang, F., Endo, S., Cleary, L. J., Eskin, A., & Byrne, J. H. (1997) · Science · doi:10.1126/science.275.5304.1318 · Cited by 186 · see citing works

Mechanisms for Generating the Autonomous cAMP-Dependent Protein Kinase Required for Long-Term Facilitation in Aplysia

Chain, D. G., Casadio, A., Schacher, S., Hegde, A. N., Valbrun, M., Yamamoto, N., Goldberg, A. L., Bartsch, D., Kandel, E. R., & Schwartz, J. H. (1999) · Neuron · doi:10.1016/s0896-6273(00)80686-8 · Cited by 186 · see citing works

Molecular Mechanisms Underlying a Unique Intermediate Phase of Memory in Aplysia

Sutton, M. A., Masters, S. E., Bagnall, M. W., & Carew, T. J. (2001) · Neuron · doi:10.1016/s0896-6273(01)00342-7 · Cited by 178 · see citing works

Cellular Correlates of Long-Term Sensitization in<i>Aplysia</i>

Cleary, L. J., Lee, W. L., & Byrne, J. H. (1998) · The Journal of Neuroscience · doi:10.1523/jneurosci.18-15-05988.1998 · Cited by 178 · see citing works

Serotonin Release Evoked by Tail Nerve Stimulation in the CNS ofAplysia: Characterization and Relationship to Heterosynaptic Plasticity

Marinesco, S., & Carew, T. J. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-06-02299.2002 · Cited by 176 · see citing works

Long-Term Sensitization in Aplysia : Biophysical Correlates in Tail Sensory Neurons

Scholz, K. P., & Byrne, J. H. (1987) · Science · doi:10.1126/science.2433766 · Cited by 169 · see citing works

A High-Efficiency Protein Transduction System Demonstrating the Role of PKA in Long-Lasting Long-Term Potentiation

Matsushita, M., Tomizawa, K., Moriwaki, A., Li, S., Terada, H., & Matsui, H. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-16-06000.2001 · Cited by 167 · see citing works

Involvement of a Calcineurin Cascade in Amygdala Depotentiation and Quenching of Fear Memory

Lin, C.-H., Lee, C.-C., & Gean, P. (2003) · Molecular Pharmacology · doi:10.1124/mol.63.1.44 · Cited by 158 · see citing works

Repeated pulses of serotonin required for long-term facilitation activate mitogen-activated protein kinase in sensory neurons of Aplysia

Michael, D., Martin, K. C., Seger, R., Ning, M., Baston, R., & Kandel, E. R. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.4.1864 · Cited by 141 · see citing works

Parallel Molecular Pathways Mediate Expression of Distinct Forms of Intermediate-Term Facilitation at Tail Sensory–Motor Synapses in Aplysia

Sutton, M. A., & Carew, T. J. (2000) · Neuron · doi:10.1016/s0896-6273(00)81152-6 · Cited by 136 · see citing works

Active Site Mutations Define the Pathway for the Cooperative Activation of cAMP-Dependent Protein Kinase

Herberg, F. W., Taylor, S. S., & Dostmann, W. R. (1996) · Biochemistry · doi:10.1021/bi951647c · Cited by 135 · see citing works

Differential Induction of Long-Term Synaptic Facilitation by Spaced and Massed Applications of Serotonin at Sensory Neuron Synapses of <i>Aplysia californica</i>

Mauelshagen, J., Sherff, C. M., & Carew, T. J. (1998) · Learning &amp; Memory · doi:10.1101/lm.5.3.246 · Cited by 129 · see citing works

Serotonin Induces Temporally and Mechanistically Distinct Phases of Persistent PKA Activity in Aplysia Sensory Neurons

Müller, U., & Carew, T. J. (1998) · Neuron · doi:10.1016/s0896-6273(00)80660-1 · Cited by 128 · see citing works

Expression of a Peptide Inhibitor of Protein Phosphatase 1 Increases Phosphorylation and Activity of CREB in NIH 3T3 Fibroblasts

