The immunopathogenesis of sepsis

Early goal-directed therapy in the treatment of severe sepsis and septic shock

Rivers, E., Nguyen, B., Havstad, S., Ressler, J., Muzzin, A., Knoblich, B., Peterson, E., & Tomlanovich, M. (2001) · New England Journal of Medicine · doi:10.1056/nejmoa010307 · Cited by 10,743

Intensive insulin therapy in critically ill patients.

Van den Berghe, G., Wouters, P., Weekers, F., Verwaest, C., Bruyninckx, F., Schetz, M., Vlasselaers, D., Ferdinande, P., Lauwers, P., & Bouillon, R. (2001) · New England Journal of Medicine · doi:10.1056/nejmoa011300 · Cited by 9,977

Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care

Angus, D. C., Linde-Zwirble, W. T., Lidicker, J., Clermont, G., Carcillo, J., & Pinsky, M. R. (2001) · Critical Care Medicine · doi:10.1097/00003246-200107000-00002 · Cited by 8,503

Defective LPS Signaling in C3H/HeJ and C57BL/10ScCr Mice: Mutations in Tlr4 Gene

Poltorak, A., He, X., Smirnova, I., Liu, M.-Y., Huffel, C. V., Du, X., Birdwell, D., Alejos, E., Silva, M., Galanos, C., et al. (1998) · Science · doi:10.1126/science.282.5396.2085 · Cited by 7,631

A human homologue of the Drosophila Toll protein signals activation of adaptive immunity

Medzhitov, R., Preston-Hurlburt, P., & Janeway, C. A. J. (1997) · Nature · doi:10.1038/41131 · Cited by 6,137

Efficacy and Safety of Recombinant Human Activated Protein C for Severe Sepsis

Bernard, G. R., Vincent, J., Laterre, P., LaRosa, S. P., Dhainaut, J.-F., Lopez-Rodriguez, A., Steingrub, J. S., Garber, G. E., Helterbrand, J. D., Ely, E. W., et al. (2001) · New England Journal of Medicine · doi:10.1056/nejm200103083441001 · Cited by 6,124

CD14, a Receptor for Complexes of Lipopolysaccharide (LPS) and LPS Binding Protein

Wright, S. D., Ramos, R., Tobias, P. S., Ulevitch, R. J., & Mathison, J. C. (1990) · Science · doi:10.1126/science.1698311 · Cited by 3,996

Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components.

Takeuchi, O., Hoshino, K., Kawai, T., Sanjo, H., Takada, H., Ogawa, T., Takeda, K., & Akira, S. (1999) · Immunity · doi:10.1016/s1074-7613(00)80119-3 · Cited by 3,680

The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5

Hayashi, F., Smith, K. D., Ozinsky, A., Hawn, T. R., Yi, E. C., Goodlett, D. R., Eng, J. K., Akira, S., Underhill, D. M., & Aderem, A. A. (2001) · Nature · doi:10.1038/35074106 · Cited by 3,605

HMG-1 as a Late Mediator of Endotoxin Lethality in Mice

Wang, H., Bloom, O., Zhang, M., Vishnubhakat, J. M., Ombrellino, M., Che, J., Frazier, A., Yang, H., Ivanova, S., Borovikova, L. V., et al. (1999) · Science · doi:10.1126/science.285.5425.248 · Cited by 3,386

Protein-energy malnutrition decreases the expression of TLR-4/MD-2 and CD14 receptors in peritoneal macrophages and reduces the synthesis of TNF-α in response to lipopolysaccharide (LPS) in mice

Fock, R. A., Vinolo, M. A. R., Rocha, V., de Sá-Rocha, L. C., & Borelli, P. (2007) · Cytokine · doi:10.1016/j.cyto.2007.08.007 · Cited by 89

Host genetics and outcome in meningococcal disease: a systematic review and meta-analysis

Brouwer, M. C., Read, R. C., & van de Beek, D. (2010) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(10)70045-1 · Cited by 88

Neurodegenerative changes and neuroapoptosis induced by systemic lipopolysaccharide administration are reversed by dexmedetomidine treatment in mice

