Cited by 2,742Sepsis Diagnosis and TreatmentInflammation biomarkers and pathwaysImmune Response and Inflammation

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The immunopathogenesis of sepsis

Cohen, Jonathan·2002·Nature

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Abstract

Sepsis is a condition that results from a harmful or damaging host response to infection. Many of the components of the innate immune response that are normally concerned with host defences against infection can, under some circumstances, cause cell and tissue damage and hence multiple organ failure, the clinical hallmark of sepsis. Because of the high mortality of sepsis in the face of standard treatment, many efforts have been made to improve understanding of the dysregulation of the host response in sepsis. As a result, much has been learnt of the basic principles governing bacterial-host interactions, and new opportunities for therapeutic intervention have been revealed.

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Authors: Cohen, J.
Affiliations: Brighton and Sussex Medical School (GB)
Corresponding author: Cohen, Jonathan
ORCID: Cohen, Jonathan
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 2002-12
Volume: 420
Issue: 6917
Pages: 885-891
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/nature01326
OpenAlex: W2088220499
Cited by: 2,742
References: 74
Citations by year: 2026: 31 · 2025: 58 · 2024: 63 · 2023: 59 · 2022: 96 · 2021: 115 · 2020: 120 · 2019: 113 · 2018: 108 · 2017: 135 · 2016: 124 · 2015: 149 · 2014: 205 · 2013: 223 · 2012: 153
FWCI: 10.59
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
RePEc: Research Papers in Economics (submittedVersion)
Topics: Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Sepsis Diagnosis and Treatment
Life Sciences › Immunology and Microbiology › Immunology › Inflammation biomarkers and pathways
Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Keywords: sepsis, immunopathogenesis, innate immune response, host response to infection, multiple organ failure, host-bacteria interactions, sepsis mortality, therapeutic interventions
MeSH terms: Animals, Bacterial Infections, Host-Parasite Interactions, Humans, Inflammation, Multiple Organ Failure, Polymorphism, Genetic, Signal Transduction, Sepsis, Genetic Predisposition to Disease

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