Alberts, A. S., Montminy, M., Shenolikar, S., & Feramisco, J. R. (1994) · Molecular and Cellular Biology · doi:10.1128/mcb.14.7.4398 · Cited by 128 · see citing works

Differential Role of Mitogen-Activated Protein Kinase in Three Distinct Phases of Memory for Sensitization in<i>Aplysia</i>

Sharma, S. K., Sherff, C. M., Shobe, J., Bagnall, M. W., Sutton, M. A., & Carew, T. J. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-09-03899.2003 · Cited by 125 · see citing works

Interaction between Amount and Pattern of Training in the Induction of Intermediate- and Long-Term Memory for Sensitization in <i>Aplysia</i>

Sutton, M. A., Ide, J., Masters, S. E., & Carew, T. J. (2002) · Learning &amp; Memory · doi:10.1101/lm.44802 · Cited by 125 · see citing works

Levels of Serotonin in the Hemolymph ofAplysiaAre Modulated by Light/Dark Cycles and Sensitization Training

Levenson, J. M., Byrne, J. H., & Eskin, A. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-18-08094.1999 · Cited by 121 · see citing works

Activation of a Tyrosine Kinase-MAPK Cascade Enhances the Induction of Long-Term Synaptic Facilitation and Long-Term Memory in Aplysia

Purcell, A. L., Sharma, S. K., Bagnall, M. W., Sutton, M. A., & Carew, T. J. (2003) · Neuron · doi:10.1016/s0896-6273(03)00030-8 · Cited by 119 · see citing works

Reversible inhibition of

Velumian, A. A., Zhang, L., Pennefather, P., & Carlen, P. L. (1996) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s004240050286 · Cited by 118 · see citing works

Multiple sensory neuronal correlates of site-specific sensitization in Aplysia

Walters, E. T. (1987) · Journal of Neuroscience · doi:10.1523/jneurosci.07-02-00408.1987 · Cited by 116 · see citing works

Membrane responses and changes in cAMP levels in Aplysia sensory neurons produced by serotonin, tryptamine, FMRFamide and small cardioactive peptideB (SCPB)

Ocorr, K. A., & Byrne, J. H. (1985) · Neuroscience Letters · doi:10.1016/0304-3940(85)90004-7 · Cited by 115 · see citing works

Multiple Serotonergic Mechanisms Contributing to Sensitization in Aplysia : Evidence of Diverse Serotonin Receptor SubtypesPreprint

Barbas, D., DesGroseillers, L., Castellucci, V. F., Carew, T. J., & Marinesco, S. (2003) · Learning & Memory · doi:10.1101/lm.66103 · Cited by 112 · see citing works

Intermediate and long-term memories of associative learning are differentially affected by transcriptionversustranslation blockers inLymnaea

Sangha, S., Scheibenstock, A., McComb, C., & Lukowiak, K. (2003) · Journal of Experimental Biology · doi:10.1242/jeb.00301 · Cited by 108 · see citing works

Dynamics of Induction and Expression of Long-Term Synaptic Facilitation inAplysia

Mauelshagen, J., PARKER, G., & Carew, T. J. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-22-07099.1996 · Cited by 103 · see citing works

The Neurobiology of Memory: Concepts, Findings, Trends

Neary, D. (1990) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.53.7.628-a · Cited by 94 · see citing works

Upregulation of cAMP Response Element-Mediated Gene Expression during Experience-Dependent Plasticity in Adult Neocortex

Barth, A. L., McKenna, M. A., Glazewski, S., Hill-Feltham, P., Impey, S., Storm, D. R., & Fox, K. D. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-11-04206.2000 · Cited by 93 · see citing works

Site-specific sensitization of defensive reflexes in Aplysia: a simple model of long-term hyperalgesia

Walters, E. T. (1987) · Journal of Neuroscience · doi:10.1523/jneurosci.07-02-00400.1987 · Cited by 92 · see citing works