Ning, Q., Liu, Z., Wang, X., Zhang, R., Zhang, J., Yang, M., Sun, H., Han, F., Zhao, W., & Zhang, X. (2017) · Neurological Research · doi:10.1080/01616412.2017.1281197 · Cited by 88

Cytokine Removal in Extracorporeal Blood Purification: An in vitro Study

Harm, S., Schildböck, C., & Hartmann, J. (2019) · Blood Purification · doi:10.1159/000502680 · Cited by 88

A Cationic Metal–Organic Framework to Scavenge Cell-Free DNA for Severe Sepsis Management

Liu, F., Shu, S., Shao, D., Xiao, Y., Zhong, Y., Zhou, J., Quek, C. H., Wang, Y., Hu, Z., Liu, H., et al. (2021) · Nano Letters · doi:10.1021/acs.nanolett.0c04759 · Cited by 88

Lung inflammatory responses

Thacker, E. L. (2006) · Veterinary Research · doi:10.1051/vetres:2006011 · Cited by 88

Phospholipase D2 drives mortality in sepsis by inhibiting neutrophil extracellular trap formation and down-regulating CXCR2

Lee, S. K., Kim, S. D., Kook, M., Lee, H. Y., Ghim, J., Choi, Y., Zabel, B. A., Ryu, S. H., & Bae, Y. (2015) · The Journal of Experimental Medicine · doi:10.1084/jem.20141813 · Cited by 88

Toll-like receptor 2 plays a critical role in cardiac dysfunction during polymicrobial sepsis*

Zou, L., Feng, Y., Chen, Y.-J., Si, R., Shen, S., Zhou, Q., Ichinose, F., Scherrer‐Crosbie, M., & Chao, W. (2010) · Critical Care Medicine · doi:10.1097/ccm.0b013e3181d99e67 · Cited by 88

High-volume hemofiltration in adult burn patients with septic shock and acute kidney injury: a multicenter randomized controlled trial

for the Randomized controlled Evaluation of high-volume hemofiltration in adult burn patients with Septic shoCk and acUte kidnEy injury (RESCUE) Investigators, Chung, K. K., Coates, E. C., Smith, D. J., Karlnoski, R., Hickerson, W. L., Arnold-Ross, A., Mosier, M. M., Halerz, M. M., Sprague, A., et al. (2017) · Critical Care · doi:10.1186/s13054-017-1878-8 · Cited by 87

Microarray Analysis Identifies Changes in Inflammatory Gene Expression in Response to Amyloid-β Stimulation of Cultured Human Retinal Pigment Epithelial Cells

Kurji, K. H., Cui, J. Z., Lin, T. R., Harriman, D. I., Prasad, S. S., Kojic, L., & Matsubara, J. A. (2010) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.09-3622 · Cited by 90

Structural Origin of Endotoxin Neutralization and Antimicrobial Activity of a Lactoferrin-based Peptide

Japelj, B., Pristovšek, P., Majerle, A., & Jerala, R. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m500266200 · Cited by 87

Functional and genetic evidence that the Mal/TIRAP allele variant 180L has been selected by providing protection against septic shock

Ferwerda, B., Alonso, S., Banahan, K., McCall, M. B. B., Giamarellos‐Bourboulis, E. J., Ramakers, B. P., Mouktaroudi, M., Fain, P. R., Izagirre, N., Syafruddin, D., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0811273106 · Cited by 93

Combined dysfunctions of immune cells predict nosocomial infection in critically ill patients

Morris, A. C., Anderson, N., Brittan, M., Wilkinson, T. S., McAuley, D. F., Antonelli, J., McCulloch, C., Barr, L. C., Dhaliwal, K., Jones, R. O., et al. (2013) · British Journal of Anaesthesia · doi:10.1093/bja/aet205 · Cited by 87

Influence of Toll-Like Receptor 4, CD14, Tumor Necrosis Factor, and Interleukine-10 Gene Polymorphisms on Clinical Outcome in Japanese Critically Ill Patients

Nakada, T., Hirasawa, H., Oda, S., Shiga, H., Matsuda, K., Nakamura, M., Watanabe, E., Abe, R., Hatano, M., & Tokuhisa, T. (2005) · Journal of Surgical Research · doi:10.1016/j.jss.2005.05.020 · Cited by 87

