The DOI matches its Crossref record; 74 of the 74 references it cites were found in a registry or an index.
The immunopathogenesis of sepsis
Abstract
Sepsis is a condition that results from a harmful or damaging host response to infection. Many of the components of the innate immune response that are normally concerned with host defences against infection can, under some circumstances, cause cell and tissue damage and hence multiple organ failure, the clinical hallmark of sepsis. Because of the high mortality of sepsis in the face of standard treatment, many efforts have been made to improve understanding of the dysregulation of the host response in sepsis. As a result, much has been learnt of the basic principles governing bacterial-host interactions, and new opportunities for therapeutic intervention have been revealed.
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“Systemic production of IL-10 following the onset of a cytokine storm is a marker of a counter-anti-inflammatory response that has been termed “immunoparalysis,” in that it is associated with downregulation of neutrophil and monocyte function in the systemic circulation (32,42,49).”
From Into the Eye of the Cytokine Storm (2012) · cites this paper as [32]
Citations
Cites
Early goal-directed therapy in the treatment of severe sepsis and septic shock
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Defective LPS Signaling in C3H/HeJ and C57BL/10ScCr Mice: Mutations in Tlr4 Gene
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A human homologue of the Drosophila Toll protein signals activation of adaptive immunity
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Efficacy and Safety of Recombinant Human Activated Protein C for Severe Sepsis
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CD14, a Receptor for Complexes of Lipopolysaccharide (LPS) and LPS Binding Protein
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Autonomic regulation of liver regeneration after partial hepatectomy in mice
Ikeda, O., Ozaki, M., Murata, S., Matsuo, R., Nakano, Y., Watanabe, M., Hisakura, K., Myronovych, A., Kawasaki, T., Kohno, K., et al. (2009) · Journal of Surgical Research · doi:10.1016/j.jss.2008.02.059 · Cited by 32
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Hamburger, T., Broecker-Preuss, M., Hartmann, M., Schade, F. U., de Groot, H., & Petrat, F. (2013) · Journal of Surgical Research · doi:10.1016/j.jss.2013.01.024 · Cited by 28
Hareendran, S., Ramakrishna, B., & Jayandharan, G. R. (2016) · European Journal of Immunology · doi:10.1002/eji.201545867 · Cited by 10
Metadata
- Authors
- Cohen, J.
- Affiliations
- Brighton and Sussex Medical School (GB)
- Corresponding author
- Cohen, Jonathan
- ORCID
- Cohen, Jonathan
- Venue
- Nature
- Published
- 2002-12
- Volume
- 420
- Issue
- 6917
- Pages
- 885-891
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W2088220499
- Cited by
- 2,742
- References
- 74
- Citations by year
- 2026: 31 · 2025: 58 · 2024: 63 · 2023: 59 · 2022: 96 · 2021: 115 · 2020: 120 · 2019: 113 · 2018: 108 · 2017: 135 · 2016: 124 · 2015: 149 · 2014: 205 · 2013: 223 · 2012: 153
- FWCI
- 10.59
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Topics
- Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Sepsis Diagnosis and Treatment
- Life Sciences › Immunology and Microbiology › Immunology › Inflammation biomarkers and pathways
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Keywords
- sepsis, immunopathogenesis, innate immune response, host response to infection, multiple organ failure, host-bacteria interactions, sepsis mortality, therapeutic interventions
- MeSH terms
- Animals, Bacterial Infections, Host-Parasite Interactions, Humans, Inflammation, Multiple Organ Failure, Polymorphism, Genetic, Signal Transduction, Sepsis, Genetic Predisposition to Disease
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