Persistent activation of cAMP-dependent protein kinase by regulated proteolysis suggests a neuron-specific function of the ubiquitin system in Aplysia

Chain, D. G., Hegde, A., Yamamoto, N., Liu-Marsh, B., & Schwartz, J. H. (1995) · Journal of Neuroscience · doi:10.1523/jneurosci.15-11-07592.1995 · Cited by 86 · see citing works

Localized Neuronal Outgrowth Induced by Long-Term Sensitization Training in<i>Aplysia</i>

Wainwright, M. L., Zhang, H., Byrne, J. H., & Cleary, L. J. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-10-04132.2002 · Cited by 78 · see citing works

Induction of long-term facilitation in Aplysia sensory neurons by local application of serotonin to remote synapses.

Clark, G. A., & Kandel, E. R. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.23.11411 · Cited by 71 · see citing works

A regulatory subunit of the cAMP-dependent protein kinase down-regulated in aplysia sensory neurons during long-term sensitization

Bergold, P. J., Beushausen, S. A., Sacktor, T. C., Cheley, S., Bayley, H., & Schwartz, J. H. (1992) · Neuron · doi:10.1016/0896-6273(92)90304-v · Cited by 63 · see citing works

Long-term regulation of neuronal high-affinity glutamate and glutamine uptake in Aplysia

Levenson, J. M., Endo, S., Kategaya, L. S., Fernandez, R. I., Brabham, D. G., Chin, J., Byrne, J. H., & Eskin, A. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.220256497 · Cited by 59 · see citing works

Inhibition of calcineurin facilitates the induction of memory for sensitization in Aplysia : Requirement of mitogen-activated protein kinase

Sharma, S. K., Bagnall, M. W., Sutton, M. A., & Carew, T. J. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0830994100 · Cited by 57 · see citing works

cAMP Response Element-binding Protein Monomers Cooperatively Assemble to Form Dimers on DNA*

Wu, X.-L., Spiro, C., Owen, W. G., & McMurray, C. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.33.20820 · Cited by 49 · see citing works

The cytoplasmic polyadenylation element binding protein and polyadenylation of messenger RNA in Aplysia neurons

Liu, J., & Schwartz, J. H. (2002) · Brain Research · doi:10.1016/s0006-8993(02)03729-0 · Cited by 43 · see citing works

The Two Regulatory Subunits ofAplysiacAMP-Dependent Protein Kinase Mediate Distinct Functions in Producing Synaptic Plasticity

Liu, J., Hu, J., Schacher, S., & Schwartz, J. H. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.4331-03.2004 · Cited by 43 · see citing works

Protein Synthesis–Dependent and mRNA Synthesis–Independent Intermediate Phase of Memory in Hermissenda

Crow, T., Xue‐Bian, J., & Siddiqi, V. (1999) · Journal of Neurophysiology · doi:10.1152/jn.1999.82.1.495 · Cited by 41 · see citing works

Parallel somatic and synaptic processing in the induction of intermediate-term and long-term synaptic facilitation in Aplysia

Sherff, C. M., & Carew, T. J. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0402163101 · Cited by 40 · see citing works

Long-Term Enhancement but Not Short-Term inHermissendaIs Dependent upon mRNA Synthesis

Crow, T., Siddiqi, V., & Dash, P. K. (1997) · Neurobiology of Learning and Memory · doi:10.1006/nlme.1997.3779 · Cited by 38 · see citing works

The Neurobiology of Memory: Concepts, Findings, Trends

Logan, C., & Thompson, R. F. (1990) · Trends in Neurosciences · doi:10.1016/0166-2236(90)90126-u · Cited by 35 · see citing works

Bag cell extract inhibits tail-siphon withdrawal reflex, suppresses long-term but not short-term sensitization, and attenuates sensory-to- motor neuron synapses in Aplysia

Goldsmith, J., & Byrne, J. (1993) · Journal of Neuroscience · doi:10.1523/jneurosci.13-04-01688.1993 · Cited by 32 · see citing works