Apoptotic cells suppress mast cell inflammatory responses via the CD300a immunoreceptor

Nakahashi-Oda, C., Tahara‐Hanaoka, S., Shoji, M., Okoshi, Y., Nakano-Yokomizo, T., Ohkohchi, N., Yasui, T., Kikutani, H., Honda, S.-I., Shibuya, K., et al. (2012) · The Journal of Experimental Medicine · doi:10.1084/jem.20120096 · Cited by 87

Circulating Interferon-gamma and White Matter Brain Damage in Preterm Infants

Pupp, I. H., Harling, S., Berg, A., Cilio, C., Hellström-Westas, L. K., & Ley, D. (2005) · Pediatric Research · doi:10.1203/01.pdr.0000182592.76702.e8 · Cited by 87

Wearable sweat sensing for prolonged, semicontinuous, and nonobtrusive health monitoring

Moonen, E. J. M., Haakma, J. R., Peri, E., Pelssers, E., Mischi, M., & den Toonder, J. M. J. (2020) · VIEW · doi:10.1002/viw.20200077 · Cited by 86

Inflammasome mRNA Expression in Human Monocytes during Early Septic Shock

Fahy, R. J., Exline, M. C., Gavrilin, M. A., Bhatt, N. Y., Besecker, B. Y., Sarkar, A., Hollyfield, J. L., Duncan, M., Nagaraja, H. N., Knatz, N. L., et al. (2008) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200703-418oc · Cited by 86

Improved survival of children with sepsis and purpura: effects of age, gender, and era

Maat, M., Buysse, C., Emonts, M., Spanjaard, L., Joosten, K. F. M., de Groot, R., & Hazelzet, J. A. (2007) · Critical Care · doi:10.1186/cc6161 · Cited by 86

The Significance and Regulatory Mechanisms of Innate Immune Cells in the Development of Sepsis

Luan, Y., Dong, N., Xie, M., Xiao, X., & Yao, Y.-M. (2013) · Journal of Interferon & Cytokine Research · doi:10.1089/jir.2013.0042 · Cited by 86

Phage-based delivery systems: engineering, applications, and challenges in nanomedicines

Wang, H., Yang, Y., Xu, Y. S., Chen, Y., Zhang, W., Liu, T., Chen, G., & Wang, K. (2024) · Journal of Nanobiotechnology · doi:10.1186/s12951-024-02576-4 · Cited by 94

Lipoproteins in Staphylococcus aureus Mediate Inflammation by TLR2 and Iron-Dependent Growth In Vivo

Schmaler, M., Nyffenegger, N., Ferracin, F., Landolt, L. Z., Biswas, L., Götz, F., & Landmann, R. M. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0804292 · Cited by 87

Potential utility of melatonin as an antioxidant during pregnancy and in the perinatal period

Aversa, S., Pellegrino, S., Barberi, I., Reiter, R. J., & Gitto, E. (2011) · The Journal of Maternal-Fetal & Neonatal Medicine · doi:10.3109/14767058.2011.573827 · Cited by 85

Effects of Continuous Erythropoietin Receptor Activator in Sepsis-Induced Acute Kidney Injury and Multi-Organ Dysfunction

Rodrigues, C. E., Sanches, T. R., Volpini, R. A., Shimizu, M. H. M., Semedo, P., Câmara, N. O. S., Seguro, A. C., & Andrade, L. (2012) · PLoS ONE · doi:10.1371/journal.pone.0029893 · Cited by 85

Dual functionality of interleukin‐1 family cytokines: implications for anti‐interleukin‐1 therapy

Luheshi, N., Rothwell, N. J., & Brough, D. (2009) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2009.00331.x · Cited by 87

Neuropeptide Y inhibits interleukin-1β-induced phagocytosis by microglial cells

Ferreira, R., Santos, T., Viegas, M. S., Cortes, L., Bernardino, L. I., Vieira, O. V., & Malva, J. O. (2011) · Journal of Neuroinflammation · doi:10.1186/1742-2094-8-169 · Cited by 85

Apolipoprotein A-I mimetic peptide treatment inhibits inflammatory responses and improves survival in septic rats

Zhang, Z., Datta, G., Zhang, Y., Miller, A. P., Mochon, P., Chen, Y.-F., Chatham, J. C., Anantharamaiah, G. M., & White, C. R. (2009) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01232.2008 · Cited by 85

Roles of TLR/MyD88/MAPK/NF-κB Signaling Pathways in the Regulation of Phagocytosis and Proinflammatory Cytokine Expression in Response to E. faecalis Infection

Zou, J., & Shankar, N. (2015) · PLoS ONE · doi:10.1371/journal.pone.0136947 · Cited by 87

Bacterial Clearance in Septic Mice Is Modulated by MCP-1/CCL2 and Nitric Oxide

Gomes, R. N., Teixeira-Cunha, M. G. A., Figueiredo, R. T., de Almeida, P. E., Alves, S. C., Bozza, P. T., Bozza, F. A., Bozza, M. T., Zimmerman, G. A., & Castro-Faria-Neto, H. C. (2012) · Shock · doi:10.1097/shk.0b013e31827802b5 · Cited by 87

Niacin attenuates lung inflammation and improves survival during sepsis by downregulating the nuclear factor-κB pathway*

Kwon, W. Y., Suh, G. J., Kim, K. S., & Kwak, Y. H. (2010) · Critical Care Medicine · doi:10.1097/ccm.0b013e3181feeae4 · Cited by 85

Neutrophil and Alveolar Macrophage-Mediated Innate Immune Control of Legionella pneumophila Lung Infection via TNF and ROS

Ziltener, P., Reinheckel, T., & Oxenius, A. (2016) · PLoS Pathogens · doi:10.1371/journal.ppat.1005591 · Cited by 84

Soluble MD-2 activity in plasma from patients with severe sepsis and septic shock

Pugin, J., Stern-Voeffray, S., Daubeuf, B., Matthay, M. A., Elson, G., & Dunn-Siegrist, I. (2004) · Blood · doi:10.1182/blood-2003-04-1290 · Cited by 84

Statins and sepsis.

Gao, F., Linhartova, L., Johnston, A. M., & Thickett, D. R. (2008) · British Journal of Anaesthesia · doi:10.1093/bja/aem406 · Cited by 83

β1-Adrenergic Inhibition Improves Cardiac and Vascular Function in Experimental Septic Shock*

Kimmoun, A., Louis, H., Kattani, N. A., Delemazure, J., Dessalles, N., Wei, C., Marie, P., Issa, K., & Lévy, B. (2015) · Critical Care Medicine · doi:10.1097/ccm.0000000000001078 · Cited by 83

Application of endotoxin and cytokine adsorption haemofilter in septic acute kidney injury due to Gram-negative bacterial infection

Shum, H., Chan, K., Kwan, M., & Yan, W. (2013) · Hong Kong Medical Journal · doi:10.12809/hkmj133910 · Cited by 83

How to Identify Systemic Sepsis-Induced Immunoparalysis

Monneret, G. (2005) · Cited by 82

Gallium Nanodroplets are Anti-Inflammatory without Interfering with Iron Homeostasis

Zhang, C., Yang, B., Biazik, J. M., Webster, R. F., Xie, W., Tang, J., Allioux, F., Abbasi, R., Mousavi, M., Goldys, E. M., et al. (2022) · ACS Nano · doi:10.1021/acsnano.1c10981 · Cited by 82

TLR4 Mediates LPS-Induced VEGF Expression in Odontoblasts

Botero, T. M., Shelburne, C. E., Holland, G. R., Hanks, C. T., & Nor, J. E. (2006) · Journal of Endodontics · doi:10.1016/j.joen.2006.03.018 · Cited by 82

Neutrophil infiltration during inflammation is regulated by PILRα via modulation of integrin activation

Wang, J., Shiratori, I., Uehori, J., Ikawa, M., & Arase, H. (2012) · Nature Immunology · doi:10.1038/ni.2456 · Cited by 83

Toll-like Receptors and Innate Immunity

Yuk, J., & Jo, E. (2011) · Journal of Bacteriology and Virology · doi:10.4167/jbv.2011.41.4.225 · Cited by 86

From frog integument to human skin: dermatological perspectives from frog skin biology