Expression of a Peptide Inhibitor of Protein Phosphatase 1 Increases Phosphorylation and Activity of CREB in NIH 3T3 Fibroblasts

Alberts, A. S., Montminy, M., Shenolikar, S., et al. (1994) · Molecular and Cellular Biology · doi:10.1128/mcb.14.7.4398-4407.1994 · Cited by 28 · see citing works

Role of protein phosphatases in the modulation of neuronal membrane currents

Ichinose, M., & Byrne, J. H. (1991) · Brain Research · doi:10.1016/0006-8993(91)90611-x · Cited by 27 · see citing works

Dissociation of Morphological and Physiological Changes Associated With Long-Term Memory in Aplysia

Wainwright, M. L., Byrne, J. H., & Cleary, L. J. (2004) · Journal of Neurophysiology · doi:10.1152/jn.00335.2004 · Cited by 26 · see citing works

Serotonin persistently activates the extracellular signal-related kinase in sensory neurons of Aplysia independently of cAMP or protein kinase C

Dyer, J. R., Manseau, F., Castellucci, V. F., & Sossin, W. S. (2003) · Neuroscience · doi:10.1016/s0306-4522(02)00566-3 · Cited by 18 · see citing works

Developmental Emergence of Long-Term Memory for Sensitization inAplysia

Wright, W. G., McCance, E. F., & Carew, T. J. (1996) · Neurobiology of Learning and Memory · doi:10.1006/nlme.1996.0031 · Cited by 10 · see citing works

The right time to learn: Mechanisms and optimization of spaced learning

Smolen, P., Zhang, Y., & Byrne, J. H. (2016) · Nature Reviews Neuroscience · doi:10.1038/nrn.2015.18 · Cited by 326 · see citing works

Serotonin and Brain: Evolution, Neuroplasticity, and Homeostasis

Azmitia, E. C. (2006) · International review of neurobiology · doi:10.1016/s0074-7742(06)77002-7 · Cited by 150 · see citing works

Computational design of enhanced learning protocols

Zhang, Y., Liu, R.-Y., Heberton, G. A., Smolen, P., Baxter, D. A., Cleary, L. J., & Byrne, J. H. (2012) · Nature Neuroscience · doi:10.1038/nn.2990 · Cited by 80 · see citing works

Protein degradation and memory formation

Fioravante, D., & Byrne, J. H. (2010) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2010.11.002 · Cited by 75 · see citing works

cAMP-response Elements in Aplysia creb1, creb2, and Ap-uch Promoters

Mohamed, H. A., Yao, W., Fioravante, D., Smolen, P. D., & Byrne, J. H. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m502541200 · Cited by 75 · see citing works

Dynamics of a Minimal Model of Interlocked Positive and Negative Feedback Loops of Transcriptional Regulation by cAMP-Response Element Binding Proteins

Song, H., Smolen, P. D., Av-Ron, E., Baxter, D. A., & Byrne, J. H. (2007) · Biophysical Journal · doi:10.1529/biophysj.106.096891 · Cited by 72 · see citing works

A Model of the Roles of Essential Kinases in the Induction and Expression of Late Long-Term Potentiation

Smolen, P., Baxter, D. A., & Byrne, J. H. (2006) · Biophysical Journal · doi:10.1529/biophysj.105.072470 · Cited by 61 · see citing works

Molecular computation in neurons: a modeling perspective

Bhalla, U. S. (2013) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2013.11.006 · Cited by 59 · see citing works

Memory

Reissner, K. J., Shobe, J. L., & Carew, T. J. (2006) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-006-6022-x · Cited by 44 · see citing works

Evolution of serotonin: sunlight to suicide

Azmitia, E. C. (2020) · Handbook of behavioral neuroscience · doi:10.1016/b978-0-444-64125-0.00001-3 · Cited by 42 · see citing works