Haslam, I. S., Roubos, E. W., Mangoni, M. L., Yoshizato, K., Vaudry, H., Kloepper, J. E., Pattwell, D. M., MADERSON, P. F. A., & Paus, R. (2013) · Biological reviews/Biological reviews of the Cambridge Philosophical Society · doi:10.1111/brv.12072 · Cited by 82

Periodontal innate immune mechanisms relevant to atherosclerosis and obesity: Influence of periodontal disease on obesity and atherosclerosis

Zelkha, S. A., Freilich, R. W., & Amar, S. (2010) · Periodontology 2000 · doi:10.1111/j.1600-0757.2010.00358.x · Cited by 81

Dietary plant extracts improve immune responses and growth efficiency of pigs experimentally infected with porcine reproductive and respiratory syndrome virus1

Liu, Y., Che, T. M., Song, M., Lee, J. J., Almeida, J. A. S., Bravo, D., Alstine, W. G. V., & Pettigrew, J. E. (2013) · Journal of Animal Science · doi:10.2527/jas.2013-6495 · Cited by 81

T CELLS ARE POTENT EARLY MEDIATORS OF THE HOST RESPONSE TO SEPSIS

Kasten, K. R., Tschöp, J., Adediran, S., Hildeman, D. A., & Caldwell, C. C. (2010) · Shock · doi:10.1097/shk.0b013e3181e14c2e · Cited by 82

Preclinical Investigations Reveal the Broad-Spectrum Neutralizing Activity of Peptide Pep19-2.5 on Bacterial Pathogenicity Factors

Heinbockel, L., Sánchez-Gómez, S., de Tejada, G. M., Doemming, S., Brandenburg, J., Kaconis, Y., Hornef, M. W., Dupont, A., Marwitz, S., Goldmann, T., et al. (2013) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.02066-12 · Cited by 81

In Silico Identification and Biological Evaluation of Antimicrobial Peptides Based on Human Cathelicidin LL-37

Sigurðardóttir, Þ., Andersson, P., Davoudi, M., Malmsten, M., Schmidtchen, A., & Bodelsson, M. (2006) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.01583-05 · Cited by 81

Presymptomatic Prediction of Sepsis in Intensive Care Unit Patients

Lukaszewski, R. A., Yates, A., Jackson, M. C., Swingler, K. M., Scherer, J. M., Simpson, A. J. H., Sadler, P. J., McQuillan, P., Titball, R. W., Brooks, T. J. G., et al. (2008) · Clinical and Vaccine Immunology · doi:10.1128/cvi.00486-07 · Cited by 83

Bacteria-Instructed Click Chemistry between Functionalized Gold Nanoparticles for Point-of-Care Microbial Detection

Mou, X., Chen, X., Wang, J., Zhang, Z., Yang, Y., Shou, Z., Tu, Y., Du, X., Wu, C., Zhao, Y., et al. (2019) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.9b09279 · Cited by 81

Fitness Trade-Offs in Phage Cocktail-Resistant Salmonella enterica Serovar Enteritidis Results in Increased Antibiotic Susceptibility and Reduced Virulence

Gao, D., Ji, H., Wang, L., Li, X., Hu, D., Zhao, J., Wang, S., Pan, T., Li, X., & Qian, P. (2022) · Microbiology Spectrum · doi:10.1128/spectrum.02914-22 · Cited by 80

Neuropeptide Y inhibits interleukin‐1 beta‐induced microglia motility

Ferreira, R., Santos, T., Cortes, L., Cochaud, S., Agasse, F., Silva, A. P., Xapelli, S., & Malva, J. O. (2011) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2011.07541.x · Cited by 80

MicroRNA-146a Is Upregulated by and Negatively Regulates TLR2 Signaling

Quinn, E. M., Wang, J. H., O'Callaghan, G. P., & Redmond, H. P. (2013) · PLoS ONE · doi:10.1371/journal.pone.0062232 · Cited by 82

Human anti-microbial cathelicidin peptide LL-37 suppresses the LPS-induced apoptosis of endothelial cells

Suzuki, K., Murakami, T., Kuwahara‐Arai, K., Tamura, H., Hiramatsu, K., & Nagaoka, I. (2011) · International Immunology · doi:10.1093/intimm/dxq471 · Cited by 80

Milk Fat Globule Epidermal Growth Factor-Factor VIII Is Down-Regulated in Sepsis via the Lipopolysaccharide-CD14 Pathway

Komura, H., Miksa, M., Wu, R., Goyert, S. M., & Wang, P. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.182.1.581 · Cited by 80

Dexmedetomidine Alleviates Lipopolysaccharide-Induced Acute Kidney Injury by Inhibiting p75NTR-Mediated Oxidative Stress and Apoptosis

Wang, Z., Wu, J., Hu, Z., Luo, C., Wang, P., Zhang, Y., & Li, H. (2020) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2020/5454210 · Cited by 79

Inter-Alpha Inhibitor Protein Administration Improves Survival From Neonatal Sepsis in Mice

Singh, K., Zhang, L. X., Bendelja, K., Heath, R. D., Murphy, S. P., Sharma, S., Padbury, J. F., & Lim, Y. (2010) · Pediatric Research · doi:10.1203/pdr.0b013e3181e9fdf0 · Cited by 79

Bacterial Immune Evasion through Manipulation of Host Inhibitory Immune Signaling

Avondt, K. V., van Sorge, N. M., & Meyaard, L. (2015) · PLoS Pathogens · doi:10.1371/journal.ppat.1004644 · Cited by 79

Local Anesthetics Reduce Mortality and Protect against Renal and Hepatic Dysfunction in Murine Septic Peritonitis

Gallos, G., Jones, D. R., Nasr, S. H., Emala, C. W., & Lee, H. T. (2004) · Anesthesiology · doi:10.1097/00000542-200410000-00015 · Cited by 79

A cyanobacterial LPS antagonist prevents endotoxin shock and blocks sustained TLR4 stimulation required for cytokine expression

Macagno, A., Molteni, M., Rinaldi, A., Bertoni, F., Lanzavecchia, A., Rossetti, C., & Sallusto, F. (2006) · The Journal of Experimental Medicine · doi:10.1084/jem.20060136 · Cited by 79

Frataxin deficiency induces Schwann cell inflammation and death

Lu, C., Schoenfeld, R. A., Shan, Y., Tsai, H.-J., Hammock, B. D., & Cortopassi, G. A. (2009) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2009.07.011 · Cited by 79

Neutrophil extracellular traps induce IL-1β production by macrophages in combination with lipopolysaccharide

Hu, Z., Murakami, T., Tamura, H., Reich, J., Kuwahara‐Arai, K., Iba, T., Tabe, Y., & Nagaoka, I. (2017) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2017.2870 · Cited by 79

Splenectomy protects aged mice from injury after experimental stroke

Chauhan, A., Mamun, A. A., Spiegel, G., Harris, N., Zhu, L., & McCullough, L. D. (2017) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2017.09.022 · Cited by 81

The impact of immobilisation and inflammation on the regulation of muscle mass and insulin resistance: different routes to similar end‐points

Crossland, H., Skirrow, S., Puthucheary, Z., Constantin‐Teodosiu, D., & Greenhaff, P. L. (2018) · The Journal of Physiology · doi:10.1113/jp275444 · Cited by 84

Changes in the Novel Orphan, C5a Receptor (C5L2), during Experimental Sepsis and Sepsis in Humans

Huber-Lang, M. S., Sarma, J. V., Rittirsch, D., Schreiber, H. A., Weiss, M., Flierl, M. A., Younkin, E. M., Schneider, M., Suger-Wiedeck, H., Gebhard, F. T., et al. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.2.1104 · Cited by 80

Gene knockout of the KCNJ8‐encoded Kir6.1 K ATP channel imparts fatal susceptibility to endotoxemia

Kane, G. C., Lam, C., O’Cochlain, F., Hodgson, D. M., Reyes, S., Liu, X., Miki, T., Seino, S., Katušić, Z. S., & Terzic, A. (2006) · The FASEB Journal · doi:10.1096/fj.06-6349com · Cited by 79