Toward a better understanding on the role of prediction error on memory processes: From bench to clinic

Krawczyk, M. C., Fernández, R. S., Pedreira, M. E., & Boccia, M. M. (2016) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2016.12.011 · Cited by 40 · see citing works

Bifurcation and Singularity Analysis of a Molecular Network for the Induction of Long-Term Memory

Song, H., Smolen, P. D., Av-Ron, E., Baxter, D. A., & Byrne, J. H. (2006) · Biophysical Journal · doi:10.1529/biophysj.105.074500 · Cited by 34 · see citing works

Evolution of Serotonin: Sunlight to Suicide

Azmitia, E. C. (2010) · Handbook of behavioral neuroscience · doi:10.1016/s1569-7339(10)70069-2 · Cited by 31 · see citing works

Prediction and validation of a mechanism to control the threshold for inhibitory synaptic plasticity

Kitagawa, Y., Hirano, T., & Kawaguchi, S.-Y. (2009) · Molecular Systems Biology · doi:10.1038/msb.2009.39 · Cited by 32 · see citing works

Interlinked dual-time feedback loops can enhance robustness to stochasticity and persistence of memory

Smolen, P. D., Baxter, D. A., & Byrne, J. H. (2009) · Physical Review E · doi:10.1103/physreve.79.031902 · Cited by 27 · see citing works

Opportunities for multiscale computational modelling of serotonergic drug effects in Alzheimer's disease

Joshi, A., Wang, D., Watterson, S., McClean, P. L., Behera, C. K., Sharp, T., & Wong‐Lin, K. (2020) · Neuropharmacology · doi:10.1016/j.neuropharm.2020.108118 · Cited by 22 · see citing works

Beta-Boswellic Acid and Ethanolic Extract of Olibanum Regulating the Expression Levels of CREB-1 and CREB-2 Genes.

Jebelli, A., Khalaj‐Kondori, M., Bonyadi, M. J., Feizi, M. A. H., & Rahmati‐Yamchi, M. (2019) · PubMed Central · doi:10.22037/ijpr.2019.1100665 · Cited by 21 · see citing works

The sensitivity of memory consolidation and reconsolidation to inhibitors of protein synthesis and kinases: Computational analysisPreprint

Zhang, Y., Smolen, P., Baxter, D. A., & Byrne, J. H. (2010) · Learning & Memory · doi:10.1101/lm.1844010 · Cited by 20 · see citing works

Computational model of a positive BDNF feedback loop in hippocampal neurons following inhibitory avoidance trainingPreprint

Zhang, Y., Smolen, P. D., Alberini, C. M., Baxter, D. A., & Byrne, J. H. (2016) · Learning & Memory · doi:10.1101/lm.042044.116 · Cited by 20 · see citing works

The Rates of Protein Synthesis and Degradation Account for the Differential Response of Neurons to Spaced and Massed Training Protocols

Naqib, F., Farah, C. A., Pack, C. C., & Sossin, W. S. (2011) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1002324 · Cited by 17 · see citing works

Toward a multiscale modeling framework for understanding serotonergic function

Wong‐Lin, K., Wang, D., Moustafa, A. A., Cohen, J. Y., & Nakamura, K. (2017) · Journal of Psychopharmacology · doi:10.1177/0269881117699612 · Cited by 16 · see citing works

Quantitative description of the interactions among kinase cascades underlying long-term plasticity of Aplysia sensory neurons

Zhang, Y., Smolen, P. D., Cleary, L. J., & Byrne, J. H. (2021) · Scientific Reports · doi:10.1038/s41598-021-94393-0 · Cited by 16 · see citing works

Dynamic impact of temporal context of Ca2+ signals on inhibitory synaptic plasticity

Kawaguchi, S., Nagasaki, N., & Hirano, T. (2011) · Scientific Reports · doi:10.1038/srep00143 · Cited by 15 · see citing works

Synaptic Plasticity In Vitro and In Silico: Insights into an Intracellular Signaling Maze

Ajay, S. M., & Bhalla, U. S. (2006) · Physiology · doi:10.1152/physiol.00009.2006 · Cited by 13 · see citing works

Decomposing the Parameter Space of Biological Networks via a Numerical Discriminant Approach

Harrington, H. A., Mehta, D. B., Byrne, H. M., & Hauenstein, J. D. (2020) · Communications in computer and information science · doi:10.1007/978-3-030-41258-6_9 · Cited by 12 · see citing works

Comparing Theories for the Maintenance of Late LTP and Long-Term Memory: Computational Analysis of the Roles of Kinase Feedback Pathways and Synaptic Reactivation

Smolen, P. D., Baxter, D. A., & Byrne, J. H. (2020) · Frontiers in Computational Neuroscience · doi:10.3389/fncom.2020.569349 · Cited by 9 · see citing works

Stochastic modulation evidences a transitory EGF-Ras-ERK MAPK activity induced by PRMT5

Jurado, M., Castaño, Ó., & Zorzano, A. (2021) · Computers in Biology and Medicine · doi:10.1016/j.compbiomed.2021.104339 · Cited by 9 · see citing works

Multiscale Modeling and Synaptic Plasticity

Bhalla, U. S. (2014) · Progress in molecular biology and translational science · doi:10.1016/b978-0-12-397897-4.00012-7 · Cited by 8 · see citing works

A multifarious exploration of synaptic tagging and capture hypothesis in synaptic plasticity: Development of an integrated mathematical model and computational experiments

Khan, R., Kulasiri, D., & Samarasinghe, S. (2022) · Journal of Theoretical Biology · doi:10.1016/j.jtbi.2022.111326 · Cited by 8 · see citing works

From reversible to irreversible bistable switches via bifurcations in a gene regulatory network

Hao, L., Yang, Z., Shen, D., & Xing, M. (2020) · Physical Biology · doi:10.1088/1478-3975/ab7bf5 · Cited by 7 · see citing works

Dynamical Mechanisms for Gene Regulation Mediated by Two Noncoding RNAs in Long-Term Memory Formation

Hao, L., & Yang, Z. (2021) · Neural Plasticity · doi:10.1155/2021/6668389 · Cited by 6 · see citing works

Stochasticity and bifurcations in a reduced model with interlinked positive and negative feedback loops of CREB1 and CREB2 stimulated by 5-HT

Hao, L., Yang, Z., & Bi, Y. (2016) · Mathematical Biosciences · doi:10.1016/j.mbs.2016.01.009 · Cited by 6 · see citing works

Modeling suggests combined-drug treatments for disorders impairing synaptic plasticity via shared signaling pathways

Smolen, P. D., Wood, M. A., Baxter, D. A., & Byrne, J. H. (2020) · Journal of Computational Neuroscience · doi:10.1007/s10827-020-00771-4 · Cited by 4 · see citing works

Dynamics and Mechanisms of ERK Activation after Different Protocols that Induce Long-Term Synaptic Facilitation in Aplysia

Zhang, Y., Liu, R., Smolen, P. D., Cleary, L. J., & Byrne, J. H. (2022) · Oxford Open Neuroscience · doi:10.1093/oons/kvac014 · Cited by 5 · see citing works

Bifurcation analysis of a delay differential equation model associated with the induction of long-term memory

Hao, L., Yang, Z., & Lei, J. (2015) · Chaos Solitons & Fractals · doi:10.1016/j.chaos.2015.09.013 · Cited by 5 · see citing works

Synapse formation changes the rules for desensitization of PKC translocation inAplysia

Farah, C. A., Naqib, F., Weatherill, D. B., Pack, C. C., & Sossin, W. S. (2014) · European Journal of Neuroscience · doi:10.1111/ejn.12794 · Cited by 4 · see citing works

A singular value homotopy for finding critical parameter values

Collins, J. B., & Hauenstein, J. D. (2020) · Applied Numerical Mathematics · doi:10.1016/j.apnum.2020.11.009 · Cited by 4 · see citing works