Structure and reactivity of LpxD, the N -acyltransferase of lipid A biosynthesis

Buetow, L., Smith, T. K., Dawson, A., Fyffe, S., & Hunter, W. N. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0606356104 · Cited by 78

Combination Therapy with Milrinone and Esmolol for Heart Protection in Patients with Severe Sepsis: A Prospective, Randomized Trial

Wang, Z., Wu, Q., Nie, X., Guo, J., & Yang, C. (2015) · Clinical Drug Investigation · doi:10.1007/s40261-015-0325-3 · Cited by 78

Serum levels of inflammatory and regulatory cytokines in patients with hemorrhagic fever with renal syndrome

Saksida, A., Wraber, B., & Avšič‐Županc, T. (2011) · BMC Infectious Diseases · doi:10.1186/1471-2334-11-142 · Cited by 78

Obesity and inflammation in children

Schwarzenberg, S. J., & Sinaiko, A. R. (2006) · Paediatric Respiratory Reviews · doi:10.1016/j.prrv.2006.08.002 · Cited by 80

The Genotoxin Colibactin Exacerbates Lymphopenia and Decreases Survival Rate in Mice Infected With Septicemic Escherichia coli

Marcq, I., Martín, P., Payros, D., Ramos, G. C., Boury, M., Watrin, C., Nougayrède, J., Olier, M., & Oswald, É. (2014) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiu071 · Cited by 87

Hydrogen Sulfide and Neurogenic Inflammation in Polymicrobial Sepsis: Involvement of Substance P and ERK-NF-κB Signaling

Ang, S.-F., Moochhala, S., MacAry, P. A., & Bhatia, M. (2011) · PLoS ONE · doi:10.1371/journal.pone.0024535 · Cited by 78

Isoacteoside, a dihydroxyphenylethyl glycoside, exhibits anti‐inflammatory effects through blocking toll‐like receptor 4 dimerization

Gao, H., Cui, Y., Kang, N., Liu, X., Liu, Y., Zou, Y., Zhang, Z., Li, X., Yang, S., Li, J., et al. (2017) · British Journal of Pharmacology · doi:10.1111/bph.13912 · Cited by 78

CCR1 and CC Chemokine Ligand 5 Interactions Exacerbate Innate Immune Responses during Sepsis

Ness, T. L., Carpenter, K. J., Ewing, J. L., Gerard, C. J., Hogaboam, C. M., & Kunkel, S. L. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.173.11.6938 · Cited by 78

Dysregulated Inflammatory Response toCandida albicansin a C5-Deficient Mouse Strain

Mullick, A., Elias, M., Picard, S., Bourget, L., Jovcevski, O., Gauthier, S., Tuite, A. R., Harakidas, P., Bihun, C., Bernard Massie, B., et al. (2004) · Infection and Immunity · doi:10.1128/iai.72.10.5868-5876.2004 · Cited by 78

A novel ligand-independent peptide inhibitor of TREM-1 suppresses tumor growth in human lung cancer xenografts and prolongs survival of mice with lipopolysaccharide-induced septic shock

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Dimethyl fumarate and 4-octyl itaconate are anticoagulants that suppress Tissue Factor in macrophages via inhibition of Type I Interferon

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The ginsenoside metabolite compound K, a novel agonist of glucocorticoid receptor, induces tolerance to endotoxin‐induced lethal shock

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Resurrecting Inactive Antimicrobial Peptides from the Lipopolysaccharide Trap

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Endotoxemia causes central downregulation of sympathetic vasomotor tone in healthy humans

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Applications of Lipopolysaccharide Derived from Pantoea Agglomerans (IP-PA1) for Health Care Based on Macrophage Network Theory

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Ly6Chigh Monocytes Protect against Kidney Damage during Sepsis via a CX3CR1-Dependent Adhesion Mechanism

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Design, Synthesis, and Structure–Activity Relationship Study of Novel Indole-2-carboxamide Derivatives as Anti-inflammatory Agents for the Treatment of Sepsis

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Lipopolysaccharide-Induced CD300b Receptor Binding to Toll-like Receptor 4 Alters Signaling to Drive Cytokine Responses that Enhance Septic Shock

Voss, O. H., Murakami, Y., Peña, M., Lee, H., Tian, L., Margulies, D. H., Street, J. M., Yuen, P. S. T., Qi, C., Krzewski, K., et al. (2016) · Immunity · doi:10.1016/j.immuni.2016.05.005 · Cited by 77

Novel resveratrol-based flavonol derivatives: Synthesis and anti-inflammatory activity in vitro and in vivo

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Essential Role of STAT1 in Caspase-Independent Cell Death of Activated Macrophages through the p38 Mitogen-Activated Protein Kinase/STAT1/Reactive Oxygen Species Pathway

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Functional polymers as therapeutic agents: Concept to market place

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Recognition of LPS by TLR4: Potential for Anti-Inflammatory Therapies

Nijland, R., Hofland, T., & van Strijp, J. A. G. (2014) · Marine Drugs · doi:10.3390/md12074260 · Cited by 76

Prokaryotic selectivity and LPS-neutralizing activity of short antimicrobial peptides designed from the human antimicrobial peptide LL-37

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Inactivation of Transcription Factor Gene ACE2 in the Fungal Pathogen Candida glabrata Results in Hypervirulence

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Improved treatment of systemic blood infections using antibiotics with extracorporeal opsonin hemoadsorption

Didar, T. F., Cartwright, M. J., Rottman, M., Graveline, A. R., Gamini, N., Watters, A. L., Leslie, D. C., Mammoto, T., Rodas, M. J., Kang, J. H., et al. (2015) · Biomaterials · doi:10.1016/j.biomaterials.2015.07.046 · Cited by 75

Expression of the cyclooxygenase isoforms in the prodromal stage of black walnut-induced laminitis in horses

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Total tanshinones exhibits anti-inflammatory effects through blocking TLR4 dimerization via the MyD88 pathway

Gao, H., Liu, X., Sun, W. C., Kang, N., Liu, Y., Yang, S., Xu, Q., Wang, C., & Chen, X. (2017) · Cell Death and Disease · doi:10.1038/cddis.2017.389 · Cited by 75

Tocilizumab attenuates acute lung and kidney injuries and improves survival in a rat model of sepsis via down-regulation of NF-κB/JNK: a possible role of P-glycoprotein

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Anti-Inflammatory Effect of Wogonin on RAW 264.7 Mouse Macrophages Induced with Polyinosinic-Polycytidylic Acid

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Monoacylglycerol Lipase (MAGL) Inhibition Attenuates Acute Lung Injury in Mice

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Protection ofStaphylococcus aureus-infected septic mice by suppression of early acute inflammation and enhanced antimicrobial activity by ginsan

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Pulmonary Inflammation Triggered by Ricin Toxin Requires Macrophages and IL-1 Signaling

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New diagnostic strategy for sepsis-induced disseminated intravascular coagulation: a prospective single-center observational study

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A NOVEL SELECTIVE EXTRACORPOREAL INTERVENTION IN SEPSIS

Schefold, J. C., von Haehling, S., Corsepius, M., Pohle, C., Kruschke, P., Zuckermann, H., Volk, H., & Reinke, P. (2007) · Shock · doi:10.1097/shk.0b013e31804f5921 · Cited by 74

Toll-like receptor 3 plays a central role in cardiac dysfunction during polymicrobial sepsis*

Gao, M., Ha, T., Zhang, X., Liu, L., Wang, X., Kelley, J., Singh, K., Kao, R. L., Gao, X., Williams, D. L., et al. (2012) · Critical Care Medicine · doi:10.1097/ccm.0b013e3182535aeb · Cited by 73

A Role for Stefin B (Cystatin B) in Inflammation and Endotoxemia

Maher, K., Kokelj, B. J., Butinar, M., Mikhaylov, G., Manček‐Keber, M., Stoka, V., Vasiljeva, O. S., Turk, B., Grigoryev, S. A., & Kopitar‐Jerala, N. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.609396 · Cited by 73

A review on immunopathology of sepsis

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The pathogenesis and molecular biology of sepsis

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Host–Pathogen Interaction and Immune Dysregulation in Sepsis

Eser, F., & Oktay, Z. (2025) · doi:10.59537/saupress.2490

Society for Complexity in Acute Illness and Sepsis

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Host–pathogen interactions in sepsis

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