Mathematical modeling and bistability analysis for synaptic tagging and synapse-specific long-term facilitation in Aplysia

Hao, L., & Yang, Z. (2021) · The European Physical Journal Special Topics · doi:10.1140/epjs/s11734-021-00341-4 · Cited by 2 · see citing works

Computational analysis of memory consolidation following inhibitory avoidance (IA) training in adult and infant rats: Critical roles of CaMKIIα and MeCP2

Zhang, Y., Smolen, P. D., Alberini, C. M., Baxter, D. A., & Byrne, J. H. (2022) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1010239 · Cited by 2 · see citing works

Dynamics and multi-scale modeling with time delays for three stages of synaptic facilitation

Hao, L., & Yang, Z. (2024) · Nonlinear Dynamics · doi:10.1007/s11071-024-09536-5 · Cited by 1 · see citing works

Electrocorticogram (ECoG)

He, B. J. (2015) · Encyclopedia of Computational Neuroscience · doi:10.1007/978-1-4614-6675-8_545 · Cited by 1 · see citing works

Extracellular Signal-Regulated Kinases, Models of

Neves, S. R. (2015) · Encyclopedia of Computational Neuroscience · doi:10.1007/978-1-4614-6675-8_188 · Cited by 1 · see citing works

and validation of a mechanism to control the threshold for inhibitory synaptic plasticity

Kitagawa, Y., Hirano, T., & Kawaguchi, S. (2009)

Models of Extracellular Signal-Regulated Kinases

Neves, S. R. (2013) · Encyclopedia of Computational Neuroscience · doi:10.1007/978-1-4614-7320-6_188-1

Extracellular Signal-Regulated Kinases, Models of

Neves, S. R. (2022) · Encyclopedia of Computational Neuroscience · doi:10.1007/978-1-0716-1006-0_188

Dynamics and mechanisms of ERK activation after different protocols that induce long-term facilitation in AplysiaPreprint

Zhang, Y., Liu, R.-Y., Smolen, P. D., Cleary, L. J., & Byrne, J. H. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.08.05.502983

Computational Analyses of Learning Networks

Baxter, D. A., Cataldo, E., & Byrne, J. H. (2013) · Handbook of behavioral neuroscience · doi:10.1016/b978-0-12-415823-8.00007-1

User Evaluation of Biospice

Av-Ron, E., & Byrne, J. H. (2006) · Defense Technical Information Center (DTIC)

Molecular Mechanisms Underlying a Unique Intermediate Phase of Memory in Aplysia

Sutton, M. A., Masters, S. E., Bagnall, M. W., & Carew, T. J. (2001) · Neuron · doi:10.1016/s0896-6273(01)00342-7 · Cited by 178 · see citing works

Bifurcation and Singularity Analysis of a Molecular Network for the Induction of Long-Term Memory

Song, H., Smolen, P. D., Av-Ron, E., Baxter, D. A., & Byrne, J. H. (2006) · Biophysical Journal · doi:10.1529/biophysj.105.074500 · Cited by 34 · see citing works

Local synaptic integration of mitogen-activated protein kinase and protein kinase A signaling mediates intermediate-term synaptic facilitation in Aplysia

Ye, X., Marina, A., & Carew, T. J. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1209956109 · Cited by 11 · see citing works

Dynamics and mechanisms of ERK activation after different protocols that induce long-term facilitation in AplysiaPreprint

Zhang, Y., Liu, R.-Y., Smolen, P. D., Cleary, L. J., & Byrne, J. H. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.08.05.502983

Dynamics and Mechanisms of ERK Activation after Different Protocols that Induce Long-Term Synaptic Facilitation in Aplysia

Zhang, Y., Liu, R., Smolen, P. D., Cleary, L. J., & Byrne, J. H. (2022) · Oxford Open Neuroscience · doi:10.1093/oons/kvac014 · Cited by 5 · see citing works